scholarly journals Genome Sequences of Community Carriage Strains of Staphylococcus aureus from Yuma, Arizona

2021 ◽  
Vol 10 (37) ◽  
Author(s):  
Talima Pearson ◽  
Crystal Hepp ◽  
Robert T. Trotter ◽  
Mimi Mbegbu ◽  
Benjamin Russakoff ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genomic Diversity ◽  
Genome Sequences ◽  
Content Type ◽  
Asymptomatic Carriage ◽  
Increased Risk

Staphylococcus aureus exists as a pathogen and commensal. Individuals with asymptomatic carriage serve as a reservoir for transmission and are at increased risk of infecting themselves. In order to characterize the genomic diversity of S. aureus circulating in the community, we sequenced 166 genomes collected from individuals in Yuma, AZ.

scholarly journals Genome Sequences of a Staphylococcus aureus Clinical Isolate, Strain SMA0034-04 (UGA22), from Siaya County Referral Hospital in Siaya, Kenya

2019 ◽  
Vol 8 (17) ◽  
Author(s):  
Gary Xie ◽  
Qiuying Cheng ◽  
Hajnalka Daligault ◽  
Karen Davenport ◽  
Cheryl Gleasner ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Isolate ◽  
Referral Hospital ◽  
Genome Sequences ◽  
Content Type

Here, we report the genome sequences of a Staphylococcus aureus clinical isolate, strain SMA0034-04 (UGA22), which contains one chromosome and one plasmid. We also reveal that isolate SMA0034-04 (UGA22) contains loci in the genome that encode multiple exotoxins.

scholarly journals Species-Wide Collection of Escherichia coli Isolates for Examination of Genomic Diversity

2017 ◽  
Vol 5 (50) ◽  
Author(s):  
Jayanthi Gangiredla ◽  
Mark K. Mammel ◽  
Tammy J. Barnaba ◽  
Carmen Tartera ◽  
Solomon T. Gebru ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Human Health ◽  
Potential Risk ◽  
Phylogenetic Relationships ◽  
Genomic Diversity ◽  
Genome Sequences ◽  
Content Type ◽  
E Coli

ABSTRACT Pathogenic and nonpathogenic Escherichia coli strains present a vast genomic diversity. We report the genome sequences of 2,244 E. coli isolates from multiple animal and environmental sources. Their phylogenetic relationships and potential risk to human health were examined.

scholarly journals Complete Genome Sequences of Methicillin-Resistant Staphylococcus aureus Strains 110900 and 128254, Two Representatives of the CRISPR-Cas-Carrying Sequence Type 630/spa Type t4549 Lineage

2020 ◽  
Vol 9 (41) ◽  
Author(s):  
Raphael N. Sieber ◽  
Søren Overballe-Petersen ◽  
Hülya Kaya ◽  
Anders R. Larsen ◽  
Andreas Petersen
Keyword(s):  
Staphylococcus Aureus ◽  
Complete Genome ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Nordic Countries ◽  
Sequence Type ◽  
Genome Sequences ◽  
Methicillin Resistant ◽  
Content Type ◽  
Spa Type

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) sequence type 630 (ST630) and spa type t4549 is an emerging lineage in Nordic countries, and some representatives carry the CRISPR-Cas system. Here, the complete genome sequences of two isolates from this lineage are presented, comprising chromosomes of 2,918,239 and 2,877,083 nucleotides, respectively, and a 2,473-nucleotide plasmid carrying erm(C).

scholarly journals Clearance of Staphylococcus aureus Nasal Carriage Is T Cell Dependent and Mediated through Interleukin-17A Expression and Neutrophil Influx

2013 ◽  
Vol 81 (6) ◽  
pp. 2070-2075 ◽  
Author(s):  
Nathan K. Archer ◽  
Janette M. Harro ◽  
Mark E. Shirtliff
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
T Cell ◽  
Immune Responses ◽  
Neutrophil Migration ◽  
Nasal Carriage ◽  
Causal Connection ◽  
Content Type ◽  
Neutrophil Influx ◽  
Increased Risk

ABSTRACTThe anterior nares of humans are the major reservoir forStaphylococcus aureuscolonization. Approximately 20% of the healthy human population is persistently and 80% is intermittently colonized withS. aureusin the nasal cavity. Previous studies have shown a strong causal connection betweenS. aureusnasal carriage and increased risk of nosocomial infection, as well as increased carriage due to immune dysfunction. However, the immune responses that permit persistence or mediate clearance ofS. aureuson the nasal mucosa are fundamentally undefined. In this study, we developed a carriage model in C57BL/6J mice and showed that clearance begins 14 days postinoculation. In contrast, SCID mice that have a deficient adaptive immune response are unable to eliminateS. aureuseven after 28 days postinoculation. Furthermore, decolonization was found to be T cell mediated but B cell independent by evaluating carriage clearance in T-cell receptor β/δ (TCR-β/δ) knockout (KO) and IgH-μ KO mice, respectively. Upregulation of the cytokines interleukin 1β (IL-1β), KC (also termed CXC ligand 1 [CXCL1]), and IL-17A occurred following inoculation with intranasalS. aureus. IL-17A production was crucial for clearance, since IL-17A-deficient mice were unable to effectively eliminateS. aureuscarriage. Subsequently, cell differential counts were evaluated from nasal lavage fluid obtained from wild-type and IL-17A-deficient colonized mice. These counts displayed IL-17A-dependent neutrophil migration. Antibody-mediated depletion of neutrophils in colonized mice caused reduced clearance compared to that in isotype-treated controls. Our data suggest that the Th17-associated immune response is required for nasal decolonization. This response is T cell dependent and mediated via IL-17A production and neutrophil influx. Th17-associated immune responses may be targeted for strategies to mitigate distal infections originating from persistentS. aureuscarriage in humans.

scholarly journals Draft Genome Sequences of 27 Staphylococcus aureus Strains and 3 Staphylococcus Species Strains Isolated from Bovine Intramammary Infections

2020 ◽  
Vol 9 (19) ◽  
Author(s):  
Soyoun Park ◽  
Dongyun Jung ◽  
Simon Dufour ◽  
Jennifer Ronholm
Keyword(s):  
Staphylococcus Aureus ◽  
Draft Genome ◽  
Bovine Mastitis ◽  
Holstein Cows ◽  
Whole Genome ◽  
Genome Sequences ◽  
Content Type ◽  
Intramammary Infections ◽  
Intramammary Infection ◽  
Etiological Agents

Staphylococcus aureus is one of the most common etiological agents responsible for contagious bovine mastitis. Here, we report the draft whole-genome sequences, with annotations, of 27 S. aureus strains and 3 Staphylococcus species strains that were isolated from Holstein cows with intramammary infection in Canada.

scholarly journals Draft Genome Sequences of Lysostaphin-Resistant (K07-204) and Lysostaphin-Susceptible (K07-561) Staphylococcus aureus Sequence Type 72 Strains Isolated from Patients in South Korea

2020 ◽  
Vol 9 (49) ◽  
Author(s):  
Nayab Batool ◽  
Kwan Soo Ko ◽  
Akhilesh Kumar Chaurasia ◽  
Kyeong Kyu Kim
Keyword(s):  
Staphylococcus Aureus ◽  
South Korea ◽  
Genome Sequencing ◽  
Draft Genome ◽  
Sequence Type ◽  
Genome Sequences ◽  
Content Type ◽  
Subtractive Genomics ◽  
Draft Genome Sequencing ◽  
Different Levels

ABSTRACT Methicillin-resistant Staphylococcus aureus sequence type 72 (ST72) is prevalent in South Korea and has shown resistance to multiple antimicrobials. ST72 isolates display different levels of resistance to the antistaphylococcal lysostaphin. Draft genome sequencing of ST72 human isolates exhibiting lysostaphin resistance or susceptibility was performed to better understand the mechanism of lysostaphin resistance using subtractive genomics.

scholarly journals Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan

2019 ◽  
Vol 8 (47) ◽  
Author(s):  
Miyako Hikichi ◽  
Miki Nagao ◽  
Kazunori Murase ◽  
Chihiro Aikawa ◽  
Takashi Nozawa ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Soft Tissue ◽  
Complete Genome ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Manifestations ◽  
Invasive Disease ◽  
Genome Sequences ◽  
Methicillin Resistant ◽  
Content Type ◽  
Mrsa Strains

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen causing nosocomial infections, and the clinical manifestations of MRSA range from asymptomatic colonization of the nasal mucosa to soft tissue infection to fulminant invasive disease. Here, we report the complete genome sequences of eight MRSA strains isolated from patients in Japan.

scholarly journals Draft Genome Sequences of 64 Salmonella enterica Serotype Enteritidis Isolates Obtained from Wild Mice

2017 ◽  
Vol 5 (36) ◽  
Author(s):  
Jean Guard ◽  
Guojie Cao ◽  
George J. Kastanis ◽  
Sherrill Davison ◽  
Michael McClelland ◽  
...  
Keyword(s):  
Salmonella Enterica ◽  
Draft Genome ◽  
Foodborne Pathogen ◽  
Genomic Diversity ◽  
Genome Sequences ◽  
Wild Mice ◽  
Content Type ◽  
Baseline Information ◽  
Foodborne Outbreaks ◽  
Global Concern

ABSTRACT Salmonella enterica serotype Enteritidis is a foodborne pathogen of global concern, because it is frequently isolated from foods and patients. Draft genome sequences are reported here for 64 S. Enteritidis strains isolated from the intestines and spleens of mice caught live on chicken farms in the U.S. Northeast. The availability of these genomes provides baseline information on the genomic diversity of S. Enteritidis during the 1990s, when foodborne outbreaks traced to internal contamination of eggs were prevalent.

scholarly journals Complete Genome Sequences of Mycobacterium kansasii Strains Isolated from Rhesus Macaques

2017 ◽  
Vol 5 (16) ◽  
Author(s):  
Aruna Panda ◽  
Sushma Nagaraj ◽  
Xuechu Zhao ◽  
Hervé Tettelin ◽  
Louis J. DeTolla
Keyword(s):  
Complete Genome ◽  
Opportunistic Infections ◽  
Rhesus Macaques ◽  
Genomic Diversity ◽  
Nontuberculous Mycobacterium ◽  
Mycobacterium Kansasii ◽  
Environmental Isolates ◽  
Genome Sequences ◽  
Content Type ◽  
Genome Comparisons

ABSTRACT Mycobacterium kansasii is a nontuberculous mycobacterium. It causes opportunistic infections with pulmonary and extrapulmonary manifestations. We report here the complete genome sequences of two M. kansasii strains isolated from rhesus macaques. We performed genome comparisons with human and environmental isolates of M. kansasii to assess the genomic diversity of this species.

scholarly journals Draft Genome Sequences of Two Staphylococcus aureus Strains Isolated in Succession from a Case of Bacteremia

2017 ◽  
Vol 5 (23) ◽  
Author(s):  
M. D. S. Basco ◽  
J. R. Revollo ◽  
P. B. McKinzie ◽  
S. Agnihothram ◽  
A. Kothari ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Draft Genome ◽  
Genome Sequences ◽  
Content Type

ABSTRACT Staphylococcus aureus strains MEH1 and MEH7 were successively isolated from the blood of a patient with recurrent bacteremia. The submitted draft genomes of strains MEH1 and MEH7 are 2,914,972 and 2,911,704 bp, respectively.

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