Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study 5

AbstractThe safety profiles of sodium-glucose co-transporter 2 (SGLT2) inhibitors may depend on races/ethnicities. We aimed to assess the safety profiles of SGLT2 inhibitors in Japanese patients with diabetes mellitus (DM). The electronic databases MEDLINE, CENTRAL, and Ichushi-web were searched for studies with no language restriction from their inception to August 2019. Trials were included in the analysis if they were randomized controlled trials (RCTs) comparing the effects of SGLT2 inhibitors with a placebo in Japanese patients with DM > 18 years and reporting HbA1c and at least 1 adverse event. We calculated risk ratios with 95% CIs and used a random-effects model. Of the 22 RCTs included in our review, only 1 included patients with type 1 DM. The durations of RCTs ranged between 4 and 24 weeks. In comparison with a placebo, SGLT2 inhibitors were associated with similar risks of hypoglycemia, urinary tract infection, genital infection, hypovolemia, and fracture. The outcomes of treatment with SGLT2 inhibitors among Japanese patients with DM suggest favorable safety profiles. However, further evidence from studies with a longer duration, involving more diverse populations, such as patients with different types of DM, or including individual SGLT2 inhibitors is needed to resolve the limitations of the present study.

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High prevalence of fragmented QRS on electrocardiography in Japanese patients with diabetes irrespective of metabolic syndrome

Journal of Diabetes Investigation ◽

10.1111/jdi.13524 ◽

2021 ◽

Author(s):

Kunimasa Yagi ◽

Yoshiki Nagata ◽

Takashi Yamagami ◽

Daisuke Chujo ◽

Miki Kamigishi ◽

...

Keyword(s):

Metabolic Syndrome ◽

Japanese Patients ◽

Fragmented Qrs ◽

High Prevalence ◽

Patients With Diabetes

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Nutritional status in patients with diabetes and chronic kidney disease: a prospective study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/85.1.96 ◽

2007 ◽

Vol 85 (1) ◽

pp. 96-101 ◽

Cited By ~ 15

Author(s):

Christelle Raffaitin ◽

Catherine Lasseur ◽

Philippe Chauveau ◽

Nicole Barthe ◽

Henri Gin ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Nutritional Status ◽

Prospective Study ◽

Patients With Diabetes ◽

A Prospective Study

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Prognostic value of myocardial perfusion imaging for cardiovascular events among asymptomatic Japanese patients with type 2 diabetes and mild renal dysfunction

Nuclear Medicine Communications ◽

10.1097/mnm.0b013e32835e89ab ◽

2013 ◽

Vol 34 (4) ◽

pp. 328-332 ◽

Cited By ~ 1

Author(s):

Chio Okuyama ◽

Kenichi Nakajima ◽

Yoshimitsu Yamasaki ◽

Tsunehiko Nishimura

Keyword(s):

Type 2 Diabetes ◽

Myocardial Perfusion Imaging ◽

Myocardial Perfusion ◽

Renal Dysfunction ◽

Perfusion Imaging ◽

Cardiovascular Events ◽

Prognostic Value ◽

Japanese Patients

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Features of Stroke in Chinese Diabetes Patients: A Hospital-based Study

Journal of International Medical Research ◽

10.1177/147323000703500414 ◽

2007 ◽

Vol 35 (4) ◽

pp. 540-546 ◽

Cited By ~ 7

Author(s):

X-D Zhang ◽

Y-R Chen ◽

L Ge ◽

Z-M Ge ◽

Y-H Zhang

Keyword(s):

Risk Factors ◽

Hospital Mortality ◽

Ischaemic Stroke ◽

Cerebral Haemorrhage ◽

Mortality Rates ◽

Demographic Characteristics ◽

Major Influence ◽

Diabetic Patients ◽

Clinical Factors ◽

Patients With Diabetes

In this study, demographic characteristics, risk factors, stroke subtypes and outcome were compared in 2532 patients with and without diabetes hospitalized for first-ever stroke. Diabetes was present in 471 (18.6%) of the patients. Patients with diabetes presented more frequently with ischaemic stroke (92.1% versus 71.3%), especially lacunar infarction (41.2% versus 35.2%), compared with non-diabetics. Cerebral haemorrhage was less frequent in diabetics than non-diabetics (4.2% versus 18.1%). In-hospital mortality rates from ischaemic stroke were similar in the two groups (18.2% in diabetics and 16.9% in non-diabetics). Predictors of in-hospital mortality in diabetic patients included decreased consciousness, congestive heart failure and atrial fibrillation. In conclusion, stroke in diabetic patients was different to stroke in non-diabetic patients: in diabetics the frequency of cerebral haemorrhage was lower and the rate of lacunar infarct syndrome was higher, but in-hospital mortality from ischaemic stroke was not increased. Clinical factors evident at the onset of stroke have a major influence on in-hospital mortality and may help clinicians provide a more accurate prognosis.

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