scholarly journals Draft Genome Sequences of Three Multiantibiotic-Resistant Campylobacter jejuni Strains (2865, 2868, and 2871) Isolated from Poultry at Retail Outlets in Malaysia

2016 ◽  
Vol 4 (3) ◽  
Author(s):  
Amy Huei Teen Teh ◽  
Sui Mae Lee ◽  
Gary A. Dykes
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Campylobacter Jejuni ◽  
Draft Genome ◽  
Health Concern ◽  
Foodborne Disease ◽  
Public Health Concern ◽  
Genome Sequences ◽  
Retail Outlets

Campylobacter jejuni is a frequent cause of human bacterial gastrointestinal foodborne disease worldwide. Antibiotic resistance in this species is of public health concern. The draft genome sequences of three multiantibiotic-resistant C. jejuni strains (2865, 2868, and 2871) isolated from poultry at retail outlets in Malaysia are presented here.

scholarly journals Draft Genome Sequences of Antibiotic-Resistant Escherichia coli Isolates from U.S. Wastewater Treatment Plants

2019 ◽  
Vol 8 (23) ◽  
Author(s):  
Vicente Gomez-Alvarez ◽  
Jill Hoelle
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Wastewater Treatment Plants ◽  
Draft Genome ◽  
Health Concern ◽  
Public Health Concern ◽  
Genome Sequences ◽  
Antibiotic Resistant ◽  
Content Type ◽  
Geographically Dispersed

The spread of antibiotic-resistant microorganisms is a major public health concern. Here, we report the draft genome sequences of three Escherichia coli isolates from primary effluent collected from geographically dispersed U.S.

scholarly journals Prevalence of Staphylococcus Aureus Isolated from Hamburger Samples in Tehran and their Antibiotic Susceptibility

2019 ◽  
Author(s):  
Negin Momtaz Bokharaei ◽  
Zahra Rajabi ◽  
MohammadMehdi Soltan Dallal
Keyword(s):  
Public Health ◽  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Inhibitory Concentration ◽  
Food Poisoning ◽  
Health Concern ◽  
Diffusion Method ◽  
Public Health Concern ◽  
Disk Diffusion Method ◽  
Food Borne

Introduction:Staphylococcal food poisoning is one of the most common food-borne diseases. The antibiotic resistance of Staphylococcus aureus has been reported globally. Today, strains of Staphylococcus aureus in food have become a problem in clinical infections and are considerde as a serious public health concern. Methods: A total of 100 samples were tested in the laboratory; including 75 handmade and 25 industrial hamburger samples. The Staphylococcus aureus samples were isolated and identified according to the National Iranian Standard No. 6806-3. Antibiotic resistance was determined by disk diffusion method and minimum inhibitory concentration was performed. In this study, the antibiotics penicillin, ciprofloxacin, erythromycin, clindamycin, chloramphenicol, cefoxitin, trimethoprim-sulfamethoxazole, tetracycline, gentamicin, vancomycin, and oxacillin were used. Results: Of 100 analyzed hamburger samples, 39 samples were infected with Staphylococcus aureus (23 industrial and 16 ­ handmade samples). All isolates of Staphylococcus aureus (100%) were susceptible to gentamicin and vancomycin antibiotics. Conclusions: Due to the importance of Staphylococcus aureus, as the supergene antigen and its role in causing food poisoning, contamination of foodstuffs with Staphylococcus aureus can threaten the consumers' health.

Superbugs: Antibiotic Resistance Is Becoming a Major Public Health Concern

2016 ◽  
Vol 29 (2) ◽  
pp. 130-133 ◽  
Author(s):  
Patricia T. Alpert
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Clostridium Difficile ◽  
Current Treatment ◽  
Health Concern ◽  
Treatment Modalities ◽  
Public Health Concern ◽  
Carbapenem Resistant ◽  
Control And Prevention ◽  
Carbapenem Resistant Enterobacteriaceae

Antibiotic resistance has led to the development of so-called “superbugs” that no longer respond to the current treatment modalities. The array of antibiotics available to treat these infections is dwindling with very few antibiotics in the pipeline. This article discussed the pathogens the Centers for Disease Control and Prevention (CDC) has placed in their urgent category: (1) Clostridium difficile, (2) Carbapenem-resistant Enterobacteriaceae, and (3) Neisseria gonorrhoeae. In addition, a few suggestions for prevention of resistance are offered.

scholarly journals Integration of Mobile Devices and Point-Of-Care Diagnostic Devices—The Case of C-Reactive Protein Diagnosis

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 181 ◽  
Author(s):  
Xin-Fang Wu ◽  
Ching-Fen Shen ◽  
Chao-Min Cheng
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Mobile Devices ◽  
Point Of Care ◽  
Health Concern ◽  
Global Public Health ◽  
C Reactive Protein ◽  
Public Health Concern ◽  
Reactive Protein

In recent years, the misuse and overuse of antibiotics has promoted antibiotic resistance, which has now become a global public health concern [...]

scholarly journals Draft Genome Sequences of Interpatient and Intrapatient Epidemiologically Linked Neisseria gonorrhoeae Isolates

2018 ◽  
Vol 6 (16) ◽  
pp. e00319-18
Author(s):  
Sonja Hirk ◽  
Sarah Lepuschitz ◽  
Adriana Cabal Rosel ◽  
Steliana Huhulescu ◽  
Marion Blaschitz ◽  
...  
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Neisseria Gonorrhoeae ◽  
Draft Genome ◽  
World Health ◽  
Genome Sequences ◽  
Content Type ◽  
The World ◽  
Public Health Threat ◽  
Health Organization

ABSTRACT Neisseria gonorrhoeae is the causative agent of gonorrhea and was identified by the World Health Organization as an urgent public health threat due to emerging antibiotic resistance. Here, we report 13 draft genome sequences of N. gonorrhoeae isolates derived from two epidemiologically linked cases from Austria.

scholarly journals Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae

2018 ◽  
Vol 115 (12) ◽  
pp. 3102-3107 ◽  
Author(s):  
Uri Obolski ◽  
José Lourenço ◽  
Craig Thompson ◽  
Robin Thompson ◽  
Andrea Gori ◽  
...  
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Population Structure ◽  
Streptococcus Pneumoniae ◽  
Bacterial Pathogen ◽  
Epidemiological Studies ◽  
Theoretical Framework ◽  
Health Concern ◽  
Public Health Concern ◽  
Pathogen Population

The bacterial pathogen Streptococcus pneumoniae is a major public health concern, being responsible for more than 1.5 million deaths annually through pneumonia, meningitis, and septicemia. Available vaccines target only a subset of serotypes, so vaccination is often accompanied by a rise in the frequency of nonvaccine serotypes. Epidemiological studies suggest that such a change in serotype frequencies is often coupled with an increase of antibiotic resistance among nonvaccine serotypes. Building on previous multilocus models for bacterial pathogen population structure, we have developed a theoretical framework incorporating variation of serotype and antibiotic resistance to examine how their associations may be affected by vaccination. Using this framework, we find that vaccination can result in a rapid increase in the frequency of preexisting resistant variants of nonvaccine serotypes due to the removal of competition from vaccine serotypes.

scholarly journals Vaccination can drive an increase in frequencies of antibiotic resistance among non-vaccine serotypes of Streptococcus pneumoniae

2017 ◽  
Author(s):  
Uri Obolski ◽  
José Lourenço ◽  
Sunetra Gupta
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Streptococcus Pneumoniae ◽  
Bacterial Pathogen ◽  
Epidemiological Studies ◽  
Health Concern ◽  
Public Health Concern ◽  
Pathogen Population ◽  
Vaccine Serotypes ◽  
Pneumococcal Carriage

AbstractThe bacterial pathogen Streptococcus pneumoniae is a major public health concern, being responsible for more than 1.5 million deaths annually through pneumonia, meningitis and septicemia. In spite of vaccination efforts, pneumococcal carriage and disease remain high, since available vaccines target only a subset of serotypes and vaccination is often accompanied by a rise in non-vaccine serotypes. Epidemiological studies suggest that such a change in serotype frequencies is often coupled with an increase of antibiotic resistance among non-vaccine serotypes. Building on previous multi-locus models for bacterial pathogen population structure, we have developed a theoretical framework incorporating variation in serotype and antibiotic resistance to examine how their associations may be affected by vaccination. Using this framework, we find that vaccination can result in rapid increase in frequency of pre-existing resistant variants of non-vaccine serotypes due to the removal of competition from vaccine serotypes.

scholarly journals Infections associated with cantaloupe consumption: a public health concern

2005 ◽  
Vol 134 (4) ◽  
pp. 675-685 ◽  
Author(s):  
A. BOWEN ◽  
A. FRY ◽  
G. RICHARDS ◽  
L. BEAUCHAT
Keyword(s):  
Public Health ◽  
United States ◽  
Escherichia Coli ◽  
Campylobacter Jejuni ◽  
The United States ◽  
Health Concern ◽  
Public Health Concern ◽  
Control And Prevention ◽  
Survival And Growth ◽  
Potential Methods

Fresh produce is an important part of a healthy diet and is consumed in greater quantity in the United States than ever before. Consumption of cantaloupe has recently been associated with several large outbreaks of infections in North America, highlighting the need for a better understanding of practices and processes that may contribute to contamination. We reviewed all cantaloupe-associated outbreaks that were reported to the Centers for Disease Control and Prevention (CDC) and published in the literature. Twenty-three outbreaks occurred between 1984 and 2002; 1434 people became ill, 42 were hospitalized, and two died in these outbreaks. Aetiological agents in the outbreaks included five serotypes of Salmonella enterica, Campylobacter jejuni, Escherichia coli O157:H7, and norovirus. We reviewed processes contributing to cantaloupe contamination, conditions affecting survival and growth of bacterial pathogens on melons, and potential methods for sanitization. For maximum safety, industry, federal, and international partners must collaborate to ensure that appropriate interventions are in place to minimize the risk of contamination and prevent the growth of pathogens during cantaloupe production, processing, storage, and preparation.

scholarly journals Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains

mSphere ◽  
2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Craig M. Stephens ◽  
Sheila Adams-Sapper ◽  
Manraj Sekhon ◽  
James R. Johnson ◽  
Lee W. Riley
Keyword(s):  
Public Health ◽  
Antibiotic Resistance ◽  
Genetic Factors ◽  
Health Concern ◽  
Public Health Concern ◽  
Antibiotic Resistant ◽  
Content Type ◽  
E Coli ◽  
Bacterial Genetic ◽  
Public Health Strategies

ABSTRACT Antibiotic resistance in bacterial pathogens is a major public health concern. This work was motivated by the observation that only a small proportion of ST95 isolates, a major pandemic lineage of extraintestinal pathogenic E. coli, have acquired antibiotic resistance, in contrast to many other pandemic lineages. Understanding bacterial genetic factors that may prevent acquisition of resistance could contribute to the development of new biological, medical, or public health strategies to reduce antibiotic-resistant infections. Extraintestinal pathogenic Escherichia coli (ExPEC) strains belonging to multilocus sequence type 95 (ST95) are globally distributed and a common cause of infections in humans and domestic fowl. ST95 isolates generally show a lower prevalence of acquired antimicrobial resistance than other pandemic ExPEC lineages. We took a genomic approach to identify factors that may underlie reduced resistance. We fully assembled genomes for four ST95 isolates representing the four major fimH-based lineages within ST95 and also analyzed draft-level genomes from another 82 ST95 isolates, largely from the western United States. The fully assembled genomes of antibiotic-resistant isolates carried resistance genes exclusively on large (>90-kb) IncFIB/IncFII plasmids. These replicons were common in the draft genomes as well, particularly in antibiotic-resistant isolates, but we also observed multiple instances of a smaller (8.3-kb) ampicillin resistance plasmid that had been previously identified in Salmonella enterica. Among ST95 isolates, pansusceptibility to antibiotics was significantly associated with the fimH6 lineage and the presence of homologs of the previously identified 114-kb IncFIB/IncFII plasmid pUTI89, both of which were also associated with reduced carriage of other plasmids. Potential mechanistic explanations for lineage- and plasmid-specific effects on the prevalence of antibiotic resistance within the ST95 group are discussed. IMPORTANCE Antibiotic resistance in bacterial pathogens is a major public health concern. This work was motivated by the observation that only a small proportion of ST95 isolates, a major pandemic lineage of extraintestinal pathogenic E. coli, have acquired antibiotic resistance, in contrast to many other pandemic lineages. Understanding bacterial genetic factors that may prevent acquisition of resistance could contribute to the development of new biological, medical, or public health strategies to reduce antibiotic-resistant infections.

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