scholarly journals Impact of preterm birth on brain development and long-term outcome: protocol for a cohort study in Scotland

BMJ Open ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. e035854 ◽  
Author(s):  
James P Boardman ◽  
Jill Hall ◽  
Michael J Thrippleton ◽  
Rebecca M Reynolds ◽  
Debby Bogaert ◽  
...  
Keyword(s):  
Cohort Study ◽  
Preterm Birth ◽  
Brain Development ◽  
Research Ethics ◽  
Brain Mri ◽  
Long Term Outcome ◽  
Open Access Journals ◽  
University Of Edinburgh ◽  
The University ◽  
Prospective Longitudinal

IntroductionPreterm birth is closely associated with altered brain development and is a leading cause of neurodevelopmental, cognitive and behavioural impairments across the life course. We aimed to investigate neuroanatomic variation and adverse outcomes associated with preterm birth by studying a cohort of preterm infants and controls born at term using brain MRI linked to biosamples and clinical, environmental and neuropsychological data.Methods and analysisTheirworld Edinburgh Birth Cohort is a prospective longitudinal cohort study at the University of Edinburgh. We plan to recruit 300 infants born at <33 weeks of gestational age (GA) and 100 healthy control infants born after 37 weeks of GA. Multiple domains are assessed: maternal and infant clinical and demographic information; placental histology; immunoregulatory and trophic proteins in umbilical cord and neonatal blood; brain macrostructure and microstructure from structural and diffusion MRI (dMRI); DNA methylation; hypothalamic–pituitary–adrenal axis activity; social cognition, attention and processing speed from eye tracking during infancy and childhood; neurodevelopment; gut and respiratory microbiota; susceptibility to viral infections; and participant experience. Main analyses include creation of novel methods for extracting information from neonatal structural and dMRI, regression analyses of predictors of brain maldevelopment and neurocognitive outcome associated with preterm birth, and determination of the quantitative predictive performance of MRI and other early life factors for childhood outcome.Ethics and disseminationEthical approval has been obtained from the National Research Ethics Service (NRES), South East Scotland Research Ethics Committee (NRES numbers 11/55/0061 and 13/SS/0143 (phase I) and 16/SS/0154 (phase II)), and NHS Lothian Research and Development (2016/0255). Results are disseminated through open access journals, scientific meetings, social media, newsletters anda study website (www.tebc.ed.ac.uk), and we engage with the University of Edinburgh public relations and media office to ensure maximum publicity and benefit.

scholarly journals Long-term Outcome After Survival of a Cardiac Arrest: A Prospective Longitudinal Cohort Study

2017 ◽  
Vol 31 (6) ◽  
pp. 530-539 ◽  
Author(s):  
Véronique R. M. Moulaert ◽  
Caroline M. van Heugten ◽  
Ton P. M. Gorgels ◽  
Derick T. Wade ◽  
Jeanine A. Verbunt
Keyword(s):  
Quality Of Life ◽  
Cardiac Arrest ◽  
Cohort Study ◽  
Anxiety And Depression ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Prospective Longitudinal ◽  
Prospective Longitudinal Cohort

Background. A cardiac arrest can lead to hypoxic brain injury, which can affect all levels of functioning. Objective. To investigate 1-year outcome and the pattern of recovery after surviving a cardiac arrest. Methods. This was a multicenter, prospective longitudinal cohort study with 1 year of follow-up (measurements 2 weeks, 3 months, 1 year). On function level, physical/cardiac function (New York Heart Association Classification), cognition (Cognitive Log [Cog-log], Cognitive Failures Questionnaire), emotional functioning (Hospital Anxiety and Depression Scale, Impact of Event Scale), and fatigue (Fatigue Severity Scale) were assessed. In addition, level of activities (Frenchay Activities Index, FAI), participation (Community Integration Questionnaire [CIQ] and return to work), and quality of life (EuroQol 5D, EuroQol Visual Analogue Scale, SF-36, Quality of Life after Brain Injury) were measured. Results. In this cohort, 141 cardiac arrest survivors were included. At 1 year, 14 (13%) survivors scored below cutoff on the Cog-log. Both anxiety and depression were present in 16 (15%) survivors, 29 (28%) experienced posttraumatic stress symptoms and 55 (52%), severe fatigue. Scores on the FAI and the CIQ were, on average, respectively 96% and 92% of the prearrest scores. Of those previously working, 41 (72%) had returned to work. Most recovery of cognitive function and quality of life occurred within the first 3 months, with further improvement on some domains of quality of life up to 12 months. Conclusions. Overall, long-term outcome in terms of activities, participation, and quality of life after cardiac arrest is reassuring. Nevertheless, fatigue is common; problems with cognition and emotions occur; and return to work can be at risk.

scholarly journals Impact of moderate and late preterm birth on neurodevelopment, brain development and respiratory health at school age: protocol for a longitudinal cohort study (LaPrem study)

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e044491
Author(s):  
Jeanie Cheong ◽  
Kate Lillian Iona Cameron ◽  
Deanne Thompson ◽  
Peter J Anderson ◽  
Sarath Ranganathan ◽  
...  
Keyword(s):  
Cohort Study ◽  
Brain Development ◽  
Respiratory Health ◽  
Brain Mri ◽  
Late Preterm ◽  
Longitudinal Cohort Study ◽  
School Age ◽  
Neurodevelopmental Outcomes ◽  
Longitudinal Cohort ◽  
Increased Risk

IntroductionChildren born moderate to late preterm (MLP, 32–36 weeks’ gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years.Methods and analysisThe ”LaPrem” (Late Preterm MRI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women’s Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression.Ethics and disseminationThis study was approved by the human research ethics committee at the Royal Children’s Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media.

scholarly journals A Multidisciplinary Prematurity Research Cohort Study

2021 ◽  
Author(s):  
Molly J Stout ◽  
Jessica Chubiz ◽  
Nandini Raghuraman ◽  
Peinan Zhao ◽  
Methodius G Tuuli ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cohort Study ◽  
Preterm Birth ◽  
Magnetic Resonance ◽  
Circadian Rhythms ◽  
Live Birth ◽  
Adverse Outcomes ◽  
Resonance Imaging ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Background Worldwide, 10% of babies are born preterm, defined as a live birth before 37 weeks of gestation. Preterm birth is the leading cause of neonatal death, and survivors face lifelong risks of adverse outcomes. New approaches with large sample sizes are needed to identify strategies to predict and prevent preterm birth. The primary aims of the Washington University Prematurity Research Cohort Study were to conduct three prospective projects addressing possible causes of preterm birth and provide data and samples for future research. Study Design Pregnant patients were recruited into the cohort between January 2017 and January 2020. Consenting patients were enrolled into the study before 20 weeks' gestation and followed through delivery. Participants completed demographic and lifestyle surveys; provided maternal blood, placenta samples, and cord blood; and participated in up to three projects focused on underlying physiology of preterm birth: cervical imaging (Project 1), circadian rhythms (Project 2), and uterine magnetic resonance imaging and electromyometrial imaging (Project 3). Results A total of 1260 participants were enrolled and delivered during the study period. Of the participants, 706 (56%) were Black/African American, 494 (39%) were nulliparous, and 185 (15%) had a previous preterm birth. Of the 1260 participants, 1220 (97%) delivered a live infant. Of the 1220 with a live birth, 163 (14.1%) had preterm birth, of which 74 (6.1%) were spontaneous preterm birth. Of the 1220 participants with a live birth, 841 participated in cervical imaging, 1047 contributed data and/or samples on circadian rhythms, and 39 underwent uterine magnetic resonance imaging. Of the 39, 25 underwent electromyometrial imaging. Conclusion We demonstrate feasibility of recruiting and retaining a diverse cohort in a complex prospective, longitudinal study throughout pregnancy. The extensive clinical, imaging, survey, and biologic data obtained will be used to explore cervical, uterine, and endocrine physiology of preterm birth and can be used to develop novel approaches to predict and prevent preterm birth.

scholarly journals UNICORNS: Uveitis in childhood prospective national cohort study protocol

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1196
Author(s):  
Salomey Kellett ◽  
Jugnoo S Rahi ◽  
Andrew D. Dick ◽  
Rachel Knowles ◽  
Valerija Tadić ◽  
...  
Keyword(s):  
Cohort Study ◽  
Structural Damage ◽  
Patient Reported Outcome Measures ◽  
Population Based ◽  
Term Outcome ◽  
Prospective Longitudinal Study ◽  
Long Term Outcome ◽  
Patient Reported ◽  
Prospective Longitudinal ◽  
The Impact

Background: Childhood uveitis is a rare inflammatory eye disease which is typically chronic, relapsing-remitting in nature, with an uncertain aetiology (idiopathic). Visual loss occurs due to structural damage caused by uncontrolled inflammation. Understanding of the determinants of long term outcome is lacking, including the predictors of therapeutic response or how to define disease control. Aims: To describe disease natural history and outcomes amongst a nationally representative group of children with non-infectious uveitis, describe the impact of disease course on quality of life for both child and family, and identify determinants of adverse visual, structural and developmental outcomes. Methods: UNICORNS is a prospective longitudinal multicentre cohort study of children newly diagnosed with uveitis about whom a core minimum clinical dataset will be collected systematically. Participants and their families will also complete patient-reported outcome measures annually from recruitment. The association of patient (child- and treatment- dependent) characteristics with outcome will be investigated using logistic and ordinal regression models which incorporate adjustment for within-child correspondence between eyes for those with bilateral disease and repeated outcomes measurement.  Discussion: Through this population based, prospective longitudinal study of childhood uveitis, we will describe the characteristics of childhood onset disease. Early (1-2 years following diagnosis) outcomes will be described in the first instance, and through the creation of a national inception cohort, longer term studies will be enabled of outcome for affected children and families.

scholarly journals Effects of in-hospital breast feeding on brain function development in preterm infants in China: study protocol for a prospective longitudinal cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e038879
Author(s):  
Rui Yang ◽  
Yao Zhang ◽  
Hua Wang ◽  
Xinfen Xu
Keyword(s):  
Cohort Study ◽  
Brain Development ◽  
Preterm Infants ◽  
Breast Feeding ◽  
Longitudinal Cohort Study ◽  
School Of Medicine ◽  
Prospective Longitudinal ◽  
Hospital School ◽  
Prospective Longitudinal Cohort

IntroductionDue to immature brain development, preterm infants are more likely to develop neurological developmental defects compared with full-term infants. Most preterm infants without neurodevelopmental damage can eventually reach the same scholastic level as their same-age peers; however, some show persistent impairment. Breast feeding (BF), which is an important public health measure, is of great significance for preterm infants. Various active substances in breast milk promote the development of the brain and central nervous system in premature infants. We present a protocol for a prospective longitudinal cohort study to explore the effect of in-hospital BF on brain development in preterm infants and possible influencing factors.Methods and analysisThis study will enrol 247 Chinese preterm infants (gestational age: 30–34 weeks) delivered in Women’s Hospital School of Medicine, Zhejiang University, and transferred to the neonatal intensive care unit. Demographic, clinical and in-hospital BF data will be collected through electronic medical records. Moreover, follow-up data will be obtained by telephone, interview or online. Measurements will be obtained using the Breastfeeding Self-Efficacy Scale-Short Form, neuroimaging with functional near-infrared spectroscopy, extrauterine growth restriction and the Ages and Stages Questionnaire. Follow-up will be performed at 3, 6 and 12 months after birth.Ethics and disseminationThis study has been approved by the Women’s Hospital School of Medicine Zhejiang University Medical Ethics Committee (2019-058). The study results are expected to be published in peer-reviewed journals and reported at relevant national and international conferences.Trial registration numberChiCTR1900027648; Pre-results.

scholarly journals Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e036560
Author(s):  
Shannon E Majowicz ◽  
Dimitra Panagiotoglou ◽  
Marsha Taylor ◽  
Mahmood R Gohari ◽  
Gilaad G Kaplan ◽  
...  
Keyword(s):  
British Columbia ◽  
Cohort Study ◽  
Research Ethics ◽  
Population Based ◽  
Physician Visits ◽  
Health Burden ◽  
Foodborne Infection ◽  
The University ◽  
Foodborne Infections

IntroductionOver one in eight Canadians is affected by a foodborne infection annually; however, the long-term consequences, including the risks and costs of sequelae, are unclear. We aim to estimate the health burden and direct costs of 14 infections commonly transmitted by food, considering the acute illness and subsequent sequelae and mortality, for the population of British Columbia, Canada (~4.7 million).Methods and analysisWe will conduct a population-based retrospective cohort study of the British Columbia provincial population, over a 10-year study period (1 January 2005 to 31 December 2014). Exposure is defined as a provincially reported illness caused by Clostridium botulinum, Campylobacter, Cryptosporidium, Cyclospora, Giardia, hepatitis A virus, Listeria, non-typhoidal Salmonella spp, Salmonella Typhi, Salmonella Paratyphi, Shiga toxin-producing Escherichia coli, Shigella, Vibrio parahaemolyticus or Yersinia (excluding pestis). We will link individual-level longitudinal data from eight province-wide administrative health and reportable disease databases that include physician visits, hospitalisations and day surgeries, deaths, stillbirths, prescription medications (except those to treat HIV) and reportable foodborne diseases. Using these linked databases, we will investigate the likelihood of various sequelae and death. Hazard models will be used to estimate the risk of outcomes and their association with the type of foodborne infection. Epidemiological analyses will be conducted to determine the progression of illness and the fraction of sequelae attributable to specific foodborne infections. Economic analyses will assess the consequent direct healthcare costs.Ethics and disseminationThis study has been approved by a University of Waterloo Research Ethics Committee (no 30645), the University of British Columbia Behavioral Research Ethics Board (no H16-00021) and McGill University’s Institutional Review Board (no A03-M12-19A). Results will be disseminated via presentations to academics, public health practitioners and knowledge users, and publication in peer-reviewed journals. Where such publications are not open access, manuscripts will also be available via the University of Waterloo’s Institutional Repository (https://uwspace.uwaterloo.ca).

John Robertson Henderson (1863–1925): Scotland, India and anomuran taxonomy

2020 ◽  
Vol 47 (1) ◽  
pp. 63-75
Author(s):  
P. G. Moore
Keyword(s):  
Natural History ◽  
Scientific Research ◽  
Christian College ◽  
Apparent Absence ◽  
University Of Edinburgh ◽  
Marine Station ◽  
The University ◽  
Crustacean Taxonomy

John Robertson Henderson was born in Scotland and educated at the University of Edinburgh, where he qualified as a doctor. His interest in marine natural history was fostered at the Scottish Marine Station for Scientific Research at Granton (near Edinburgh) where his focus on anomuran crustaceans emerged, to the extent that he was eventually invited to compile the anomuran volume of the Challenger expedition reports. He left Scotland for India in autumn 1885 to take up the Chair of Zoology at Madras Christian College, shortly after its establishment. He continued working on crustacean taxonomy, producing substantial contributions to the field; returning to Scotland in retirement in 1919. The apparent absence of communication with Alfred William Alcock, a surgeon-naturalist with overlapping interests in India, is highlighted but not resolved.

The training of a polar scientist: Patrick Geddes and the student career of William Speirs Bruce

2002 ◽  
Vol 29 (3) ◽  
pp. 287-301 ◽  
Author(s):  
G. N. SWINNEY
Keyword(s):  
Future Career ◽  
New Information ◽  
University Of Edinburgh ◽  
The University

ABSTRACT: The university career of the polar scientist William Speirs Bruce (1867–is examined in relation to new information, discovered amongst the Bruce papers in the University of Edinburgh, which elucidates the role played by Patrick Geddes in shaping Bruce's future career. Previous accounts of Bruce's university years, based mainly on the biography by Rudmose Brown (1923), are shown to be in error in several details.

Adam Ferguson and the Idea of Civil Society

2019 ◽  
Author(s):  
Craig Smith
Keyword(s):  
Civil Society ◽  
Moral Philosophy ◽  
David Hume ◽  
Adam Smith ◽  
Scottish Enlightenment ◽  
Commercial Society ◽  
University Of Edinburgh ◽  
English Speaking ◽  
English Speaking World ◽  
The University

Adam Ferguson was a Professor of Moral Philosophy at the University of Edinburgh and a leading member of the Scottish Enlightenment. A friend of David Hume and Adam Smith, Ferguson was among the leading exponents of the Scottish Enlightenment’s attempts to develop a science of man and was among the first in the English speaking world to make use of the terms civilization, civil society, and political science. This book challenges many of the prevailing assumptions about Ferguson’s thinking. It explores how Ferguson sought to create a methodology for moral science that combined empirically based social theory with normative moralising with a view to supporting the virtuous education of the British elite. The Ferguson that emerges is far from the stereotyped image of a nostalgic republican sceptical about modernity, and instead is one much closer to the mainstream Scottish Enlightenment’s defence of eighteenth century British commercial society.

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