scholarly journals Social reprogramming in ants induces longevity-associated glia remodeling

2020 ◽  
Vol 6 (34) ◽  
pp. eaba9869
Author(s):  
Lihong Sheng ◽  
Emily J. Shields ◽  
Janko Gospocic ◽  
Karl M. Glastad ◽  
Puttachai Ratchasanmuang ◽  
...  

In social insects, workers and queens arise from the same genome but display profound differences in behavior and longevity. In Harpegnathos saltator ants, adult workers can transition to a queen-like state called gamergate, which results in reprogramming of social behavior and life-span extension. Using single-cell RNA sequencing, we compared the distribution of neuronal and glial populations before and after the social transition. We found that the conversion of workers into gamergates resulted in the expansion of neuroprotective ensheathing glia. Brain injury assays revealed that activation of the damage response gene Mmp1 was weaker in old workers, where the relative frequency of ensheathing glia also declined. On the other hand, long-lived gamergates retained a larger fraction of ensheathing glia and the ability to mount a strong Mmp1 response to brain injury into old age. We also observed molecular and cellular changes suggestive of age-associated decline in ensheathing glia in Drosophila.

2020 ◽  
Vol 132 (6) ◽  
pp. 1952-1960 ◽  
Author(s):  
Seung-Bo Lee ◽  
Hakseung Kim ◽  
Young-Tak Kim ◽  
Frederick A. Zeiler ◽  
Peter Smielewski ◽  
...  

OBJECTIVEMonitoring intracranial and arterial blood pressure (ICP and ABP, respectively) provides crucial information regarding the neurological status of patients with traumatic brain injury (TBI). However, these signals are often heavily affected by artifacts, which may significantly reduce the reliability of the clinical determinations derived from the signals. The goal of this work was to eliminate signal artifacts from continuous ICP and ABP monitoring via deep learning techniques and to assess the changes in the prognostic capacities of clinical parameters after artifact elimination.METHODSThe first 24 hours of monitoring ICP and ABP in a total of 309 patients with TBI was retrospectively analyzed. An artifact elimination model for ICP and ABP was constructed via a stacked convolutional autoencoder (SCAE) and convolutional neural network (CNN) with 10-fold cross-validation tests. The prevalence and prognostic capacity of ICP- and ABP-related clinical events were compared before and after artifact elimination.RESULTSThe proposed SCAE-CNN model exhibited reliable accuracy in eliminating ABP and ICP artifacts (net prediction rates of 97% and 94%, respectively). The prevalence of ICP- and ABP-related clinical events (i.e., systemic hypotension, intracranial hypertension, cerebral hypoperfusion, and poor cerebrovascular reactivity) all decreased significantly after artifact removal.CONCLUSIONSThe SCAE-CNN model can be reliably used to eliminate artifacts, which significantly improves the reliability and efficacy of ICP- and ABP-derived clinical parameters for prognostic determinations after TBI.


2021 ◽  
Vol 92 (5) ◽  
pp. 519-527
Author(s):  
Yasmina Molero ◽  
David James Sharp ◽  
Brian Matthew D'Onofrio ◽  
Henrik Larsson ◽  
Seena Fazel

ObjectiveTo examine psychotropic and pain medication use in a population-based cohort of individuals with traumatic brain injury (TBI), and compare them with controls from similar backgrounds.MethodsWe assessed Swedish nationwide registers to include all individuals diagnosed with incident TBI between 2006 and 2012 in hospitals or specialist outpatient care. Full siblings never diagnosed with TBI acted as controls. We examined dispensed prescriptions for psychotropic and pain medications for the 12 months before and after the TBI.ResultsWe identified 239 425 individuals with incident TBI, and 199 658 unaffected sibling controls. In the TBI cohort, 36.6% had collected at least one prescription for a psychotropic or pain medication in the 12 months before the TBI. In the 12 months after, medication use increased to 45.0%, an absolute rate increase of 8.4% (p<0.001). The largest post-TBI increases were found for opioids (from 16.3% to 21.6%, p<0.001), and non-opioid pain medications (from 20.3% to 26.6%, p<0.001). The majority of prescriptions were short-term; 20.6% of those prescribed opioids and 37.3% of those with benzodiazepines collected prescriptions for more than 6 months. Increased odds of any psychotropic or pain medication were associated with individuals before (OR: 1.62, 95% CI: 1.59 to 1.65), and after the TBI (OR: 2.30, 95% CI: 2.26 to 2.34) as compared with sibling controls, and ORs were consistently increased for all medication classes.ConclusionHigh rates of psychotropic and pain medications after a TBI suggest that medical follow-up should be routine and review medication use.


2018 ◽  
pp. 1-7 ◽  
Author(s):  
Randy F. Sweis ◽  
Brian Heiss ◽  
Jeremy Segal ◽  
Lauren Ritterhouse ◽  
Sabah Kadri ◽  
...  

2020 ◽  
Vol 68 (5) ◽  
pp. 999-1014
Author(s):  
Amín Pérez

This article proposes a new understanding of the constraints and opportunities that lead intellectuals engaged in different political and social fields to create alternative modes of resistance to domination. The study of the Algerian sociologist Abdelmalek Sayad offers insights into the social conditions of this mode of committed scholarship. On the one hand, this article applies Sayad’s theory of immigration to his transnational intellectual engagements. It establishes how immigrants’ intellectual work are conditioned by their trajectories, both before and after leaving their country, and by the stages of emigration (from playing a role in the society of origin to becoming caught up in the reality of the host society). On the other hand, the article illuminates the constraints and the spaces of possible action intellectuals face while moving across national universes and disparate political and academic fields. Sayad’s marginal position within the academy constrained him to work for the French and Algerian governments and international organizations while he was simultaneously engaged with political dissidents, unionists, writers, and social movements. In tracking Sayad’s roles as an academic, expert and public sociologist, the article uncovers the conditions that grounded improbable alliances between those fields and produced new forms of critique and political action. The article concludes by drawing out some reflections that ‘collective intellectual’ engagements elicit to the sociology of intellectuals.


2017 ◽  
Vol 24 (3) ◽  
pp. 528-544 ◽  
Author(s):  
Ioannis Giotopoulos ◽  
Alexandra Kontolaimou ◽  
Aggelos Tsakanikas

Purpose The purpose of this paper is to explore potential drivers of high-growth intentions of early-stage entrepreneurs in Greece before and after the onset of the financial crisis of 2008. Design/methodology/approach To this end, the authors use individual-level data retrieved from Global Entrepreneurship Monitor annual surveys (2003-2015). Findings The results show that high-growth intentions of Greek entrepreneurs are driven by different factors in the crisis compared to the non-crisis period. Male entrepreneurs and entrepreneurs with significant work experience seem to be more likely to be engaged in growth-oriented new ventures during the crisis period. The same appears to hold for entrepreneurs who are motivated by an opportunity and also perceive future business opportunities in adverse economic conditions. On the other hand, the educational level and the social contacts of founders with other entrepreneurs are found to drive ambitious Greek entrepreneurship in the years before the crisis, while they were insignificant after the crisis outbreak. Originality/value Based on the concept of ambitious entrepreneurship, this study contributes to the literature by investigating the determinants of entrepreneurial high-growth expectations in the Greek context emphasizing the crisis period in comparison to the pre-crisis years.


2021 ◽  
pp. molcanther.0879.2020
Author(s):  
Michael Cerniglia ◽  
Joanne Xiu ◽  
Axel Grothey ◽  
Michael J Pishvaian ◽  
Yasmine Baca ◽  
...  

PEDIATRICS ◽  
1969 ◽  
Vol 44 (5) ◽  
pp. 838-847
Author(s):  
John H. Read

The two papers that follow report the results of painstaking epidemiological work on pedestrian accidents involving children. Because these papers relate the age of the child to specific behavior patterns that result in accidents and to specific injury patterns that result from such accidents, they would appear to offer a sound empirical base for the development of a variety of countermeasures, whether such countermeasures are intended to reduce accidents or to limit the severity of the resulting injuries. Unfortunately, however, the ability to generalize such data is extremely limited. A given pattern of child-pedestrian behavior is the result of a highly complex set of variables: the social class and ethnicity of the child, the ecological characteristics of the neighborhood and the broader community, the characteristics of the traffic pattern and the types and density of the vehicles that make it up, the current enforcement policy, climatic conditions, road and highway characteristics, and a host of other conditions that combine and interact in various ways. Consequently, few localities are sufficiently similar to justify the application of data from one to another. The injury patterns described by Ryan, for example, are those produced by Australian vehicles on children walking, playing, and cycling in a specific Australian city. It seems quite unlikely that the injury patterns produced in an American urban environment would resemble those that Ryan reports. Indeed, data from another Australian city might show striking differences. For the same reasons, such data as Read presents cannot be used reliably as a before-and-after measure to assess the effectiveness of a specific countermeasure. Any significant changes in the data after the introduction of a countermeasure might well be attributable not to the countermeasure itself but to changes in traffic patterns, ecology, the weather, or other events which operated to reinforce or counteract the countermeasure in question. The overwhelming obstacle to systematic research in vehicular accidents and on the assessment of countermeasure effectiveness is the investigator's inability to control the numerous variables that affect both the incidence and the consequences of accidents. The present papers, despite their inherently interesting data, are seriously limited by this problem.


2010 ◽  
Vol 8 (1) ◽  
pp. 24-28
Author(s):  
Daniela Barreto Fraguglia Quental Diniz ◽  
Daniella de Batista Depes ◽  
Ana Maria Gomes dos Santos ◽  
Simone Denise David ◽  
Salete Yatabe ◽  
...  

ABSTRACT Objective: To evaluate the intensity of pain reported by patients undergoing outpatient diagnostic hysteroscopy. Methods: Exam performed with a 5-mm lens hysteroscope, vaginal speculum, tenaculum and uterine distention with carbon dioxide gas. Before and after the examination, patients were interviewed to define, in a verbal scale from 0 to 10, pain values that they expected to feel and that they experienced after the end, and also if they would repeat it if indicated. Data were analyzed using Statistical Package for the Social Sciences 15.0, statistic significance was defined as p < 0.05 with a study power of 95%. Results: Fifty-eight patients were included with mean age of 50.9 years, with 32.8% at postmenopause and 6.9% nulliparous. Among those with previous deliveries, mean parity was 2.21 and at least one vaginal delivery had occurred in 63.8%. Only 24.1% of patients knew how the exam would be done, 62.1% needed an endometrial sample and the result was considered satisfactory in 89.7%. The means of expected and experienced pain were similar (6.0 versus 6.1), and 91.4% of women would repeat the hysteroscopy if necessary. The only factor associated with less pain after the exam was previous vaginal delivery, with a decrease of pain score from 7.1 to 5.5 (p = 0.03). Mean pain was significantly lower in those who agreed to repeat the exam (5.8 versus 9.4; p = 0.003). Conclusions: Outpatient diagnostic hysteroscopy with gas can be associated with moderate but tolerable discomfort and satisfactory results.


1999 ◽  
Vol 5 (12) ◽  
pp. 133-151
Author(s):  
Claudia de Lima Costa

This paper retraces the debates on life-histories before and after the linguistic turn in the social sciences, and, more specifically, in the anthropological tradition. It stresses how poststructuralist feminist methodological, theoretical, and political appropriations of personal narratives represent a significant textual intervention in the gendered social-cultural scripts of women’s lives.


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