Bacillus subtilis 168 Contains Two Differentially Regulated Genes Encoding l-Asparaginase
2002 ◽
Vol 184
(8)
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pp. 2148-2154
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Keyword(s):
ABSTRACT Expression of the two Bacillus subtilis genes encoding l-asparaginase is controlled by independent regulatory factors. The ansZ gene (formerly yccC) was shown by mutational analysis to encode a functional l-asparaginase, the expression of which is activated during nitrogen-limited growth by the TnrA transcription factor. Gel mobility shift and DNase I footprinting experiments indicate that TnrA regulates ansZ expression by binding to a DNA site located upstream of the ansZ promoter. The expression of the ansA gene, which encodes the second l-asparaginase, was found to be induced by asparagine. The ansA repressor, AnsR, was shown to negatively regulate its own expression.
2000 ◽
Vol 182
(7)
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pp. 1916-1922
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2004 ◽
Vol 186
(10)
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pp. 3238-3248
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2006 ◽
Vol 188
(7)
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pp. 2578-2585
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2002 ◽
Vol 184
(23)
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pp. 6508-6514
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2008 ◽
Vol 74
(8)
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pp. 2454-2460
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1992 ◽
Vol 12
(5)
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pp. 2302-2314
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1996 ◽
Vol 271
(6)
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pp. L963-L971
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Keyword(s):
2006 ◽
Vol 188
(4)
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pp. 1411-1418
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