The potential of Mangifera indica Linn. and Musa acuminata extracts to attenuate 4‐hydroxyestradiol (4‐OHE 2 )‐induced DNA oxidative damage in MCF‐10A cells by upregulating detoxifying and antioxidant enzymes

2021 ◽  
Author(s):  
Saranya Sedtananun ◽  
Kornkanok Promthep
Keyword(s):  
Antioxidant Enzymes ◽  
Oxidative Damage ◽  
Mangifera Indica ◽  
Musa Acuminata ◽  
Dna Oxidative Damage

scholarly journals Jinmaitong decreases sciatic nerve DNA oxidative damage and apoptosis in a streptozotocin-induced diabetic rat model

2015 ◽  
Vol 10 (2) ◽  
pp. 778-786 ◽  
Author(s):  
DE-HAI YIN ◽  
XIAO-CHUN LIANG ◽  
LI ZHAO ◽  
HONG ZHANG ◽  
QING SUN ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Oxidative Damage ◽  
Rat Model ◽  
Diabetic Rat ◽  
Dna Oxidative Damage ◽  
Diabetic Rat Model

scholarly journals Active paraplegics are protected against exercise-induced oxidative damage through the induction of antioxidant enzymes

Spinal Cord ◽  
2016 ◽  
Vol 54 (10) ◽  
pp. 830-837 ◽  
Author(s):  
M Inglés ◽  
P Serra-Añó ◽  
J Gambini ◽  
F Abu-Sharif ◽  
M Dromant ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Oxidative Damage ◽  
Exercise Induced

Highly sensitive detection of DNA damage in living cells by SERS and electrochemical measurements using a flexible gold nanoelectrode

The Analyst ◽  
2021 ◽  
Author(s):  
Jing Zhou ◽  
Dan Yang ◽  
Guohui Liu ◽  
Siying Li ◽  
Wennan Feng ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Damage ◽  
Living Cells ◽  
Oxidation Products ◽  
Electrochemical Measurements ◽  
Sensitive Detection ◽  
Dna Oxidative Damage ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Gold Nanoelectrode

Guanine (G) oxidation products, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-oxo-guanine (8-OXOG), have been widely studied as promising biomarkers for DNA oxidative damage.

scholarly journals Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Sangeeta Satish ◽  
Hannah Philipose ◽  
Mariana Aparecida Brunini Rosales ◽  
Magali Saint-Geniez
Keyword(s):  
Cell Death ◽  
Antioxidant Enzymes ◽  
Oxidative Damage ◽  
Therapeutic Potential ◽  
Retinal Pigment Epithelial Cell ◽  
Cell Metabolism ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Age Related

Retinal pigment epithelium (RPE) dysfunction due to accumulation of reactive oxygen species and oxidative damage is a key event in the development of age-related macular degeneration (AMD). Here, we examine the therapeutic potential of ZLN005, a selective PGC-1α transcriptional regulator, in protecting RPE from cytotoxic oxidative damage. Gene expression analysis on ARPE-19 cells treated with ZLN005 shows robust upregulation of PGC-1α and its associated transcription factors, antioxidant enzymes, and mitochondrial genes. Energetic profiling shows that ZLN005 treatment enhances RPE mitochondrial function by increasing basal and maximal respiration rates, and spare respiratory capacity. In addition, ZLN005 robustly protects ARPE-19 cells from cell death caused by H2O2, ox-LDL, and NaIO3 without exhibiting any cytotoxicity under basal conditions. ZLN005 protection against H2O2-mediated cell death was lost in PGC-1α-silenced cells. Our data indicates that ZLN005 efficiently protects RPE cells from oxidative damage through selective induction of PGC-1α and its target antioxidant enzymes. ZLN005 may serve as a novel therapeutic agent for retinal diseases associated with RPE dystrophies.

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