scholarly journals Rahnella aquatilis Sepsis in an Immunocompetent Adult

1999 ◽  
Vol 37 (12) ◽  
pp. 4161-4162 ◽  
Author(s):  
Chulhun Ludgerus Chang ◽  
Joseph Jeong ◽  
Jeong Hwan Shin ◽  
Eun Yup Lee ◽  
Han Chul Son
Keyword(s):  
Male Patient ◽  
Intravenous Fluid ◽  
Causative Organism ◽  
Immunocompromised Patients ◽  
Immunocompetent Adult ◽  
Gram Negative ◽  
Rahnella Aquatilis

Rahnella aquatilis, a rare enteric gram-negative rod which is infrequently isolated in immunocompromised patients, was isolated as a causative organism of sepsis in a 26-year-old immunocompetent male patient. The contaminated intravenous fluid was confirmed to be the source of the organism.

scholarly journals Fatal Salmonella Typhi Necrotising Fasciitis following Intra-articular Steroid Injection

2013 ◽  
Vol 1 (2) ◽  
pp. 125 ◽  
Author(s):  
Sagar Narang ◽  
Prakash Sapkota
Keyword(s):  
Steroid Injection ◽  
Salmonella Typhi ◽  
Necrotising Fasciitis ◽  
Causative Organism ◽  
Immunocompromised Patients ◽  
Gram Negative ◽  
Joint Infections ◽  
Increased Risk ◽  
Low Threshold

Intra-articular steroids administration in the absence of aseptic precautions can have disastrous consequences. Immunocompromised patients are at an increased risk of developing infections following such procedures. Salmonella has been infrequently reported as a causative organism for necrotising fasciitis. Gram negative endotoxemia with disseminated intravascular coagulation resulted in fatality in this patient. The case study is being presented to emphasise the need for aseptic precautions and sterile techniques while administering intra-articular steroids, to have a low threshold towards treating early joint infections expeditiously, and to consider possibility of a gram negative organism as a cause of septicaemia and necrotising fasciitis especially in debilitated patients.

Atypical Pharyngitis In Suppurative Otitis Media Cases

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P98-P99
Author(s):  
Alaa A Abou-Bieh ◽  
Mona F Salama
Keyword(s):  
Middle Ear ◽  
Causative Organism ◽  
Isolation And Identification ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Gram Negative ◽  
Middle Ear Infection ◽  
Gram Negative Organisms ◽  
Micro Organisms ◽  
Middle Ear Cleft

Problem Unexplained persistent or recurrent bacterial pharyngitis in some patients who suffer from infected middle ear cleft. Methods Bacteriological swabs were obtained from both the ears and the pharynx of 37 cases with chronic otorrhea and perforation, whom complain of recurrent or persistent sore-throat. Then isolation and identification of the micro-organisms were done. This included examination of direct Gram stained films and cultures. Isolated Gram negative bacilli were subjected to further identification by the biochemical reactions and antibiotyping. Identical isolates from the same patient (ear and pharyngeal swabs) were subjected to further identification by genotyping using the pulsed field gel electrophoresis technique. Results 6 cases (16%) showed identity in phenotypes and genotypes for ear and pharyngeal samples from the same patient. All pharyngeal isolates were Gram negative organisms. 4 of them were Pseudomonas aeruginosa, 1 was Proteus sp., and 1 was Escherichia coli. All of these 3 species are not known to be among the primary organisms which may cause pharyngitis. Conclusion Bacterial pharyngitis in patients with chronically infected middle ear cleft may be attributed to the same organism invaded the middle ear mucosa. Also this study highlights some organisms as a pharyngeal invaders although they are not among the previously documented causatives of bacterial pharyngitis. But the study do not confirm the method of spread of these organisms and whether this was directly via the eustachian tube. Significance The study correlates the causative organism of the middle ear infection and that infected the pharyngeal mucosa utilizing the advanced bacteriological identification and genotyping techniques.

Increased Incidence of Gram-Negative Neonatal Sepsis With Intramuscular Iron Administration

PEDIATRICS ◽  
1977 ◽  
Vol 60 (6) ◽  
pp. 908-912 ◽  
Author(s):  
D. M. J. Barry ◽  
A. W. Reeve
Keyword(s):  
Escherichia Coli ◽  
Neonatal Sepsis ◽  
Causative Organism ◽  
Iron Dextran ◽  
Gram Negative ◽  
Iron Administration ◽  
Significant Difference ◽  
High Incidence

During a five-year period the incidence of neonatal sepsis was 20 times higher in Polynesian newborns compared with European newborns (11 per 1,000 vs. 0.6 per 1,000 total births). This high incidence in Polynesians was confined to a period when the infants were being given intramuscular iron dextran. When the iron administration was stopped the incidence of disease in Polynesians decreased from 17 per 1,000 to 2.7 per 1,000 total births. An analysis of the Polynesian iron-treated and non-iron-treated groups showed a statistically significant difference in the incidence of sepsis, the type of causative organism, and mortality. The data suggest that the iron dextran injections have impaired the immunity of the treated infants, making them more susceptible to Escherichia coli sepsis.

Postoperative meningitis due to a rare pathogen; Alcaligenes xylosoxidans

Open Medicine ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. 532-535
Author(s):  
Burcin Ozer ◽  
Yurdal Serarslan ◽  
Nizami Duran ◽  
Gokhan Akdemir ◽  
Yusuf Onlen
Keyword(s):  
Male Patient ◽  
Aerobic Bacterium ◽  
Gram Negative ◽  
Clinical Specimens ◽  
Postoperative Meningitis ◽  
Soil And Water

AbstractAlcaligenes xylosoxidans is non-fermenting gram-negative bacilli found in soil and water. It is an aerobic bacterium in the genus Achromobacter. This bacterium is motile, oxidase positive, and catalase positive, which is isolated uncommonly from clinical specimens. In the present paper, we report a case of meningitis associated with A. xylosoxidans in a 38-year-old male patient post neurosurgery.

Procalcitonin Elevation Suggests a Septic Source

2014 ◽  
Vol 80 (9) ◽  
pp. 906-909 ◽  
Author(s):  
Kara E. Friend ◽  
Jessica N. Burgess ◽  
Rebecca C. Britt ◽  
Jay N. Collins ◽  
Leonard N. Weireter ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Fungal Infections ◽  
Infection Type ◽  
Causative Organism ◽  
Patient Records ◽  
Gram Negative ◽  
Good Marker ◽  
Infection Source ◽  
Antibiotic Duration ◽  
Reason For Admission

Procalcitonin is used as a marker for sepsis but there is little known about the correlation of the procalcitonin elevation with the causative organism in sepsis. All patients aged 18 to 80 years who were admitted to the surgery service from June 2010 to May 2012 and who had a procalcitonin drawn were evaluated. Culture data were reviewed to determine the causative organism. Infections analyzed included pneumonia, urinary tract infection (UTI), bloodstream infection, and Clostridium difficile. Other parameters assessed included reason for admission, body mass index, pressor use, antibiotic duration, and disposition. Two hundred thirty-two patient records were reviewed. Patients without a known infection/source of sepsis had a mean procalcitonin of 3.95. Those with pneumonia had a procalcitonin of 20.59 ( P = 0.03). Those with a UTI had a mean procalcitonin of 66.84 ( P = 0.0005). Patients with a bloodstream infection had a mean procalcitonin of 33.30 ( P = 0.003). Those with C. difficile had a procalcitonin of 47.20 ( P = 0.004). When broken down by causative organisms, those with Gram-positive sepsis had a procalcitonin of 23.10 ( P = 0.02) compared with those with Gram-negative sepsis at 32.75 ( P = 0.02). Those with fungal infections had a procalcitonin of 42.90 ( P = 0.001). These data suggest that procalcitonin elevation can help guide treatment by indicating likely causative organism and infection type. These data may provide a good marker for initiation of antifungal therapy.

scholarly journals Severe Community-Acquired Pneumonia with Bacteremia Caused by Herbaspirillum aquaticum or Herbaspirillum huttiense in an Immune-Competent Adult

2015 ◽  
Vol 53 (9) ◽  
pp. 3086-3088 ◽  
Author(s):  
Hariharan Regunath ◽  
Joanna Kimball ◽  
L. Patrick Smith ◽  
William Salzer
Keyword(s):  
Adult Male ◽  
Community Acquired Pneumonia ◽  
Gram Negative Bacteria ◽  
Immunocompetent Adult ◽  
Gram Negative ◽  
Content Type ◽  
Severe Community Acquired Pneumonia ◽  
Immunocompromised Hosts ◽  
Soil And Water

Herbaspirillumspp. are Gram-negative bacteria that inhabit soil and water. Infections caused by these organisms have been reported in immunocompromised hosts. We describe severe community-acquired pneumonia and bacteremia caused byHerbaspirillum aquaticumorH. huttiensein an immunocompetent adult male.

scholarly journals Delftia Acidovorans: A Rare Pathogen in Immunocompetent and Immunocompromised Patients

2015 ◽  
Vol 26 (5) ◽  
pp. 277-279 ◽  
Author(s):  
Huseyin Bilgin ◽  
Abdurrahman Sarmis ◽  
Elif Tigen ◽  
Guner Soyletir ◽  
Lutfiye Mulazimoglu
Keyword(s):  
Rapid Detection ◽  
Present Report ◽  
Lymphoblastic Leukemia ◽  
Immunocompromised Patients ◽  
Gram Negative ◽  
Delftia Acidovorans ◽  
Leukemia Patient ◽  
Negative Bacillus ◽  
Clinically Significant ◽  
Immunocompetent Patients

Delftia acidovoransis an aerobic, nonfermenting Gram-negative bacillus. It is usually a nonpathogenic environmental organism and is rarely clinically significant. AlthoughD acidovoransinfection most commonly occurs in hospitalized or immunocompromised patients, there are also several reports documenting the infection in immunocompetent patients. The present article describes a B cell lymphoblastic leukemia patient withD acidovoranspneumonia who was successfully treated with antibiotic therapy. The present report indicates that unusual pathogens may be clinically significant in both immunocompromised and immunocompetent patients.D acidovoransis often resistant to aminoglycosides; therefore, rapid detection of this microorganism is important.

scholarly journals 1024. Using DOOR-MAT to Theoretically Compare Three Rapid Diagnostic Tests for Gram-Negative Bloodstream Infections in Immunocompromised Patients

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S603-S604
Author(s):  
Lauren Groft ◽  
Mandee Noval ◽  
James Mease ◽  
J Kristie Johnson ◽  
Kimberly C Claeys
Keyword(s):  
Diagnostic Tests ◽  
Bloodstream Infections ◽  
Rapid Diagnostic Tests ◽  
Antibiotic Prescribing ◽  
Solid Organ ◽  
Immunocompromised Patients ◽  
Gram Negative ◽  
Significant Difference ◽  
The Mean ◽  
Organism Identification

Abstract Background Molecular rapid diagnostic tests (RDTs) for bloodstream infections (BSI) utilize a variety of technologies and differ substantially in organisms and resistance mechanisms detected. RDT platforms decrease time to optimal antibiotics; however, data on RDTs in special populations, such as immunocompromised are extremely limited. This study aimed to compare theoretical changes in antibiotics based on differences in panel identification of organisms and resistance targets among three commercially available RDT panels. Methods Retrospective cohort of immunocompromised patients treated for gram-negative BSI at University of Maryland Medical Center from January 2018 to September 2020. Immunocompromised was defined as active hematologic or solid tumor malignancy at time of BSI diagnosis, history of hematopoietic stem cell transplantation (HSCT) or solid organ transplantation (SOT), or absolute neutrophil count (ANC) < 1000 cells/mm3 at any time 30 days prior to BSI diagnosis. Verigene BC-GN was performed as standard of care. GenMark ePlex BCID and BioFire FilmArray BCID 2 results were assigned based on respective identifiable organism panels. An infectious diseases clinician blinded to final antimicrobial susceptibility testing (AST) results used RDT results to assign antibiotic treatments for each platform. Decisions were referenced against a priori DOOR-MAT matrices. A partial credit scoring system (0 to 100) was applied to each decision based on final AST results. The mean and standard deviation (SD) were compared across panels using One-Way Repeated Measures ANOVA with modified Bonferroni for multiple comparisons. Results A total of 146 patients met inclusion. Baseline characteristics are summarized in Table 1. The mean (SD) DOOR-MAT scores for the three RDT panels were: 86.1 (24.4) Verigene BC-GN vs. 88.5 (22.2) GenMark BCID vs. 87.2 (24.4) BioFire BCID 2. There was no statistically significant difference between the panels for DOOR-MAT score (P=0.6). Table 1. Baseline Patient Characteristics and Organism Identification Conclusion Within an immunocompromised patient population, differences in organism identification between three commercially available RDT panels did not impact theoretical antibiotic prescribing. Disclosures J. Kristie Johnson, PhD, D(ABMM), GenMark (Speaker’s Bureau) Kimberly C. Claeys, PharmD, GenMark (Speaker’s Bureau)

scholarly journals Coagulopathy secondary to chicken pox: a case report

2017 ◽  
Vol 4 (6) ◽  
pp. 1706
Author(s):  
Harharpreet Kaur ◽  
Gurinder Mohan ◽  
Harsehaj Singh ◽  
Gurraj Singh ◽  
Anusha .
Keyword(s):  
Case Report ◽  
Healthy Adult ◽  
Clinical Course ◽  
Hemorrhagic Disease ◽  
Immunocompromised Patients ◽  
Varicella Infection ◽  
Immunocompetent Adult ◽  
Chicken Pox ◽  
Healthy Adult Male ◽  
Life Threatening

Chickenpox often produces a self-limiting disease in children and adolescents. The clinical course is usually mild and complications are rare. The complications that are known to be associated with it are pneumonia, meningitis, myocarditis and nephritis. Severe and disseminated varicella infection with organ dysfunction can also be seen amongst diabetics and immunocompromised patients. However, it is not commonly known that varicella can be life threatening even in immunocompetent adult patients. We present a case of a healthy adult male in which this infection progressed to malignant hemorrhagic disease associated with coagulopathy.

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