Anxiety and depression prevalence in digestive cancers: a systematic review and meta-analysis

2021 ◽  
pp. bmjspcare-2021-003275
Author(s):  
Mohammad Zamani ◽  
Shaghayegh Alizadeh-Tabari
Keyword(s):  
Oesophageal Cancer ◽  
Meta Analysis ◽  
Anxiety Symptoms ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Hepatic Cancer ◽  
Early Management ◽  
Pooled Prevalence ◽  
Digestive Cancers ◽  
Gi Cancers

BackgroundCancers of the digestive system can be associated with disturbing and disabling symptoms, which can contribute to a negative psychological pressure on patients.AimTo investigate the reported prevalence of symptoms of anxiety and depression in patients with major digestive cancers, including oesophageal, gastric, colorectal, pancreatic or hepatic cancers.MethodsWe searched Embase, PubMed, Scopus and Web of Science for articles published from inception to December 2020. We included studies reporting the prevalence of anxiety or depression symptoms using validated questionnaires in adult patients (≥18 years).ResultsIn total, 51 eligible papers were finally included. Overall, the pooled prevalence of anxiety symptoms was 20.4% (95% CI 17% to 23.8%). The estimate in patients with gastrointestinal (GI) cancers was 19.1% and in patients with hepatic cancer was 29.1%. Among GI cancers, the highest pooled prevalence of anxiety symptoms related to oesophageal cancer (20.6%), while the lowest pooled prevalence pertained to gastric cancer (18.7%). Regarding depression symptoms, the overall pooled prevalence was 30.2% (95% CI 24.3% to 36.1%). The estimate in patients with GI cancers was 31% and in patients with hepatic cancer was 21.5%. Among GI cancers, the highest pooled prevalence of depression symptoms related to oesophageal cancer (45.2%), while the lowest pooled prevalence pertained to colorectal cancer (22.9%).ConclusionA considerable prevalence of anxiety and depression symptoms is observed in patients with digestive cancers. Screening and preventive measures with early management of these psychological problems by clinicians could possibly improve outcomes for these patients.PROSPERO registration numberCRD42020210079.

scholarly journals Effectiveness of school-based interventions to prevent anxiety & depression in young people

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
D. Caldwell
Keyword(s):  
Young People ◽  
Evidence Synthesis ◽  
Meta Analysis ◽  
Anxiety Symptoms ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Considerable Uncertainty ◽  
School Based ◽  
School Based Interventions ◽  
Simultaneous Comparison

Abstract Background The prevalence of anxiety and depression is increasing among children and young people (CYP). Evidence suggests 1/2 of mental illness is apparent by age 14 and 3/4 by early adulthood. Globally, there is growing interest in prevention of anxiety and depression in CYP. Methods We report the findings from a systematic review and network meta-analysis (NMA) of school-based interventions to prevent anxiety and depression in CYP. NMA enables the simultaneous comparison of multiple interventions in a single evidence synthesis, retaining the identity of each intervention analysed and ranking of interventions according to the probability that each is best for a given outcome. Bayesian analyses were conducted in OpenBUGS, & random effects NMA were conducted for the primary outcomes of post-intervention self-report anxiety and depression. Results NMA were conducted for universal and targeted populations, in primary, secondary & tertiary educational settings. In universal primary settings, there is no evidence that any intervention reduced depression or anxiety. In universal secondary settings, CBT & mindfulness-based interventions suggest a reduction in anxiety symptoms relative to usual curriculum but was not observed for depression symptoms. In targeted secondary settings, exercise appears effective for reducing anxiety symptoms relative to no intervention. For prevention of depression symptoms, CBT appears effective. In targeted primary settings, there is no evidence that any intervention is effective. Few tertiary institution-based interventions met our inclusion criteria. Conclusions standard meta-analyses require lumping over interventions such that intervention specific effects may be masked (e.g. psychological intervention vs control). This NMA has identified the specific interventions which may prevent anxiety and depression in CYP. However, we observed considerable uncertainty and no intervention appears effective across every population and setting. Key messages Network meta-analysis enables the simultaneous comparison of multiple interventions in a single evidence synthesis, retaining the distinct identity of each intervention analysed. We observed considerable uncertainty for effectiveness of school-based interventions to prevent anxiety and depression. No single intervention appears effective across every population and setting.

Anxiety and depression in patients hospitalized in cardiology

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
K Mzoughi ◽  
I Zairi ◽  
A Saadaoui ◽  
I Ben Mrad ◽  
S Kraiem
Keyword(s):  
Hospital Stay ◽  
Depressive Disorders ◽  
Length Of Hospital Stay ◽  
Anxiety Symptoms ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Active Smoking ◽  
Cross Sectional ◽  
Early Management ◽  
Coronary Syndrome

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Anxio-depressive disorders represent one of the psychiatric manifestations most frequently observed in hospitalized patients. Different factors can be involved in the onset or worsening of these disorders. Purpose The aim of our study was to evaluate the prevalence of of anxiety and depression in hospitalized cardiology patients and to determine their predictors. Methods This was a cross-sectional and descriptive study with a prospective data collection that included 150 patients hospitalized in the cardiology department of Habib Thameur hospital between November and December 2016. Anxiety and depression were assessed using the Hospital Anxiety Depression questionnaire validated in Arabic. Results Patients mean age was 60 ± 11.2 years with a gender ratio of 2.7. Seventy-nine percent of the patients had a school education, 85.3% were married and 46% were active workers. Cardiovascular risk factors were dominated by arterial hypertension found in 56.7% of patients, followed by diabetes in 55.3%, dyslipidemia in 54.7% and active smoking in 43.3%. The most frequent reason for hospitalization was acute coronary syndrome, which was found in 52.7% of cases. The mean length of hospital stay was 13.7 ± 9.3 days. The prevalence of anxiety symptoms and depression symptoms was 55.3% and 40%, respectively. In multivariate analysis, age over 65 and active smoking were significantly associated with anxiety symptoms (OR = 0.345, 95% CI 0.150-0.790; p = 0.012 and OR = 0.44, 95% CI, respectively 0.194-0.90; p = 0.045). Independent factors significantly associated with depression symptoms in hospitalized cardiology patients were age greater than 65 years and a hospital stay of more than 7 days (OR = 0.171, respectively, 95% CI 0.067-0.438; p = 0.0001 and OR = 0.462, 95% CI 0.08-0.466; p = 0.001). Conclusion Given the high prevalence of anxiety and depression in patients hospitalized in cardiology, the systematic identification of the factors associated with these disorders would facilitate screening and ensure their early management.

scholarly journals A Systematic Review and Meta-Analysis on Mental Illness Symptoms in Spain in the COVID-19 Crisis

2021 ◽  
Author(s):  
Richard Z. Chen ◽  
Stephen X. Zhang ◽  
Wen Xu ◽  
Allen Yin ◽  
Rebecca Kechen Dong ◽  
...  
Keyword(s):  
Mental Illness ◽  
General Population ◽  
Adult Students ◽  
Meta Analysis ◽  
Total Sample ◽  
Future Research ◽  
Depression Symptoms ◽  
Prevalence Rates ◽  
Pooled Prevalence ◽  
Insomnia Symptoms

AbstractObjectiveThis paper systematically reviews and assesses the prevalence of anxiety, depression, and insomnia symptoms in the general population, frontline healthcare workers (HCWs), and adult students in Spain during the COVID-19 crisis.Data sourcesArticles in PubMed, Embase, Web of Science, PsycINFO, and medRxiv from March 2020 to February 6, 2021.ResultsThe pooled prevalence of anxiety symptoms in 23 studies comprising a total sample of 85,560 was 20% (95% CI: 15% - 25%, I2 = 99.9%), that of depression symptoms in 23 articles with a total sample comprising of 86,469 individuals was 23% (95% CI: 18% - 28%, I2 = 99.8%), and that of insomnia symptoms in 4 articles with a total sample of 915 were 52% (95% CI: 42-64%, I2 = 88.9%). The overall prevalence of mental illness symptoms in frontline HCWs, general population, and students in Spain are 42%, 19%, and 50%, respectively.DiscussionThe accumulative evidence from the meta-analysis reveals that adults in Spain suffered higher prevalence rates of mental illness symptoms during the COVID-19 crisis with a significantly higher rate relative to other countries such as China. Our synthesis reveals high heterogeneity, varying prevalence rates and a relative lack of studies in frontline and general HCWs in Spain, calling future research and interventions to pay attention to those gaps to help inform evidence-based mental health policymaking and practice in Spain during the continuing COVID-19 crisis. The high prevalence rates call for preventative and prioritization measures of the mental illness symptoms during the Covid-19 pandemic.

scholarly journals Social anxiety in a multiple sclerosis clinic population

2009 ◽  
Vol 15 (3) ◽  
pp. 393-398 ◽  
Author(s):  
K Poder ◽  
K Ghatavi ◽  
JD Fisk ◽  
TL Campbell ◽  
S Kisely ◽  
...  
Keyword(s):  
Social Anxiety ◽  
Depression Scale ◽  
Research Unit ◽  
Anxiety Symptoms ◽  
Self Report ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Neurological Disability ◽  
General Anxiety ◽  
Neurologic Disability

Background Little is known about social anxiety in MS. Objective We estimated the prevalence of social anxiety symptoms and their association with demographic and clinical features in a clinic-attending sample of patients with MS. Methods Patients attending the Dalhousie MS Research Unit for regularly scheduled visits completed the Social Phobia Inventory (SPIN), the Hospital Anxiety and Depression Scale (HADS), and the Health Utilities Index (HUI). Neurological disability was determined by ratings on the Expanded Disability Status Scale (EDSS). Results A total of 251 patients completed self-report scales of anxiety and depression symptoms. In all, 245 (98%) provided sufficient data for analysis. In all, 30.6% ( n = 75) had clinically significant social anxiety symptoms as defined by a SPIN threshold score of 19. Half of those with social anxiety had general anxiety (HADSA ≥ 11) and a quarter had depression (HADSD ≥ 11). Severity of social anxiety symptoms was associated with reduced health-related quality of life and not related to neurological disability. Conclusions Social anxiety symptoms are common in persons with MS, contribute to overall morbidity, but are unrelated to the overall severity of neurologic disability. Greater awareness and routine systematic inquiry of social anxiety symptoms is an important component of comprehensive care for persons with MS.

Psychological distress in adults with congenital heart disease: focus beyond depression

2019 ◽  
Vol 29 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Lacey P. Gleason ◽  
Lisa X. Deng ◽  
Abigail M. Khan ◽  
David Drajpuch ◽  
Stephanie Fuller ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Depression Scale ◽  
Anxiety Symptoms ◽  
Satisfaction With Life Scale ◽  
Anxiety And Depression ◽  
Depression Symptoms

AbstractBackgroundAdults with congenital heart disease face psychological challenges although an understanding of depression vs. anxiety symptoms is unclear. We analyzed the prevalence of elevated symptoms of anxiety and depression and explored associations with demographic and medical factors as well as quality of life.MethodsAdults with congenital heart disease enrolled from an outpatient clinic completed the Hospital Anxiety and Depression Scale and two measures of quality of life: the Linear Analogue Scale and the Satisfaction with Life Scale. Medical data were obtained by chart review.ResultsOf 130 patients (median age = 32 years; 55% female), 55 (42%) had elevated anxiety symptoms and 16 (12%) had elevated depression symptoms on subscales of the Hospital Anxiety and Depression Scale. Most patients with elevated depression symptoms also had elevated anxiety symptoms (15/16; 94%). Of 56 patients with at least one elevated subscale, 37 (66%) were not receiving mental health treatment. Compared to patients with 0 or 1 elevated subscales, patients with elevations in both (n=15) were less likely to be studying or working (47% vs. 81%; p=0.016) and reported lower scores on the Linear Analogue Scale (60 vs. 81, p<0.001) and the Satisfaction with Life Scale (14 vs. 28, p<0.001).ConclusionsAmong adults with congenital heart disease, elevated anxiety symptoms are common and typically accompany elevated depressive symptoms. The combination is associated with unemployment and lower quality of life. Improved strategies to provide psychosocial care and support appropriate engagement in employment are required.

scholarly journals The Prevalence of Depression and Anxiety Symptoms among Overweight/Obese and Non-Overweight/Non-Obese Children/Adolescents in China: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (3) ◽  
pp. 340 ◽  
Author(s):  
Simeng Wang ◽  
Qi Sun ◽  
Lingling Zhai ◽  
Yinglong Bai ◽  
Wei Wei ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Depression Scale ◽  
Middle School Student ◽  
Chinese Economy ◽  
Anxiety Symptoms ◽  
Depression Symptoms ◽  
Depression And Anxiety ◽  
Obese Children ◽  
Prevalence Of Depression ◽  
Scale Types

With the dramatic growth of the Chinese economy, the number of children/adolescents with being overweight/having obesity is increasing, which has a certain impact on their psychology, such as depression and anxiety symptoms. Our purpose was to conduct a meta-analysis to assess the prevalence and odds ratios of depression and anxiety symptoms among overweight/obese children/adolescents and non-overweight/obese children/adolescents in China. As of July 2018, the three most comprehensive computerized academic databases in China have been systematically screened, namely China national knowledge infrastructure (CNKI) databases, Wanfang databases and Vip databases. The same operations are performed in PubMed and Web of Science (SCIE) databases without language restrictions. Case-control studies on prevalence of depression and anxiety symptoms in overweight/obese children/adolescents in China were analyzed. Study selection and evaluation were performed independently by three authors. Unweighted prevalence, pooled random-effects estimates of odds ratio (OR), and 95% confidence intervals (CI) were all calculated. A total of 11 eligible studies involving 17,894 subjects were included. The prevalence of depression and anxiety symptoms in overweight/obese children/adolescents was significantly higher than that in non-overweight/non-obese children/adolescents (depression: 21.73% vs. 17.96%, OR = 1.46, 95% CI: 1.14, 1.87, p = 0.003; anxiety: 39.80% vs. 13.99%, OR = 1.47, 95% CI: 1.21, 1.79, p < 0.001). Subgroup analyses conducted according to scale types showed that scale types have certain significance to evaluate the relationship between depression symptoms and overweight/obesity. The OR of depression symptoms between overweight/obese children/adolescents and non-overweight/non-obese children/adolescents was greatest on the Middle School Student Mental Health Scale (MSSMHS) was 2.06 (95% CI: 1.41, 3.02, I2 = 0.00%), Center for Epidemiologic Studies Depression Scale (CES-D) was 1.03 (95% CI: 0.84, 1.25, I2 = 0.00%), and Children’s Depression Inventory (CDI) was 1.21 (95% CI: 1.02, 1.42, I2 = 0.00%). We concluded that the prevalence of depression and anxiety symptoms in overweight/obese children/adolescents in China is higher than that in the non-overweight/obese children/adolescents. The results of the study indicate that the prevalence of depression and anxiety symptoms among overweight/obese children/adolescents in Chinese medical institutions should receive more attention. Physical exercise and psychological interventions should be strengthened to prevent psychological problems. However, because of some clear limitations (no clinical interview and few studies), these results should be interpreted with caution.

Systematic Review and Meta-Analysis of Anxiety and Depression in Youth With Epilepsy

2020 ◽  
Vol 45 (2) ◽  
pp. 133-144 ◽  
Author(s):  
Amelia J Scott ◽  
Louise Sharpe ◽  
Max Loomes ◽  
Milena Gandy
Keyword(s):  
Systematic Review ◽  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Control Sample ◽  
Separation Anxiety Disorder ◽  
Anxiety And Depression ◽  
Healthy Controls ◽  
Pooled Prevalence

Abstract Objective The aim of this systematic review and meta-analysis was to provide an estimate of the prevalence of anxiety and depressive disorders in youth with epilepsy (YWE). It also aimed to calculate the overall magnitude of observed differences in anxiety and depressive symptoms reported by YWE compared with healthy controls and investigate whether any factors moderated anxiety and depression outcomes in YWE. Methods Following prospective registration, electronic databases were searched up until October 2018. Studies were included if they reported on the rate of anxiety or depression in samples of YWE, and/or if they used valid measures of anxious or depressive symptomatology in YWE compared with a healthy control sample. Results Twenty-three studies met inclusion criteria. The overall pooled prevalence of anxiety disorders in YWE was 18.9% (95% confidence interval [CI] 12.0%–28.5%), and for depression the pooled prevalence was 13.5% (95% CI 8.8%–20.2%). In samples of YWE compared with healthy controls, significantly higher anxiety (d = 0.57, 95% CI 0.32–0.83, p &lt; .000) and depressive (d = 0.42, 95% CI 0.16–0.68, p &lt; .000) symptomatology was reported. Conclusions YWE report anxiety and depressive disorders and symptoms to a significantly higher degree than youth without epilepsy. There is also evidence that certain anxiety disorders (e.g. generalized anxiety disorder, separation anxiety disorder) are particularly elevated, perhaps reflecting the unique impact of epilepsy on youth psychopathology. Research is needed to understand the risk factors associated with anxiety and depressive disorders in epilepsy, and better understand how these symptoms change across development.

scholarly journals Depressive Psoriasis-Patienten können ein schlechteres Ansprechen auf Etanercept zeigen

2019 ◽  
Vol 7 (2) ◽  
pp. 75-76
Author(s):  
Wiebke Sondermann
Keyword(s):  
Clinical Response ◽  
Response Rate ◽  
Depression Scale ◽  
Female Gender ◽  
Anxiety Symptoms ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Etanercept Treatment ◽  
Depressed Patients ◽  
Pasi Score

Background/Aims: This study aimed to investigate the predicting values of depression and anxiety symptoms for clinical response to etanercept treatment in psoriasis patients. Methods: A total of 85 psoriasis patients who received 6 months of etanercept treatment were consecutively enrolled in this prospective cohort study. The Psoriasis Area and Severity Index (PASI) score was evaluated at month 0 (M0), M1, M3, and M6, and the corresponding PASI 75/90 response at each visit was assessed. Also, anxiety and depression symptoms were assessed by the Hospital Anxiety and Depression Scale (HADS) at M0, M1, M3, and M6. Results: Depression symptoms were observed to correlate with female gender (p = 0.004), longer disease duration (p = 0.018), and higher PASI score (p < 0.001), and anxiety symptoms were seen to be associated with female gender (p = 0.017), larger psoriasis-affected body surface area (p = 0.049), and higher PASI score (p = 0.017) in psoriasis patients. After etanercept treatment, HADS-Depression (HADS-D) and HADS-Anxiety (HADS-A) scores were both decreased at M1, M3, and M6 (all p < 0.001) compared with M0. Most importantly, baseline depressed patients presented with a lower PASI 75 response rate at M3 (p = 0.014) and M6 (p = 0.005), and a reduced PASI 90 response rate at M6 (p = 0.045) compared with baseline non-depressed patients. Furthermore, multivariate logistic regression analyses revealed that depression symptoms at baseline were an independent predictive factor for the lower possibility of both PASI 75 response (p = 0.048) and PASI 90 response (p = 0.048) achievements at M6 in psoriasis patients. However, no correlation of baseline anxiety symptoms with PASI 75/90 responses was observed. Conclusion: Depression symptoms at baseline independently predict a worse clinical response to etanercept treatment in psoriasis patients.

Proportions of anxiety and depression symptoms in adult cleft patients and non-cleft patients with skeletal malocclusions

2017 ◽  
Vol 41 (S1) ◽  
pp. s497-s497
Author(s):  
V. Medvedev ◽  
Y. Fofanova ◽  
V. Frolova ◽  
A. Drobyshev
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Anxiety Symptoms ◽  
Open Bite ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Class Iii ◽  
Anterior Open Bite ◽  
Skeletal Class Ii ◽  
Reactive Anxiety

IntroductionDiagnosis and treatment of patients with craniofacial anomalies such as cleft lip and palate and skeletal malocclusions present a challenge to public health. Dentofacial abnormalities may be associated with depressive and anxiety disorders and poor quality of life.The aim of this screening study was to evaluate and to compare the rates of anxiety and depression in cleft patients and non-cleft patients with skeletal malocclusions.MethodsThe study used psychometric method-HADS and State Trait Anxiety Inventory were used. The first group consisted of cleft patients, the second group consisted of non-cleft patients with skeletal Class II, Class III and anterior open bite malocclusions; the third group was control.ResultsStudy sample consists of 42 patients (33 females; 24 ± 7.2 years). In the 1st group, anxiety symptoms were detected in 34.7%; depression symptoms - in 17.2% of patients, high rates of reactive anxiety were registered in 35.8%. In the 2nd group, anxiety symptoms were detected in 29.6% of patients; depression symptoms - in 13,1% of patients, high rates of reactive anxiety were registered in 34.2%. In the 3rd group anxiety (18.7%) and depression (8.3%) symptoms and high rates of reactive anxiety (17.7%) were registered significantly less often than in 1st and 2nd groups (P < 0.005, P < 0.001 and P < 0.001 respectively).ConclusionsOur data suggest that cleft-patients and non-cleft patients with skeletal malocclusions have statistically significant higher rates of anxiety and depression than controls and require orthodontic-surgical treatment that should be organized with the assistance of psychiatrist.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Human papillomavirus type-18 prevalence in oesophageal cancer in the Chinese population: a meta-analysis

2015 ◽  
Vol 144 (3) ◽  
pp. 469-477 ◽  
Author(s):  
L. W. GUO ◽  
S. K. ZHANG ◽  
S. Z. LIU ◽  
Q. CHEN ◽  
M. ZHANG ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Oesophageal Cancer ◽  
Chinese Population ◽  
Chinese Literature ◽  
Meta Analysis ◽  
Hpv Infection ◽  
Careful Consideration ◽  
Pooled Prevalence ◽  
Hpv Status ◽  
Hpv 18

SUMMARYGlobally, the prevalence of oesophageal cancer cases is particularly high in China. Since 1982, oncogenic human papillomavirus (HPV) has been hypothesized as a risk factor for oesophageal cancer, but no firm evidence of HPV infection in oesophageal cancer has been established to date. We aimed to conduct a meta-analysis to estimate the high-risk HPV-18 prevalence of oesophageal cancer in the Chinese population. Eligible studies published from 1 January 2005 to 12 July 2014 were retrieved via computer searches of English and Chinese literature databases (including Medline, EMBASE, Chinese National Knowledge Infrastructure and Wanfang Data Knowledge Service Platform). A random-effects model was used to calculate pooled prevalence and corresponding 95% confidence intervals (CIs). A total of 2556 oesophageal cancer cases from 19 studies were included in this meta-analysis. Overall, the pooled HPV-18 prevalence in oesophageal cancer cases was 4·1% (95% CI 2·7–5·5) in China, 6·1% (95% CI 2·9–9·3) in fresh or frozen biopsies and 4·0% (95% CI 2·3–5·8) in paraffin-embedded fixed biopsies, 8·2% (95% CI 4·6–11·7) by the E6/E7 region and 2·2% (95% CI 0·9–3·6) by the L1 region of the HPV gene. This meta-analysis indicated that China has a moderate HPV-18 prevalence of oesophageal cancer compared to cervical cancer, although there is variation between different variables. Further studies are needed to elucidate the role of HPV in oesophagus carcinogenesis with careful consideration of study design and laboratory detection method, providing more accurate assessment of HPV status in oesophageal cancer.

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