scholarly journals Observations on the Temperature of the Body in Health and Disease

BMJ ◽  
1871 ◽  
Vol 1 (524) ◽  
pp. 32-32 ◽  
Author(s):  
W. Squire
Keyword(s):  
The Body ◽  
Health And Disease

scholarly journals The thymus and the science of self

2021 ◽  
Author(s):  
Vincent Geenen
Keyword(s):  
T Cells ◽  
Adaptive Immune System ◽  
Lymphoid Organ ◽  
The Body ◽  
Effector Cells ◽  
Major Organ ◽  
Organ Specific ◽  
Health And Disease ◽  
Essential State ◽  
The 1960S

AbstractThe conventional perception asserts that immunology is the science of ‘discrimination’ between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body’s own antigens, collectively known as self until now. Only then attain these effectors the responsiveness to non-self. The acquisition of this essential state of tolerance to self occurs for T cells in the thymus, the last major organ of our body that revealed its intricate function in health and disease. The ‘thymus’ as an anatomical notion was first notably documented in Ancient Greece although our present understanding of the organ’s functions was only deciphered commencing in the 1960s. In the late 1980s, the thymus was identified as the site where clones of cells reactive to self, termed ‘forbidden’ thymocytes, are physically depleted as the result of a process now known as negative selection. The recognition of this mechanism further contributed to the belief that the central rationale of immunology as a science lies in the distinction between self and non-self. This review will discuss the evidence that the thymus serves as a unique lymphoid organ able to instruct T cells to recognize and be tolerant to harmless self before adopting the capacity to defend the body against potentially injurious non-self-antigens presented in the context of different challenges from infections to exposure to malignant cells. The emerging insight into the thymus’ cardinal functions now also provides an opportunity to exploit this knowledge to develop novel strategies that specifically prevent or even treat organ-specific autoimmune diseases.

Illustrations of the Influence of the Mind upon the Body in Health and Disease, with especial reference to the Imagination

1871 ◽  
Vol 16 (76) ◽  
pp. 538-563
Author(s):  
Daniel H. Tuke
Keyword(s):  
The Body ◽  
Especial Reference ◽  
Health And Disease ◽  
The Mind ◽  
Present Section

Under the present section it remains to consider the influence of the emotions in inducing hydrophobia, tetanus, and catalepsy.

scholarly journals Toward the unity of pathological and exertional fatigue: A predictive processing model

2021 ◽  
Author(s):  
A. Greenhouse-Tucknott ◽  
J. B. Butterworth ◽  
J. G. Wrightson ◽  
N. J. Smeeton ◽  
H. D. Critchley ◽  
...  
Keyword(s):  
Prediction Error ◽  
Conscious Experience ◽  
Physical Exertion ◽  
Generative Models ◽  
The Body ◽  
Predictive Processing ◽  
Research Fields ◽  
Common Foundation ◽  
Health And Disease ◽  
Sensory Evidence

AbstractFatigue is a common experience in both health and disease. Yet, pathological (i.e., prolonged or chronic) and transient (i.e., exertional) fatigue symptoms are traditionally considered distinct, compounding a separation between interested research fields within the study of fatigue. Within the clinical neurosciences, nascent frameworks position pathological fatigue as a product of inference derived through hierarchical predictive processing. The metacognitive theory of dyshomeostasis (Stephan et al., 2016) states that pathological fatigue emerges from the metacognitive mechanism in which the detection of persistent mismatches between prior interoceptive predictions and ascending sensory evidence (i.e., prediction error) signals low evidence for internal generative models, which undermine an agent’s feeling of mastery over the body and is thus experienced phenomenologically as fatigue. Although acute, transient subjective symptoms of exertional fatigue have also been associated with increasing interoceptive prediction error, the dynamic computations that underlie its development have not been clearly defined. Here, drawing on the metacognitive theory of dyshomeostasis, we extend this account to offer an explicit description of the development of fatigue during extended periods of (physical) exertion. Accordingly, it is proposed that a loss of certainty or confidence in control predictions in response to persistent detection of prediction error features as a common foundation for the conscious experience of both pathological and nonpathological fatigue.

scholarly journals Del origen de la dietética al surgimiento de la nutrición: Consideraciones sobre los aportes científicos en el área / From the Origin of Dietetics to the Emergence of Nutrition Considerations on Scientific Contributions in the Area

2012 ◽  
Vol 1 (2) ◽  
Author(s):  
Yurimay Quintero de Rivas ◽  
Gladys Bastardo de Castaneda ◽  
Coromoto Elena Angarita Rodriguez
Keyword(s):  
Scientific Knowledge ◽  
Historical Development ◽  
Scientific Revolution ◽  
Scientific Discipline ◽  
The Body ◽  
Nutrition Science ◽  
Health And Disease

ABSTRACTNutrition and dietetics throughout history have been viewed from two fundamental aspects: as a means to restore health and as a means to prevent the disease. Since its inception the appearance of dietetics, the search was based on maintaining the balance of health and disease. Later, with the rise of the scientific revolution, as is nutrition science who focuses on the study of the different processes through which the body uses nutrients ingested. In the historical development of scientific knowledge both concepts, provided the key tools for the study of this discipline. All these important contributions, provided the fundamental basis for the development of nutrition as a scientific discipline XXI century, currently devoted to the study of many problems associated with food and modern lifestyles. Nutrition therefore rests on the discipline of scientific knowledge, is the fundamental basis for the understanding of the causes of the problems and possible solutions to search for them.RESUMENLa nutrición y dietética, a lo largo de la historia, han sido vistas desde dos vertientes fundamentales: como un medio para restablecer la salud y como un instrumento para prevenir la enfermedad. Desde sus orígenes la aparición de la dietética, se basó en la búsqueda del mantenimiento del equilibrio de la salud y enfermedad. Posteriormente con el surgir de la revolución científica, es la nutrición como ciencia, quien se centra en el estudio de los diferentes procesos a través de los cuales, el organismo utiliza los nutrientes ingeridos. En el desarrollo histórico de ambos conceptos el conocimiento científico, proporcionó las herramientas claves para el estudio de esta disciplina. Todos esos importantes aportes, sirvieron de base fundamental, para el desarrollo de la nutrición como disciplina científica del siglo XXI, actualmente dedicada al estudio de innumerables problemas derivados de la alimentación y estilos de vida modernos. La nutrición por lo tanto, apoyada sobre la disciplina del conocimiento científico, es la base fundamental para la compresión de las causas de los problemas y la posible búsqueda de las soluciones a los mismos.

scholarly journals Sex Hormones, Growth Hormone, and the Cornea

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 224
Author(s):  
Tina B. McKay ◽  
Shrestha Priyadarsini ◽  
Dimitrios Karamichos
Keyword(s):  
Growth Hormone ◽  
Wound Healing ◽  
Sex Hormones ◽  
Human Growth ◽  
The Body ◽  
Dependent Manner ◽  
Insulin Growth Factor ◽  
Epithelial Regeneration ◽  
Health And Disease ◽  
Interest Differential

The growth and maintenance of nearly every tissue in the body is influenced by systemic hormones during embryonic development through puberty and into adulthood. Of the ~130 different hormones expressed in the human body, steroid hormones and peptide hormones are highly abundant in circulation and are known to regulate anabolic processes and wound healing in a tissue-dependent manner. Of interest, differential levels of sex hormones have been associated with ocular pathologies, including dry eye disease and keratoconus. In this review, we discuss key studies that have revealed a role for androgens and estrogens in the cornea with focus on ocular surface homeostasis, wound healing, and stromal thickness. We also review studies of human growth hormone and insulin growth factor-1 in influencing ocular growth and epithelial regeneration. While it is unclear if endogenous hormones contribute to differential corneal wound healing in common animal models, the abundance of evidence suggests that systemic hormone levels, as a function of age, should be considered as an experimental variable in studies of corneal health and disease.

scholarly journals Bioactive Phenolic Compounds from Indian Medicinal Plants for Pharmaceutical and Medical Aspects

2021 ◽  
Author(s):  
Bhanu Kumar ◽  
Ankita Misra ◽  
Sharad Srivastava
Keyword(s):  
Phenolic Compounds ◽  
Medicinal Plants ◽  
Modern Medicine ◽  
The Body ◽  
Human Welfare ◽  
Therapeutic Benefits ◽  
Plant Constituents ◽  
Health And Disease ◽  
Tools And Techniques ◽  
Indian Medicinal Plants

Ayurveda is an age old system of medicine which utilizes thousands of medicinal plants, rich in secondary metabolites for their therapeutic benefits and phenolic compounds are important one. Plant phenolic compounds are one of the major group of phytomolecules having tremendous therapeutic and nutraceutical potential. Indian medicinal plants like Emblica, Terminalia spp., Withania, Tinospora etc. are some of the potential source of bioactive phenolics and had been used from ages in various Ayurvedic formulations and were scientifically validated too. In this contribution, a brief account of some common Indian medicinal plants rich in bioactive phenolics are summarized along with their therapeutic action on human health and disease. The vast array of phenolics in these plants makes them a suitable candidate for modern medicine, nutraceutical supplements, immuno-modulatory formulations etc. With the advent of modern separation tools and techniques, it is now possible to identify, isolate and purify desired phytoconstituents from plant extracts. This further opens the avenues of utilizing medicinal plants or plant constituents/metabolites as super food for strengthening the body and maintaining the healthy work-life balance. The need of the hour is to identify therapeutically potential phenolics rich plants and development of herbal formulations for human welfare.

Pathogenesis as a problem of functional incompetence and imbalance in the population of T-lymphocytes

2021 ◽  
pp. 109-119
Author(s):  
Н.М. Геворкян ◽  
Н.В. Тишевская
Keyword(s):  
T Lymphocytes ◽  
Personalized Medicine ◽  
The Body ◽  
Lymphoid Cells ◽  
Human Diseases ◽  
Regulatory Role ◽  
Total Rna ◽  
Physiological Processes ◽  
Health And Disease

Цель обзора - анализ клеточной основы патогенеза различных заболеваний в свете регуляторной роли Т-лимфоцитов. Рассматривается роль поликлонального многообразия популяции Т-лимфоцитов, особых свойств этих клеток-представителей гомеостатической системы организма в физиологических процессах в норме и при патологии. Указаны перспективы терапевтического и профилактического воздействий, связанные с использованием суммарных РНК нормальных лимфоидных клеток аллогенной и ксеногенной природы. Указана также возможность создания с помощью лимфоцитарных суммарных РНК адекватных моделей заболеваний человека на пути к развитию персонифицированной медицины. This review provides an analysis of the cellular basis of the pathogenesis of various diseases in the light of the regulatory role of T-lymphocytes. The role of the polyclonal diversity of the population of T-lymphocytes, the special properties of these cells-representatives of the homeostatic system of the body, in physiological processes in health and disease is considered. Prospects for therapeutic and prophylactic effects associated with the use of total RNA of normal lymphoid cells of allogeneic and xenogenic origin are indicated. The possibility of creating, using lymphocytic total RNA, adequate models of human diseases for the development of personalized medicine is also indicated.

An essay on human and elements, multielement profiles, and depression

2010 ◽  
Vol 1 (4) ◽  
Author(s):  
Berislav Momčilović ◽  
Juraj Prejac ◽  
Sanja Brundić ◽  
Sandra Morović ◽  
Anatoly Skalny ◽  
...  
Keyword(s):  
Analytical Study ◽  
Profile Analysis ◽  
Essential Element ◽  
Analytical Techniques ◽  
The Body ◽  
Double Blind ◽  
Cross Sectional ◽  
Health And Disease ◽  
Metabolic Impairments ◽  
Matrix Sample

AbstractThe recent development of the analytical techniques offers the unprecedented possibility to study simultaneously concentration of dozens of elements in the same biological matrix sample of 0.5–1.0 g (multielement profiles). The first part of this essay entitled “Think globally… An outline of trace elements in health and disease” aims to introduce the reader to the fascinating field of elements, there importance to our nutrition, their essentiality, deficiency, toxicity and bioavailability to the body and their overall role in health and disease, including the genetic metabolic impairments. In the second part of the essay entitled “… and act locally. The multielement profile of depression” we aimed to show the potential of such a hair multielement profile analysis for the study of human depression in a randomized, double blind, prospective, observational, cross-sectional, clinical, epidemiological, and analytical study. The preliminary results of this ongoing study lead us to put forward the hypothesis that the metabolic origin of depression may be due to some “energostat” failure, probably located in the thalamus, and activated by several essential element deficiencies.

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