AB0508 PHYSICAL ACTIVITY IN TUNISIAN ADULTS WITH ANKYLOSING SPONDYLITIS

Background:Physical activity (PA) is associated with multiple health-related benefits among the general population and adults with chronic diseases like Ankylosing spondylitis (AS) [1]. As known, AS affects primarily enthesis and can lead to loss of function and decreased mobility.Objectives:The aim of this study was to explore the PA levels of adults with AS and to examine associations between PA, sociodemographic characteristics, immunological features, disease activity and treatment type.Methods:Cross-sectional clinical and laboratory data were collected on 68 AS patients. BASDAI (Bath ankylosing spondylarthritis disease activity index) and BASFI (Bath ankylosing spondylarthritis functional index) were calculated. Physical activity was measured using IPAQ-SF (International Physical Activity Questionnaire-Short Form). Its items record the time spent on physical activity of three intensity levels (vigorous, moderate and walking) as well as the time spent on sitting (referred to as sedentary in this study) in the past week. Both continuous (expressed as metabolic equivalent of task (MET)-min /week) and categorical (3 levels proposed: low, moderate and high level of PA) scores of IPAQ-SF were determined. Sedentary time (median) was reported in minutes/week. A p value < 0.05 was considered significant.Results:Cross-sectional clinical and laboratory data were collected on 68 AS patients. BASDAI (Bath ankylosing spondylarthritis disease activity index) and BASFI (Bath ankylosing spondylarthritis functional index) were calculated. Physical activity was measured using IPAQ-SF (International Physical Activity Questionnaire-Short Form). Its items record the time spent on physical activity of three intensity levels (vigorous, moderate and walking) as well as the time spent on sitting (referred to as sedentary in this study) in the past week. Both continuous (expressed as metabolic equivalent of task (MET)-min /week) and categorical (3 levels proposed: low, moderate and high level of PA) scores of IPAQ-SF were determined. Sedentary time (median) was reported in minutes/week. A p value < 0.05 was considered significant.Conclusion:Our study proved that physical activity in people with AS decreased with age and activity disease with a concomitant increase in sedentary activity. Given the risks of developing secondary chronic disease as a result of low levels of physical activity, physical exercise should be recommended as part of comprehensive AS care.References:[1]Conigliaro P, Triggianese P, Ippolito F, Lucchetti R, Chimenti MS, Perricone R. Insights on the Role of Physical Activity in Patients with Rheumatoid Arthritis. Drug Dev Res. 2014;75:S54–6.Disclosure of Interests:None declared.

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Fibromyalgia in Spondyloarthritis: Effect on Disease Activity Assessment in Clinical Practice

The Journal of Rheumatology ◽

10.3899/jrheum.160104 ◽

2016 ◽

Vol 43 (11) ◽

pp. 2056-2063 ◽

Cited By ~ 27

Author(s):

Jean Wach ◽

Marie-Claude Letroublon ◽

Fabienne Coury ◽

Jacques Guy Tebib

Keyword(s):

Ankylosing Spondylitis ◽

Disease Activity ◽

Activity Index ◽

Short Form ◽

Disease Activity Index ◽

Patient Characteristics ◽

Cross Sectional Study ◽

Moderate Activity ◽

Cross Sectional ◽

American College Of Rheumatology

Objective.Spondyloarthritis (SpA) is the second most frequent inflammatory rheumatic disease, characterized by spinal involvement, peripheral arthritis, or enthesitis with marked pain, stiffness, and fatigue. Fibromyalgia (FM) may be associated with SpA, and shares some common symptoms. We aimed to determine how FM influences assessment of SpA disease activity, which is mainly dependent on patient-based outcome measures such as the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) or the Ankylosing Spondylitis Disease Activity Score (ASDAS).Methods.This single-center cross-sectional study included consecutive patients with SpA according to the Assessment of SpondyloArthritis International Society criteria. FM was diagnosed according to the 1990 American College of Rheumatology criteria. Patient characteristics, BASDAI, ASDAS/C-reactive protein (CRP), Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Metrology Index, and the Medical Outcomes Study Short Form-36 questionnaire were recorded and compared.Results.The study included 103 patients with SpA; 81 with axial and 22 with peripheral forms. Eighteen patients presented with concomitant FM, of whom 12 had axial SpA and 6 peripheral SpA. Demographic characteristics did not differ except for sex, with a female predominance in the FM group that was more marked in peripheral forms. BASDAI was higher in patients with FM [median (IQR): 4.2 (4.2) vs 2.2 (3.1); p = 0.0068], whereas ASDAS-CRP was not significantly different [median (IQR): 2.7 (2) vs 2 (1.3); p = 0.1264]. Nevertheless, median ASDAS-CRP corresponded to high disease activity in patients with SpA or FM compared with moderate activity in non-FM patients.Conclusion.FM is a frequent comorbidity in patients with SpA, especially in peripheral forms. In patients with SpA-FM, disease activity may be overestimated when measured by BASDAI and to a lesser extent by ASDAS-CRP, and this overestimation could lead to inappropriate treatment escalation.

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High Burden of Sexual Dysfunction in Female Patients with Rheumatoid Arthritis: Results of a Cross-sectional Study

The Journal of Rheumatology ◽

10.3899/jrheum.171287 ◽

2018 ◽

Vol 46 (1) ◽

pp. 19-26 ◽

Cited By ~ 7

Author(s):

Rudolf Puchner ◽

Judith Sautner ◽

Johann Gruber ◽

Elia Bragagna ◽

Andrea Trenkler ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Sexual Dysfunction ◽

Disease Activity ◽

Sexual Functioning ◽

Activity Index ◽

Short Form ◽

Health Assessment ◽

Disease Activity Index ◽

Cross Sectional ◽

Female Patients

Objective.To evaluate the effect of rheumatoid arthritis (RA) on impairing women’s sexuality regarding motivation, activity, and satisfaction, and to assess the correlation of disease-related physical impairment within sexual functioning.Methods.An anonymous survey among women with RA and healthy controls (HC) using standardized questionnaires, predominantly the Changes in Sexual Functioning Questionnaire-short form (CSFQ-14). In addition, disease activity, depression, and disability were evaluated.Results.There were 319 questionnaires distributed to patients and 306 to HC. Of these, 235 patient questionnaires (73.7%) and 180 HC questionnaires (58.8%) were returned, of which 203 and 169 were completed, respectively. Of the patients with RA, 47.8% had a total CSFQ-14 score of ≤ 41, indicating female sexual dysfunction (FSD), as compared to 14.2% of HC (p < 0.0001). The median CSFQ-14 score was lower in patients with RA [42 points, interquartile range (IQR) 36–48] than in HC (49 points, IQR 44–54; p < 0.0001), resulting in an OR of 5.53 (95% CI 3.19–9.57; p < 0.0001). After adjustment for confounders, given a higher mean age of patients (55.2 ± 11.3 yrs) than HC (47.4 ± 11.8 yrs; p < 0.0001), the OR for FSD in patients with RA was still 3.04 (95% CI 1.61–5.75; p = 0.001). Neither the Health Assessment Questionnaire–Disability Index nor the Clinical Disease Activity Index was associated with FSD after adjustment.Conclusion.FSD apparently is highly prevalent in female patients with RA, affects all subdomains of sexual function, and is most likely underestimated in daily clinical practice. Of note, FSD could not be linked to disability or RA disease activity.

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Deteksi Dini Faktor Risiko Penyakit Jantung dan Pembuluh Darah, Hubungan Antara Obesitas, Aktivitas Fisik dan Kolesterol Total di Kecamatan Kertapati, Kota Palembang

Jurnal Epidemiologi Kesehatan Komunitas ◽

10.14710/jekk.v5i2.6729 ◽

2020 ◽

Vol 5 (2) ◽

pp. 96-103

Author(s):

Achmad Ridwanmo ◽

Mariatul Fadillah ◽

Tri Hari Irfani

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Disease ◽

Total Cholesterol ◽

P Value ◽

Cross Sectional ◽

Cross Sectional Design ◽

Multistage Sampling ◽

The One ◽

High Level

Background: Cardiovascular disease is the first cause of death in Indonesia. The prevalence of stroke based on diagnosis rose from 7 (2013) to 10.9 per mil (2018), The prevalence of cardiovascular disease is 1.5 per mil. Research on the detection of risk factors for cardiovascular disease using a cardiovascular risk score according to WHO and the Jakarta Score has never been conducted in Palembang. The purpose of this study is to conduct early detection of risk factors to predict cardiovascular disease in the next 10 years, and find out the relationship between obesity, physical activity to reduce cholesterol.Methods: This research was conducted using an observational analytic study with cross sectional design and multistage sampling method. Samples in this study were 126 people from 3 village in Kertapati district in Palembang City.Result: The research showed that high level risk to cardiovascular disease in 10 years by using WHO non laboratory, laboratory and Jakarta Score was 4,8%, 6,7%, 61,9% respectively. Whereas, the moderate risk was 20%, 26,2% and 25,4%. There was no association between obesity and total cholesterol (p=0.682), but there was an association between physical activity and total cholesterol (p=0.030, OR 3,1). Moreover, there was a total cholesterol’s mean difference between none/mild, moderate, and severe physical activity that is 36,6 mg/dl (t test, p-value: 0,005).Conclusion: Lack of physical activity could be the one of cholesterol risk factor. Therefore, doing the physical activity could prevent the cardiovascular disease.

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The Association Between Disease Activity and Duration in Systemic Sclerosis

The Journal of Rheumatology ◽

10.3899/jrheum.090919 ◽

2010 ◽

Vol 37 (11) ◽

pp. 2299-2306 ◽

Cited By ~ 7

Author(s):

JENNIFER G. WALKER ◽

RUSSELL J. STEELE ◽

MIREILLE SCHNITZER ◽

SUZANNE TAILLEFER ◽

MURRAY BARON ◽

...

Keyword(s):

Systemic Sclerosis ◽

Disease Activity ◽

Disease Duration ◽

Activity Index ◽

Disease Onset ◽

Depression Scale ◽

Disease Activity Index ◽

Cross Sectional ◽

Diffuse Disease ◽

Patient Reported

Objective.The absence of a standardized disease activity index has been an important barrier in systemic sclerosis (SSc) research. We applied the newly derived Valentini Scleroderma Disease Activity Index (SDAI) among our cohort of patients with SSc to document changes in disease activity over time and to assess possible differences in activity between limited and diffuse disease.Methods.Cross-sectional study of a national cohort of patients enrolled in the Canadian Scleroderma Research Group Registry. Disease activity was measured using the SDAI. Depression scores were measured using the Centre for Epidemiologic Studies Depression Scale (CES-D).Results.A total of 326 out of 639 patients had complete datasets at the time of this analysis; 87% were female, of mean age 55.6 years, with mean disease duration 14.1 years. SDAI declined steeply in the first 5 years after disease onset and patients with diffuse disease had 42% higher SDAI scores than patients with limited disease with the same disease duration and depression scores (standardized relative risk 1.42, 95% CI 1.21, 1.65). Patients with higher CES-D scores had higher SDAI scores relative to patients with the same disease duration and disease subset (standardized RR 1.22, 95% CI 1.14, 1.31). Among the 10 components that make up the SDAI, only skin score (standardized OR 0.59, 95% CI 0.43, 0.82) and patient-reported change in skin (standardized OR 0.64, 95% CI 0.45, 0.92) decreased with increasing disease duration. High skin scores (standardized OR 32.2, 95% CI 15.8, 72.0) were more likely and scleredema (standardized OR 0.58, 95% CI 0.37, 0.92) was less likely to be present in patients with diffuse disease. High depression scores were associated with positive responses for patient-reported changes in skin and cardiopulmonary function.Conclusion.Disease activity declined with time and patients with diffuse disease had consistently higher SDAI scores. Depression was found to be associated with higher patient activity scores and strongly associated with patient self-response questions. The role of depression should be carefully considered in future applications of the SDAI, particularly as several components of the score rely upon patient recall.

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

F1000Research ◽

10.12688/f1000research.10763.3 ◽

2017 ◽

Vol 6 ◽

pp. 126 ◽

Cited By ~ 3

Author(s):

Abidullah Khan ◽

Iqbal Haider ◽

Maimoona Ayub ◽

Salman Khan

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Sampling Technique ◽

Cross Sectional Study ◽

Strong Positive Correlation ◽

Platelet Volume ◽

Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Spearman’s rho and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant ( P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (rs= -0.89, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (rs=0.90, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% ( P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

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The Association between Temperament, Chronotype, Depressive Symptoms, and Disease Activity among Patients with Inflammatory Bowel Disease—A Cross-Sectional Pilot Study

Life ◽

10.3390/life11121347 ◽

2021 ◽

Vol 11 (12) ◽

pp. 1347

Author(s):

Łukasz Mokros ◽

Danuta Domżał-Magrowska ◽

Tadeusz Pietras ◽

Kasper Sipowicz ◽

Renata Talar-Wojnarowska

Keyword(s):

Disease Activity ◽

Clinical Assessment ◽

Emotional Reactivity ◽

Activity Index ◽

Disease Activity Index ◽

Sensory Sensitivity ◽

Cross Sectional ◽

Total N ◽

Mayo Score ◽

Sensitivity Score

The psychological aspect may play an important role in ulcerative colitis (UC) and Crohn’s disease (CD). The aims of this study were to explore the differences between patients with UC and CD regarding chronotype, temperament and depression, and to assess the psychological factors mentioned as predictors of disease activity. In total, n = 37 patients with UC and n = 47 patients with CD were included in the study. They underwent a clinical assessment, including the Mayo score or Crohn Disease Activity Index (CDAI), and completed questionnaires: a sociodemographic survey, Formal Characteristics of Behavior–Temperament Inventory (FCB-TI), Chronotype Questionnaire (CQ), and the Beck Depression Index II (BDI). The Sensory Sensitivity score was higher among patients with CD than UC (p = 0.04). The emotional reactivity and endurance scores were higher among women than men with CD (p = 0.028 and p = 0.012 respectively). CQ Morningness–Eveningness (ME) correlated with Endurance (p = 0.041), Emotional Reactivity (p = 0.016), and Activity (p = 0.004). ME correlated with Rhythmicity among CD patients (p = 0.002). The Mayo score was predicted by Perseverance. The CDAI score was predicted by the BDI score. The pattern of the relationship between chronotype and temperament may differentiate patients with UC and CD. Personal disposition may play a role in the clinical assessment of patients with IBD.

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Relationship between Microalbuminuria and Disease Activity in Patients with Ulcerative Colitis

Middle East Journal of Digestive Diseases ◽

10.15171/mejdd.2020.161 ◽

2019 ◽

Vol 12 (1) ◽

pp. 34-38

Author(s):

Kourosh Masnadi Shirazi ◽

Sima Khayati ◽

Maryam Baradaran Binazir ◽

Zeinab Nikniaz

Keyword(s):

Ulcerative Colitis ◽

Disease Activity ◽

Activity Index ◽

Disease Activity Index ◽

Fecal Calprotectin ◽

Cross Sectional Study ◽

Inactive Disease ◽

Cross Sectional ◽

Non Invasive ◽

The Mean

BACKGROUND Introducing a non-invasive method for determining disease activity is important in patients with ulcerative colitis (UC). So in this study, we aimed to assess the association between disease activity index and microalbuminuria in patients with UC. METHODS In the present cross-sectional study, 84 patients with UC were selected. The disease activity was calculated by the partial Mayo clinic score. Microalbuminuria was assessed using the immunoturbidimetric method in a first-voided sample in the morning in two consecutive days and the mean of these two measurements was reported as urinary microalbumin level. Serum C reactive protein (CRP), erythrocyte sedimentation rate (ESR), and fecal calprotectin were measured respectively using conventional turbidimetric immunoassay, Westergren method, and ELISA methods. RESULTS The mean age of the participants was 40.01 ± 12.85 years, 60.8% of them were female and 53.5% had microalbuminuria. The frequency of microalbuminuria was significantly higher in patients with active compared with inactive inflammatory bowel disease (IBD). There were significant differences between the patients with active and inactive disease regarding CRP, ESR, and calprotectin (p < 0.001). Moreover, there was a strong correlation between microalbuminuria and CRP (r = 0.89, p < 0.001), ESR (r = 0.92, p < 0.001), and calprotectin (r = 0.91, p < 0.001). CONCLUSION Microalbuminuria could be used as a non-invasive marker of disease activity in patients with UC.

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An observational study on Assessment of disease activity in Rheumatoid Arthritis patients using Patient based Disease Activity Score 2 (PDAS 2)

10.21203/rs.3.rs-517870/v1 ◽

2021 ◽

Author(s):

Harpreet Singh ◽

Somdatta Giri ◽

Hemant Kumar ◽

Pratibha Yonzone ◽

Mahima Khatkar

Keyword(s):

Rheumatoid Arthritis ◽

Disease Activity ◽

Disease Activity Score ◽

Activity Index ◽

Statistical Significance ◽

Disease Activity Index ◽

Activity Score ◽

P Value ◽

Internal Reliability ◽

Das 28

Abstract Objective To assess the utility of Patient Based Disease Activity Score 2 (PDAS 2) in assessing the disease activity in Rheumatoid arthritis (RA). Methods A prospective cohort study was conducted on 80 patients of RA. The demographic and clinical characteristics of the patients were recorded. They were assessed for disease activity using “Disease Activity Score 28” (DAS 28), “Clinical Disease Activity Index” (CDAI) and PDAS 2 score at baseline (M0), at 2 months (M2) and at 4 months(M4) while they were on treatment. Data was analyzed for correlation of PDAS-2 with other scores and internal reliability. P < 0.05 was considered for statistical significance. Results The mean age was 40.13\(\pm\) 11.74 years with 70 females and 10 males. There was significant reduction in DAS28, CDAI and PDAS 2 score over 4 month follow up (all scores’ p values < 0.001). Internal reliability (as assessed by Cronbach’s Alpha) of PDAS 2 was 0.578. PDAS 2 showed significant correlation with DAS28 at M0, M2 and M4 (r = 0.792, 0.757 and 0.669 respectively, p value < 0.001) and CDAI (r = 0.861, 0.832 and 0.695 respectively, p value < 0.001). Overall there was a significant agreement between DAS 28 and PDAS 2 (K = 0.788,p < 0.001) and between CDAI and PDAS 2 (K = 0.766,p < 0.001). Conclusion PDAS-2 score can be routinely used in the clinical practice owing to its correlation with DAS-28/CDAI and because of the advantage that it assessed the patients’ daily living activities.

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Mean Platelet Volume (MPV) as an indicator of disease activity and severity in lupus

F1000Research ◽

10.12688/f1000research.10763.2 ◽

2017 ◽

Vol 6 ◽

pp. 126 ◽

Cited By ~ 5

Author(s):

Abidullah Khan ◽

Iqbal Haider ◽

Maimoona Ayub ◽

Salman Khan

Keyword(s):

Disease Activity ◽

Lupus Erythematosus ◽

Mean Platelet Volume ◽

Activity Index ◽

Disease Activity Index ◽

Sampling Technique ◽

Cross Sectional Study ◽

Strong Positive Correlation ◽

Platelet Volume ◽

Cross Sectional

Background: Amongst the different clinical and laboratory parameters used to monitor disease activity in systemic lupus erythematosus (SLE), mean platelet volume (MPV) is a novel biomarker. Although MPV has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult SLE needs to be defined, especially in Pakistan. Methods: The aim of this study was to evaluate the role of MPV as a biomarker of disease activity in SLE. Fifty patients were recruited through a consecutive non-probability sampling technique for this cross-sectional study. On the basis of their SLE disease activity index (SLEDAI) score of greater or lesser than 5, these 50 participants were divided into two equal groups respectively;25 patients with active SLE, and another 25 participants with stable, inactive lupus. MPV was measured in each group and compared using SPSS version 16. MPV was also correlated with SLEDAI and erythrocyte sedimentation rate (ESR). Independent sample t-test and Pearson’s correlation tests were applied. Sensitivity and specificity of MPV were checked through ROC analysis. Results: The MPV of patients with active SLE (n=25, mean [M]=7.12, SD=1.01) was numerically lower than those in the inactive-SLE group (n=25, M= 10.12, SD=0.97), and this was statistically significant (P<0.001). MPV had an inverse relationship with both ESR (r=-0.93, P<0.001) and SLEDAI (r= -0.94, P<0.001). However, there was a strong positive correlation between ESR and SLEDAI (r=0.95, P<0.001). For MPV, a cutoff value of less than 8.5fl had a sensitivity of 92% and a specificity of 100% (P< 0.001). Conclusions: Higher disease activity in SLE is associated with a correspondingly low MPV.

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Analysis of Physical Activity and Comorbidities in Spanish Asthmatics

Sustainability ◽

10.3390/su12135256 ◽

2020 ◽

Vol 12 (13) ◽

pp. 5256

Author(s):

Sheila Sánchez Castillo ◽

Lee Smith ◽

Arturo Díaz Suárez ◽

Guillermo Felipe López Sánchez

Keyword(s):

Physical Activity ◽

Short Form ◽

National Health Survey ◽

Lumbar Pain ◽

Chronic Obstructive ◽

Cross Sectional ◽

Obstructive Pulmonary Disease ◽

Metabolic Equivalent Of Task ◽

Cross Sectional Design ◽

Chronic Anxiety

The prevalence of comorbidities in asthmatics is high. Comorbidities may complicate the clinical management of asthma, increasing the risk for exacerbation and even death. The objective of the present research was to establish the prevalence of 31 asthma comorbidities and to assess the association of these comorbidities with physical activity (PA) in Spanish asthmatics. Data of the Spanish National Health Survey 2017 (cross-sectional design) were used in this study. A total of 1014 people (42.1% males) with asthma participated in this study (age range 15–69 years). The IPAQ (International Physical Activity Questionnaire) short form was the instrument administered to evaluate PA (exposure), and the self-reported answer to the question “Have you ever been diagnosed with…?” determined the presence of comorbidities (outcomes). This association was assessed by multivariable logistic regression. Results demonstrated a huge presence of comorbidities (89.3%). The most prevalent were chronic allergy (61.1%), chronic lumbar pain (28.7%), chronic cervical pain (24.2%), high cholesterol (20.9%), Chronic Obstructive Pulmonary Disease (COPD) (19.4%), migraine (19.2%) and hypertension (19.3%). PA level under 600 metabolic equivalent of task (MET)·min/week showed a significant association with urinary incontinence (3.10 [1.62–5.94]), osteoporosis (1.90 [1.00–3.61]) and chronic anxiety (1.69 [1.13–2.53]). Therefore, comorbidities and PA levels should be considered in the prevention and treatment of asthmatics, in order to improve their quality of life.

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