Digital Microfluidic Platform for 3-D Tissue Based High Throughput Screening
Keyword(s):
Pharmaceutical drug development requires exhaustive testing of potential drugs in before animal and human clinical trials. Only one in ten drugs entering clinical trials receive the final approval. Most drugs fail in later stages due to lack of efficacy or toxicity which are discovered later on, after having cleared in vitro trials [1]. This highlights the need for improved laboratory testing methods to screen out failure candidates. It should be noted that 3-dimensional (3D) tissue constructs provide a better environment to mimic physiological processes as compared to conventional 2-dimensional (2D) cell based testing systems [2]
2007 ◽
Vol 12
(7)
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pp. 956-965
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2020 ◽
2020 ◽
Vol 27
(29)
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pp. 4778-4788
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2020 ◽
Vol 12
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pp. 175883592092006
Keyword(s):