Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels
2016 ◽
Vol 60
(9)
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pp. 5595-5599
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Keyword(s):
ABSTRACTLow posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearmanr= 0.754;P< 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state.
2020 ◽
Vol 48
(10)
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pp. 030006052096908
2019 ◽
Vol 47
(3)
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pp. 1298-1311
2018 ◽
Vol 45
(6)
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pp. 835-840
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2020 ◽