Serum levels of perfluorooctanoic acid and perfluorooctane sulfonic acid in pregnant women: Maternal predictors and associations with birth outcomes in the PIPA Project

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

Download Full-text

Dehydroepiandrosterone (DHEA) Serum Levels Indicate Cerebrospinal Fluid Levels of DHEA and Estradiol (E2) in Women at Term Pregnancy

Reproductive Sciences ◽

10.1007/s43032-021-00541-2 ◽

2021 ◽

Author(s):

Pardes Habib ◽

Joseph Neulen ◽

Shahin Habib ◽

Benjamin Rösing

Keyword(s):

Pregnant Women ◽

Strong Correlation ◽

Serum Levels ◽

Neuroactive Steroids ◽

Term Pregnancy ◽

Serum Samples ◽

Functional Changes ◽

The Central Nervous System ◽

Csf Levels ◽

Fluid Levels

AbstractNeuroactive steroids such as dehydroepiandrosterone (DHEA), estradiol (E2), and progesterone (P4) are associated with structural and functional changes in the central nervous system (CNS). Measurement of steroid levels in the CNS compartments is restricted in accessibility. Consequently, there is only limited human data on the distributional equilibrium for steroid levels between peripheral and central compartments. While some neuroactive steroids including DHEA and E2 have been reported to convey excitatory and proconvulsant properties, the opposite was demonstrated for P4. We aimed to elucidate the correlation between peripheral and central DHEA, E2, and P4 levels in women at term pregnancy. CSF and serum samples of 27 healthy pregnant women (22–39 years) at term pregnancy were collected simultaneously under combined spinal and epidural anesthesia and used for DHEA ELISA and E2, and P4 ECLIA. All three neuroactive steroids were detected at markedly lower levels in CSF compared to their corresponding serum concentrations (decrease, mean ± SD, 97.66 ± 0.83%). We found a strong correlation for DHEA between its serum and the corresponding CSF levels (r = 0.65, p = 0.003). Serum and CSF levels of E2 (r = 0.31, p = 0.12) appeared not to correlate in the investigated cohort. DHEA serum concentration correlated significantly with E2 (r = 0.58, p = 0.0016) in CSF. In addition, a strong correlation was found between DHEA and E2, both measured in CSF (r = 0.65, p = 0.0002). Peripheral DHEA levels might serve as an indicator for central nervous levels of the neuroactive steroids DHEA and E2 in pregnant women.

Download Full-text

Serum levels of TGF-β1, cytokines, angiogenic, and anti-angiogenic factors in pregnant women who smoke

Journal of Reproductive Immunology ◽

10.1016/j.jri.2021.103351 ◽

2021 ◽

pp. 103351

Author(s):

Courtney Lynn Schubert ◽

Kamran Yusuf

Keyword(s):

Pregnant Women ◽

Serum Levels ◽

Angiogenic Factors ◽

Tgf Β1

Download Full-text

Maternal predictors related to quality of life in pregnant women in the Northeast of Brazil

Health and Quality of Life Outcomes ◽

10.1186/s12955-018-0917-8 ◽

2018 ◽

Vol 16 (1) ◽

Cited By ~ 7

Author(s):

Cinthia Gondim Pereira Calou ◽

Mirna Fontenele de Oliveira ◽

Francisco Herlânio Costa Carvalho ◽

Paula Renata Amorim Lessa Soares ◽

Raylla Araújo Bezerra ◽

...

Keyword(s):

Quality Of Life ◽

Pregnant Women ◽

Maternal Predictors

Download Full-text

The Effect of Changes in Sex Hormones Serum Levels On Gingival Tissue Health in Pregnant Women

Mansoura Journal of Dentistry ◽

10.21608/mjd.2015.201723 ◽

2015 ◽

Vol 2 (7) ◽

pp. 21-24

Keyword(s):

Pregnant Women ◽

Sex Hormones ◽

Serum Levels ◽

Gingival Tissue

Download Full-text

Childhood maltreatment and inflammation among pregnant women with gestational diabetes mellitus: A pilot study

Obstetric Medicine ◽

10.1177/1753495x17701320 ◽

2017 ◽

Vol 10 (3) ◽

pp. 120-124 ◽

Cited By ~ 6

Author(s):

Margaret Bublitz ◽

Suzanne De La Monte ◽

Susan Martin ◽

Lucia Larson ◽

Ghada Bourjeily

Keyword(s):

Diabetes Mellitus ◽

Pilot Study ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnant Women ◽

Birth Outcomes ◽

Childhood Maltreatment ◽

Secondary Data ◽

Past Research ◽

Increased Risk

Background Women with childhood maltreatment histories are at increased risk for adverse birth outcomes. Mechanisms explaining this link are poorly understood. Past research is limited by sampling pregnant women at low risk for adverse maternal and neonatal outcomes. Methods This pilot study was a secondary data analysis of 24 women with gestational diabetes mellitus; 17% of the sample also reported a maltreatment history. Women provided a blood sample to measure inflammatory cytokines and insulin resistance, and saliva samples to measure diurnal cortisol. Birth outcomes for past and current pregnancies were recorded. Results Histories of maltreatment were associated with elevated interleukin-15 and a marginally greater incidence of preterm delivery in current and past pregnancies. Conclusions This pilot study was the first to demonstrate an association between childhood maltreatment history and inflammatory cytokine levels in pregnant women diagnosed with gestational diabetes mellitus.

Download Full-text

Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term

Acta Endocrinologica ◽

10.1530/eje.0.1470785 ◽

2002 ◽

pp. 785-793 ◽

Cited By ~ 35

Author(s):

NA Bersinger ◽

N Groome ◽

S Muttukrishna

Keyword(s):

Pregnant Women ◽

Protein A ◽

Placental Tissue ◽

Serum Levels ◽

Activin A ◽

Placental Lactogen ◽

Compensatory Mechanism ◽

Protein Markers ◽

Inhibin A ◽

Placental Disease

OBJECTIVE: Pre-eclampsia is a placental disease of unknown cause. Maternal circulating concentrations of a number of protein markers are altered (mainly increased) in pre-eclampsia in comparison with controls of matched gestational age. Inhibin A and activin A were found to be elevated even before the onset of the disease. The aim of this study was to compare the levels of inhibin A, activin A: follistatin ratio, leptin, pregnancy-associated plasma protein-A (PAPP-A), human placental lactogen (HPL), placenta growth factor (PLGF) and pregnancy-specific beta1-glycoprotein (SP1) in placental extracts of normal pregnant women and pre-eclampsia patients at term. METHODS: Placental tissue from normal pregnancies (n=14) and patients with pre-eclampsia (n=13) were collected at term (> or =37 weeks of gestation) and stored at -80 degrees C. The frozen tissue pieces were homogenised and the above-mentioned proteins were measured by specific enzyme-linked immunosorbent assays. RESULTS: Placental contents of inhibin A and PAPP-A were significantly higher (P<0.05) in pre-eclampsia placental extracts compared with the controls. Activin A:follistatin ratio was higher (23) in pre-eclampsia extracts than in the controls (15). Leptin, PLGF, SP1 and HPL levels were not altered in the term pre-eclampsia placenta. Inhibin A and PAPP-A contents were increased in the placental extracts of pre-eclampsia patients. CONCLUSION: Our data suggest that the placenta, possibly by a compensatory mechanism, is at least in part responsible for the altered serum levels observed in pre-eclampsia.

Download Full-text

Utilization of preconception care and associated factors in Hosanna Town, Southern Ethiopia

PLoS ONE ◽

10.1371/journal.pone.0261895 ◽

2022 ◽

Vol 17 (1) ◽

pp. e0261895

Author(s):

Meron Admasu Wegene ◽

Negeso Gebeyehu Gejo ◽

Daniel Yohannes Bedecha ◽

Amene Abebe Kerbo ◽

Shemsu Nuriye Hagisso ◽

...

Keyword(s):

Child Health ◽

Pregnant Women ◽

Birth Outcomes ◽

Preconception Care ◽

Previous History ◽

Care Utilization ◽

Adverse Birth Outcomes ◽

Care Services ◽

History Of ◽

And Child Health

Introduction There is substantial body of evidence that portrays gap in the existing maternal and child health continuum of care; one is less attention given to adolescent girls and young women until they get pregnant. Besides, antenatal care is too late to reduce the harmful effects that a woman’s may have on the fetus during the critical period of organogenesis. Fortunately, preconception care can fill these gaps, enhance well-being of women and couples and improve subsequent pregnancy and child health outcomes. Therefore, the main aim of the current study was to assess preconception care utilization and associated factors among pregnant women attending antenatal care clinics of public health facilities in Hosanna town. Methods A facility based cross-sectional study design was carried out from July 30, 2020 to August 30, 2020. Data were collected through face-to-face interview among 400 eligible pregnant women through systematic sampling technique. Epi-data version 3.1 and SPSS version 24 was used for data entry and analysis respectively. Both bivariable and multivariable logistic regression analysis was conducted to identify association between dependent and independent variables. Crude and adjusted odds ratio with respective 95% confidence intervals was computed and statistical significance was declared at p-value <0.05. Result This study revealed that 76 (19%, 95% Cl (15.3, 23.2) study participants had utilized preconception care. History of family planning use before the current pregnancy (AOR = 2.45; 95% Cl (1.270, 4.741), previous history of adverse birth outcomes (AOR = 3.15; 95% Cl (1.650, 6.005), poor knowledge on preconception care (AOR = 0.18; 95% Cl (0.084, 0.379) and receiving counseling on preconception care previously (AOR = 2.82; 95% Cl (1.221, 6.493) were significantly associated with preconception care utilization. Conclusions The present study revealed that nearly one-fifth of pregnant women have utilized preconception care services. History of family planning use before the current pregnancy, previous history of adverse birth outcomes, poor knowledge on preconception care and receiving counseling on preconception care previously were significantly associated with preconception care utilization. Integrating preconception care services with other maternal neonatal child health, improving women’s/couples knowledge & strengthening counseling services is pivotal.

Download Full-text