Proprioception Considerations in Surgery

1994 ◽  
Vol 3 (1) ◽  
pp. 105-115 ◽  
Author(s):  
Marc R. Safran ◽  
George L. Caldwell ◽  
Freddie H. Fu
Keyword(s):  
Time Course ◽  
Indications For Surgery ◽  
Prosthetic Replacement ◽  
Postoperative Patient ◽  
Postoperative Rehabilitation ◽  
Current Role ◽  
Main Components ◽  
Tissue Tension ◽  
Results Of Surgery

The role of surgery in proprioception, and the current role of proprioception in surgery, is unclear due to the lack of scientific research and clinical studies. The main components of proprioception in surgery are viewed to be preservation of afferents, promotion of regeneration of mechanoreceptors, and modification of protective reflex arcs in the postoperative patient. Soft tissue tension is hypothesized to be important in the efficiency of proprioceptors. Further, postoperative rehabilitation concentrating on proprioception may improve the results of surgery. With better understanding by clinicians, proprioception may play a bigger role in surgical technique, prosthetic replacement choice, and even indications for surgery. Further, proprioceptive testing may help determine the time course for optimal functional outcome following procedures. Thus, the future for proprioception in surgery and clinical application is expanding rapidly.

The Current Role of Ethics in Industrial- Organizational Psychology

2012 ◽  
Author(s):  
Jeffrey M. Saltzman ◽  
Eric Brasher ◽  
Frank Guglielmo ◽  
Joel M. Lefkowitz ◽  
Walter Reichman
Keyword(s):  
Organizational Psychology ◽  
Current Role ◽  
Industrial Organizational Psychology

The current role of gemcitabine in ovarian cancer

2001 ◽  
Vol 28 (2D) ◽  
pp. 18-24
Author(s):  
Robert F. Ozols
Keyword(s):  
Ovarian Cancer ◽  
Current Role

Collagen-Induced Platelet Aggregation: -Evidence Against the Essential Role of Platelet Adenosine Diphosphate

1979 ◽  
Vol 42 (04) ◽  
pp. 1193-1206 ◽  
Author(s):  
Barbara Nunn
Keyword(s):  
Platelet Aggregation ◽  
Time Course ◽  
Essential Role ◽  
Atp Release ◽  
Adenosine Diphosphate ◽  
Human Platelets ◽  
High Doses ◽  
Induced Aggregation

SummaryThe hypothesis that platelet ADP is responsible for collagen-induced aggregation has been re-examined. It was found that the concentration of ADP obtaining in human PRP at the onset of aggregation was not sufficient to account for that aggregation. Furthermore, the time-course of collagen-induced release in human PRP was the same as that in sheep PRP where ADP does not cause release. These findings are not consistent with claims that ADP alone perpetuates a collagen-initiated release-aggregation-release sequence. The effects of high doses of collagen, which released 4-5 μM ADP, were not inhibited by 500 pM adenosine, a concentration that greatly reduced the effect of 300 μM ADP. Collagen caused aggregation in ADP-refractory PRP and in platelet suspensions unresponsive to 1 mM ADP. Thus human platelets can aggregate in response to collagen under circumstances in which they cannot respond to ADP. Apyrase inhibited aggregation and ATP release in platelet suspensions but not in human PRP. Evidence is presented that the means currently used to examine the role of ADP in aggregation require investigation.

Practical consensus recommendations - Current role of immune response evaluation criteria in solid tumors criteria in the management of cancer patients receiving immunotherapy

2019 ◽  
Vol 4 ◽  
pp. 21-23
Author(s):  
Purvish M. Parikh ◽  
T. P. Sahoo ◽  
Randeep Singh ◽  
Bahl Ankur ◽  
Talvar Vineet ◽  
...  
Keyword(s):  
Immune Response ◽  
Solid Tumors ◽  
Evaluation Criteria ◽  
Supporting Evidence ◽  
Response Evaluation ◽  
Consensus Recommendation ◽  
Current Role ◽  
New Class ◽  
Response Evaluation Criteria

Response evaluation criteria in solid tumors (RECIST) are a method used to evaluate and document the response to cancer treatment in solid tumors. The availability of a new class of immuneoncology drugs has resulted in the need to modify RECIST criteria methodology. The first leadership immuno-oncology network (LION) master course brought together experts in oncology and immuno-oncology. Six questions were put to the experts and their opinion, supporting evidence, and experience were discussed to arrive at a practical consensus recommendation. n this nascent field, the availability of a practical consensus recommendation developed by experts in the field is of immense value to the community oncologist and other health-care consultants.

scholarly journals Role of Thermal Ablation in Colorectal Cancer Lung Metastases

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 908
Author(s):  
Alexandre Delpla ◽  
Thierry de Baere ◽  
Eloi Varin ◽  
Frederic Deschamps ◽  
Charles Roux ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Thermal Ablation ◽  
Medical Oncology ◽  
Pulmonary Metastases ◽  
Lung Metastases ◽  
Stereotactic Ablative Radiotherapy ◽  
Chest Drainage ◽  
Results Of Surgery

Background: Consensus guidelines of the European Society for Medical Oncology (ESMO) (2016) provided recommendations for the management of lung metastases. Thermal ablation appears as a tool in the management of these secondary pulmonary lesions, in the same manner as surgical resection or stereotactic ablative radiotherapy (SABR). Methods: Indications, technical considerations, oncological outcomes such as survival (OS) or local control (LC), prognostic factors and complications of thermal ablation in colorectal cancer lung metastases were reviewed and put into perspective with results of surgery and SABR. Results: LC rates varied from 62 to 91%, with size of the metastasis (<2 cm), proximity to the bronchi or vessels, and size of ablation margins (>5 mm) as predictive factors of LC. Median OS varied between 33 and 68 months. Pulmonary free disease interval <12 months, positive carcinoembryonic antigen, absence of neoadjuvant chemotherapy and uncontrolled extra-pulmonary metastases were poor prognostic factors for OS. While chest drainage for less than 48 h was required in 13 to 47% of treatments, major complications were rare. Conclusions: Thermal ablation of a selected subpopulation of patients with colorectal cancer lung metastases is safe and can provide excellent LC and delay systemic chemotherapy.

scholarly journals Radiological Anatomy of Stomach and Duodenum with Clinical Significance

2021 ◽  
Author(s):  
Zainab Vora ◽  
Ankur Goyal ◽  
Raju Sharma
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Clinical Significance ◽  
Normal Anatomy ◽  
Resonance Imaging ◽  
Radiological Anatomy ◽  
Current Role ◽  
Accurate Imaging

AbstractAnatomy is the key to accurate imaging interpretation. It is essential for radiologists to thoroughly understand the normal anatomy and spatial relationships of the stomach and duodenum to accurately localize the site of abnormality. In this article, we describe in detail the gross and applied radiological anatomy of the stomach and duodenum, and the current role of various radiological investigations (including barium studies, endoscopic ultrasonography, computed tomography, and magnetic resonance imaging) in the evaluation of the diseases involving the stomach and duodenum.

scholarly journals Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior

2021 ◽  
Author(s):  
Young-Min Han ◽  
Min Sun Kim ◽  
Juyeong Jo ◽  
Daiha Shin ◽  
Seung-Hae Kwon ◽  
...  
Keyword(s):  
Inhibitory Action ◽  
Time Course ◽  
Molecular Mechanisms ◽  
Late Phase ◽  
Fine Tuning ◽  
Dependent Manner ◽  
Middle Phase ◽  
Temporal Shift

AbstractThe fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how GR is involved in the dynamics of NFκB in vivo. In this study, we used an improved lentiviral-based reporter to elucidate the time course of NFκB and GR activities during behavioral changes from sickness to depression induced by a systemic lipopolysaccharide challenge. The trajectory of NFκB activity established a behavioral basis for the NFκB signal transition involved in three phases, sickness-early-phase, normal-middle-phase, and depressive-like-late-phase. The temporal shift in brain GR activity was differentially involved in the transition of NFκB signals during the normal and depressive-like phases. The middle-phase GR effectively inhibited NFκB in a glucocorticoid-dependent manner, but the late-phase GR had no inhibitory action. Furthermore, we revealed the cryptic role of basal GR activity in the early NFκB signal transition, as evidenced by the fact that blocking GR activity with RU486 led to early depressive-like episodes through the emergence of the brain NFκB activity. These results highlight the inhibitory action of GR on NFκB by the basal and activated hypothalamic-pituitary-adrenal (HPA)-axis during body-to-brain inflammatory spread, providing clues about molecular mechanisms underlying systemic inflammation caused by such as COVID-19 infection, leading to depression.

scholarly journals History, Colonialism, and Archival Methods in Socio-Hydrological Scholarship: A Case Study of the Boerasirie Conservancy in British Guiana

World ◽  
2020 ◽  
Vol 1 (3) ◽  
pp. 205-215
Author(s):  
Joshua Mullenite
Keyword(s):  
Environmental History ◽  
Cross Section ◽  
Science And Technology Studies ◽  
Model Development ◽  
Human Geography ◽  
Hydrological Models ◽  
British Guiana ◽  
Current Role

In this article, I review a cross-section of research in socio-hydrology from across disciplines in order to better understand the current role of historical-archival analysis in the development of socio-hydrological scholarship. I argue that despite its widespread use in environmental history, science and technology studies, anthropology, and human geography, archival methods are currently underutilized in socio-hydrological scholarship more broadly, particularly in the development of socio-hydrological models. Drawing on archival research conducted in relation to the socio-hydrology of coastal Guyana, I demonstrate the ways in which such scholarship can be readily incorporated into model development.

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