Omega-3 polyunsaturated fatty acids reduce insulin resistance and triglycerides in obese children and adolescents

2013 ◽  
Vol 14 (5) ◽  
pp. 377-383 ◽  
Author(s):  
Carlos Juárez-López ◽  
Miguel Klünder-Klünder ◽  
Adrián Madrigal-Azcárate ◽  
Samuel Flores-Huerta
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Children And Adolescents ◽  
Omega 3 ◽  
Obese Children ◽  
Reduce Insulin Resistance

scholarly journals The Relationship of Insulin Resistance With SNP 276G>T at Adiponectin Gene and Plasma Long-Chain Polyunsaturated Fatty Acids in Obese Children

2009 ◽  
Vol 66 (3) ◽  
pp. 346-349 ◽  
Author(s):  
Elvira Verduci ◽  
Silvia Scaglioni ◽  
Carlo Agostoni ◽  
Giovanni Radaelli ◽  
Marialuisa Biondi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Adiponectin Gene ◽  
Obese Children ◽  
Relationship Of ◽  
The Relationship ◽  
Long Chain

Long-Chain Omega-3 Polyunsaturated Fatty Acids in the Blood of Children and Adolescents with Juvenile Bipolar Disorder

Lipids ◽  
2008 ◽  
Vol 43 (11) ◽  
pp. 1031-1038 ◽  
Author(s):  
Edward H. Clayton ◽  
Tanya L. Hanstock ◽  
Stephen J. Hirneth ◽  
Colin J. Kable ◽  
Manohar L. Garg ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bipolar Disorder ◽  
Polyunsaturated Fatty Acids ◽  
Children And Adolescents ◽  
Omega 3 ◽  
Long Chain

scholarly journals Adipose tissue inflammation in insulin resistance: review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids

2017 ◽  
Vol 65 (7) ◽  
pp. 1021-1027 ◽  
Author(s):  
Mandana Pahlavani ◽  
Theresa Ramalho ◽  
Iurii Koboziev ◽  
Monique J LeMieux ◽  
Shasika Jayarathne ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Review Paper ◽  
Nutritional Intervention ◽  
Adipose Tissue Inflammation ◽  
Omega 3 ◽  
The Metabolic Syndrome ◽  
Mediators Of Inflammation ◽  
Micro Rnas

Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity. The purpose of this review paper is to discuss some of the known roles of miRNAs as mediators of inflammation-associated obesity and IR and how omega-3 polyunsaturated fatty acids may be used as a nutritional intervention for these disorders.

scholarly journals MICRONUTRIENT DEFICIENCY IN THE PATHOGENESIS OF INSULIN RESISTANCE AND WAYS TO CORRECT IT

2021 ◽  
Vol 78 (4) ◽  
pp. 135-145
Author(s):  
Myroslava Mykytyuk
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mediterranean Diet ◽  
Micronutrient Deficiency ◽  
The Body ◽  
Omega 3 ◽  
Increased Risk

The review discusses modern views on the pathogenesis of insulin resistance (IR), in particular the role of micronutrient deficiency. The spread of IR in various somatic pathologies indicates an adaptive IR value not only for glucose homeostasis disorders, but also for metabolism in the body as a whole. A promising area of therapy for IR and cardiovascular diseases closely related to obesity and metabolic syndrome (MS) is the use of modulators of products by the human body of endogenous regulatory factors based on omega-3 polyunsaturated fatty acids. The American Diabetic Association supports adherence to a Mediterranean diet enriched with omega-3 polyunsaturated fatty acids. A meta-analysis of 50 clinical, prospective and cross-examination studies has proven the positive protection effect of the Mediterranean diet on MS components. The development of IR can be associated with a deficiency of chromium and magnesium, and the additional intake of these trace elements with nutritional supplements reduces the severity of IR. Pancreatic β-cell dysfunction, IR, increased risk of MS and type 2 diabetes associated with hypomagnemia. It has been shown that the combination of oral food additives chromium (160 icg/day) and magnesium (200 mg/day) reduces IR more effectively than their use separately, which may be associated with increased induction and repression, respectively, the expression of glucose transporter 4 and glycogen-synthase kinase 3. Thus, micronutrients can be used in complex therapy of patients with IR and associated pathological conditions, such as excess body weight/obesity, type 2 diabetes and MS.

scholarly journals Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation

2014 ◽  
Vol 127 (5) ◽  
pp. 315-322 ◽  
Author(s):  
Francis B. Stephens ◽  
Buddhike Mendis ◽  
Chris E. Shannon ◽  
Scott Cooper ◽  
Catharine A. Ortori ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Intravenous Infusion ◽  
Human Skeletal Muscle ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Healthy Males

Intravenous infusion of lipid into healthy males caused insulin resistance. Addition of fish oil omega-3 polyunsaturated fatty acids to the lipid infusion partially prevented the insulin resistance. This effect was not due to differences in muscle acylcarnitine content.

Long chain omega-3 polyunsaturated fatty acids in the treatment of psychiatric illnesses in children and adolescents

2007 ◽  
Vol 19 (2) ◽  
pp. 92-103 ◽  
Author(s):  
Edward H. Clayton ◽  
Tanya L. Hanstock ◽  
Manohar L. Garg ◽  
Philip L. Hazell
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Children And Adolescents ◽  
Bipolar Depression ◽  
First Episode Psychosis ◽  
First Episode ◽  
Controlled Trials ◽  
Omega 3 ◽  
Episode Psychosis ◽  
Long Chain

Objective:Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adolescents.Methods:A search of Psychlit, PubMed and Cochrane Databases was conducted using the terms child, adolescent, bipolar, depression, psychosis, first-episode psychosis, schizophrenia, attention deficit hyperactivity disorder (ADHD), autism, psychiatric, omega-3, n-3, docosahexaenoic acid and eicosapentaenoic acid. Further studies were identified from the bibliographies of published reviews.Results:One small randomized controlled trial with LCn-3PUFA supplementation in depression in children found a small beneficial effect over placebo. Four placebo-controlled trials showed uncertain benefit of LCn-3PUFA for ADHD. Single placebo-controlled trials showed no benefit in autism or bipolar disorder. There is an absence of studies examining benefit for first-episode psychosis or schizophrenia in children and adolescents.Conclusions:While children and adolescents are receiving LCn-3PUFA for a range of psychiatric indications, there is only evidence of likely benefit for unipolar depression.

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