Influence of Surface Nano-Roughness on Osseointegration of Zirconia Implants in Rabbit Femur Heads Using Selective Infiltration Etching Technique

2013 ◽  
Vol 39 (5) ◽  
pp. 583-590 ◽  
Author(s):  
Moustafa N. Aboushelib ◽  
Noha A. Salem ◽  
Ahmed L. Abo Taleb ◽  
Naglaa M. Abd El Moniem
Keyword(s):  
Bone Density ◽  
White Male ◽  
Titanium Implants ◽  
Implant Surface ◽  
Etching Technique ◽  
Bone Implant ◽  
Bone Implant Contact ◽  
Zirconia Implants ◽  
Rabbit Femur ◽  
Zirconia Implant

This study evaluates osseous healing of selective infiltration-etched (SIE) zirconia implants compared to as-sintered zirconia and titanium implants. Twenty implants of each group were inserted in 40 adult New Zealand white male rabbits. After 4 and 6 weeks, bone blocks containing the implants were retrieved, sectioned, and processed to evaluate bone-implant contact (BIC) and peri-implant bone density. SIE zirconia implants had significantly higher BIC and marginally higher bone density. The results suggest that selective infiltration-etched zirconia implant surface may improve implant osseointegration.

scholarly journals Titanium Implants Coated with a Bifunctional Molecule with Antimicrobic Activity: A Rabbit Study

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3613 ◽  
Author(s):  
Antonio Scarano ◽  
Francesco Carinci ◽  
Tiziana Orsini ◽  
Luca Valbonetti ◽  
Erda Qorri ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Titanium Implants ◽  
P Value ◽  
Implant Surface ◽  
Bone Implant ◽  
Bifunctional Molecule ◽  
Significant Difference ◽  
Bone Implant Contact ◽  
Antimicrobic Activity

Background: Various surface treatments have been tested for titanium implants aiming at increasing their surface biocompatibility and their biological characteristics, but also the efficiency of the implant surface will have to be improved to drastically decrease peri-implantite and mucosite. In fact, the peri-implantitis and peri-implant mucositis have a high incidence in clinical practice. The nanofabrication techniques that offer the possibility to achieve the implant surface that reduces bacterial colonization could influence the osteointegration. The aim of this research was to evaluate the bone response to titanium implants coated with a bifunctional molecule with antimicrobic activity consisting of a combination of silver ions covalently bound to titanium dioxide nanoparticles. Methods: A total of 36 implants were inserted into 18 older New Zealand white male rabbits. They had two different surfaces. The implants Control group was characterized by an acid-etched and sandblasted surface treatment, and the Test implants had an acid-etched and sandblasted surface coated with a silver ion covalently bound to titanium dioxide nanoparticles in the solution. Results: No statistically significant difference of the bone density was evidenced between Control and Test implants at two weeks (p-value = 0.623), four weeks (p-value = 0.339), and eight weeks (p-value = 0.461). Moreover, no statistically significant difference of the bone-implant contact percentage was evidenced between Control and Test implants at two weeks (p-value = 0.938), four weeks (p-value = 0.307), and eight weeks (p-value = 0.294). The effectiveness of the present investigation demonstrated no adverse effects on osseointegration, and no statistically significant differences were observed in the bone density and percentage of bone-implant contact between Test and Control implants at all the experimental time points (two, four, and eight weeks). Conclusions: Titanium implants coated with the silver-anatase solution bind very well to the bone and did not have an adverse effect on the bone tissue in a rabbit model. These facts suggest possible clinical applications for the silver composition.

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

scholarly journals Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Warwick J. Duncan ◽  
Min-Ho Lee ◽  
Tae-Sung Bae ◽  
Sook-Jeong Lee ◽  
Jennifer Gay ◽  
...  
Keyword(s):  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Stability ◽  
Bone Implant ◽  
Implant Stability Quotient ◽  
Phosphate Ions ◽  
Surface Control ◽  
Bone Implant Contact ◽  
The Subject ◽  
Clinically Significant

Spark discharge anodic oxidation forms porous TiO2films on titanium implant surfaces. This increases surface roughness and concentration of calcium and phosphate ions and may enhance early osseointegration. To test this, forty 3.75 mm × 13 mm titanium implants (Megagen, Korea) were placed into healed mandibular postextraction ridges of 10 sheep. There were 10 implants per group: RBM surface (control), RBM + anodised, RBM + anodised + fluoride, and titanium alloy + anodised surface. Resonant frequency analysis (RFA) was measured in implant stability quotient (ISQ) at surgery and at sacrifice after 1-month unloaded healing. Mean bone-implant contact (% BIC) was measured in undemineralised ground sections for the best three consecutive threads. One of 40 implants showed evidence of failure. RFA differed between groups at surgery but not after 1 month. RFA values increased nonsignificantly for all implants after 1 month, except for controls. There was a marked difference in BIC after 1-month healing, with higher values for alloy implants, followed by anodised + fluoride and anodised implants. Anodisation increased early osseointegration of rough-surfaced implants by 50–80%. RFA testing lacked sufficient resolution to detect this improvement. Whether this gain in early bone-implant contact is clinically significant is the subject of future experiments.

Histologic Evaluation of a Provisional Implant Retrieved From Man 7 Months After Placement in a Sinus Augmented With Calcium Sulphate: A Case Report

2007 ◽  
Vol 33 (2) ◽  
pp. 89-95 ◽  
Author(s):  
Giovanna Iezzi ◽  
Elisabetta Fiera ◽  
Antonio Scarano ◽  
Gabriele Pecora ◽  
Adriano Piattelli
Keyword(s):  
Close Contact ◽  
Calcium Sulphate ◽  
Titanium Implants ◽  
Implant Surface ◽  
Sinus Augmentation ◽  
Bone Implant ◽  
Native Bone ◽  
Osteocyte Lacunae ◽  
Histologic Evaluation

Abstract Little is known about the in vivo healing processes at the interface of implants placed in different grafting materials. For optimal sinus augmentation, a bone graft substitute that can regenerate high-quality bone and enable the osseointegration of load-bearing titanium implants is needed in clinical practice. Calcium sulphate (CaS) is one of the oldest biomaterials used in medicine, but few studies have addressed its use as a sinus augmentation material in conjunction with simultaneous implant placement. The aim of the present study was to histologically evaluate an immediately loaded provisional implant retrieved 7 months after simultaneous placement in a human sinus grafted with CaS. During retrieval bone detached partially from one of the implants which precluded its use for histologic analysis. The second implant was completely surrounded by native and newly formed bone, and it underwent histologic evaluation. Lamellar bone, with small osteocyte lacunae, was present and in contact with the implant surface. No gaps, epithelial cells, or connective tissues were present at the bone–implant interface. No residual CaS was present. Bone–implant contact percentage was 55% ± 8%. Of this percentage, 40% was represented by native bone and 15% by newly formed bone. CaS showed complete resorption and new bone formation in the maxillary sinus; this bone was found to be in close contact with the implant surface after immediate loading.

Histologic Evaluation of Human Bone Integration on Machined and Sandblasted Acid-etched Titanium Surfaces in Type IV Bone

2007 ◽  
Vol 33 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Sauro Grassi ◽  
Adriano Piattelli ◽  
Daniel S. Ferrari ◽  
Luciene C. Figueiredo ◽  
Magda Feres ◽  
...  
Keyword(s):  
Pure Titanium ◽  
Surrounding Tissue ◽  
Commercially Pure Titanium ◽  
Machined Surface ◽  
Implant Surface ◽  
Bone Implant ◽  
Healing Period ◽  
Posterior Maxilla ◽  
Bone Implant Contact ◽  
Etched Surface

Abstract The aim of this preliminary study was to evaluate the influence of a sandblasted acid-etched surface on bone-implant contact percentage (BIC%) as well as the bone density in the threads area (BD%) in type 4 bone after 2 months of unloaded healing. Five subjects (mean age = 42.6 years) received 2 microimplants each during conventional implant surgery in the posterior maxilla. The microimplants with commercially pure titanium surface (machined) and sandblasted acid-etched surface served as the control and test surfaces, respectively. After a healing period of 2 months, the microimplants and the surrounding tissue were removed and prepared for ground sectioning and histomorphometric analysis. One microimplant with a machined surface was found to be clinically unstable at the time of retrieval. Histometric evaluation indicated mean BIC% was 20.66 ± 14.54% and 40.08 ± 9.89% for machined and sandblasted acid-etched surfaces, respectively (P = .03). The BD% was 26.33 ± 19.92% for machined surface and 54.84 ± 22.77% for sandblasted acid-etched surface (P = .015). Within the limits of this study, the data suggest that the sandblasted acid-etched implant surface presented a higher percentage of bone-implant contact compared with machined surfaces, under unloaded conditions in posterior maxilla after a healing period of 2 months.

Does surface anodisation of titanium implants change osseointegration and make their extraction from bone any easier?

2008 ◽  
Vol 21 (03) ◽  
pp. 202-210 ◽  
Author(s):  
J. Langhoff ◽  
J. Mayer ◽  
L. Faber ◽  
S. Kaestner ◽  
G. Guibert ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
High Bone ◽  
Titanium Surfaces ◽  
Anodized Titanium ◽  
Titanium Implant Surface

Summary Objectives: Titanium implants have a tendency for high bone-implant bonding, and, in comparison to stainless steel implants are more difficult to remove. The current study was carried out to evaluate, i) the release strength of three selected anodized titanium surfaces with increased nanohardness and low roughness, and ii) bone-implant bonding in vivo. These modified surfaces were intended to give improved anchorage while facilitating easier removal of temporary implants. Material and methods: The new surfaces were referenced to a stainless steel implant and a standard titanium implant surface (TiMAX™). In a sheep limb model, healing period was 3 months. Bone-implant bonding was evaluated either biomechanically or histologically. Results: The new surface anodized screws demonstrated similar or slightly higher bone-implantcontact (BIC) and torque release forces than the titanium reference. The BIC of the stainless steel implants was significant lower than two of the anodized surfaces (p=0.04), but differences between stainless steel and all titanium implants in torque release forces were not significant (p=0.06). Conclusion: The new anodized titanium surfaces showed good bone-implant bonding despite a smooth surface and increased nanohardness. However, they failed to facilitate implant removal at 3 months.

Classification and Effects of Implant Surface Modification on the Bone: Human Cell–Based In Vitro Studies

2017 ◽  
Vol 43 (1) ◽  
pp. 58-83 ◽  
Author(s):  
Miriam Ting ◽  
Steven R. Jefferies ◽  
Wei Xia ◽  
Håkan Engqvist ◽  
Jon B. Suzuki
Keyword(s):  
Surface Modification ◽  
Human Cell ◽  
Surface Characterization ◽  
Implant Surface ◽  
Bone Implant ◽  
Oral Environment ◽  
Bone Implant Contact ◽  
Functional Loading

Implant surfaces are continuously being improved to achieve faster osseointegration and a stronger bone to implant interface. This review will present the various implant surfaces, the parameters for implant surface characterization, and the corresponding in vitro human cell–based studies determining the strength and quality of the bone-implant contact. These in vitro cell-based studies are the basis for animal and clinical studies and are the prelude to further reviews on how these surfaces would perform when subjected to the oral environment and functional loading.

Advanced Glycation Endproducts and Rat Dental Implant Osseointegration

2010 ◽  
Vol 36 (2) ◽  
pp. 97-103 ◽  
Author(s):  
David G. Quintero ◽  
Julia N. Winger ◽  
Rania Khashaba ◽  
James L. Borke
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Marker ◽  
Advanced Glycation Endproducts ◽  
Biomechanical Properties ◽  
Titanium Implants ◽  
Contact Ratio ◽  
Advanced Glycation ◽  
Bone Implant ◽  
Glycation Endproducts ◽  
Bone Implant Contact

Abstract Advanced glycation endproducts (AGEs) are a diverse group of molecular adducts formed in environments high in reducing sugars that accumulate with aging and in diabetes. This study tests the hypothesis that AGEs inhibit the stabile osseointegration of dental implants through tissue interactions that interfere with bone turnover and compromise the biomechanical properties at the bone-implant interface. Maxillary first molars were extracted from 32 rats and allowed to heal for 4 weeks. Titanium implants (1 mm × 3 mm) were placed in the healed sockets of 2 groups of 16 rats consisting of 8 rats injected 3 times/wk for 1 month with AGE (prepared from glucose and lysine) and 8 rats injected with vehicle as a control. AGE injections continued for an additional 14 or 28 days before sacrifice. X-ray images, blood, and tissues were collected to examine bone/implant contact ratio, serum pyridinoline ([PYD] a collagen breakdown marker), osteocalcin ([OSC] a bone formation marker), and for immunohistochemistry with antibodies to AGE and the bone turnover-marker protein matrix metalloproteinase1. Compared with the AGE-treated groups, the controls showed significantly higher bone/implant contact at both 14- and 28-day time points. PYD (P < .05) and OSC (trend) levels from controls showed decreases at 28 days when compared with AGE-treated groups. Immunohistochemistry with AGE-specific and bone turnover marker antibodies showed stronger staining associated with the implant/tissue interface in AGE-treated rats. Our studies indicate an association between AGE and inhibition of bone turnover, suggesting that the formation of AGE in high glycemic conditions, such as diabetes, may contribute to a slower rate of osseointegration that negatively affects implant stability.

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