scholarly journals Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study

BMJ Open ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. e035010
Author(s):  
Ernest O Asante ◽  
Yi-Qian Sun ◽  
Tom Ivar Lund Nilsen ◽  
Bjørn Olav Åsvold ◽  
Elin Pettersen Sørgjerd ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Behaviour ◽  
Leisure Time Physical Activity ◽  
Self Report ◽  
Incident Diabetes ◽  
Middle Aged ◽  
Increased Risk ◽  
Middle Aged Adults ◽  
Lying Down

ObjectiveWe aimed to examine relationship between hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults, and to assess if leisure-time physical activity and body mass index (BMI) modified this relationship.DesignA population-based prospective cohort study.SettingNord-Trøndelag, Norway.ParticipantsThe cohort included 17 058 diabetes-free adults, at an age of 20–55 years in 1995–1997, who were followed-up to 2006–2008.Primary outcome measuresIncident diabetes was defined by self-report of diabetes or non-fasting glucose levels greater than 11 mmol/L at the follow-up.MethodsMultivariable logistic regression models were used to obtain OR with 95% CI for risk of diabetes by the categories of hours lying down (≤7, 8 and ≥9 hours/day).Results362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the ORs associated with lying down ≥9 hours/day were 1.41 (95% CI 1.05 to 1.90) and 0.90 (95% CI 0.23 to 3.55), respectively, among the less active and highly active individuals (pinteraction=0.048). There was little evidence that the association differed by BMI status (pinteraction=0.62).ConclusionsProlonged hours lying down per day was associated with an increased risk of diabetes in young and middle-aged adults. The positive association appeared to be modified by physical activity but not by BMI.

Abstract P060: Plasma Osteocalcin And Incident Diabetes Mellitus: The Atherosclerosis Risk In Communities (ARIC) Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Jeffrey R Misialek ◽  
Elizabeth R Stremke ◽  
Elizabeth Selvin ◽  
Sanaz Sedaghat ◽  
James S Pankow ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cox Regression ◽  
Self Report ◽  
Incident Diabetes ◽  
Blood Levels ◽  
Total Plasma ◽  
Phone Calls ◽  
Increased Risk ◽  
Primary Model

Introduction: Diabetes is a major risk factor for cardiovascular disease. Osteocalcin is a vitamin K-dependent, bone-derived hormone that functions as an endocrine regulator of energy metabolism, male fertility, and cognition. Early studies of endocrine effects of osteocalcin have shown that genomic deletion of osteocalcin in mice resulted in a diabetic phenotype (i.e. glucose intolerance, and insulin resistance). However, results from clinical studies have shown mixed associations between blood levels of osteocalcin and risk of incident type 2 diabetes mellitus. Hypothesis: Lower values of plasma osteocalcin would be associated with an increased risk of diabetes. Methods: A total of 11,557 ARIC participants without diabetes at baseline were followed from ARIC visit 3 (1993-1995) through 2018. Diabetes cases were identified through self-report on annual and semi-annual follow-up phone calls. Plasma osteocalcin data was measured using an aptamer-based proteomic profiling platform (SomaLogic). We used Cox regression to evaluate the association of quintiles of plasma osteocalcin and incident diabetes. The primary model adjusted for age, sex, and race-center. Results: Participants were age 60 ± 5.6 years at visit 3, 56% identified as female, 21% identified as Black. There were 3,031 incident diabetes cases over a median follow-up of 17.9 years. Mean ± SD was 10.053 ± 0.775. When comparing the highest quintile of plasma osteocalcin (values 10.42 to 14.66) to the lowest quintile (values 9.03 to 9.52), there was no association with incident diabetes (HRs [95% CIs]: 0.92 [0.81, 1.02]). There was also no significant trend across the quintiles (p = 0.19). Results were similar when adjusting for additional potential confounders, and when limiting the follow-up time to 10 years. Conclusions: These data do not support the hypothesis that total plasma osteocalcin, as measured by Somalogic proteomic panel, is a biomarker associated with diabetes risk. It is possible that total plasma or serum osteocalcin and/or other isoforms of osteocalcin protein (i.e. gamma carboxylated or uncarboxylated osteocalcin) measured via other validated methodologies may be linked to diabetes.

Changes in Leisure-Time Physical Activity and Subsequent Sickness Absence Due to Any Cause, Musculoskeletal, and Mental Causes

2016 ◽  
Vol 13 (8) ◽  
pp. 867-873 ◽  
Author(s):  
Ansku Holstila ◽  
Ossi Rahkonen ◽  
Eero Lahelma ◽  
Jouni Lahti
Keyword(s):  
Physical Activity ◽  
Sickness Absence ◽  
Social Insurance ◽  
Leisure Time ◽  
Negative Binomial ◽  
Response Rate ◽  
Leisure Time Physical Activity ◽  
Activity Level ◽  
Middle Aged

Background:The association between changes in physical activity and sickness absence is poorly understood. The aim of this study was to examine the association between changes in leisure-time physical activity and long-term sickness absence due to any cause and musculoskeletal and mental causes.Methods:We measured physical activity at baseline in 2000–2002 (response rate 67%) and at follow-up in 2007 (response rate 83%) among middle-aged employees of the City of Helsinki, Finland. The survey data were linked to the Finnish Social Insurance Institute’s register data on sickness benefit periods > 9 days, including diagnoses (ICD-10; International Statistical Classification of Diseases and Related Health Problems, 10th revision) (mean follow-up 2.3 years). We used a negative binomial model to calculate rate ratios. The analyses included 4010 respondents (81% women).Results:Those who were persistently vigorously active and those whose physical activity level changed from low to moderate or vigorous, from moderate to vigorous, or from vigorous to moderate were at lower risk for sickness absence than were the persistently low-activity group. For sickness absence due to musculoskeletal causes, vigorous activity showed stronger associations, whereas mental causes showed no such associations.Conclusions:To reduce sickness absence due to both musculoskeletal and mental causes, middle-aged and aging employees should be encouraged to engage in physical activity.

scholarly journals Associations between dietary patterns, physical activity (leisure-time and occupational) and television viewing in middle-aged French adults

2011 ◽  
Vol 105 (6) ◽  
pp. 902-910 ◽  
Author(s):  
Hélène Charreire ◽  
Emmanuelle Kesse-Guyot ◽  
Sandrine Bertrais ◽  
Chantal Simon ◽  
Basile Chaix ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sedentary Behaviour ◽  
Dietary Patterns ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Smoking Status ◽  
Physical Activities ◽  
Middle Aged ◽  
Tv Viewing ◽  
Cross Sectional

Diet and physical activity are considered to be major components of a healthy lifestyle. However, few studies have examined in detail the relationships between specific types of physical activity, sedentary behaviour and diet in adults. The objective of the present study was to assess differential relationships between dietary patterns, leisure-time and occupational physical activities and time spent watching television (TV), as an indicator of sedentary behaviour, in middle-aged French subjects. We performed a cross-sectional analysis using data from 1359 participants in the SUpplémentation en VItamines et Minéraux AntioXydants study, who completed a detailed physical activity questionnaire and at least six 24 h dietary records. Sex-specific dietary patterns were derived using factor analysis; their relationships with leisure-time and occupational physical activities and TV viewing were assessed using ANCOVA, after adjustment for age, educational level and smoking status. Three dietary patterns were identified in each sex. After adjustment for potential confounders, leisure-time physical activity was positively associated with a ‘healthy’ food pattern in both men (P for trend < 0·01) and women (P for trend < 0·03) and negatively associated with an ‘alcohol/meat’ pattern in men (P for trend < 0·01). TV viewing was positively associated with a ‘convenience’ pattern in men and with a ‘alcohol-appetiser’ pattern in women. In conclusion, identification of relationships between dietary patterns, physical activity and sedentary behaviour can enable identification of different types of lifestyle and should help to target at-risk groups in nutrition prevention programmes.

Multimorbidity, mortality, and physical activity

2016 ◽  
Vol 12 (4) ◽  
pp. 272-280 ◽  
Author(s):  
Paul D Loprinzi ◽  
Ovuokerie Addoh ◽  
Chelsea Joyner
Keyword(s):  
Physical Activity ◽  
Mortality Risk ◽  
Physical Inactivity ◽  
Self Report ◽  
Minimal Effect ◽  
Increased Risk ◽  
All Cause Mortality ◽  
The Government ◽  
Physician Diagnosis

Objectives Multimorbidity and physical inactivity are individually associated with increased mortality risk, but the possibility for physical activity to moderate the multimorbidity–mortality relationship has yet to be investigated. Methods Data from the 1999–2006 NHANES were employed, with 16,091 participants constituting the analytic sample. Participants were followed through 2011, including a median follow-up of 99 months. Physical activity was assessed via self-report with multimorbidity assessed from physician diagnosis. Results After adjustment, for every 1 morbidity increase, participants had a 23% increased risk of all-cause mortality (HR = 1.23; 95% CI: 1.19–1.28; p < 0.001). Multimorbidity mostly remained associated with all-cause mortality across all levels of physical activity, with the exception of those achieving four times the dose of the government guidelines. Discussion With the exception of those who engaged in high levels of self-reported physical activity, physical activity had a minimal effect on the multimorbidity–mortality relationship.

Association between physical activity and risk of hospitalisation in bronchiectasis

2020 ◽  
Vol 55 (6) ◽  
pp. 1902138
Author(s):  
Victoria Alcaraz-Serrano ◽  
Elena Gimeno-Santos ◽  
Giulia Scioscia ◽  
Albert Gabarrús ◽  
Adria Navarro ◽  
...  
Keyword(s):  
Physical Activity ◽  
Hospital Admission ◽  
Sedentary Behaviour ◽  
Sedentary Time ◽  
Hospitalised Patients ◽  
Increased Risk ◽  
Severity Scores ◽  
Physical Activity Variable ◽  
Activity Variable

BackgroundPatients with bronchiectasis have a less active lifestyle than healthy peers, but the association with hospital admission has not been explored. The aim of this study was to investigate the association between 1) any physical activity variable; and 2) sedentary time, with hospitalisation due to exacerbation in adults with bronchiectasis.MethodsIn this prospective observational study, baseline lung function, quality of life, exercise tolerance, severity of bronchiectasis and physical activity were recorded. Physical activity was objectively assessed over a week using a SenseWear armband and the results were expressed in steps·day–1 and sedentary time. Number of hospitalisations due to a bronchiectasis exacerbation and time to first event were recorded after 1-year follow-up.ResultsSixty-four patients with bronchiectasis were analysed, of whom 15 (23%) were hospitalised during the follow-up. Hospitalised patients showed poor baseline clinical and severity outcomes, fewer steps walked per day and more sedentary behaviour than the non-hospitalised group. Patients who walked ≤6290 steps·day–1 or spent ≥7.8 h·day–1 in sedentary behaviour had an increased risk of hospital admission due to bronchiectasis exacerbation at 1-year follow-up. Specifically, ≥7.8 h·day–1 of sedentary behaviour was associated with a 5.9-fold higher risk of hospital admission in the following year.ConclusionsLow levels of physical activity and high sedentary time at baseline were associated with a higher risk of hospitalisation due to bronchiectasis exacerbation. If these findings are validated in future studies, it might be appropriate to include physical activity and sedentary behaviour as an item in severity scores.

scholarly journals Leisure-Time Physical Activity, Falls, and Fall Injuries in Middle-Aged Adults

2015 ◽  
Vol 49 (6) ◽  
pp. 888-901 ◽  
Author(s):  
Alberto J. Caban-Martinez ◽  
Theodore K. Courtney ◽  
Wen-Ruey Chang ◽  
David A. Lombardi ◽  
Yueng-Hsiang Huang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Middle Aged ◽  
Fall Injuries ◽  
Middle Aged Adults

Physical Activity Among Preadolescents Modifies the Long-Term Association Between Sedentary Time Spent Using Digital Media and the Increased Risk of Being Overweight

2021 ◽  
pp. 1-8
Author(s):  
Elina Engberg ◽  
Marja H. Leppänen ◽  
Catharina Sarkkola ◽  
Heli Viljakainen
Keyword(s):  
Physical Activity ◽  
Digital Media ◽  
Leisure Time ◽  
Media Use ◽  
Leisure Time Physical Activity ◽  
Normal Weight ◽  
Web Based ◽  
Increased Risk

Background: This study aimed to examine whether sedentary digital media use in preadolescence increases the risk of being overweight 3 years later, and whether this association differs based on preadolescents’ leisure-time physical activity (LTPA) levels. Methods: The authors conducted a 3-year follow-up study among 4661 participants with a mean (SD) age of 11 (1) years at baseline and 14 (1) years at follow-up. A web-based questionnaire assessed sedentary digital media use and LTPA. The authors categorized baseline LTPA duration into 3 levels: 0 to 5 (low), 6 to 8 (moderate), and ≥9 (high) hours per week. In addition, the authors categorized adolescents as normal weight or overweight/obese at follow-up. Results: Greater amounts of sedentary digital media use at baseline associated with an increased risk of being overweight 3 years later even after adjusting for confounders. This only held for preadolescents with low baseline LTPA (OR = 1.14; 95% confidence interval, 1.05–1.24), but not among those with moderate (OR = 1.02; 0.91–1.15) or high (OR = 0.96; 0.85–1.08) LTPA. Conclusions: Preadolescent LTPA modified the long-term association between sedentary digital media use and being overweight; specifically, 6 hours per week or more of LTPA mitigated the increased risk of being overweight associated with higher amounts of digital media use.

Abstract 10068: Cardiorespiratory Fitness Modifies the Association Between Leisure-Time Physical Activity and the Risk of Sudden Cardiac Death Among Middle-Aged Men

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Magnus J Hagnäs ◽  
Timo A Lakka ◽  
Sudhir Kurl ◽  
Timo H Mäkikallio ◽  
Kai Savonen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sudden Cardiac Death ◽  
Cardiorespiratory Fitness ◽  
Cardiac Death ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Population Sample ◽  
Middle Aged ◽  
Metabolic Equivalents ◽  
Increased Risk

Aim: We investigated whether cardiorespiratory fitness (CRF) modifies the association between leisure-time physical activity (LTPA) and the risk of sudden cardiac death (SCD) among middle-aged men. Methods: The participants were a population sample of 2656 Finnish men aged 42-60 years at baseline. The mean follow-up time was 21 years. LTPA was assessed with a questionnaire and was expressed in kilocalories per day (kcal/d). CRF was measured directly using respiratory gas analysis during maximal exercise test and was expressed in metabolic equivalents (METs). The participants were divided into following 4 groups using the lowest tertiles of CRF (7.9 METs) and LTPA (< 191 kcal/d) as cut-offs: high CRF and LTPA, high CRF and low LTPA, low CRF and high LTPA and low CRF and LTPA. The risk of SCD was analysed using Cox regression models adjusted for age, smoking, alcohol consumption, body mass index, systolic blood pressure, low density lipoprotein cholesterol, C-reactive protein, prevalent type 2 diabetes and prevalent coronary heart disease. Results: Men with low CRF and low LTPA had a 1.8 (95% confidence interval 1.3-2.6, p=0.001) times higher risk of SCD than men with high CRF and high LTPA. The amount of LTPA did not significantly alter the risk of SCD among men with high CRF. Figure 1 shows the cumulative survival from SCD in the 4 groups. Conclusions: Our study shows that men with low CRF and low LTPA have increased risk of SCD. This finding emphasizes increasing LTPA to prevent SCD among men and particularly among those with low CRF.

Sign in / Sign up

Export Citation Format

Share Document