THU0504 The Relationship Between Weight Loss and Reduced Cartilage Loss in the Medial Knee Joint is Non-Linear in Obese People

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A334.1-A334
Author(s):  
A. Wluka ◽  
A. Teichtahl ◽  
S. Tanamas ◽  
Y. Wang ◽  
B. Strauss ◽  
...  
Keyword(s):  
Weight Loss ◽  
Knee Joint ◽  
Cartilage Loss ◽  
Obese People ◽  
Medial Knee ◽  
Non Linear ◽  
The Relationship

scholarly journals The relationship between urinary C-Telopeptide fragments of type II collagen, knee joint load, pain, and physical function in individuals with medial knee osteoarthritis

2020 ◽  
Author(s):  
Luiz Fernando Approbato Selistre ◽  
Glaucia Helena Gonçalves ◽  
Fernando Augusto Vasilceac ◽  
Paula Regina Mendes da Silva Serrão ◽  
Theresa Helissa Nakagawa ◽  
...  
Keyword(s):  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Medial Knee ◽  
Medial Knee Osteoarthritis ◽  
Knee Joint Load ◽  
Joint Load ◽  
The Relationship

Weight change and change in tibial cartilage volume and symptoms in obese adults

2014 ◽  
Vol 74 (6) ◽  
pp. 1024-1029 ◽  
Author(s):  
Andrew J Teichtahl ◽  
Anita E Wluka ◽  
Stephanie K Tanamas ◽  
Yuanyuan Wang ◽  
Boyd J Strauss ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Gain ◽  
Knee Joint ◽  
Weight Change ◽  
Cartilage Volume ◽  
Volume Loss ◽  
Obese People ◽  
Tibial Cartilage ◽  
Percentage Weight ◽  
Cartilage Volume Loss

IntroductionThere is a paucity of data examining the effects of weight change on knee joint structures and symptoms. This study examined the effect of weight change on change in knee cartilage volume and symptoms in an obese cohort.Methods112 obese subjects (Body Mass Index ≥30 kg/m2) were recruited from various community sources to examine the effect of obesity on musculoskeletal health. Tibial cartilage volume, determined by MRI, and knee symptoms, determined by the Western Ontario and McMaster Osteoarthritis Index (WOMAC) were collected at baseline and an average of 2.3 years later.ResultsPercentage weight change was associated with change in medial tibial cartilage volume (β −1.2 mm3, 95% CI −2.3 to −0.1 mm3, p=0.03) that was consistent throughout the spectrum of weight loss through to mild weight gain. Percentage weight change was not associated with change in the lateral tibial (p=0.93) or patella (p=0.32) cartilage volumes. Percentage weight change was associated with change in all WOMAC subscales (all p≤0.01): pain (β −1.8 mm, 95% CI −3.2 to −0.4 mm), stiffness (β −1.6 mm, 95% CI −2.5 to −0.7 mm) and function (β −6.9 mm, 95% CI −11.6 to −2.1 mm).ConclusionsThe linearity of effect implies that weight loss is associated with reduced medial cartilage volume loss and improved knee symptoms, while weight gain is associated with increased medial cartilage volume loss and worse knee symptoms. These results suggest that in obese people, small amounts of weight change may have the potential for a disease modifying effect on both knee joint structure and symptoms. While weight loss is an important primary management strategy in obese individuals, avoidance of further weight gain should also be a clinical goal.

scholarly journals A prospective study of relationship between medial joint pain and mild knee osteoarthritis

2018 ◽  
Vol 4 (4) ◽  
pp. 655
Author(s):  
Brajesh Dadarya ◽  
Ashish Sirsikar ◽  
Ashok Vidyarthi
Keyword(s):  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Joint Pain ◽  
Radiological Investigation ◽  
Duration Of Symptoms ◽  
Medial Knee ◽  
Knee Oa ◽  
Important Symptom ◽  
A Prospective Study ◽  
The Relationship

<p class="abstract"><strong>Background:</strong> The relationship between joint pain and osteoarthritis is poorly understood, however, the most common patterns associated with knee osteoarthritis are diffuse or medial joint pain. The objective of the study was to test the sensitivity of medial knee joint pain for the diagnosis of mild knee osteoarthritis, and thence its relationship.</p><p class="abstract"><strong>Methods:</strong> This is a prospective analytical study of 124 patients visiting to our out-patient setup in the year 2017, with complaint of medial knee joint pain, which after thorough clinical examination, were investigated radiologically.<strong></strong></p><p class="abstract"><strong>Results:</strong> In our study of 124 patients, there were 69 female (55.5%) and 55 male (47.5%), with a mean age of 59.3 years. The average duration of symptoms was 3.2 years, and the average VAS for severity of pain was 59.3. The sensitivity of medial knee joint pain for mild OA was thus calculated to be 79.8%.</p><p><strong>Conclusions:</strong> Medial knee joint pain is a very important symptom to raise a suspicion and also to warrant further radiological investigation for the early diagnosis and management of knee OA.</p>

Analysis of Maximum Expiratory Flow Volume Curves Using Canonical Correlation Analysis

1985 ◽  
Vol 24 (02) ◽  
pp. 91-100 ◽  
Author(s):  
W. van Pelt ◽  
Ph. H. Quanjer ◽  
M. E. Wise ◽  
E. van der Burg ◽  
R. van der Lende
Keyword(s):  
Correlation Analysis ◽  
Canonical Correlation Analysis ◽  
Canonical Correlation ◽  
Flow Volume ◽  
Non Linear ◽  
Maximum Expiratory Flow ◽  
Expiratory Flow ◽  
Relationship Of ◽  
The Relationship ◽  
Age And Sex

SummaryAs part of a population study on chronic lung disease in the Netherlands, an investigation is made of the relationship of both age and sex with indices describing the maximum expiratory flow-volume (MEFV) curve. To determine the relationship, non-linear canonical correlation was used as realized in the computer program CANALS, a combination of ordinary canonical correlation analysis (CCA) and non-linear transformations of the variables. This method enhances the generality of the relationship to be found and has the advantage of showing the relative importance of categories or ranges within a variable with respect to that relationship. The above is exemplified by describing the relationship of age and sex with variables concerning respiratory symptoms and smoking habits. The analysis of age and sex with MEFV curve indices shows that non-linear canonical correlation analysis is an efficient tool in analysing size and shape of the MEFV curve and can be used to derive parameters concerning the whole curve.

Pound Wise and Penny Foolish? Weight Loss and The Dynamics of Health Care Spending

2011 ◽  
Vol 14 (2) ◽  
Author(s):  
Thomas G Koch
Keyword(s):  
Weight Loss ◽  
Cost Savings ◽  
Cost Effective ◽  
Economic Consequences ◽  
Health Care Spending ◽  
Order Of Magnitude ◽  
Dynamic Measures ◽  
The Cost ◽  
The Impact ◽  
The Relationship

Current estimates of obesity costs ignore the impact of future weight loss and gain, and may either over or underestimate economic consequences of weight loss. In light of this, I construct static and dynamic measures of medical costs associated with body mass index (BMI), to be balanced against the cost of one-time interventions. This study finds that ignoring the implications of weight loss and gain over time overstates the medical-cost savings of such interventions by an order of magnitude. When the relationship between spending and age is allowed to vary, weight-loss attempts appear to be cost-effective starting and ending with middle age. Some interventions recently proven to decrease weight may also be cost-effective.

scholarly journals $$ T\overline{T} $$-like flows in non-linear electrodynamic theories and S-duality

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
H. Babaei-Aghbolagh ◽  
Komeil Babaei Velni ◽  
Davood Mahdavian Yekta ◽  
H. Mohammadzadeh
Keyword(s):  
Type Theory ◽  
Free Action ◽  
Momentum Tensor ◽  
Flow Equation ◽  
Supersymmetric Model ◽  
Deformation Problem ◽  
Dimensional Spacetime ◽  
Non Linear ◽  
The Relationship ◽  
Simple Integration

Abstract We investigate the $$ T\overline{T} $$ T T ¯ -like flows for non-linear electrodynamic theories in D(=2n)-dimensional spacetime. Our analysis is restricted to the deformation problem of the classical free action by employing the proposed $$ T\overline{T} $$ T T ¯ operator from a simple integration technique. We show that this flow equation is compatible with $$ T\overline{T} $$ T T ¯ deformation of a scalar field theory in D = 2 and of a non-linear Born-Infeld type theory in D = 4 dimensions. However, our computation discloses that this kind of $$ T\overline{T} $$ T T ¯ flow in higher dimensions is essentially different from deformation that has been derived from the AdS/CFT interpretations. Indeed, the gravity that may be exist as a holographic dual theory of this kind of effective Born-Infeld action is not necessarily an AdS space. As an illustrative investigation in D = 4, we shall also show that our construction for the $$ T\overline{T} $$ T T ¯ operator preserves the original SL(2, ℝ) symmetry of a non-supersymmetric Born-Infeld theory, as well as $$ \mathcal{N} $$ N = 2 supersymmetric model. It is shown that the corresponding SL(2, ℝ) invariant action fixes the relationship between the $$ T\overline{T} $$ T T ¯ operator and quadratic form of the energy-momentum tensor in D = 4.

scholarly journals AB0867 INCREASED ADIPONECTIN LEVELS ARE ASSOCIATED WITH HIGHER RADIOGRAPHIC SCORES IN THE KNEE JOINT, BUT NOT IN THE HAND JOINT: THE DONG-GU STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1740.1-1740
Author(s):  
J. H. Kang ◽  
S. E. Choi ◽  
H. Xu ◽  
D. J. Park ◽  
S. S. Lee
Keyword(s):  
Body Mass Index ◽  
Knee Joint ◽  
Body Mass ◽  
Linear Regression Analysis ◽  
Joint Space ◽  
Serum Adiponectin ◽  
Hand Osteoarthritis ◽  
X Rays ◽  
Subchondral Cyst ◽  
The Relationship

Background:Several studies have evaluated the association between serum adiponectin levels and knee and hand osteoarthritis (OA), with mixed results.Objectives:The aim of this study was to investigate the relationship between OA and serum adiponectin levels according to the radiographic features of knee and hand OA.Methods:A total of 2,402 subjects were recruited from the Dong-gu Study. Baseline characteristics were collected via a questionnaire, and X-rays of knee and hand joints were scored by a semi-quantitative grading system. The relationship between serum adiponectin levels and radiographic severity was evaluated by linear regression analysis.Results:Subjects with higher tertiles of serum adiponectin were older and had a lower body mass index than those with lower tertiles. In the knee joint scores, serum adiponectin levels were positively associated with the total score (P<0.001), osteophyte score (P=0.003), and joint space narrowing (JSN) score (P<0.001) among the three tertiles after adjustment for age, sex, body mass index, smoking, alcohol consumption, education, and physical activity. In the hand joint scores, no association was found between serum adiponectin levels and the total score, osteophyte score, JSN score, subchondral cyst score, sclerosis score, erosion score, and malalignment score among the three tertiles after adjustment.Conclusion:In this study, we found that increased adiponectin levels were associated with higher radiographic scores in the knee joint, but not in the hand joint, suggesting different pathophysiologic mechanisms in the development of OA.Disclosure of Interests:None declared

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