scholarly journals Melissa officinalis L. hydro‐alcoholic extract inhibits anxiety and depression through prevention of central oxidative stress and apoptosis

2020 ◽  
Vol 105 (4) ◽  
pp. 707-720 ◽  
Author(s):  
Javid Ghazizadeh ◽  
Sanaz Hamedeyazdan ◽  
Mohammadali Torbati ◽  
Fereshteh Farajdokht ◽  
Ali Fakhari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Anxiety And Depression ◽  
Alcoholic Extract ◽  
Melissa Officinalis

scholarly journals The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid Profile and Oxidative Stress in Fructose-Fed Rats

2020 ◽  
Vol 29 (3) ◽  
pp. 198-207
Author(s):  
Maryam Mohammad-Sadeghipour ◽  
Mehdi Afsharinasab ◽  
Maryam Mohamadi ◽  
Mehdi Mahmoodi ◽  
Soudeh Khanamani Falahati-pour ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Alcoholic Extract ◽  
Fenugreek Seeds ◽  
And Oxidative Stress

scholarly journals Protective effect of Melissa officinalis extract against H2O2-induced oxidative stress in human vascular endothelial cells

2016 ◽  
Vol 11 (5) ◽  
pp. 383 ◽  
Author(s):  
Leila Safaeian ◽  
SeyyedEbrahim Sajjadi ◽  
ShaghayeghHaghjooy Javanmard ◽  
Hossein Montazeri ◽  
Fariba Samani
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Protective Effect ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Melissa Officinalis

scholarly journals The Comparative Effect of Hydro Alcoholic and Hydro Distillation Extracts of Melissa officinalis on Acne and Pimple

2019 ◽  
Vol 12 ◽  
pp. 35-43 ◽  
Author(s):  
Giti Sabet Teymouri ◽  
Mozhgan Sabet Teimouri
Keyword(s):  
Essential Oil ◽  
Rosmarinic Acid ◽  
Dry Matter ◽  
Water Extract ◽  
Distilled Water ◽  
Alcoholic Extract ◽  
Melissa Officinalis ◽  
Sebaceous Glands ◽  
Comparative Effect ◽  
The People

One of the famous plants in family Lamiaceae isMelissa officinaliswhich is one of the important herbs for health and Medicine. Melisa contains Rosmarinic acid, flavonoids and phenolic. These components have tightening and rejuvenation effect on skin. Also, it has monoterpenes and di-terpenes which are antibacterial. Essential oil of Melisa forms a good complex with sebum, so it can decrease inflammation and acne pain 30 gr of dry leaves and stems of Melisa in 500 ml of distilled water were used for hydro-distillation. For hydro alcoholic extract, we used 150 gr of dry matter (leaves and stems) in 500 ml of ethyl alcohol at 25 °C for 10 days. Then, the alcoholic extract was diluted 5 times with water 20 persons were under experiment for 3 months. Extracts were sprayed on skin 3-5 times a day. The results showed that all the people treated got the best result of this treatment. After the application of the water extract of Melissa, we observed 75% of clients improved the skin pore, 65% of clients improved neurological problems and Acne infections and 92% recovery of hyper secretion of Sebaceous glands. We observed the same results with Hydro Alcoholic extracts. 75% recovery of clients with improved skin pore, 95% of clients with improved neurological problems and Acne infections and 90% recovery of hyper secretion of Sebaceous glands. The results showed that Melisa extract has value of applying on some skin problems.

scholarly journals Effect of a hydro-alcoholic extract of Melissa officinalis on passive avoidance learning and memory

2019 ◽  
Vol 8 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Zahra Dehbani ◽  
Alireza Komaki ◽  
Farshid Etaee ◽  
Siamak Shahidi ◽  
Masoumeh Taheri ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Learning And Memory ◽  
Avoidance Learning ◽  
Saline Group ◽  
Passive Avoidance Learning ◽  
Male Rats ◽  
Control Group ◽  
Alcoholic Extract ◽  
Melissa Officinalis ◽  
Significant Difference

Introduction: Melissa officinalis (MO) or lemon balm is traditionally used as a sedative and anti-spasm herbal medicine. There is also evidence that this plant has effects on learning and memory. This study examined the effect of a hydro-alcoholic extract of MO on passive avoidance learning (PAL) and memory in male rats. Methods: A total of 40 adult male Wistar rats were randomly distributed into four groups (200 to 220 g; n = 10 per group); three dose groups (50, 100, and 200 mg/kg of the hydro-alcoholic extract of MO) and vehicle control (saline) group. Saline or doses of extract were administered daily for 14 days by oral gavage. The rats were trained to enter the shuttle box to record their behavior in the PAL task. A retrieval test was performed 24 hours following training. Results: A significant difference was seen in performance among MO groups and the control. MO administered animals had a decreased number of acquisition trials (P < 0.05). In the retention task, MO administered animals had an increased step-through latency (SLT) (P < 0.01), and a decreased latency in the dark compartment (P < 0.001) compared to the control group. Conclusion: The results of the study show that MO can improve learning and memory in the PAL task. Further investigation is needed to enhance our understanding of the neurobiological mechanisms of the MO extract and its effects on learning and memory.

scholarly journals Methodologies to Assess the Bioactivity of an Herbal Extract on Immunity, Health, Welfare and Production Performance in the Chicken: The Case of Melissa officinalis L. Extract

2021 ◽  
Vol 8 ◽  
Author(s):  
Angélique Travel ◽  
Angélique Petit ◽  
Perrine Barat ◽  
Anne Collin ◽  
Camille Bourrier-Clairat ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Cells ◽  
Ex Vivo ◽  
Redox Balance ◽  
Herbal Extracts ◽  
Melissa Officinalis ◽  
Starting Conditions ◽  
Anti Inflammatory ◽  
And Oxidative Stress

The potential of herbal extracts containing bioactive compounds to strengthen immunity could contribute to reducing antimicrobial use in poultry. This study aimed at developing a reliable and robust methodological pipeline to assess the ability of herbal extracts to strengthen chicken innate defenses, especially concerning inflammation and oxidative stress. This methodology was applied to Melissa officinalis L. (MEL) extract, recognized for its biological activities including antioxidant and anti-inflammatory properties. Different methods were used to (1). guarantee the quality of MEL extract and its capacity to stimulate the innate immune system; (2). evaluate the relevance of an ex vivo model to mimic inflammatory and oxidative stress challenges to replace LPS injection in chickens; (3). analyse the effects of feed supplemented with MEL extract on inflammation and oxidative stress induced ex vivo; (4). assess the effects of MEL extract on the redox balance, health, welfare and performance in broilers exposed to suboptimal starting conditions through a large-scale approach. The quality of MEL extract preparations, through phytochemical quantification of rosmarinic acid (RA), revealed varying concentrations of RA in the different MEL extracts. RA concentrations remained stable for at least 9 months and in feed three months after incorporating MEL extract. When incubated with chicken cell lines MEL extract showed potential metabolic activation and ability to stimulate immune functions but induced cytotoxicity at high concentrations. The original ex vivo model of inflammation developed on chicken blood cells enabled inflammation and oxidative stress biomarkers to be expressed and revealed antioxidative and anti-inflammatory properties of blood cells from chickens fed MEL extract. The experimental model of chicken suboptimal starting conditions validated beneficial effects of MEL extract on the redox balance and also evidenced improved performance during the growth phase, a tendency for fewer muscle defects but a higher severity of pododermatitis lesions without affecting other welfare indicators. This study grouped methods and tools that could be combined according to the plant extract, the needs of professionals working in poultry production systems and staff responsible for animal health, welfare and feeding.

scholarly journals New Insights Into the Anticonvulsant Effects of Essential Oil From Melissa officinalis L. (Lemon Balm)

2021 ◽  
Vol 12 ◽  
Author(s):  
Ben A. Chindo ◽  
Melanie-Jayne R. Howes ◽  
Sawsan Abuhamdah ◽  
Musa I. Yakubu ◽  
Godwin I. Ayuba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Essential Oil ◽  
Brain Slice ◽  
Neuronal Cell ◽  
Cell Loss ◽  
Repetitive Firing ◽  
Melissa Officinalis ◽  
Seizure Severity ◽  
Neuronal Cell Loss ◽  
Anticonvulsant Effects

Melissa officinalis L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the in vitro and in vivo models of epilepsy to probe the anticonvulsant potentials of essential oil from M. officinalis (MO) to gain insight into the scientific basis for its applications in traditional medicine for the management of convulsive disorders. MO was evaluated for effects on maximal electroshock (MES) and pentylenetetrazole (PTZ) -induced seizures in mice, on 4–aminopyridine (4-AP)-brain slice model of epilepsy and sustained repetitive firing of current clamped neurons; and its ameliorative effects were examined on seizure severity, anxiety, depression, cognitive dysfunction, oxidative stress and neuronal cell loss in PTZ-kindled rats. MO reversibly blocked spontaneous ictal-like discharges in the 4-AP-brain slice model of epilepsy and secondary spikes from sustained repetitive firing, suggesting anticonvulsant effects and voltage-gated sodium channel blockade. MO protected mice from PTZ– and MES–induced seizures and mortality, and ameliorated seizure severity, fear-avoidance, depressive-like behavior, cognitive deficits, oxidative stress and neuronal cell loss in PTZ–kindled rats. The findings warrant further study for the potential use of MO and/or its constituent(s) as adjunctive therapy for epileptic patients.

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