scholarly journals Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case–control study

BMJ Open ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. e025246 ◽  
Author(s):  
Leon Alexander Mclaren Berge ◽  
Bettina Kulle Andreassen ◽  
Jo Steinson Stenehjem ◽  
Inger Kristin Larsen ◽  
Kari Furu ◽  
...  
Keyword(s):  
Drug Use ◽  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Prescription Database ◽  
Melanoma Risk ◽  
Data Set ◽  
Melanoma Diagnosis ◽  
Control Study

IntroductionThe incidence of cutaneous melanoma (hereafter melanoma) has increased dramatically among fair-skinned populations worldwide. In Norway, melanoma is the most rapidly growing type of cancer, with a 47% increase among women and 57% among men in 2000–2016. Intermittent ultraviolet exposure early in life and phenotypic characteristics like a fair complexion, freckles and nevi are established risk factors, yet the aetiology of melanoma is multifactorial. Certain prescription drugs may have carcinogenic side effects on the risk of melanoma. Some cardiovascular, antidepressant and immunosuppressive drugs can influence certain biological processes that modulate photosensitivity and immunoregulation. We aim to study whether these drugs are related to melanoma risk.Methods and analysisA population-based matched case–control study will be conducted using nation-wide registry data. Cases will consist of all first primary, histologically verified melanoma cases diagnosed between 2007 and 2015 identified in the Cancer Registry of Norway (14 000 cases). Ten melanoma-free controls per case (on date of case melanoma diagnosis) will be matched based on sex and year of birth from the National Registry of Norway. For the period 2004—2015, and by using the unique personal identification numbers assigned to all Norwegian citizens, the case–control data set will be linked to the Norwegian Prescription Database for information on drugs dispensed prior to the melanoma diagnosis, and to the Medical Birth Registry of Norway for data regarding the number of child births. Conditional logistic regression will be used to estimate associations between drug use and melanoma risk, taking potential confounding factors into account.Ethics and disseminationThe project is approved by the Regional Committee for Medical Research Ethics in Norway and by the Norwegian Data Protection Authority. The study is funded by the Southeastern Norway Regional Health Authority. Results will be published in peer-reviewed journals and disseminated further through scientific conferences, news media and relevant patient interest groups.

scholarly journals Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: A case-control study

2008 ◽  
Vol 122 (9) ◽  
pp. 2077-2084 ◽  
Author(s):  
Chunying Li ◽  
Zhensheng Liu ◽  
Li E. Wang ◽  
Jeffrey E. Gershenwald ◽  
Jeffrey E. Lee ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
Vdr Gene ◽  
Control Study

Contribution of melanocortin-1 receptor gene variants to sporadic cutaneous melanoma risk in a population in central Italy: a case???control study

2006 ◽  
Vol 16 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Maria Concetta Fargnoli ◽  
Emma Altobelli ◽  
Gisela Keller ◽  
Sergio Chimenti ◽  
Heinz H??fler ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Receptor Gene ◽  
Central Italy ◽  
Case Control ◽  
Gene Variants ◽  
Melanoma Risk ◽  
Melanocortin 1 Receptor ◽  
Control Study

scholarly journals Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case–control study

2017 ◽  
Vol 117 (3) ◽  
pp. 432-438 ◽  
Author(s):  
Marcella Malavolti ◽  
Carlotta Malagoli ◽  
Catherine M. Crespi ◽  
Furio Brighenti ◽  
Claudia Agnoli ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Population Based ◽  
Glycaemic Index ◽  
Case Control ◽  
Melanoma Risk ◽  
Glycaemic Load ◽  
Increased Risk ◽  
Incident Cases ◽  
Control Study

AbstractGlycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case–control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2·38; 95 % CI 1·25, 4·52 for the highest v. the lowest quintile of GL score, Pfor trend 0·070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.

scholarly journals Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Marco Vinceti ◽  
Carlotta Malagoli ◽  
Laura Iacuzio ◽  
Catherine M. Crespi ◽  
Sabina Sieri ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Melanoma Risk ◽  
Percentage Composition ◽  
Control Study

Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community.Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids.Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type.Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.

scholarly journals Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study

2018 ◽  
Vol 178 (5) ◽  
pp. e372-e372 ◽  
Author(s):  
A.M. Laino ◽  
E.G. Berry ◽  
K. Jagirdar ◽  
K.J. Lee ◽  
D.L. Duffy ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
Pigmented Lesions ◽  
Australian Case ◽  
Control Study

Iris pigmented lesions as a marker of cutaneous melanoma risk: an Australian case-control study

2018 ◽  
Vol 178 (5) ◽  
pp. 1119-1127 ◽  
Author(s):  
A.M. Laino ◽  
E.G. Berry ◽  
K. Jagirdar ◽  
K.J. Lee ◽  
D.L. Duffy ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Case Control Study ◽  
Case Control ◽  
Melanoma Risk ◽  
Pigmented Lesions ◽  
Australian Case ◽  
Control Study

scholarly journals Ocular Comorbidities in Rosacea: A Case-Control Study Based on Seven Institutions

2021 ◽  
Vol 10 (13) ◽  
pp. 2897
Author(s):  
Yu Ri Woo ◽  
Minah Cho ◽  
Hyun Jeong Ju ◽  
Jung Min Bae ◽  
Sang Hyun Cho ◽  
...  
Keyword(s):  
Dry Eye ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Dry Eye Syndrome ◽  
Data Set ◽  
Ocular Symptoms ◽  
Inflammatory Dermatosis ◽  
Control Study ◽  
Surface Changes

Rosacea is a facial inflammatory dermatosis that is linked with various systemic illnesses. With regards to the eye, rosacea patients have been described to manifest ocular surface changes, such as blepharitis and conjunctivitis. However, studies that examine the association of rosacea with a wider array of ocular diseases are limited. Thus, our aim was to identify the range of ocular comorbidities in the Korean patient population and create a reference data set. A multi-institutional, case-control study was conducted, where 12,936 rosacea patients and an equal number of sex- and age-matched control subjects were extracted over a 12-year period. We were able to discover a notable association between rosacea and blepharitis (adjusted odds ratio (aOR) 3.44; 95% confidence interval, 2.71–4.36, p < 0.001), conjunctivitis (aOR 1.65; 95% CI, 1.50–1.82, p < 0.001), glaucoma (aOR 1.93; 95% CI, 1.70–2.20, p < 0.001), dry eye syndrome (aOR 1.89; 95% CI, 1.70–2.09, p < 0.001), and chalazion (aOR 3.26; 95% CI, 1.41–7.57, p = 0.006) from logistic regression analysis. Female subjects and individuals younger than 50 exclusively showed higher odds for chalazion. Our study suggests that ocular comorbidities (i.e., glaucoma, dry eye syndrome, and chalazion as well as blepharitis and conjunctivitis) are more prevalent among Koreans with rosacea. Clinicians should proactively check ocular symptoms in rosacea and employ joint care with an ophthalmologist in cases of need.

scholarly journals Diabetes mellitus, anti-secretory drugs and other risk factors for campylobacter gastro-enteritis in adults: a case-control study

1997 ◽  
Vol 119 (3) ◽  
pp. 307-311 ◽  
Author(s):  
K. R. NEAL ◽  
R. C. B. SLACK
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Postal Questionnaire ◽  
Foreign Travel ◽  
Drinking Milk ◽  
Campylobacter Infection ◽  
Control Study

The epidemiology of notified cases of campylobacter gastroenteritis in adults in Nottingham Health District was investigated using a case-control study with a postal questionnaire to ascertain data on risk factors. Over a 14-month period 531 cases (a 73% response rate of all laboratory confirmed cases) and 512 controls replied.Conditional logistic regression analysis was used to determine independent associations with infection. These included foreign travel (odds ratio (OR) 3·4; 95% confidence intervals (CI) 2·0–5·7), diabetes mellitus (OR 4·1, CI 1·1–17), medication with omeprazole (OR 3·5, CI 1·1–12) and H2 and H2 antagonists (OR 3·7, CI 1·3–15), contact with puppies (OR11·3, CI1·2–105), eating chicken (OR 1·4, CI 1·1–1·8) and drinking milk from bottles with tops damaged by a bird (OR 3·3, CI 1·0–11). Preparing main meals (OR 0·9, CI 0·8–1·0) and drinking delivered milk (OR 0·6, CI 0·4–0·9) were associated with a reduced risk of campylobacter infection.Foreign travel was reported in 25% of cases and another 15% had significant associations with other risk factors. The majority of cases, 60%, remained unexplained, indicating the need for further evolution of sporadic cases.

scholarly journals 717. Antibiotic treatment of Shiga toxin-producing Escherichia coli related gastroenteritis and the risk of hemolytic uremic syndrome: a population based matched case-control study in Japan

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S409-S410
Author(s):  
Shota Myojin ◽  
Kyongsun Pak ◽  
Mayumi Sako ◽  
Tohru Kobayashi ◽  
Takuri Takahashi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Shiga Toxin ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Population Based ◽  
Case Control ◽  
Age Group ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract Background The role of therapeutic intervention, particularly antibiotics, for Shiga toxin-producing Escherichia coli (STEC) related infection is controversial. Methods We performed a population based matched case-control study to assess the association between treatment (antibiotics, antidiarrheal agents and probiotics) for STEC related infections and HUS development. We identified all STEC HUS patients as cases and matched five non-HUS patients as controls using the data from the National Epidemiological Surveillance of Infectious Diseases (NESID) between January 1, 2017, and December 31, 2018. Further medical information was obtained by standardized questionnaires answered by physicians who registered each patient. We used multivariate conditional logistic regression model to evaluate the association between exposures (use of antibiotics, use of antidiarrheal agents, days between disease onset and fosfomycin administration [within two or three days]) and the development of HUS, by matched odds ratios (OR) and 95% confidence intervals (CI). Covariates we used were sex, age group, area code, presence of diarrhea and other factors. We also performed subgroup analyses using age (adults and children) as a stratification factor. Results 7,760 STEC related patients were registered in the NESID. We selected patients who had a record of HUS diagnosis (n=182) and matched controls without HUS (n=910). After collecting standardized paper-based questionnaires, we enrolled 90 HUS patients and 371 non-HUS patients for analysis. In the main analysis, matched OR of fosfomycin was 0.75(0.47-1.20) in all ages, 1.41(0.51-3.88) in adults and 0.58(0.34-1.01) in children. Matched OR of antidiarrheal agents was 2.07(1.07-4.03) in all ages, 1.84(0.32-10.53) in adults, 2.65(1.21-5.82) in children. Matched OR of probiotics was 0.86(0.46-1.61) in all ages, 0.76(0.21-2.71) in adults, 1.00(0.48-2.09) in children. There was no significant association between the timing of fosfomycin use in the first two or five days of illness and HUS development in any age group. Conclusion Our results suggest that fosfomycin might decrease the risk of HUS in children younger than 15 years of age with STEC confirmed bacterial gastroenteritis. Disclosures All Authors: No reported disclosures

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