scholarly journals Iron Regulation in Athletes: Exploring the Menstrual Cycle and Effects of Different Exercise Modalities on Hepcidin Production

2014 ◽  
Vol 24 (2) ◽  
pp. 177-187 ◽  
Author(s):  
Marc Sim ◽  
Brian Dawson ◽  
Grant Landers ◽  
Debbie Trinder ◽  
Peter Peeling
Keyword(s):  
Oral Contraceptive ◽  
Inflammatory Cytokine ◽  
Iron Absorption ◽  
Current Knowledge ◽  
Oral Contraceptive Pill ◽  
Well Being ◽  
The Body ◽  
Iron Regulation ◽  
Future Research ◽  
Exercise Induced

The trace element iron plays a number of crucial physiological roles within the body. Despite its importance, iron deficiency remains a common problem among athletes. As an individual’s iron stores become depleted, it can affect their well-being and athletic capacity. Recently, altered iron metabolism in athletes has been attributed to postexercise increases in the iron regulatory hormone hepcidin, which has been reported to be upregulated by exercise-induced increases in the inflammatory cytokine interleukin-6. As such, when hepcidin levels are elevated, iron absorption and recycling may be compromised. To date, however, most studies have explored the acute postexercise hepcidin response, with limited research seeking to minimize/attenuate these increases. This review summarizes the current knowledge regarding the postexercise hepcidin response under a variety of exercise scenarios and highlights potential areas for future research—such as: a) the use of hormones though the female oral contraceptive pill to manipulate the postexercise hepcidin response, b) comparing the use of different exercise modes (e.g., cycling vs. running) on hepcidin regulation.

Business model innovation: past research, current debates, and future directions

2017 ◽  
Vol 10 (3) ◽  
pp. 342-359 ◽  
Author(s):  
Mokter Hossain
Keyword(s):  
Literature Review ◽  
Business Model ◽  
Systematic Literature Review ◽  
Current Knowledge ◽  
Past Research ◽  
Business Model Innovation ◽  
The Body ◽  
Future Research ◽  
Content Type ◽  
Body Of Knowledge

Purpose The purpose of this paper is to provide state-of-the-art knowledge about business model innovation (BMI) and suggest avenues for future research. Design/methodology/approach A systematic literature review approach was adopted with thematic analysis being conducted on 92 articles. Findings The body of knowledge for this concept is in its infancy and is highly fragmented. This study therefore attempts to consolidate this fragmented knowledge. It reveals dominant themes, establishes coherence, and identifies conflicting arguments in the current literature. It also points out gaps in the research and highlights new directions for research. Research limitations/implications This study analyzed articles that were found based on a systematic literature review approach. Practical implications This study identifies some fundamental issues that managers need to understand regarding BMI. Originality/value The main value of this study lies in its synthesis of the current knowledge of BMI.

scholarly journals MIlitary Combat Mental Health Framework

2020 ◽  
pp. bmjmilitary-2020-001439
Author(s):  
Martin Bricknell
Keyword(s):  
Mental Health ◽  
Military Service ◽  
Current Knowledge ◽  
Armed Forces ◽  
Well Being ◽  
Therapeutic Interventions ◽  
Future Research ◽  
The Subject ◽  
Mental Well Being ◽  
Military Combat

This paper describes a framework for understanding military combat mental health based on the possible mental ill-health consequences of exposure to ‘potential trauma events’ for members of the armed forces and after their military service as veterans. It uses a life course approach that maps an individual’s mental well-being against four ‘states’: fit, reacting, injured and ill. It then considers five categories of factors that influence the risk of mental illness from this exposure based on research evidence; prejoining vulnerability, resilience, precipitating, treatment and recovery. This framework offers a structure to debate current knowledge, inform policy and therapeutic interventions, provide education and to guide future research into the subject.

scholarly journals From Medication to Meditation: A Critical Disability Studies Analysis of Mindfulness-Based Practices for Children With Learning Disabilities

2019 ◽  
Vol 3 (3) ◽  
pp. 1
Author(s):  
Emma Peddigrew ◽  
John McNamara
Keyword(s):  
Disability Studies ◽  
Emotional Regulation ◽  
Well Being ◽  
Social Contexts ◽  
The Body ◽  
Children And Youth ◽  
Future Research ◽  
Self Advocacy ◽  
Critical Disability Studies ◽  
The Impact

Throughout the past 70 years, the field of LDs has aimed to support children, youth, as well as their families, to generate definitions, understand neurological contributions and create meaningful policies and practices. However, despite decades of research, an emphasis on early identification and prevention, and significant policy documents, children and youth with LDs continue to face equally as important difficulties related to one’s social and emotional well-being. Critical disability studies (CDS) identifies how political, educational, and social contexts serve as sites for (in)justice (Shildrick, 2007). A CDS framework aims to resist the emphasis of individual impairment and deficiency while incorporating the interests and voices of the individuals with disabilities themselves. Few studies have analyzed the impact of mindfulness on how children with LDs cope with stress, ‘failure’, and understand their bodies. As a result, this paper will ask: how can mindfulness-based practices be used as a tool to improve the overall well-being of children and youth with a LD? With support from CDS and the utilization of mindfulness-based practices, children and youth with LDs can become connected to the body and mind. This study will enable future research on the importance of self-advocacy, coping, confidence, attention, and emotional regulation for children with LDs. It is through these liberating frameworks that children with LDs can become emancipated from political, historic, social, and cultural constraints.

Interleukin-6 is higher in naturally menstruating women as compared to oral contraceptive pill users during the low hormone phase

2021 ◽  
Author(s):  
Lauren E. Eagan ◽  
Catalina A. Chesney ◽  
Sara E. Mascone ◽  
Ninette Shenouda ◽  
Sushant M. Ranadive
Keyword(s):  
Oral Contraceptive ◽  
Interleukin 6 ◽  
Vascular Function ◽  
Inflammatory Cytokine ◽  
Oral Contraceptive Pill ◽  
Flow Mediated Dilation ◽  
Contraceptive Pill ◽  
Endogenous Estrogen ◽  
Menstruating Women ◽  
Artery Flow

Endogenous sex hormone concentrations vary between healthy naturally menstruating (non-OCP) and oral contraceptive pill-using (OCP) women, as well as across cycles. The aim of this study was to investigate potential differences in concentrations of inflammatory cytokine, interleukin-6 (IL-6), vasoconstrictive substance, endothelin-1 (ET-1), and measures of vascular function among relatively lower and higher hormone phases of non-OCP and OCP. Concentrations of estrogen, progesterone, IL-6 and ET-1 and measures of vascular function were collected in 22 women (22±1 y, OCP: n=12) during the early follicular (EF, ≤5 days of menstruation onset) and early luteal (EL, 4±2 days post-ovulation) phases of non-OCP and were compared to the placebo pill (PP, ≤5 days of PP onset) and active pill (AP, ≤5 days of highest dose AP) phases of OCP. Vascular function was assessed via brachial artery flow-mediated dilation (%FMD). Concentrations of endogenous estrogen and progesterone were higher in the EL phase as compared to the EF phase of non-OCP (p=0.01) but were similar between phases of OCP (p>0.05). IL-6 was higher in non-OCP during the EF phase as compared to the EL phase as well as compared to OCP during the PP phase (p=0.002) but was similar between groups during the EL and AP phases, respectively (p>0.05). Concentrations of ET-1 and measures of %FMD were similar between groups and unaffected by phase (p>0.05). Thus, there exists variation in inflammation between young, healthy non-OCP and OCP during the lower hormone phase, despite similarities in vascular function and concentrations of ET-1 between groups and phases.

Practices, drivers and barriers of implementing green leases: lessons from South Australia

2017 ◽  
Vol 19 (1) ◽  
pp. 36-52 ◽  
Author(s):  
Raufdeen Rameezdeen ◽  
Jian Zuo ◽  
Jack Stevens
Keyword(s):  
Real Life ◽  
South Australia ◽  
Well Being ◽  
Legal Aspects ◽  
The Body ◽  
Environmental Benefits ◽  
Future Research ◽  
Staff Retention ◽  
Structured Interviews ◽  
Content Type

Purpose This paper aims to investigate the practices, drivers and barriers which influence the implementation of green leases in South Australia. Despite some efforts on legal aspects of green leases, only a few studies have examined these aspects from an operational perspective. In addition, very little empirical evidence was presented in previous studies to show how green leases work in real-life settings. Design/methodology/approach Data were collected using semi-structured interviews with landlord and tenant representatives who have considerable experience in green leases. These interviewees were selected via a purposive sampling technique that identified buildings which use green leases in South Australia. The concept of interface management (IM) was used to operationalize this research. Findings The green leases were found to be mainly initiated by tenants while government involvement, economic and environmental benefits are the main drivers in South Australia. Drivers such as staff retention, well-being and corporate social responsibility are found to be more relevant to tenants. Lack of awareness and transaction costs are the main barriers to the implementation of green leases. Research limitations/implications This study focuses on the South Australian context and mainly covers dark green leases. There are implications for the government’s continued involvement and the promotion of lighter shades of green leases to overcome operational issues and barriers identified in this study. Originality/value This study contributes to the body of knowledge on the subject of green lease implementation from an operational perspective. In addition, the study introduces a conceptual framework via IM that could be used in future research endeavours.

scholarly journals Oral contraceptive pill use and the susceptibility to markers of exercise-induced muscle damage

2017 ◽  
Vol 117 (7) ◽  
pp. 1393-1402 ◽  
Author(s):  
K. M. Hicks ◽  
G. Onambélé-Pearson ◽  
K. Winwood ◽  
C. I. Morse
Keyword(s):  
Creatine Kinase ◽  
Oral Contraceptive ◽  
Muscle Damage ◽  
Vastus Lateralis ◽  
Oral Contraceptive Pill ◽  
Knee Extension ◽  
Patella Tendon ◽  
Contraceptive Pill ◽  
Exercise Induced ◽  
Tendon Properties

Abstract Purpose Firstly, to establish whether oral contraceptive pill (OCP) users are more susceptible to muscle damage compared to non-users, and secondly, to establish whether differences can be attributed to differences in patella tendon properties. Methods Nine female OCP users and 9 female non-users participated in the investigation. Combining dynamometry, electromyography and ultrasonography, patella tendon properties and vastus lateralis architectural properties were measured pre and during the first of 6 sets of 12 maximal voluntary eccentric knee extensions. Serum oestrogen levels were measured on the 7th day of the pill cycle and the 14th day of menstrual cycle in OCP users and non-users, respectively. Maximal voluntary isometric knee extension torque loss, creatine kinase and muscle soreness were measured 48 h pre-damage, post-damage, and 48, 96 and 168 h post-damage. Results Oestrogen levels were significantly lower in OCP users compared to non-users (209 ± 115 and 433 ± 147 pg/ml, respectively, p = 0.004). Proposed determinants of muscle damage, patella tendon stiffness and maximal eccentric torque did not differ between OCP users and non-users. The change in creatine kinase from pre to peak was significantly higher in OCP users compared to non-users (962 ± 968 and 386 ± 474 Ul, respectively, p = 0.016). There were no other differences in markers of muscle damage. Conclusion Although our findings suggest that, when compared to non-users, the OCP may augment the creatine kinase response following eccentric exercise, it does not increase the susceptibility to any other markers of muscle damage.

scholarly journals What Should I Eat before Exercise? Pre-Exercise Nutrition and the Response to Endurance Exercise: Current Prospective and Future Directions

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3473
Author(s):  
Jeffrey A. Rothschild ◽  
Andrew E. Kilding ◽  
Daniel J. Plews
Keyword(s):  
Endurance Training ◽  
Current Knowledge ◽  
Exercise Duration ◽  
Future Research ◽  
Carbohydrate Ingestion ◽  
Training Performance ◽  
Performance Improvements ◽  
And Performance ◽  
Exercise Induced ◽  
Intensity Of Exercise

The primary variables influencing the adaptive response to a bout of endurance training are exercise duration and exercise intensity. However, altering the availability of nutrients before and during exercise can also impact the training response by modulating the exercise stimulus and/or the physiological and molecular responses to the exercise-induced perturbations. The purpose of this review is to highlight the current knowledge of the influence of pre-exercise nutrition ingestion on the metabolic, physiological, and performance responses to endurance training and suggest directions for future research. Acutely, carbohydrate ingestion reduces fat oxidation, but there is little evidence showing enhanced fat burning capacity following long-term fasted-state training. Performance is improved following pre-exercise carbohydrate ingestion for longer but not shorter duration exercise, while training-induced performance improvements following nutrition strategies that modulate carbohydrate availability vary based on the type of nutrition protocol used. Contrasting findings related to the influence of acute carbohydrate ingestion on mitochondrial signaling may be related to the amount of carbohydrate consumed and the intensity of exercise. This review can help to guide athletes, coaches, and nutritionists in personalizing pre-exercise nutrition strategies, and for designing research studies to further elucidate the role of nutrition in endurance training adaptations.

I. Visions of epithelial research

2003 ◽  
Vol 284 (4) ◽  
pp. G547-G550 ◽  
Author(s):  
Marshall H. Montrose
Keyword(s):  
Epithelial Cells ◽  
Laser Capture Microdissection ◽  
Current Knowledge ◽  
The Body ◽  
Transepithelial Transport ◽  
Future Research ◽  
New Methodologies ◽  
Functionally Diverse ◽  
Microarray Analyses ◽  
Laser Capture

Epithelial cells are gatekeepers that sit at the interface between two compartments. By controlling the flow of molecules and information between two compartments, epithelial cells provide unique benefit to the body. This article provides a brief appraisal of our current knowledge about the functions of gastrointestinal epithelial cells as a functionally diverse set of cells mediating transepithelial transport and as a continually renewing layer of cells. The convergence of new methodologies in laser capture microdissection, microarray analyses, microscopic analyses, and generation of mutant animals provides an exciting template for future research.

scholarly journals Sadness and Other Health Complaints among Swedish Adolescents: A Cross-Sectional Study

2021 ◽  
Vol 18 (8) ◽  
pp. 3999
Author(s):  
Tide Garnow ◽  
Eva-Lena Einberg ◽  
Anna-Karin Edberg ◽  
Pernilla Garmy
Keyword(s):  
Well Being ◽  
Cross Sectional Study ◽  
The Body ◽  
Public Health Issue ◽  
Future Research ◽  
Health Complaints ◽  
Global Public Health ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

Health complaints are increasing among adolescents and are recognized as a global public health issue. Health complaints are an indicator for subjective ill-being, but little is known about the relationship between sadness and other health complaints. The aim of this study was to investigate sadness and other health complaints among Swedish adolescents. A survey with a cross-sectional design was completed by adolescents (n = 1489, 15–17 years old) in the south of Sweden. A logistic regression analysis was used to analyze the relationship between sadness and other health complaints. The result show that sadness and other health complaints were common among adolescents, and sadness was related to health complaints (headache (OR: 1.58), sleeping difficulties (OR: 2.00), reduced appetite (OR: 1.43), tension (OR: 2.44), and concentration difficulties (OR: 2.75)). When adolescents express sadness or other health complaints it is important to reflect on what these complaints are an expression of, and take into account the body as physical and psychological intertwined. This might entail person-centered support that hopefully leads to an improvement in adolescents’ well-being. Future research that profoundly highlights adolescents’ existential health is needed.

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