scholarly journals The impact of extirpation of non-palpable/normal-sized regional lymph nodes on staging of canine cutaneous mast cell tumours: A multicentric retrospective study

2018 ◽  
Vol 16 (4) ◽  
pp. 505-510 ◽  
Author(s):  
R. Ferrari ◽  
L. Marconato ◽  
P. Buracco ◽  
P. Boracchi ◽  
C. Giudice ◽  
...  
Keyword(s):  
Mast Cell ◽  
Retrospective Study ◽  
Lymph Nodes ◽  
Regional Lymph Nodes ◽  
Cutaneous Mast Cell ◽  
The Impact

Extracutaneous Mast-Cell Tumor in the Dog

1982 ◽  
Vol 19 (6) ◽  
pp. 608-615 ◽  
Author(s):  
A. K. Patnaik ◽  
E. G. MacEwen ◽  
A. P. Black ◽  
S. Luckow
Keyword(s):  
Duodenal Ulcer ◽  
Mast Cell ◽  
Lymph Nodes ◽  
Cell Tumor ◽  
Regional Lymph Nodes ◽  
Duodenal Ulcers ◽  
Mast Cell Tumors ◽  
Mast Cell Tumor ◽  
Cutaneous Mast Cell ◽  
Limited Metastasis

Three neoplasms of extracutaneous mast-cell origin, arising from the nasopharynx, oral cavity, and hepatopancreatic lymph nodes respectively, were diagnosed in three dogs. The neoplasms had histologic features similar to those of cutaneous mast-cell tumors, but had limited metastasis mostly involving the regional lymph nodes. One dog had a perforating duodenal ulcer, suggesting that duodenal ulcers can occur with extracutaneous tumors as they do with some cutaneous mast-cell tumors in the dog.

scholarly journals Role of Androgen Deprivation Therapy for Node-Positive Prostate Cancer

2009 ◽  
Vol 27 (1) ◽  
pp. 100-105 ◽  
Author(s):  
Yu-Ning Wong ◽  
Stephen Freedland ◽  
Brian Egleston ◽  
Gary Hudes ◽  
J. Sanford Schwartz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Nodes ◽  
Androgen Deprivation Therapy ◽  
Specific Antigen ◽  
Androgen Deprivation ◽  
Regional Lymph Nodes ◽  
Node Positive ◽  
Survival Difference ◽  
Significant Difference ◽  
The Impact

Purpose To determine the impact of adjuvant androgen deprivation therapy (ADT) for patients who have node-positive prostate cancer in the prostate-specific antigen (PSA) era. Patients and Methods We used linked Surveillance, Epidemiology and End Results-Medicare data to construct a cohort of men who underwent radical prostatectomy (RP) between 1991 and 1999 and who had positive regional lymph nodes. We classified men as receiving adjuvant ADT if they received ADT within 120 days of RP, and we compared them to the men who had not received adjuvant ADT. We used propensity scores to balance potential confounders of receiving adjuvant ADT (ie, tumor characteristics, extent of nodal disease, demographics, receipt of radiation therapy) and Cox proportional hazard methods to measure the impact of adjuvant ADT on overall survival (OS), stratified by propensity score quintile. We conducted a sensitivity analysis that used 90, 150, 180, and 365 days as the definition for adjuvant ADT. Results A total of 731 men were identified, 209 of whom received ADT within 120 days of RP. There was no statistically significant difference in OS between the adjuvant ADT and non-ADT group (HR, 0.97; 95% CI, 0.71 to 1.27). There was no statistically significant survival difference with 90, 150, 180, and 365 days as the adjuvant ADT definition. Conclusion Deferring immediate ADT in men with positive lymph nodes after RP may not significantly compromise survival. Because observational studies should be considered hypothesis-generating studies, these results should be validated in a prospective fashion in a similar patient population.

Sentinel lymph node in colorectal cancer — 5 years follow up

Open Medicine ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. 271-278
Author(s):  
Jacek Zielinski ◽  
Radoslaw Jaworski ◽  
Pawel Kabata ◽  
Robert Rzepko ◽  
Wiesław Kruszewski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Histopathological Examination ◽  
Survival Rates ◽  
Surgical Oncology ◽  
Blue Dye ◽  
Chi Square ◽  
Regional Lymph Nodes ◽  
Term Survival ◽  
The Impact

AbstractTo assess the impact of micrometastases in sentinel and non-sentinel lymph nodes on long-term survival rates of patients treated for colorectal cancer (CRC). Data of 57 patients diagnosed with CRC and treated in the Department of Surgical Oncology in Gdansk in the years 2002–2006 were retrospectively analyzed. Clinico-histopathological data were analyzed using chi-square tests. The effect on long-time survival rates was analyzed using Kaplan-Meier survival probability estimates. Identification of the SLN was performed using the blue dye staining method. All regional lymph nodes were subject to standard histopathological examination. Additionally in 32(56.14%) patients whose nodes were found negative for metastases on standard staining further immunohistochemical analyses were performed. In the analyzed group SLNB was performed in 42(73.7%) patients with colon cancer and in 15(26.3%) with rectal cancer. Identification of the SLN was possible in 45(78.9%) patients. The sensitivity of SLNB was 33%. False negatives were found in 66%. SLNB is a feasible method in CRC patients. We presume that lack of micrometastases in the SLN and non-SLN cannot be regarded as a prognostic factor.

Severe toxicity risk factor analysis of salvage radiotherapy for oligo-recurrence in the lymph nodes (LN) of esophagus carcinoma: From multi-institutional retrospective study.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 186-186
Author(s):  
Toshihiko Matsumoto ◽  
Tomohiro Nishina ◽  
Yuzuru Niibe ◽  
Hideomi Yamashita ◽  
Kuniaki Katsui ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Retrospective Study ◽  
Lymph Nodes ◽  
Severe Toxicity ◽  
Regional Lymph Nodes ◽  
Exact Test ◽  
Esophageal Bleeding ◽  
Esophagus Carcinoma ◽  
Radiation Induced

186 Background: This multi-institutional retrospective study suggested that salvage radiotherapy (RT) or chemoradiation therapy (CRT) for oligo-recurrence in the lymph nodes (LN) of esophagus carcinoma was one of therapeutic options. However risk factors of severe toxicities of these therapies are unclear. Methods: Between January 2000 and April 2015, a total of 237 cases that met the study criteria of oligo-recurrence were treated by RT or CRT in five hospitals. We investigated risk factors of severe toxicities in these patients. We used the fisher’s exact test and Cox proportional hazard model. Toxicities were evaluated by CTCAE v4.0. Results: The median follow-up time for 93 living cases was 29.6 months (range; 1.9-154.0 months). Systemic chemotherapy was administrated to 210 cases (88.6%). Median biological effective dose(BED) was 72 Gy(range: 48-84Gy).The 3-year overall survival (OS) was 37%, local control was 45%, progression-free survival was 24%. Radiation induced Grade 3 or worse adverse events were observed in 11 patients (4.6%), which were fistula (4patients,1.7%), pneumonia (2patients,0.8%), pleural effusion (2patients,0.8%), esophageal bleeding (1 patient, 0.4%), esophageal stenosis (1patient,0.4%), cardiac tamponade (1patient,0.4%), and hyperglycemia (1patient,0.4%) ) Treatment related death occurred in 4 patients, these deaths were attributed to drug-induced or radiation-induced interstitial pneumoniae, pleural effusion, esophageal bleeding, and esophago-bronchial fistula. Severe toxicity was only observed in patients with oligo-recurrence in regional lymph nodes or BED ³a60 Gy. In univariate analysis by Fisher’s exact test, Karnofsky performance status (KPS) <80 (p=0.0006) and oligo-recurrence in regional lymph nodes (p=0.0078) were the risk factor of severe toxicity. In multivariate analysis, KPS<80 (HR:11.81,95% CI: 2.67-51.29, p=0.0017) was the risk factor of severe toxicity. Conclusions: This study suggested that KPS<80 and oligo-recurrence in regional lymph nodes is the risk factor for severe toxicity in patients who received RT or CRT for oligo-recurrence in the LNs of esophagus.

scholarly journals Impact of rotational stress on immunity parameters. Role of opiate receptors

2003 ◽  
Vol 49 (6) ◽  
pp. 56-58 ◽  
Author(s):  
S. V. Gein ◽  
T. A. Simonenko ◽  
S. P. Tendryakova
Keyword(s):  
Lymph Nodes ◽  
Considerable Increase ◽  
Opiate Receptors ◽  
Opiate Receptor ◽  
Delayed Type Hypersensitivity ◽  
Promoting Effect ◽  
Regional Lymph Nodes ◽  
The Impact ◽  
Stimulation Of

Experiments on non-inbred male mice used a model of rotational stress to examine the impact of 8-, p- к-opiate receptor blockade on antibody formation, delayed-type hypersensitivity (DTH), changes in the count of antibody-forming cells (AFC) and nucleated cells of lymph nodes and spleen during a local immune response. Rotational stress was found to cause a slightly pronounced inhibition of immune inflammation in DTH, a considerable increase in the count of AFC and nucleated cells in the regional lymph nodes, without changing the titers of antibodies from peripheral blood. Naloxone blockade of 8-, p- к-opiate receptors abolished these effects of stress. It has been suggested that abolishment of the promoting effect of rotational stress on the count of AFC and on the depression of DTH may be associated with the blockade of effects of ^-endorphin and met-enkephalin that act predominantly via stimulation of 8-receptors.

scholarly journals The Role of PET/CT with 68Ga‑PSMA in the Primary Diagnosis of Prostate Cancer

2021 ◽  
Vol 4 (4) ◽  
pp. 20-27
Author(s):  
A. L. Dolbov ◽  
A. A. Stanjevskiy ◽  
D. N. Maistrenko ◽  
M. I. Shkolnik ◽  
А. Yu. Pakhomov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Computed Tomography ◽  
Lymph Nodes ◽  
Bone Scan ◽  
Specific Antigen ◽  
Malignant Neoplasms ◽  
Optimal Method ◽  
Regional Lymph Nodes ◽  
Pet Ct ◽  
The Impact

Relevance: Prostate cancer is one of the most frequently diagnosed malignant neoplasms of the genitourinary system in men in the world. Recently, there has been an active introduction into clinical practice of positron emission tomography technology combined with computed tomography (PET/CT) with 68Ga‑PSMA‑617 based on prostate‑specific membrane antigen (PSMA), the capabilities of which significantly increase the effectiveness of the diagnosis of prostate cancer at various clinical stages compared with routine methods used in the staging of prostate cancer.Purpose: To compare the diagnostic effectiveness of PET/CT with 68Ga‑PSMA‑617 with traditional methods of radiation imaging (computed tomography, magnetic resonance imaging and bone scan) in the staging of prostate cancer and to clarify the impact of this technology on the choice of surgical treatment.Material and methods: PET/CT with 68Ga‑PSMA was performed in our center in order to stage the verified prostate cancer in 109 patients aged 48 to 80 years (median 64.5). The selection criteria were: a PSA level of more than 5 ng/ml, the presence of a newly identified, histologically verified prostate cancer, lack of treatment, suspicion of metastatic lesion of the lymph nodes of the pelvis and skeleton. Patients were divided into groups by prostate‑specific antigen level, Gleason score, and d’Amico.Results: In the analysis of PET/CT results and MRI/CT comparison and Bone scan, 56 (51.4 %) of 109 patients showed a change in the TNM stage. A change in the data on the local spread of the tumor with an increase in the stage according to criterion T due to the detection of pathological accumulation of RFP in seminal vesicles was detected in 21 (37.5 %) of 56 patients. Additionally, according to PET/CT data, 13 (23.2 %) of 56 patients were found to have lesions of regional lymph nodes (N). Metastatic lesions of distant lymph nodes (M1a) and bones (M1b), not visualized during routine radiation examination, were observed in 32 (57.1 %) and 36 (64.3 %) of 56 patients, respectively.Conclusions: The use of PET/CT 68Ga‑PSMA‑617 in patients with newly diagnosed prostate cancer at the staging stage allows us to obtain valuable additional information about the local, regional and long‑term prevalence of the pathological process, and in some cases — to change the stage of the disease by TNM (usually by increasing it), which has a significant impact on the tactics of therapeutic measures and the choice of the optimal method of therapy for prostate cancer.

scholarly journals Benzo[a]pyrene aggravates atopic dermatitis-like skin lesions in mice

2021 ◽  
pp. 096032712110361
Author(s):  
Rie Yanagisawa ◽  
Eiko Koike ◽  
Hirohisa Takano
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cell ◽  
Lymph Nodes ◽  
T Cell Activation ◽  
Cell Activation ◽  
Systemic Exposure ◽  
Skin Inflammation ◽  
Skin Lesions ◽  
Mite Allergen ◽  
Regional Lymph Nodes

Background: Benzo[a]pyrene (BaP) affects the immune system and causes mutagenic and carcinogenic effects. Purpose: We aimed to evaluate the effects of systemic exposure to BaP on mite allergen–induced atopic dermatitis (AD)–like skin lesions in mice. Methods: Mite allergen ( Dermatophagoides pteronyssinus; Dp) was injected intradermally into the right ears of NC/Nga male mice on eight occasions every 2–3 days. Benzo[a]pyrene was administered intraperitoneally in the equivalent doses of 0, 2, 20, 200, or 2000 μg/kg/day, once a week on four occasions. Results: AD-like skin inflammation related to mite allergen worsened by BaP exposure at 2, 20 µg/kg/day doses; this was in parallel with eosinophil and mast cell infiltration and mast cell degranulation. A trend was also observed toward increased proinflammatory molecule expression, including macrophage inflammatory protein-1 alpha, interleukin (IL)-4, IL-13, and IL-18, in the ear tissue. However, 200 or 2000 µg/kg/day BaP attenuated the enhancing effects. In the regional lymph nodes, 2 µg/kg/day BaP with Dp enhanced antigen-presenting cell and T cell activation compared with Dp alone. Conclusions: This suggests that BaP exposure can aggravate Dp-induced AD-like skin lesions through TH2-biased responses in the inflamed sites and the activation of regional lymph nodes. Therefore, BaP may be responsible for the recent increase in AD incidence.

Clinicopathological Analysis and Prognostic Assessment of TCN1 in Patients with Gastric Cancer

2021 ◽  
pp. 155335062110453
Author(s):  
Xinqiang Zhu ◽  
Gang Zhou ◽  
Meimei Ma ◽  
Daorong Hou ◽  
Hailong Huang ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Survival Time ◽  
Tumor Tissue ◽  
Survival Rates ◽  
High Expression ◽  
Tumor Diameter ◽  
Gastrointestinal Tumor ◽  
Regional Lymph Nodes ◽  
Clinical Prognosis ◽  
The Impact

Background Stomach cancer is the fourth most common type of cancer worldwide. TCN1 mainly encodes the vitamin B12 transporter, transcobalamin. TCN1 is a marker of gastrointestinal tumor progression, but the impact of TCN1 on survival is unclear. Material/Methods Gastrointestinal tumor records were reviewed and analyzed, clinicopathological data were summarized, immunohistochemical detection of TCN1 was performed again, and the protein expression in tumor tissue, non-tumor tissue, and lymph nodes was semi-quantitatively analyzed. Patients were followed up for 5 years to determine the 5-year survival rates. Results The strong immune reactivity of the TCN1 protein was significantly correlated with tumor invasion depth, regional lymph nodes, and a tumor diameter of >5 cm (Z = −2.531 and P = .016; Z = 3.785 and P < .001; Z = 2.541 and P = .049). Kaplan–Meier survival analysis showed that the total survival time of patients in the low-expression TCN1 group was significantly longer than that in the high-expression TCN1 group (P = .001; Table 2 and Figure 5 ). The mean survival time of all patients was 49.774 months (95% CI: 47.871–51.676; Table 4 ) and the 5-year overall survival rates were 73.3, 50.8, and 34.0%, respectively. Multivariate analysis revealed that regional lymph nodes (HR = 1.253; 95% CI: 1.031–1.747, P = .012), TCN1 immune expression status (HR = 2.707; 95% CI: 1.068–1.886, P = .016), and pTNM staging (HR = 2.293; 95% CI: 1.583–3.321; P = .001) were independent risk factors for poor survival. Conclusion The high expression of TCN1 in gastric tumor tissues was found to be associated with the clinicopathological factors of patients, and the high expression of TCN1 was shown to indicate a poor clinical prognosis.

Prognosis Following Surgical Excision of Canine Cutaneous Mast Cell Tumors With Histopathologically Tumor-Free Versus Nontumor-Free Margins: A Retrospective Study of 31 Cases

2002 ◽  
Vol 38 (5) ◽  
pp. 458-466 ◽  
Author(s):  
Gina M. Michels ◽  
Deborah W. Knapp ◽  
Dennis B. DeNicola ◽  
Nita Glickman ◽  
Patty Bonney
Keyword(s):  
Mast Cell ◽  
Retrospective Study ◽  
Small Sample Size ◽  
Surgical Excision ◽  
Local Relapse ◽  
Small Sample ◽  
Mast Cell Tumors ◽  
Statistical Support ◽  
Cutaneous Mast Cell ◽  
Tumor Related Death

The purpose of this study was to determine if the presence of histopathologically tumor-free versus nontumor-free margins was prognostic for relapse or tumor-related death in dogs following surgical excision of single or multiple cutaneous mast cell tumors confined to the skin without evidence of metastasis to lymph nodes or other noncutaneous sites. Differences in tumor-related death or frequency of relapse between the two groups were not significant. Failure to achieve histopathological tumor-free margins frequently did not lead to local relapse. All tumor-related deaths occurred following local relapse. The lack of statistical support for an association between prognosis and histopathological tumor-free versus nontumor-free margins may be a result of small sample size.

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