Metabolomics Studies in Psoriatic Disease: A Review

Metabolomics investigates a broad range of small molecules, allowing researchers to understand disease-related changes downstream of the genome and proteome in response to external environmental stimuli. It is an emerging technology that holds promise in identifying biomarkers and informing the practice of precision medicine. In this review, we summarize the studies that have examined endogenous metabolites in patients with psoriasis and/or psoriatic arthritis using nuclear magnetic resonance (NMR) or mass spectrometry (MS) and were published through 26 January 2021. A standardized protocol was used for extracting data from full-text articles identified by searching OVID Medline ALL, OVID Embase, OVID Cochrane Central Register of Controlled Trials and BIOSIS Citation Index in Web of Science. Thirty-two studies were identified, investigating various sample matrices and employing a wide variety of methods for each step of the metabolomics workflow. The vast majority of studies identified metabolites, mostly amino acids and lipids that may be associated with psoriasis diagnosis and activity. Further exploration is needed to identify and validate metabolomic biomarkers that can accurately and reliably predict which psoriasis patients will develop psoriatic arthritis, differentiate psoriatic arthritis patients from patients with other inflammatory arthritides and measure psoriatic arthritis activity.

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Safety of Cochlear Implantation in Children 12 Months or Younger: Systematic Review and Meta-analysis

Otolaryngology ◽

10.1177/01945998211067741 ◽

2022 ◽

pp. 019459982110677

Author(s):

Firas Sbeih ◽

Malek H. Bouzaher ◽

Swathi Appachi ◽

Seth Schwartz ◽

Michael S. Cohen ◽

...

Keyword(s):

Systematic Review ◽

Cochlear Implants ◽

Cochlear Implantation ◽

Meta Analysis ◽

Cochrane Central Register ◽

Ovid Medline ◽

Central Register ◽

Data Source ◽

Anesthetic Complications ◽

Full Text Screening

Objective To systematically review the literature to determine safety of cochlear implantation in pediatric patients 12 months and younger. Data Source Ovid MEDLINE, EMBASE, CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched from inception to March 20, 2021. Review Methods Studies that involved patients 12 months and younger with report of intraoperative or postoperative complication outcomes were included. Studies selected were reviewed for complications, explants, readmissions, and prolonged hospitalizations. Two independent reviewers screened all studies that were selected for the systematic review and meta-analysis. All studies included were assessed for quality and risk of bias. Results The literature search yielded 269 studies, of which 53 studies underwent full-text screening, and 18 studies were selected for the systematic review and meta-analysis. A total of 449 patients and 625 cochlear implants were assessed. Across all included studies, major complications were noted in 3.1% of patients (95% CI, 0.8-7.1) and 2.3% of cochlear implantations (95% CI, 0.6-5.2), whereas minor complications were noted in 2.4% of patients (95% CI, 0.4-6.0) and 1.8% of cochlear implantations (95% CI, 0.4-4.3). There were no anesthetic complications reported across all included studies. Conclusion The results of this systematic review and meta-analysis suggest that cochlear implantation in patients 12 months and younger is safe with similar rates of complications to older cohorts.

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Febuxostat use and risks of CVD events, death from cardiac-cause and all-cause mortality: metaanalysis of randomized controlled trials

The Journal of Rheumatology ◽

10.3899/jrheum.200307 ◽

2020 ◽

pp. jrheum.200307

Author(s):

Hao Deng ◽

Bao Long Zhang ◽

Jin Dong Tong ◽

Xiu Hong Yang ◽

Hui Min Jin

Keyword(s):

Web Of Science ◽

Meta Analysis ◽

Relevant Literature ◽

Controlled Trials ◽

Cochrane Central Register ◽

Inclusion Criteria ◽

Randomized Controlled ◽

Central Register ◽

Increased Risk ◽

All Cause Mortality

Objective To assess whether febuxostat use increases the risk of developing cardiovascular events, death from cardiac-cause and all-cause mortalities. Methods The relevant literature was searched in several databases including the MEDLINE (PubMed, 1 Jan. 1966–29 Feb. 2020), Web of science, EMBASE (1 Jan. 1974–29 Feb. 2020), ClinicalTrials.gov and Cochrane Central Register for Controlled Trials. Manual searches for references cited in the original studies and relevant review articles were also performed. All studies included in this metanalysis were published in English. Results In the end, 20 studies that met our inclusion criteria were included in this meta-analysis. Use of febuxostat was found not to be associated with an increased risk of all-cause mortality (RR = 0.87, 95% CI 0.57–1.32, P =0.507). Also, there was no association between febuxostat use and mortalities arising from cardiovascular diseases (CVD) (RR = 0.84, 95% CI 0.49–1.45, P=0.528). The RR also revealed that febuxostat use was not associated with CVD events (RR = 0.98, 95% CI 0.83–1.16, P =0.827). Furthermore, the likelihood of occurrence of CVD events was found not to be dependent on febuxostat dose (RR = 1.04, 95% CI 0.84–1.30, P =0.723). Conclusion Febuxostat use is not associated with increased risks of all-cause mortality, death from CVD or CVD events. Accordingly, it is a safe drug for the treatment of gout. Systematic review registration: PROSPERO CRD42019131872

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Psoriatic disease and body composition: a systematic review of the literature

10.1101/2020.05.18.20104802 ◽

2020 ◽

Author(s):

Tim Blake ◽

Nicola J Gullick ◽

Charles E Hutchinson ◽

Thomas M Barber

Keyword(s):

Body Mass Index ◽

Body Composition ◽

Psoriatic Arthritis ◽

Body Mass ◽

Assessment Method ◽

Assessment Tools ◽

Cochrane Central Register ◽

Anthropometric Parameters ◽

Anthropometric Measures ◽

Psoriatic Disease

Background. Obesity is a leading comorbidity in psoriatic disease, including both psoriasis (Pso) and psoriatic arthritis (PsA), and is associated with adverse metabolic and cardiovascular (CV) outcomes. Anthropometric parameters, such as weight, body mass index (BMI) and waist-to-hip ratio, have been extensively reported in psoriatic disease. However, the associations of body composition and fat distribution with psoriasis have not been fully defined. Objectives. To identify whether patients with psoriatic disease, including psoriatic arthritis, have altered body composition compared with the general population, and to review existing modalities for the assessment of body composition. Methods. Electronic searches of the literature were conducted in PubMed, Medline (Ovid), Embase (Ovid), Cochrane Central Register and Google Scholar. Titles and abstracts were reviewed by two authors independently against a set of prespecified inclusion/exclusion criteria. Results. Twenty-five full text articles met the inclusion criteria and were included in the final narrative analysis. The studies were of heterogeneous design and used a range of objective measures to assess body composition, including simple anthropometric measures, bioimpedance analysis (BIA), dual energy X-ray absorptiometry (DXA) and computed tomography (CT). Few studies met all the quality assessment criteria. Conclusions. Patients with psoriatic disease reveal defined body composition changes that are independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. These findings emphasize that patients with psoriatic disease should be screened for abnormal adipose effects beyond their weight and body mass index (BMI). Our findings show that the last decade has seen an exciting expansion of research interest in the development and validation of new modalities for the assessment of body composition. There is no consensus on the optimal assessment method of body composition for this diverse group, hence there is a need for validation of existing modalities and standardization of assessment tools.

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Weaning and Extubation Assisted with Conversational Hypnosis : A Systematic Review

10.21203/rs.3.rs-273882/v3 ◽

2021 ◽

Author(s):

Johan Wormser ◽

Christophe Romanet ◽

Aurel Bellaïche ◽

François Philippart

Keyword(s):

Systematic Review ◽

Oxygen Saturation ◽

Web Of Science ◽

Case Series ◽

Anxiety Reduction ◽

Cochrane Central Register ◽

Central Register ◽

Registration Number ◽

The One ◽

Present Systematic Review

Abstract Background : Patients admitted in intensive care units often receive mechanical ventilation. Prior to extubation, weaning process could be a major cause of dyspnea and anxiety in awake intubated patients. Hypnosis is commonly used to manage anxiety and pain. Our hypothesis is that hypnosis would decrease stress during the weaning and extubation process. Methods: This systematic review follows PRISMA Guidelines and was registered in PROSPERO (CRD42020171445). Web of Science, MEDLINE and Cochrane Central Register of Controlled Trials databases were searched until 11 March 2020. We included all interventional trials assessing hypnotherapy for intubated patients whom were undergoing weaning or extubation. Two of the authors independently screened studies, extracted data and assessed risk of bias from identified trials. Results: One study fulfilled our selection. This case series included 2 patients. Eleven sessions were completed. Dyspnea was not assessed/reported. Hypnotherapy decreased anxiety during the weaning process from a median of 1 point (Interquartile Range: 1.0-2.5). Increase in oxygen saturation is also reported. There was no evidence of neither an anxiety reduction or an oxygen saturation improvement. This is due to the scarcity of publication and the methodological design of the one selected study. Conclusions: We cannot conclude whether or not hypnosis could be recommended in the weaning process of intubated patients. Further studies are needed to assess hypnosis effects. Registration: The present systematic review was registered in the International prospective register of systematic reviews (PROSPERO) under registration number CRD42020171445.

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Updating the use of the Madrid Sonographic Enthesis Index (MASEI): a systematic review of the literature

Rheumatology ◽

10.1093/rheumatology/kez356 ◽

2019 ◽

Vol 59 (5) ◽

pp. 1031-1040 ◽

Cited By ~ 3

Author(s):

Cristina Macía-Villa ◽

Eugenio De Miguel

Keyword(s):

Systematic Review ◽

Psoriatic Arthritis ◽

Data Extraction ◽

Cochrane Central Register ◽

X Rays ◽

Review Of The Literature ◽

Central Register ◽

Study Characteristics ◽

Mediterranean Fever ◽

Ultrasound Score

Abstract Objective To perform a systematic review of the literature to evaluate the use of the enthesis ultrasound Madrid Sonographic Entesis Index (MASEI) from its publication. Methods A systematic search of MEDLINE, EMBASE, and Cochrane Central Register databases was performed. The search strategy was constructed to identify publications containing terms related to enthesis and ultrasound. The only applied filter was studies conducted in humans. One reviewer systematically screened the search. A second reviewer verified the selection. The data extraction was focused on study characteristics, including population and components of the OMERACT filter. Results Sixty-eight of the 1581 identified studies had used MASEI, including 41 (60%) abstracts and 27 (40%) articles. Of the 27 articles, MASEI was mainly used for spondyloarthritis and related diseases in 12 (44%) articles, followed by both psoriatic arthritis and rheumatoid arthritis in five (19%) articles; however, it was also used in diseases such as Behçet disease, FM, familiar Mediterranean fever, SS, crystal arthropathies and systemic sclerosis. The feasibility of MASEI was reported in three (11%) articles, and the reliability in 12 (44%) with good to excellent values. No article evaluated the responsiveness to treatment. The construct validity of MASEI was assessed using biomarkers in seven (26%) articles, clinical examination in 13 (48%) and imaging procedures (only X-rays) in two (7%). The discriminative validity was assessed in 16 (59%) articles, not only in SpAs. Conclusion MASEI is a feasible, reliable and valid ultrasound score for the study of enthesis in spondyloarthritis, psoriatic arthritis and other diseases.

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Cochrane corner: water for wound cleansing

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193412443640 ◽

2012 ◽

Vol 37 (4) ◽

pp. 375-376 ◽

Cited By ~ 1

Author(s):

J. Henton ◽

A. Jain

Keyword(s):

Tap Water ◽

Data Extraction ◽

Healing Process ◽

Cost Effective ◽

Cochrane Library ◽

Controlled Trials ◽

Cochrane Central Register ◽

Ovid Medline ◽

Central Register ◽

The Cochrane Library

Background: Although various solutions have been recommended for cleansing wounds, normal saline is favoured as it is an isotonic solution and does not interfere with the normal healing process. Tap water is commonly used in the community for cleansing wounds because it is easily accessible, efficient and cost effective; however, there is an unresolved debate about its use. Objectives: The objective of this review was to assess the effects of water compared with other solutions for wound cleansing. Search strategy: For this update we searched the Cochrane Wounds Group Specialised Register (Searched 22 February 2010); The Cochrane Central Register of Controlled Trials (CENTRAL) ( The Cochrane Library, 2010 Issue 1); Ovid MEDLINE – 2007 to February Week 2 2010; Ovid MEDLINE – In-Process & Other Non-Indexed Citations (Searched19 February 2010); Ovid EMBASE – 2007 to 2010 Week 06; EBSCO CINAHL – 2007 to 22 February 2010. Selection criteria: Randomized and quasi-randomized controlled trials that compared the use of water with other solutions for wound cleansing were eligible for inclusion. Additional criteria were outcomes that included objective or subjective measures of wound infection or healing. Data collection and analysis: Two review authors independently carried out trial selection, data extraction and quality assessment. We settled differences in opinion by discussion. We pooled some data using a random-effects model.

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Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review

Anais da Academia Brasileira de Ciências ◽

10.1590/0001-3765201520140701 ◽

2015 ◽

Vol 87 (2 suppl) ◽

pp. 1415-1420 ◽

Cited By ~ 3

Author(s):

MARIA INÊS DA ROSA ◽

SUÉLI L. SOUZA ◽

BRUNA F. DE FARIAS ◽

PATRÍCIA D.S. PIRES ◽

EDUARDO R. DONDOSSOLA ◽

...

Keyword(s):

Systematic Review ◽

Herpes Simplex ◽

Literature Search ◽

Reference Lists ◽

Web Of Science ◽

Meta Analysis ◽

Grey Literature ◽

Cochrane Central Register ◽

Herpes Labialis ◽

Central Register

We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p<0.001).This result suggests that an early episodic treatment with the combination of an antiviral and a steroid is beneficial for herpes simplex labialis treatment.

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Urine Leukotriene E4: Implications as a Biomarker in Chronic Rhinosinusitis

Otolaryngology ◽

10.1177/01945998211011060 ◽

2021 ◽

pp. 019459982110110

Author(s):

Garret Choby ◽

Christopher M. Low ◽

Joshua M. Levy ◽

Janalee K. Stokken ◽

Carlos Pinheiro-Neto ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Disease Severity ◽

State Of The Art ◽

Cochrane Central Register ◽

Diagnostic Biomarker ◽

Ovid Medline ◽

Potential Marker ◽

Cochrane Database ◽

Central Register

Objective To provide a comprehensive state-of-the-art review of the emerging role of urine leukotriene E4 (uLTE4) as a biomarker in the diagnosis of chronic rhinosinusitis (CRS), aspirin-exacerbated respiratory disease (AERD), and asthma. Data Sources Ovid MEDLINE(R), Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, and Scopus. Review Methods A state-of-the-art review was performed investigating the role of uLTE4 as a diagnostic biomarker, predictor of disease severity, and potential marker of selected therapeutic efficacy. Conclusions uLTE4 has been shown to be a reliable and clinically relevant biomarker for CRS, AERD, and asthma. uLTE4 is helpful in ongoing efforts to better endotype patients with CRS and to predict disease severity. Implications for Practice Aside from being a diagnostic biomarker, uLTE4 is also able to differentiate aspirin-tolerant patients from patients with AERD and has been associated with objective disease severity in patients with CRS with nasal polyposis. uLTE4 levels have also been shown to predict response to medical therapy, particularly leukotriene-modifying agents.

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Potencial Evocado Auditivo Mismatch Negativity em músicos e não músicos: Revisão sistematica

Research Society and Development ◽

10.33448/rsd-v10i1.12170 ◽

2021 ◽

Vol 10 (1) ◽

pp. e59610112170

Author(s):

Ainoã Ruthy Farias Silva Veras ◽

Ysa Karen Santos Macambira ◽

Ruth Raquel Soares de Farias

Keyword(s):

New York ◽

Mismatch Negativity ◽

Clinical Evidence ◽

Web Of Science ◽

York Academy ◽

Controlled Trials ◽

Cochrane Central Register ◽

Bibliographic Database ◽

Long Latency ◽

Central Register

O potencial evocado de longa latência Mismatch Negativity (MMN) se refere de forma objetiva como método eletrofisiológico às habilidades de discriminação sonora, processamento auditivo, memória auditiva e atenção involuntária em nível central. Tais habilidades são encontradas de maneira distinta entre músicos e não músicos e o MMN é utilizado de forma objetiva para detecta-las. Objetivo: realizar uma revisão sistemática para verificar se existe diferenças de latência e amplitude apresentadas por meio do MMN em músicos e não músicos. Método: A pesquisa foi realizada entre setembro e novembro de 2020, nas bases eletrônicas Pubmed, ScienceDirect, BVS (Lilacs), Scopus, Circumpolar Health Bibliographic Database, SciELO, Embase, Web of science e Cochrane Central Register of Controlled Trials (CENTRAL), bem como as bases de literatura cinzenta OpenGrey.eu, DissOnline, The New York Academy of Medicine, Clinical Evidence e Clinical Trials, utilizando os descritores da seguinte forma Music OR musician OR musicians AND potencial mismatch negavitity OR MMN OR evoked potentials auditory OR Long Latency. Resultados: Foram encontrados 9 artigos , sendo que 7 abordavam que os músicos superavam os não músicos em suas latências e amplitudes de MMN, em contraste 2 artigos não diferenciavam as latências e amplitudes entre músicos e não músicos. Conclusão: Os músicos apresentaram em uma grande maioria dos estudos uma superioridade aos não músicos em amplitude, o que significa que as habilidades neurais de discriminação auditiva e comportamentais dos músicos superam aos de não músicos, os músicos apresentaram menor latência de MMN ainda assim superando os não músicos.

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Producción científica y redes de colaboración en la Seguridad Social del Perú (EsSalud): Análisis bibliométrico 2008-2020

Revista del Cuerpo Médico del HNAAA ◽

10.35434/rcmhnaaa.2021.142.1030 ◽

2021 ◽

Vol 14 (2) ◽

pp. 145-154

Author(s):

Christoper A: Alarcón-Ruiz ◽

Andrea G. Cortez-Soto ◽

Anthony Romero-Cerdan ◽

Alejandro Benites-Bullón ◽

Euler Faraday Altamirano-Farfá ◽

...

Keyword(s):

Web Of Science ◽

Citation Index ◽

Ovid Medline ◽

De Medicina

Introducción: La producción científica de EsSalud ha aumentado progresivamente. Sin embargo, no se ha descrito su producción científica e identificado sus redes de colaboración en las principales bases de datos bibliográficas a nivel internacional. Objetivos: Describir la producción científica de EsSalud en revistas científicas indizadas durante el periodo 2008-2020. Material y Métodos: Estudio bibliométrico que evaluó artículos científicos y resúmenes de congresos, con al menos una filiación institucional relacionada a EsSalud entre sus autores, que se encuentren indizadas en las bases de datos bibliográficas de Scopus, Web of Science, Ovid-Medline o Scielo Citation Index durante el periodo 2008-2020. Se reporta la producción científica anual total y por separado, según base. Se identificaron las redes de colaboración intra y extrainstitucionales. Resultados: Se obtuvieron 4159 registros y, tras aplicar los criterios de selección, quedaron 2333 artículos. Se observó un incremento de publicaciones en todas las bases de datos, excepto en Scielo Citation Index. La mayoría de los artículos fueron originales, observacionales y autofinanciados. Dos hospitales nacionales de EsSalud aportaron casi dos tercios de toda la producción científica evaluada. Se identifico poca colaboración entre instituciones de EsSalud de Lima con las de otras regiones y entre regiones, pero sí con las universidades locales. El área médica que más fue abordada por las publicaciones científicas fue la relacionada con las especialidades de medicina clínica. Conclusiones: La producción científica de EsSalud ha aumentado y ha mejorado en calidad, con una importante colaboración con universidades locales. Es importante impulsar iniciativas que promuevan la investigación y colaboración dentro de EsSalud, en el marco de las prioridades de investigación y de las principales causas de mayor carga de enfermedad en la institución y el país.

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