Low serum level of high-sensitivity C-reactive protein in a Japanese patient with maturity-onset diabetes of the young type 3 (MODY3)

Background: Psoriasis, a chronic inflammatory disease, is associated with systemic comorbidities. The blood levels of various inflammatory markers are increased in psoriasis. One of them is high sensitivity C-reactive protein (hs-CRP). The serum level of hs-CRP is increased in many inflammatory diseases like psoriasis, cardio vascular diseases, infections, arthritis and others. The objectives of the study were to determine serum level of hs-CRP in psoriasis in relation to its PASI score, which is a subjective method to determine severity of the disease, whereas hs-CRP is an objective and more reliable method. And to have a better idea of systemic inflammatory process caused by psoriasis, serum level of hs-CRP was evaluated in psoriasis patients.Methods: A case control study was conducted including 38 patients of chronic plaque psoriasis from dermatology outpatient department of Maharaja Agrasen Medical College (MAMC), Agroha, India, and 38 healthy controls.Results: The serum level of hs-CRP was significantly raised in psoriasis patients (p<0.001). The mean hs-CRP level in psoriasis patients was 6.824±8.562 mg/l whereas it was 1.072±0.929 mg/l in controls. Two observations were noticed, one, the increase in hs-CRP level correlated with PASI score and second, it was much higher in psoriatic patients as compared to controls.Conclusions: The much higher hs-CRP levels in psoriasis as compared to controls and its correlation with severity of psoriasis has led us to propose that this much high hs-CRP is a biomarker of systemic inflammatory process of psoriasis as well as inflamed cutaneous lesions.

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Effects of hepatocyte nuclear factor-1A and -4A on pancreatic stone protein/regenerating protein and C-reactive protein gene expression: implications for maturity-onset diabetes of the young

Journal of Translational Medicine ◽

10.1186/1479-5876-11-156 ◽

2013 ◽

Vol 11 (1) ◽

pp. 156 ◽

Cited By ~ 3

Author(s):

Ma P Kyithar ◽

Caroline Bonner ◽

Siobhan Bacon ◽

Seán M Kilbride ◽

Jasmin Schmid ◽

...

Keyword(s):

Gene Expression ◽

Protein Gene ◽

Nuclear Factor ◽

Maturity Onset Diabetes ◽

Hepatocyte Nuclear Factor ◽

Pancreatic Stone Protein ◽

C Reactive Protein ◽

Pancreatic Stone ◽

Reactive Protein ◽

Onset Diabetes

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Association of High Sensitivity C-Reactive Protein with In-Hospital Mortality in Patients with Acute St-Segment Elevation Myocardial Infarction

Nepalese Heart Journal ◽

10.3126/njh.v17i2.32676 ◽

2020 ◽

Vol 17 (2) ◽

pp. 33-37

Author(s):

Samir K Poudel ◽

Aryan Parajuli ◽

Lata Gautam ◽

Ram K Shah ◽

Arun Maskey ◽

...

Keyword(s):

Myocardial Infarction ◽

Emergency Department ◽

Chest Pain ◽

Serum Level ◽

Hospital Mortality ◽

High Sensitivity ◽

C Reactive Protein ◽

Acute Stemi ◽

Reactive Protein ◽

Hs Crp

Background and Aims: Among the various biomarkers, high sensitivity C-Reactive Protein (hs-CRP) has been widely studied and is easy to use in the prognostication of patients with acute ST elevation myocardial infarction (STEMI). This study aimed to associate serum level of hs-CRP with in-hospital mortality in patients presented with acute STEMI. Methods: This was a hospital-based prospective observational study conducted in Shahid Gangalal National Heart Centre among patients presented to the emergency department with chest pain of less than 24 hours duration, who were diagnosed subsequently to have STEMI. Patients who had known chronic inflammatory diseases, septic foci and chest pain of over 24 hours were excluded from the study. Blood sample for Hs-CRP was sent from the emergency department and was measured with Finecare TM FIA system; Model number: FS-112. The study was conducted from April 2019 to March 2020. Patient outcomes were stratified as per the four groups of serum level of hs-CRP and among them the relationship between mortality and hs-CRP level was tested with chi-square test. The p-value across the groups was again tested for inter-group significance using the Bonferroni adjusted significance level. Results: 140 patients (112 males and 28 females) with mean age of 58.1±14.86 years were enrolled in the study. There was no increased in-hospital mortality in acute STEMI patients who had serum level of hs-CRP below 3 mg/l. In-hospital mortality showed an increasing trend above this level but it reached statistical significance beyond 10 mg/l only. Thirty five percent of our patients of acute STEMI were found to have serum level of hs-CRP above this threshold. The total in-hospital mortality was 13 (9.28%). Conclusion: The increased serum level of hs-CRP was associated with increased in-hospital mortality in patients with acute STEMI.

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