scholarly journals Converting Molecular Meshes Into Smooth Interpolatory Spline Solid Models

Author(s):  
Joel Daniels ◽  
Elaine Cohen ◽  
David Johnson

The study and understanding of molecules, once the domain of blackboards and stick-and-ball models, has become more and more exclusively linked to the use of computer-aided visualizations. Our project seeks to return the physical facsimile to the biologists, allowing the use of tactile senses while interacting with and manipulating a physical model, thus aiding educational and research endeavors. To increase the effectiveness of such a tool, the model is constructed such that multiple levels of information are viewable within the single physical form, stressing the interaction between the assorted components within the molecule. We use the term 3-D physical visualizations to refer to the fabricated model, to avoid confusion with the common usage of model as a virtual representation on the computer. To effectively combine multiple components into a smooth manufacturable physical visualization, all components of the model must be in a homogeneous format. Our research sets forth a method for converting triangulated mesh data, as provided by the molecular modeling packages, into spline models. Spline models have the attractive qualities that they are smooth without triangular facets, can be combined using traditional boolean operations (and, or, not), and can be directly fabricated using modern CAD/CAM techniques. Our method divides the polyhedral representation into multiple rectangular grids, then fits interpolatory spline surfaces to the data in each region, while focusing on smoothly stitching the boundaries and corners of the spline surfaces in order to create a near G1 continuous model.

Gesture ◽  
2005 ◽  
Vol 4 (2) ◽  
pp. 157-195 ◽  
Author(s):  
Jennifer Gerwing ◽  
Janet Bavelas

Hand gestures in face-to-face dialogue are symbolic acts, integrated with speech. Little is known about the factors that determine the physical form of these gestures. When the gesture depicts a previous nonsymbolic action, it obviously resembles this action; however, such gestures are not only noticeably different from the original action but, when they occur in a series, are different from each other. This paper presents an experiment with two separate analyses (one quantitative, one qualitative) testing the hypothesis that the immediate communicative function is a determinant of the symbolic form of the gesture. First, we manipulated whether the speaker was describing the previous action to an addressee who had done the same actions and therefore shared common ground or to one who had done different actions and therefore did not share common ground. The common ground gestures were judged to be significantly less complex, precise, or informative than the latter, a finding similar to the effects of common ground on words. In the qualitative analysis, we used the given versus new principle to analyze a series of gestures about the same actions by the same speaker. The speaker emphasized the new information in each gesture by making it larger, clearer, etc. When this information became given, a gesture for the same action became smaller or less precise, which is similar to findings for given versus new information in words. Thus the immediate communicative function (e.g., to convey information that is common ground or that is new) played a major role in determining the physical form of the gestures.


Author(s):  
Jack Chang ◽  
Mark Ganter ◽  
Duane Storti

Abstract Computer-aided design/manufacturing (CAD/CAM) systems intended to support automated design and manufacturing applications such as shape generation and solid free-form fabrication (SFF) must provide not only methods for creating and editing models of objects to be manufactured, but also methods for interrogating the models. Interrogation refers to any process that derives information from the model. Typical interrogation tasks include determine surface area, volume or inertial properties, computing surface points and normals for rendering, and computing slice descriptions for SFF. While currently available commercial modeling systems generally employ a boundary representation (B-rep) implementation of solid modeling, research efforts have considered implicit modeling schemes as a potential source of improved robustness. Implicit implementations are available for a broad range of modeling operations, but interrogation operations have been widely considered too costly for many applications. This paper describes a method based on interval analysis for interrogating implicit solid models that aims at achieving both robustness and efficiency.


2017 ◽  
Vol 20 (1) ◽  
pp. 90-98
Author(s):  
Md Sazzadul Islam ◽  
Md Saiful Islam Pathan

Ibuprofen is one of the common NSAIDs having poor water solubility, low dissolution, weak flow properties and reduced compressibility. These downsides of ibuprofen crystal upraise crucial challenges during development of a dosage form. The aim of this present work was to modify the physical form of ibuprofen by changing micromeritic properties. Seven different formulations of ibuprofen agglomerates such as F-1, F-2, F-3, F-4, F-5, F-6 and F-7 were prepared to convert the needle shaped ibuprofen crystals into agglomerates so that the desired micromeritic properties can be achieved. In this study, agglomerates of ibuprofen were prepared by Quasi emulsion solvent diffusion (QESD) method in association with two surfactants (sodium lauryl sulphateand Tween 80) at three different concentrations for each. The micromeritic properties of the prepared agglomerates were evaluated for bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose along with the release behavior of agglomerates. From dissolution study, it was observed that the release of drug was directly proportional to the surfactant concentration. Here, it was also revealed that there was no interaction among ibuprofen and other excipients as evident from DSC and FTIR studies.Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017


2020 ◽  
pp. 105971232092474
Author(s):  
André Cyr ◽  
Julie Morand-Ferron ◽  
Frédéric Thériault

Spatial information can be valuable, but new environments may be perceived as risky and thus often evoke fear responses and risk-averse exploration strategies such as thigmotaxis or wall-following behavior. Individual differences in risk-taking (boldness) and thigmotaxis have been reported in natural taxa, which may benefit their survival. In neurorobotic, the common approach is to reproduce cognitive phenomena with multiple levels of bio-inspiration into robotic scenarios. Since autonomous robots may benefit from these different behaviors in exploration tasks, this study aims at simulating two exploration strategies in a virtual robot controlled by a spiking neural network. The experimental context consists in a visual learning task solved through an operant conditioning procedure. Results suggest that the proposed neural architecture sustains both behaviors, switching from one to the other by external cues. This original bio-inspired model could be used as a first step toward further investigations of neurorobotic personality modulated by learning and complex exploration contexts.


Author(s):  
Urve Läänemets ◽  
Katrin Kalamees-Ruubel ◽  
Anu Sepp ◽  
Kristi Kiilu

Several factors, such as international trends of globalisation, technological innovation, changing learning environments as well as internal developments in socio-cultural contexts and educational policy-making are constantly shaping values of people and causing difficulties with specification of their identity building. Our study is based on comparative research carried out in Estonia and Finland in 2015-2018 (N = 217) with future music teachers, who were asked to write essays where they highlighted and explained meaningful for them cultural landmarks in their countries. The method used was hermeneutical analysis, as this allows to focus on the text produced according to the question asked as an expression of the respondents’ personal experiences and accepted values. The information presented in texts was analyzed at multiple levels and different viewpoints. Parallel analyses by authors were carried out in order to guarantee the validity of the overall results. Finally, the results were grouped, which allowed to draw preliminary conclusions what the common cultural landmarks were and why they have been accepted  and recognised  as meaningful and valuable by future music teachers both in Estonia and Finland and what their potential could be developing cultural cohesion in society.  


2007 ◽  
Vol 336-338 ◽  
pp. 1587-1589
Author(s):  
Wen Xu Li ◽  
Hua Zhao ◽  
Ying Song ◽  
Bin Su ◽  
Fu Ping Wang

Ca3(PO4)2/ZrO2 dental composite ceramics using for CAD/CAM system were prepared and the effects of weak phases on microstructures and mechanical properties were studied. The results showed that intergranular spreads happened with the increasing Ca3(PO4)2 contents due to the discontinuity of weak interfaces between Zirconia and Calcium phosphate in matrix. So the flexural strength and hardness of the Ca3(PO4)2/ZrO2 composite ceramics were decreased effectively, which improved the machinability of the composites. On the other hand, strong interfaces between Zirconias increased the integrality of the ceramic structures. ZrO2 composite Ceramics with 15% Ca3(PO4)2 were sintered at 1350°C. The flexural strength is 300.44MPa, fracture toughness is 4.36 MPam1/2, and hardness is 6.69 GPa. The cutting exponent of the Ca3(PO4)2/ZrO2 composite ceramics is obviously lower than that of the common commercial Vita Mark II and Dicor MGC ceramics, which shows good mechanical properties and machinability.


Author(s):  
Joel Gittelsohn ◽  
Rachel Novotny ◽  
Angela Trude ◽  
Jean Butel ◽  
Bent Mikkelsen

Multi-level multi-component (MLMC) strategies have been recommended to prevent and reduce childhood obesity, but results of such trials have been mixed. The present work discusses lessons learned from three recently completed MLMC interventions to inform future research and policy addressing childhood obesity. B’more Healthy Communities for Kids (BHCK), Children’s Healthy Living (CHL), and Health and Local Community (SoL) trials had distinct cultural contexts, global regions, and study designs, but intervened at multiple levels of the socioecological model with strategies that address multiple components of complex food and physical activity environments to prevent childhood obesity. We discuss four common themes: (i) How to engage with community partners and involve them in development of intervention and study design; (ii) build and maintain intervention intensity by creating mutual promotion and reinforcement of the intervention activities across the multiple levels and components; (iii) conduct process evaluation for monitoring, midcourse corrections, and to engage stakeholder groups; and (iv) sustaining MLMC interventions and its effect by developing enduring and systems focused collaborations. The paper expands on each of these themes with specific lessons learned and presents future directions for MLMC trials.


2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Matt Ratto

From 2014 until 2020, I participated in the development of a novel CAD/CAM system for lower-limb prosthetic sockets for use in Lower and Middle Income Countries (LMIC) orthopaedic clinical settings. This article provides an overview of the value principles that guided that work and the ways in which we attempted to support the clinical needs of our prosthetists and others in the clinical contexts. It will highlight how the health economic framework that is key to this special issue well describes the design choices we made in order to attend to the multiple levels of concerns and stakeholders we identified as key to success.     Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/36188/28345 How To Cite: Ratto M. Designing a digital toolchain for prosthetics: A retrospective. Canadian Prosthetics & Orthotics Journal. 2021; Volume 4, Issue 2, No.16. https://doi.org/10.33137/cpoj.v4i2.36188 Corresponding Author: Matt Ratto, PhDFaculty of Information, University of Toronto, Canada.E-Mail: [email protected] ID: https://orcid.org/0000-0002-3554-4513  


2020 ◽  
Author(s):  
Hartono .

The art of gamelan in Javanese culture contains aesthetical, ethical, and historical elements. The aesthetical element or the beauty of gamelan art reflects the common artistic principle dulce et utile which means entertaining and valuable. The creative activities of each artist is distinct. In other words, artists are able to create new modes in an artistic expression. Art does not only enrich psychological well-being but also serves as a media to communicate culture to the society. Gilbert Chesterton stated that the development of science and arts is inseparable. Whereas science studies the generic aspect of a physical form of something, arts deal with a more private matter that is the unique and solitary human. The ombak gong tuning system has become the unique characteristic of the accoustic tuning system of the gong instrument in Javanese gamelan in the current digital music era. Keywords: ombak gong, aesthetic of accoustic, digital music


Author(s):  
Robert Kirkwood ◽  
James A. Sherwood

Abstract Computer-aided design/computer-aided manufacturing/computer-aided engineering (CAD/CAM/CAE) integration offers designers, analysts, and manufacturers the opportunity to share the data throughout the product development process. Finite element (FE) meshing applications integrated with the solid model data from CAD systems represent a major subset of CAD/CAM/CAE integration. In an earlier paper, it was demonstrated that virtual persistent identifiers (VPIs) can be used to assure or repair sustained integration with successive versions of neutral-format solid models. From that article, several follow-on issues become apparent. The geometry as per the CAE model often differs from the CAD model, so even with cross-format issues resolved, significant obstacles to sustained CAD/CAE integration remain. Along with simplification, the current article investigates additional techniques for further automating the recognition of changes between CAD models, reducing the manual interaction to just a few minutes. The article goes on to demonstrate how associativity can be sustained when using current versions of neutral formats like STEP and IGES. The overall point of the paper is to show that given a precise recognition of the differences between two solid models, a generalized means of ad-hoc integration is possible. This point is demonstrated through two case studies where simplifications of the CAD geometry are made to facilitate the meshing of the part. The integration is shown to be maintained across successive versions and to address a range of simplification processing. A summary of best practices for efficiently accommodating sustained CAD/CAE integration is also presented.


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