The application of metabolomics in ovarian cancer management: a systematic review

Metabolomics, the global analysis of metabolites in a biological specimen, could potentially provide a fast method of biomarker identification for ovarian cancer. This systematic review aims to examine findings from studies that apply metabolomics to the diagnosis, prognosis, treatment, and recurrence of ovarian cancer. A systematic search of English language publications was conducted on PubMed, Science Direct, and SciFinder. It was augmented by a snowball strategy, whereby further relevant studies are identified from reference lists of included studies. Studies in humans with ovarian cancer which focus on metabolomics of biofluids and tumor tissue were included. No restriction was placed on the time of publication. A separate review of targeted metabolomic studies was conducted for completion. Qualitative data were summarized in a comprehensive table. The studies were assessed for quality and risk of bias using the ROBINS-I tool. 32 global studies were included in the main systematic review. Most studies applied metabolomics to diagnosing ovarian cancer, within which the most frequently reported metabolite changes were a down-regulation of phospholipids and amino acids: histidine, citrulline, alanine, and methionine. Dysregulated phospholipid metabolism was also reported in the separately reviewed 18 targeted studies. Generally, combinations of more than one significant metabolite as a panel, in different studies, achieved a higher sensitivity and specificity for diagnosis than a single metabolite; for example, combinations of different phospholipids. Widespread metabolite differences were observed in studies examining prognosis, treatment, and recurrence, and limited conclusions could be drawn. Cellular processes of proliferation and invasion may be reflected in metabolic changes present in poor prognosis and recurrence. For example, lower levels of lysine, with increased cell invasion as an underlying mechanism, or glutamine dependency of rapidly proliferating cancer cells. In conclusion, this review highlights potential metabolites and biochemical pathways which may aid the clinical care of ovarian cancer if further validated.

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Challenges and opportunities for ovarian cancer management in the epidemic of Covid-19: lessons learned from Wuhan, China

Journal of Ovarian Research ◽

10.1186/s13048-021-00784-2 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Zhilan Chen ◽

Chun Zhang ◽

Jiu Yin ◽

Xin Xin ◽

Hemei Li ◽

...

Keyword(s):

Ovarian Cancer ◽

Large Scale ◽

Treatment Plan ◽

Clinical Care ◽

Gynecologic Cancer ◽

Treatment Phase ◽

Tumor Stage ◽

Current Treatment ◽

Lessons Learned ◽

Cancer Management

AbstractChina and the rest of the world are experiencing an outbreak of the 2019 novel coronavirus disease (COVID-19). Patients with cancer are more susceptible to viral infection and are more likely to develop severe complications, as compared to healthy individuals. The growing spread of COVID-19 presents challenges for the clinical care of patients with gynecological malignancies. Ovarian debulking surgery combined with the frequent need for chemotherapy is most likely why ovarian cancer was rated as the gynecologic cancer most affected by COVID-19. Therefore, ovarian cancer presents a particular challenging task. Concerning the ovarian cancer studies with confirmed COVID-19 reported from large-scale general hospitals in Wuhan, we hold that the treatment plan was adjusted appropriately and an individualized remedy was implemented. The recommendations discussed here were developed mainly based on the experience from Wuhan. We advise that the management strategy for ovarian cancer patients should be adjusted in the light of the local epidemic situation and formulated according to the pathological type, tumor stage and the current treatment phase. Online medical service is an effective and convenient communication platform during the pandemic.

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Nanog-mediated stem cell properties is critical for MBNL3 associated paclitaxel resistance of ovarian cancer

The Journal of Biochemistry ◽

10.1093/jb/mvab021 ◽

2021 ◽

Author(s):

Xueqin Sun ◽

Xinghua Diao ◽

Xiaolin Zhu ◽

Xuexue Yin ◽

Guangying Cheng

Keyword(s):

Ovarian Cancer ◽

Cell Viability ◽

Drug Targets ◽

Xenograft Model ◽

Underlying Mechanism ◽

Multi Drug Resistance ◽

Ovarian Cancer Cells ◽

Loss Of Function ◽

Cancer Management ◽

Nanog Gene

Abstract Paclitaxel (PTX) is the standard first-line treatment of ovarian cancer, but its efficacy is limited by multi-drug resistance. Therefore, it is crucial to identify effective drug targets to facilitate PTX-sensitivity for ovarian cancer treatment. Seventy PTX-administrated ovarian cancer patients were recruited in this study for gene expression and survival rate analyses. Muscleblind-like-3 (MBNL3) gain- and loss-of-function experiments were carried out in ovarian cancer cells (parental and PTX-resistant) and xenograft model. Cancer cell viability, apoptosis, spheroids formation, Nanog gene silencing were examined and conducted to dissect the underlying mechanism of MBNL3-mediated PTX-resistance. High expression of MBNL3 was positively correlated with PTX-resistance and poor prognosis of ovarian cancer. MBNL3 increased cell viability and decreased apoptosis in ovarian stem-like cells, through up-regulating Nanog. This study suggests the MBNL3-Nanog axis is a therapeutic target for the treatment of PTX-resistance in ovarian cancer management.

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Evolution of Clinical Trials in Ovarian Cancer Management over the Past 20 Years: Never Settle Down, Always Go Beyond

Journal of Oncology ◽

10.1155/2021/1682532 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Francesca De Felice ◽

Laura Vertechy ◽

Elena Giudice ◽

Raffaella Ergasti ◽

Serena Boccia ◽

...

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Progression Free Survival ◽

Future Research ◽

Molecular Biomarker ◽

Free Survival ◽

Cancer Management ◽

Number Of Patients ◽

Survival Endpoint ◽

Based Medicine

Purpose. A practice synthesis of available evidence-based medicine data in ovarian cancer (OC), aiming to provide directions for future research. Materials and Methods. We performed a systematic review. PubMed was searched for relevant OC trials between January 2000 and December 2019. Results. Out of 865 references screened, 199 trials were found eligible for inclusion. Most trials were multicenter (83.9%). There was a trend reduction in the number of patients enrolled/per study over the years. Studies testing targeted/biological therapies dominated the second decade (60 trials in 2010–2019 versus 2 trials in 2000–2009). The proportion of trials with positive survival and clinical outcomes significantly increased from 23.8% in early 2000s to 54.1% in the last 5 years. Trials with histology/molecular biomarker criteria were more likely to meet progression-free survival endpoint than those without these selection criteria (69.2% versus 32.6%). Conclusion. This systematic review suggests a trend of increased positive studies, mainly linked to precision medicine.

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Laparoscopy vs. laparotomy for advanced ovarian cancer: a systematic review of the literature

Minerva Medica ◽

10.23736/s0026-4806.19.06132-9 ◽

2019 ◽

Vol 110 (4) ◽

Cited By ~ 1

Author(s):

Salvatore Gueli Alletti ◽

Vito A. Capozzi ◽

Andrea Rosati ◽

Ilaria De Blasis ◽

Stefano Cianci ◽

...

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Advanced Ovarian Cancer ◽

Review Of The Literature

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Chasing the Anchor: A Systematic Review and Meta-analysis of Perceptual Anchoring Deficits in Developmental Dyslexia

10.31234/osf.io/amzpj ◽

2020 ◽

Author(s):

Kurt D Shulver ◽

Nicholas A Badcock

Keyword(s):

Systematic Review ◽

Reading Ability ◽

English Language ◽

Prediction Interval ◽

Meta Analysis ◽

Visual Assessment ◽

Individual Performance ◽

Future Research ◽

Significant Heterogeneity ◽

Eligibility Criteria

We report the results of a systematic review and meta-analysis investigating the relationship between perceptual anchoring and dyslexia. Our goal was to assess the direction and degree of effect between perceptual anchoring and reading ability in typical and atypical (dyslexic) readers. We performed a literature search of experiments explicitly assessing perceptual anchoring and reading ability using PsycInfo (Ovid, 1860 to 2020), MEDLINE (Ovid, 1860 to 2019), EMBASE (Ovid, 1883 to 2019), and PubMed for all available years up to June (2020). Our eligibility criteria consisted of English-language articles and, at minimum, one experimental group identified as dyslexic - either by reading assessment at the time, or by previous diagnosis. We assessed for risk of bias using an adapted version of the Newcastle-Ottawa scale. Six studies were included in this review, but only five (n = 280 participants) were included in the meta-analysis (we were unable to access the necessary data for one study).The overall effect was negative, large and statistically significant; g = -0.87, 95% CI [-1.47, 0.27]: a negative effect size indicating less perceptual anchoring in dyslexic versus non-dyslexic groups. Visual assessment of funnel plot and Egger’s test suggest minimal bias but with significant heterogeneity; Q (4) = 9.70, PI (prediction interval) [-2.32, -0.58]. The primary limitation of the current review is the small number of included studies. We discuss methodological limitations, such as limited power, and how future research may redress these concerns. The variability of effect sizes appears consistent with the inherent variability within subtypes of dyslexia. This level of dispersion seems indicative of the how we define cut-off thresholds between typical reading and dyslexia populations, but also the methodological tools we use to investigate individual performance.

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Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy

Current Cancer Drug Targets ◽

10.2174/1568009618666181010091246 ◽

2019 ◽

Vol 19 (6) ◽

pp. 449-467

Author(s):

Zhiquan Liang ◽

Ziwen Lu ◽

Yafei Zhang ◽

Dongsheng Shang ◽

Ruyan Li ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Receptor Binding ◽

Cytoreductive Surgery ◽

Therapeutic Strategies ◽

Membrane Receptors ◽

Ovarian Cancer Cells ◽

Advanced Stage ◽

Targeted Therapeutics ◽

Cellular Processes

Ovarian cancer is a leading cause of death worldwide from gynecological malignancies, mainly because there are few early symptoms and the disease is generally diagnosed at an advanced stage. In addition, despite the effectiveness of cytoreductive surgery for ovarian cancer and the high response rates to chemotherapy, survival has improved little over the last 20 years. The management of patients with ovarian cancer also remains similar despite studies showing striking differences and heterogeneity among different subtypes. It is therefore clear that novel targeted therapeutics are urgently needed to improve clinical outcomes for ovarian cancer. To that end, several membrane receptors associated with pivotal cellular processes and often aberrantly overexpressed in ovarian cancer cells have emerged as potential targets for receptor-mediated therapeutic strategies including specific agents and multifunctional delivery systems based on ligand-receptor binding. This review focuses on the profiles and potentials of such strategies proposed for ovarian cancer treatment and imaging.

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Covid-19 and Autoimmune Diseases: A Systematic Review of Reported Cases

Current Rheumatology Reviews ◽

10.2174/1573397116666201029155856 ◽

2020 ◽

Vol 16 ◽

Author(s):

Mariam Ahmed Saad ◽

Mostafa Alfishawy ◽

Mahmoud Nassar ◽

Mahmoud Mohamed ◽

Ignatius N Esene ◽

...

Keyword(s):

Systematic Review ◽

Autoimmune Disease ◽

Kawasaki Disease ◽

Autoimmune Diseases ◽

English Language ◽

Clinical Evidence ◽

Eligibility Criteria ◽

Thrombocytopenic Purpura ◽

Pubmed Database ◽

Viral Illness

Introduction: Over 4.9 million cases of Coronavirus disease 2019 (COVID-19) have been confirmed since the worldwide pandemic began. Since the emergence of COVID-19, a number of confirmed cases reported autoimmune manifestations. Herein, we reviewed the reported COVID-19 cases with associated autoimmune manifestations. Methods: We searched PubMed database using all available keyword for COVID-19. All related studies between January 1st, 2020 to May 22nd, 2020 were reviewed. Only studies published in English language were considered. Articles were screened based on titles and abstract. All reports of confirmed COVID-19 patients who have associated clinical evidence of autoimmune disease were selected. Results: Among 10006 articles, searches yielded, Thirty-two relevant articles for full-text assessment. Twenty studies meet the eligibility criteria. The twenty eligible articles reported 33 cases of confirmed COVID-19 diagnosis who developed an autoimmune disease after the onset of covid-19 symptoms. Ages of patients varied from a 6 months old infant to 89 years old female (Mean=53.9 years of 28 cases); five cases had no information regarding their age. The time between symptoms of viral illness and onset of autoimmune symptoms ranged from 2 days to 33 days (Mean of the 33 cases=9.8 days). Autoimmune diseases were one case of subacute thyroiditis (3%), two cases of Kawasaki Disease (6.1%), three cases of coagulopathy and antiphospholipid syndrome (9.1%), three cases of immune thrombocytopenic purpura (9.1%), eight cases of autoimmune hemolytic anemia (24.2%), and sixteen cases of Guillain–Barré syndrome (48.5%). Conclusions: COVID-19 has been implicated in the development in a range of autoimmune diseases which may shed a light on the association between autoimmune diseases and infections.

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Effectiveness of mHealth Interventions on Physical Activity and Physical Fitness in Outpatient and Home-Based Cardiac Rehabilitation Programs: A Systematic Review (Preprint)

10.2196/preprints.13972 ◽

2019 ◽

Author(s):

Sheeba Nadarajah ◽

Susan Buchholz ◽

Kristen Dickins

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Physical Fitness ◽

Cardiac Rehabilitation ◽

Text Messaging ◽

English Language ◽

Rehabilitation Program ◽

Cardiac Rehabilitation Program ◽

Mixed Effect ◽

Home Based

BACKGROUND Globally, cardiovascular disease is the leading cause of death. Cardiovascular mortality can be decreased by participation in cardiac rehabilitation. Researchers are exploring the use of mHealth technology in cardiac rehabilitation. OBJECTIVE The aim of this systematic review is to examine the effectiveness of randomized controlled trials that use a mHealth intervention as a part of an outpatient and/or home-based cardiac rehabilitation program on improving physical activity and physical fitness outcomes. METHODS For this systematic review, mHealth interventions were limited to text messaging, mobile apps, and use of a mobile phone network for data transmission, used to deliver cardiac rehabilitation program. Using six databases, the search strategy included published English language studies through 2016. Data was extracted independently by two reviewers, and then synthesized. RESULTS The initial search yielded 149 articles, of which 15 articles that represented nine studies met inclusion criteria. Articles were published from 2010 to 2016 and came from two continents. The majority (84%) of participants were male. Generally, the participant mean age was late 50s to early 60s. Text messaging was the most frequently used intervention. The results of the physical activity and physical fitness findings were mixed. Effect sizes for intervention as measured by the 6-minute walk test ranged from 0.46 to 0.58 and peak VO2 ranged from 0.03 to 1.35. CONCLUSIONS Globally, use of mHealth in outpatient and/or home-based cardiac rehabilitation is being studied with greater attention. However, these studies are limited by geography, gender, and age. Therefore, further research in the area of cardiac rehabilitation and mHealth is recommended, especially in developing countries, among women, and older adults.

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Candidate RNA biomarkers in biofluids for early diagnosis of ovarian cancer: A systematic review

Gynecologic Oncology ◽

10.1016/j.ygyno.2020.11.018 ◽

2020 ◽

Author(s):

Eva Hulstaert ◽

Annelien Morlion ◽

Keren Levanon ◽

Jo Vandesompele ◽

Pieter Mestdagh

Keyword(s):

Systematic Review ◽

Ovarian Cancer ◽

Early Diagnosis ◽

Rna Biomarkers

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Reticular erythematous mucinosis: Literature review and case report of a 24-year-old patient with systemic erythematosus lupus

Lupus ◽

10.1177/0961203320965702 ◽

2020 ◽

pp. 096120332096570

Author(s):

Juliana P Ocanha-Xavier ◽

Camila O Cola-Senra ◽

Jose Candido C Xavier-Junior

Keyword(s):

Systematic Review ◽

Case Report ◽

Literature Review ◽

English Language ◽

Case Reports ◽

Histopathological Diagnosis ◽

Skin Disorders ◽

Histopathological Findings ◽

Inflammatory Skin

Reticular erythematous mucinosis (REM) was first described 50 years ago, but only around 100 case reports in English have been published. Its relation with other inflammatory skin disorders is still being debated. We report a case of REM, including the clinical and histopathological findings. Also, a systematic review of 94 English-language reported cases is provided. The described criteria for clinical and histopathological diagnosis are highlighted in order to REM can be confidently diagnosed.

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