scholarly journals Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

Science ◽  
2020 ◽  
Vol 370 (6512) ◽  
pp. 66-69 ◽  
Author(s):  
Tim Bartels ◽  
Sebastiaan De Schepper ◽  
Soyon Hong
Keyword(s):  
Global Health ◽  
Cross Talk ◽  
Adult Brain ◽  
Neuronal Function ◽  
Brain Health ◽  
Health Crisis ◽  
Early Biomarkers ◽  
Parkinson’S Diseases ◽  
The World

Dementia is a rapidly rising global health crisis that silently disables families and ends lives and livelihoods around the world. To date, however, no early biomarkers or effective therapies exist. It is now clear that brain microglia are more than mere bystanders or amyloid phagocytes; they can act as governors of neuronal function and homeostasis in the adult brain. Here, we highlight the fundamental role of microglia as tissue-resident macrophages in neuronal health. Then, we suggest how chronic impairment in microglia-neuron cross-talk may secure the permanence of the failure of synaptic and neuronal function and health in Alzheimer’s and Parkinson’s diseases. Understanding how to assess and modulate microglia-neuron interactions critical for brain health will be key to developing effective therapies for dementia.

scholarly journals The Covid infodemic

2021 ◽  
Author(s):  
Ken Hyland ◽  
Feng (Kevin) Jiang
Keyword(s):  
Social Anxiety ◽  
Global Health ◽  
Medical Research ◽  
World Health Organization ◽  
Research Methods ◽  
World Health ◽  
Health Crisis ◽  
The World ◽  
Health Organization ◽  
Highly Cited

Abstract Covid-19, the greatest global health crisis for a century, brought a new immediacy and urgency to international bio-medical research. The pandemic generated intense competition to produce a vaccine and contain the virus, creating what the World Health Organization referred to as an ‘infodemic’ of published output. In this frantic atmosphere, researchers were keen to get their research noticed. In this paper, we explore whether this enthusiasm influenced the rhetorical presentation of research and encouraged scientists to “sell” their studies. Examining a corpus of the most highly cited SCI articles on the virus published in the first seven months of 2020, we explore authors’ use of hyperbolic and promotional language to boost aspects of their research. Our results show a significant increase in hype to stress certainty, contribution, novelty and potential, especially regarding research methods, outcomes and primacy. Our study sheds light on scientific persuasion at a time of intense social anxiety.

scholarly journals Global Governance and the WHO’s Mandate Post-COVID-19 Crisis

2021 ◽  
Author(s):  
Jean Vilbert
Keyword(s):  
Global Health ◽  
Negative Relationship ◽  
World Health ◽  
First Year ◽  
Health Crisis ◽  
Nation States ◽  
Democratic Principle ◽  
The World ◽  
Distribution Of Power ◽  
Health Organization

The COVID-19 has renovated the debate about global health governance. A number of scholars have proposed that the World Health Organization should assume the position of a central coordinator with hierarchical powers, demanding nation-states to “share their sovereignty”. This article presents four main objections to this project. First, when international institutions receive leverage, they use to impose “one-size-fits-all” policies, which conflicts with the characteristic heterogeny across countries. Second, geopolitical questions and the distribution of power in multilateral institutions put developing countries in a position of vulnerability within a hierarchical order. Third, the risk of crowding out parallel initiatives, especially from non-state actors. Fourth, decisions about health can have a major impact on countries, which may thwart the internal democratic principle. A Pareto improvement would be possible by strengthening the WHO’s operational capacity and its ability to issue technical guidance and coordinate with countries. To test this hypothesis, this study analyses the possible influence of the WHO’s guidance in the first year of the coronavirus health crisis, from January 2020 to January 2021, in 37 countries reported in the World Values Survey Wave 7 (2017-2020). The OLS regression performed shows a statistically significant negative relationship between the trust in the WHO, assumed as a proxy for the level of the organization's penetration, and the number of cases of COVID-19 (per million people) in the countries of the sample. These findings reinforce the hypothesis that there is a valid case for the countries to strengthen the WHO’s mandate post-COVID-19, but they should enhance the operations of provision of reliable information and support. Nation-states, in particular the developing ones, should eschew the temptation to create a hierarchical global health structure, which may not only fail due to countries’ asymmetries but is likely to create losers in the process.

scholarly journals The Changing Role of the WORLD BANK in Global Health

2005 ◽  
Vol 95 (1) ◽  
pp. 60-70 ◽  
Author(s):  
Jennifer Prah Ruger
Keyword(s):  
Global Health ◽  
World Bank ◽  
The World Bank ◽  
The World ◽  
Changing Role

scholarly journals Needs assessment and impact of COVID-19 on pharmacy professionals in 31 commonwealth countries

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Diane Ashiru-Oredope ◽  
◽  
Amy Hai Yan Chan ◽  
Omotayo Olaoye ◽  
Victoria Rutter ◽  
...  
Keyword(s):  
Global Health ◽  
Emergency Preparedness ◽  
World Health ◽  
Global Public Health ◽  
Online Questionnaire ◽  
Health Crisis ◽  
Frequency Distributions ◽  
The World ◽  
Pandemic Response ◽  
The Impact

Abstract Background The declaration of COVID-19 a pandemic by the World Health Organization on 11 March 2020 marked the beginning of a global health crisis of an unprecedented nature and scale. The approach taken by countries across the world varied widely, however, the delivery of frontline healthcare was consistently recognised as being central to the pandemic response. This study aimed to identify and explore the issues currently facing pharmacy teams across Commonwealth countries during the COVID-19 pandemic. The study also evaluates pharmacy professionals’ understanding of key knowledge areas from the COVID-19 webinar hosted by the Commonwealth Pharmacists’ Association (CPA). Method A quantitative survey-based approach was adopted, using a 32-item questionnaire developed from the literature on pharmacy and pandemic response. The survey was hosted on Survey Monkey and pilot tested. The final survey was disseminated by CPA member organisations. A 6-item online questionnaire was sent via email to all attendees of CPA's COVID-19 webinar. Descriptive statistics on frequency distributions and percentages were used to analyse the responses. Data were analysed using Microsoft® Excel (2010). Results There were 545 responses from pharmacy professionals across 31/54 Commonwealth countries in Africa, Asia, the Americas, Europe and the Pacific. Majority of the respondents reported being at least somewhat worried (90%) and more than 65% were very worried or extremely about the impact of COVID-19 on them personally and professionally. Nearly two-thirds of respondents stated finding it somewhat difficult or very difficult to work effectively during the pandemic. Challenges mostly faced by pharmacy professionals working remotely included; general anxiety about the impact of COVID-19 on their lives (12%), and difficulties in communicating with their co-workers (12%). Most pharmacy professionals had not previously been actively involved in a global health emergency (82%) nor obtained training on global/public health emergency preparedness (62%). Between 45 and 97% of the COVID-19 webinar attendees provided the correct answers to post-webinar questions, suggesting some improvement in knowledge. Conclusion Our study confirms pharmacy professionals’ concerns about practice during a pandemic and provides preliminary data on the challenges and learning needs of the profession. The CPA has since acted on these findings, providing ongoing opportunities to develop and refine resources for the profession as the pandemic evolves. Pharmacy professionals have also demonstrated improved knowledge on the management of COVID-19 and resources available for professionals.

scholarly journals The World Health Organization in Crisis—Lessons to be Learned Beyond the Ebola Outbreak

2016 ◽  
Vol 2 (1) ◽  
pp. 1-29 ◽  
Author(s):  
Nadja Meisterhans
Keyword(s):  
Global Health ◽  
World Health Organization ◽  
Legal Theory ◽  
World Health ◽  
Health Crisis ◽  
Democratic Reform ◽  
The World ◽  
The Media ◽  
Health Organization ◽  
Do So

Blaming the World Health Organization (who) for its failures in the Ebola crisis was a common reaction of the media. However, exclusively denouncing the who for the spread of Ebola falls short as it does not recognize the structural deficits of those recent governance procedures financing global health that lead to a chronic underfunding of the who. Against this background, the article reflects perspectives of a democratic reform of global health funding. It concludes that only the who can provide a leadership on global health matters, but to do so it depends on states willing to rebuild the who’s capacities to act. To address the global health crisis properly, the revitalization of who’s constitutional mandate is critically necessary. The discussion is based on normative legal theory, which argues that processes of globalization have transformed international law into a global rule of law, placing specific duties on states and international institutions.

scholarly journals The role of vaccination in global health

2014 ◽  
Vol 83 (2) ◽  
pp. 17-19
Author(s):  
Keegan Guidolin ◽  
Gaby Meglei
Keyword(s):  
Infectious Disease ◽  
Global Health ◽  
Infectious Diseases ◽  
Financial Support ◽  
Action Plan ◽  
Preventable Death ◽  
Eradication Program ◽  
The World ◽  
The Future

Perhaps the greatest medical advancement in history was the development of the vaccine. While previously helpless to stop the spread of deadly infectious diseases, humanity has since harnessed the power of vaccination and decreased the incidence of infectious disease across the globe. Smallpox was the first disease to be eradicated—the greatest of our triumphs. This success was due to the global coordinated effort of the Intensified Smallpox Eradication Program. Presently, measles is the top cause of vaccine-preventable death in the world, and despite enormous vaccination efforts, eradication is still distant. This is due in part to the antivaccination movement, which was fueled by an article by Wakefield, published in the Lancet in 1998. The future of vaccination is an ambitious and unclear one—with tremendous financial support and involvement, the Global Vaccine Action Plan (GVAP) aims to eliminate vaccine preventable illness within what they call the “Decade of Vaccines”.

scholarly journals Doctoral Candidates’ Academic Writing Output and Strategies: Navigating the Challenges of Academic Writing During a Global Health Crisis

10.28945/4755 ◽  
2021 ◽  
Vol 16 ◽  
pp. 291-317
Author(s):  
Basil Cahusac de Caux
Keyword(s):  
Global Health ◽  
Thematic Analysis ◽  
Academic Writing ◽  
Future Research ◽  
Substantial Impact ◽  
Health Crisis ◽  
Research Activities ◽  
The World ◽  
The Impact ◽  
Doctoral Candidates

Aim/Purpose: To date, few studies have investigated the impact of global health crises on the academic writing of doctoral candidates. This paper seeks to start a conversation about the impact of the ongoing COVID-19 pandemic on doctoral candidates’ academic writing output and strategies. Background: This paper employs and analyses data elicited from surveys and interviews involving doctoral candidates from around the world. Data were collected during April 2020, at a time when government-mandated lockdowns and restrictions on movement were in full force in many countries around the world. Methodology: Surveys were conducted with 118 doctoral candidates from over 40 institutions based in four continents. Follow-up interviews were carried out with four doctoral candidates enrolled in an Australian institution. A qualitative descriptive design, employing thematic analysis, is used to assess the impact of the COVID-19 pandemic on doctoral candidates’ writing output and strategies. The data analysis includes statistical descriptions of the surveys. Contribution: This paper provides insights into the myriad challenges and obstacles facing doctoral candidates during the COVID-19 pandemic. It describes the writing strategies adopted by doctoral candidates during a period of significant societal disruption, and illustrates how thematic analysis can be employed in research involving global health crises. Findings: Despite the adoption of novel approaches to academic writing, which appear in an insignificant minority of respondents, doctoral candidates’ overall commitment to academic writing has been negatively impacted by the pandemic. Similarly, delays to academic research activities caused by the pandemic have resulted in a significant decline in commitment (motivation) to academic writing and a substantial impact on doctoral candidates’ ability to write about their research. Recommendations for Practitioners: Supervisors and mentors should strive to provide doctoral candidates with timely feedback during the pandemic. Given the impact of the pandemic on doctoral candidates’ mental health and motivation to write, increased institutional and peer support is required to help doctoral candidates overcome academic issues during the pandemic and future health crises. This researcher recommends consulting regularly with and offering individually tailored solutions to doctoral candidates who are struggling to work on their theses during the pandemic. Similarly, institutions should empower supervisors in ways that allow them to provide greater levels of support to doctoral candidates. Recommendation for Researchers: Further research on the impacts of the pandemic on various academic cohorts, such as early career researchers (doctoral candidates, postdoctoral researchers, and assistant professors) and student cohorts (e.g., undergraduate and postgraduate), will clarify the extent to which the pandemic is impacting the academic writing of doctoral candidates. Impact on Society: The pressure placed on doctoral candidates to produce quality academic writing seems to have been heightened by the pandemic. This has a range of adverse effects for the higher education sector, particularly administrators responsible for managing doctoral candidate success and the academe, which recruits many of its faculty from holders of doctorate degrees. Future Research: Additional focus on academic writing of doctoral candidates during the pandemic is needed. Research should include randomised samples and represent a range of academic disciplines.

scholarly journals Geography and covid-19: reflections from the evolution of the pandemic in Uberlândia, Brazil

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Josimar dos Reis de Souza ◽  
Tatiana Silva Souza ◽  
Beatriz Ribeiro Soares
Keyword(s):  
First Year ◽  
Theoretical Discussion ◽  
Health Crisis ◽  
Virus Identification ◽  
Rapid Spread ◽  
The World ◽  
Current Scenario ◽  
Using Data ◽  
The City

From the complex sanitary moment faced by Brazil, related to COVID-19, in particular due to the collapse of the health system that has occurred in medium-sized cities, this article aimed to analyze the evolution of the COVID-19 pandemic in Uberlândia, according to reflections from geographic science, in order to help to understand the facts that led to the current scenario of the disease in the city. To achieve the objective, we carried out a theoretical discussion about how Geography faces recent events, especially in relation to the role of the Globalization process, both in the dissemination of information about the emergence of COVID-19 and other events, as well as in the rapid spread of the virus around the world. Based on these reflections, we analyzed the evolution of the pandemic, using data provided by the Municipality of Uberlândia and the Ministry of Health, with a cut-off date of March 18, 2021, in order to understand the chronological path of the facts. The choice for this cut-off date for data clipping is justified by our intention to analyze the first year of virus identification in the municipality. The results showed the negative evolution of the pandemic in the city, mainly over the months of February and March 2021, with 100% of the ICU beds occupied, which demonstrates the complexity and the long way to go to overcome this health crisis.

scholarly journals COVID-19 E OS IMPACTOS NA INDÚSTRIA PETROLÍFERA: CONSIDERAÇÕES INICIAIS

2020 ◽  
Keyword(s):  
Saudi Arabia ◽  
Global Health ◽  
World Economy ◽  
Current Situation ◽  
Health Crisis ◽  
Oil Markets ◽  
The World ◽  
Oil Sector ◽  
Market Changes

SINOPSE Este artigo tem como objetivo analisar os impactos iniciais da Covid-19 nos mercados globais de petróleo. A atual conjuntura possui a particularidade de apresentar alterações de mercado tanto na demanda, por efeitos das medidas de contenção da crise sanitária global, quanto na oferta, como resultado das disputas entre grandes produtores de petróleo, em particular Arábia Saudita e Rússia. Considera-se que os efeitos da pandemia podem resultar em profundas transformações para o setor petrolífero e a economia mundial, a depender da duração e dos desdobramentos da crise. ABSTRACT This article analyzes the initial impacts of Covid-19 on global oil markets. The current situation has the particularity of presenting market changes both in demand, due to the measures to contain the global health crisis, and in supply, as a result of the disputes between large oil producers, in particular Saudi Arabia and Russia. It is considered that the effects of the pandemic may result in profound changes for the oil sector and the world economy, depending on the duration and developments of the crisis.

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