Chronic migraine reversal and prevention with the LIFE diet: a nutrient dense whole food plant-based diet (WFPBD)

2021 ◽  
Vol 14 (12) ◽  
pp. e243987
Author(s):  
Brittany Marie Perzia ◽  
Joshua L Dunaief ◽  
David M Dunaief
Keyword(s):  
Complete Blood Count ◽  
High Sensitivity ◽  
Beta Carotene ◽  
Food Plant ◽  
Leafy Vegetables ◽  
Hydration Status ◽  
Migraine Treatment ◽  
Green Leafy Vegetables ◽  
Reactive Protein ◽  
Dark Green

We report a case of a 60-year-old man who struggled with frequent migraines for 12.5 years, which were refractory to all conventional therapies. Six months before initial consultation, these migraines become chronic. The patient was then advised to follow the Low Inflammatory Foods Everyday (LIFE) diet, a nutrient-dense, dark green leafy vegetable-rich, whole food plant-based diet. Within 2 months, his headache frequency declined from 18 to 24 headache days per month to 1, and he discontinued his preventive and abortive migraine medications. After 3 months, the patient had no headaches. These results far exceed the goal of migraine treatment with medication, which is to reduce migraine frequency by >50% per month. In addition, the results were durable; this patient has been migraine-free for 7.5 years. Serum beta-carotene more than tripled after the patient started the LIFE diet, consistent with its high content of dark green leafy vegetables. Weight, high-sensitivity C-reactive protein (hsCRP), complete blood count (CBC), hydration status, sodium and other electrolytes remained constant throughout the study.

scholarly journals Rising Plasma Beta-Carotene Is Associated With Diminishing C-Reactive Protein in Patients Consuming a Dark Green Leafy Vegetable–Rich, Low Inflammatory Foods Everyday (LIFE) Diet

2019 ◽  
pp. 155982761989495 ◽  
Author(s):  
Hannah Schultz ◽  
Gui-Shuang Ying ◽  
Joshua L. Dunaief ◽  
David M. Dunaief
Keyword(s):  
Everyday Life ◽  
Chronic Diseases ◽  
Retrospective Chart Review ◽  
Beta Carotene ◽  
Leafy Vegetables ◽  
Community Practice ◽  
C Reactive Protein ◽  
Green Leafy Vegetables ◽  
Reactive Protein ◽  
Dark Green

Chronic inflammation contributes to a number of chronic diseases and can be assessed with C-reactive protein (CRP). In this longitudinal retrospective chart review, we investigate whether patients intensively counseled to eat a specific diet high in dark green leafy vegetables, and thus high beta-carotene, have reductions in plasma high-sensitivity CRP (hsCRP). We term this the Low Inflammatory Foods Everyday (LIFE) diet. Forty-three patients in a community practice instructed to eat the LIFE diet met inclusion criteria. The CRP levels were measured at least twice over the course of up to a year. Adherence to the diet was objectively assessed by measurement of plasma beta-carotene, which is abundant in dark green leafy vegetables, and subjectively by serial interviews. The change in beta-carotene was inversely correlated with change in CRP ( r = −0.68, P < .0001). Additionally, patients subjectively classified as adherent had higher beta-carotene ( P < .0001) and lower CRP ( P = .002) as compared with patients who were classified as nonadherent. These longitudinal findings suggest that adherence to the LIFE diet leads to increased beta-carotene and decreased CRP. Thus, this type of diet may reduce risk or severity of chronic diseases involving inflammation.

scholarly journals 045 Carotenoid Antioxidant Levels in Spinach

HortScience ◽  
1999 ◽  
Vol 34 (3) ◽  
pp. 448F-449
Author(s):  
J.A. Kirkpatrick ◽  
J.B. Murphy ◽  
T.E. Morelock
Keyword(s):  
Antioxidant Activities ◽  
Health Benefits ◽  
Beta Carotene ◽  
Leafy Vegetables ◽  
Critical Function ◽  
Breeding Lines ◽  
Green Leafy Vegetables ◽  
Spinach Plant ◽  
Significant Difference ◽  
Dark Green

Interest in the health benefits of vegetables prompted an investigation of the levels of carotenoids in commercial varieties and UA breeding lines of spinach. Plant carotenoids perform a critical function as antioxidants, providing protection against a variety of reactive oxygen species generated primarily during photosynthesis. When ingested by humans, these compounds maintain their antioxidant activities and are receiving considerable attention in relation to multiple health benefits, including cancer prevention. While the best-known and most-studied carotenoid is beta-carotene, other carotenoids are now receiving attention due to their higher antioxidant activity compared to beta-carotene. Most dark-green leafy vegetables, such as spinach and kale, are relatively high in carotenoids, especially lutein. In this study, significant differences in average content of both lutein and beta-carotene were found between genetic lines of spinach. Some lines exhibited considerable variation between plants, while others were highly uniform. There was a very high correlation (r2 = 0.96) between lutein content and betacarotene content. The significant difference between spinach lines suggests that improvement of general carotenoid antioxidants and lutein could be obtained through a breeding program.

scholarly journals Determinants and Suitability of Carotenoid Reflection Score as a Measure of Carotenoid Status

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 113 ◽  
Author(s):  
Elaine Rush ◽  
Isaac Amoah ◽  
Tung Diep ◽  
Shabnam Jalili-Moghaddam
Keyword(s):  
Body Size ◽  
Health Outcomes ◽  
Daily Intake ◽  
Leafy Vegetables ◽  
Carotenoid Concentration ◽  
Dairy Foods ◽  
Green Leafy Vegetables ◽  
Positive Correlations ◽  
Dark Green ◽  
Negative Health Outcomes

Carotenoids, orange-coloured pigments found in vegetables, fruit, eggs and dairy foods, act as antioxidants and vitamin A precursors in the human body. Skin carotenoid concentration is a biomarker of vegetable and fruit intake. The aim was to identify determinants of skin carotenoid concentration by measuring “Veggie Meter™” carotenoid reflection spectroscopy scores (CRS) from the fingertip of adults with a range of ages, ethnicity and body size. Frequencies of daily intake of vegetables and fruit and weekly intake of pumpkin and carrot, dark green leafy vegetables (DGLV), eggs (yolk), and dairy were determined from a self-completed food-frequency-questionnaire. A total of 571 (324 Women, 247 Men) adults, aged 16 to 85 years, completed measurements. The CRS ranged from 83 to 769, with a median of 327. Women and men did not score differently. For all participants there were negative correlations of CRS with weight (r = −0.312) and BMI (r = −0.338) and positive correlations with weekly intakes of DGLV (r = 0.242) and carrots and pumpkin (r = 0.202). Based on a review of health outcomes associated with plasma carotenoids, 82% of the participants in the current study are at moderate risk, or more, of negative health outcomes. Determinants of carotenoid status were body size, intake of DGLV, carrots and pumpkin, and ethnicity.

scholarly journals Dietary Diversity in Cambodian Garment Workers: The Role of Free Lunch Provision

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1010 ◽  
Author(s):  
Jan Makurat ◽  
Eleonore Kretz ◽  
Frank Wieringa ◽  
Chhoun Chamnan ◽  
Michael Krawinkel
Keyword(s):  
Vitamin A ◽  
Dietary Intake ◽  
Dietary Diversity ◽  
Controlled Trial ◽  
Leafy Vegetables ◽  
Food Groups ◽  
Green Leafy Vegetables ◽  
Garment Workers ◽  
Dark Green ◽  
Randomised Controlled

The objective of this paper is to compare food consumption by Cambodian garment workers with and without access to a free model lunch provision through a factory-based canteen. Data from an exploratory randomised controlled trial were analysed. In total, 223 female Cambodian garment workers were allocated to an intervention arm (six-month lunch provision) or a control arm. Dietary intake on workdays was assessed by qualitative 24-h recalls at baseline and twice at follow-ups during the period of lunch provision using the Food and Agricultural Organization (FAO) guideline on assessing women’s dietary diversity. In total, 158 participants provided complete data on the dietary intake over workdays at all interviews. Lunch provision resulted in a more frequent consumption of dark green leafy vegetables (DGLV), vitamin A-rich fruits, other fruits, and oils and fats during lunch breaks. In contrast, flesh meats, legumes, nuts and seeds, as well as sweets, were eaten at a lower frequency. Except for a higher consumption rate of vitamin A-rich fruits and a lower intake frequency of sweets, lunch provision had a less clear impact on total 24-h intake from different food groups and was not associated with a higher women’s dietary diversity score (WDDS). A more gap-oriented design of the lunch sets taking into account underutilised foods and the nutritional status of the workers is recommended.

scholarly journals Evaluation of Systemic Renin and Angiotensin II Levels in Normal Tension Glaucoma

2020 ◽  
Vol 9 (12) ◽  
pp. 3838
Author(s):  
Soo Ji Jeon ◽  
Hyung Bin Hwang ◽  
Na Young Lee
Keyword(s):  
Angiotensin Ii ◽  
Complete Blood Count ◽  
Low Density Lipoprotein ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Normal Tension Glaucoma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Reactive Protein ◽  
Hs Crp

The purpose of this study was to investigate the function of the renin–angiotensin–aldosterone system (RAAS) in normal tension glaucoma (NTG) patients by measuring the level of renin and angiotensin II (AngII) in the plasma. Twenty-four patients with NTG and 38 control subjects were included in this study. Renin and AngII were measured in the blood samples of all subjects by enzyme-linked immunosorbent assay (ELISA). No significant differences were found in the complete blood count, fasting glucose, low-density lipoprotein (LDL), and high-sensitivity C-reactive protein (hs-CRP) levels between the control and NTG groups. The systemic concentration and variability of the renin concentration in the blood was significantly higher in the NTG group (p = 0.005 and 0.005, respectively). According to multivariate logistic regression analysis, the variability of the renin concentration was associated with NTG (p = 0.006). In conclusion, the systemic concentration and variability of renin levels were elevated in NTG patients. An altered renin concentration could represent a difference in RAAS function in NTG patients.

scholarly journals Considerations for the design of nutrition-sensitive production programmes in rural South Africa

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
S. L. Hendriks ◽  
A. Viljoen ◽  
D. Marais ◽  
F. A. M. Wenhold ◽  
A. M. McIntyre ◽  
...  
Keyword(s):  
South Africa ◽  
At Risk ◽  
Food Insecurity ◽  
Crop Production ◽  
Dietary Diversity ◽  
Leafy Vegetables ◽  
Green Leafy Vegetables ◽  
Populations At Risk ◽  
Dark Green ◽  
Home Consumption

Abstract Background Very little has been researched about the efficacy, effectiveness, feasibility, sustainability and impact of food-based approaches on the diets and nutritional status of populations at risk of hunger and food insecurity. This study contributes knowledge about the impact of food-based approaches on the diets of populations at risk of hunger and food insecurity in four of the poorest rural communities in South Africa. The study investigated the consumption and production patterns of rural households (278 in summer and 280 in winter) in four sites in the poorest municipalities in South Africa. Methods A multistage stratified random sampling technique was applied to identify the communities and sample households for the quantitative survey and qualitative assessments. Qualitative and quantitative data were collected between 2013 and 2015 through focus group discussions (FGDs), key informant interviews and the two-round panel survey to cover both the summer and winter seasons at each site. Results Home gardening led to a significant positive increase in the consumption of white roots and tubers, dark green leafy vegetables, orange-coloured fruit and other fruit in the 24 h prior to the survey. Participation in a community garden led to significant increases in the consumption of dark green leafy vegetables and other vegetables. School gardening did not demonstrate any statistical relationships with the consumption of foods from the crop-related food groups. Crop production improved dietary diversity. Selling produce and irrigation showed a stronger improvement in dietary diversity. Seasonality affected the availability of fresh fruit and vegetables for home consumption in winter. Conclusions Producing beyond that solely for home consumption has greater benefits for dietary diversity and a consumption-smoothing effect during the post-harvest period. Politicians and the scientific community should recognise the role that household and small-scale crop production plays in supporting household consumption and the provision of essential micronutrients despite constraints and disincentives. Production and education programmes should focus on strengthening existing good consumption patterns and promoting the consumption of foods that can improve dietary diversity.

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