Establishing objective benchmarks in robotic virtual reality simulation at the level of a competent surgeon using the RobotiX Mentor simulator

2018 ◽  
Vol 94 (1111) ◽  
pp. 270-277 ◽  
Author(s):  
William Watkinson ◽  
Nicholas Raison ◽  
Takashige Abe ◽  
Patrick Harrison ◽  
Shamim Khan ◽  
...  

BackgroundTo establish objective benchmarks at the level of a competent robotic surgeon across different exercises and metrics for the RobotiX Mentor virtual reality (VR) simulator suitable for use within a robotic surgical training curriculum.MethodsThis retrospective observational study analysed results from multiple data sources, all of which used the RobotiX Mentor VR simulator. 123 participants with varying experience from novice to expert completed the exercises. Competency was established as the 25th centile of the mean advanced intermediate score. Three basic skill exercises and two advanced skill exercises were used.SettingKing’s College London.Participants84 Novice, 26 beginner intermediates, 9 advanced intermediates and 4 experts were used in this retrospective observational study.ResultsObjective benchmarks derived from the 25th centile of the mean scores of the advanced intermediates provided suitably challenging yet also achievable targets for training surgeons. The disparity in scores was greatest for the advanced exercises. Novice surgeons are able to achieve the benchmarks across all exercises in the majority of metrics.ConclusionWe have successfully created this proof-of-concept study, which requires validation in a larger cohort. Objective benchmarks obtained from the 25th centile of the mean scores of advanced intermediates provide clinically relevant benchmarks at the standard of a competent robotic surgeon that are challenging yet also attainable. That can be used within a VR training curriculum allowing participants to track and monitor their progress in a structured and progressional manner through five exercises. Providing clearly defined targets, ensuring that a universal training standard has been achieved across training surgeons.

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Rebecchi ◽  
N Salmeri ◽  
C Patruno ◽  
R Villanacci ◽  
P Rover Querini ◽  
...  

Abstract Study question To investigate differences in In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) outcomes between endometriosis women who do or don’t have a concomitant autoimmune disease. Summary answer Despite a higher oocyte yield, a trend for reduction in clinical pregnancy rates was observed in the autoimmunity group compared to women without concomitant autoimmunity. What is known already Endometriosis is an inflammatory chronic gynaecological disorder with a known detrimental impact on fertility. Endometriosis pathogenesis is still unclear. It has been postulated a role of both innate and adaptive immune system. The coexistence of endometriosis and autoimmunity is a well-documented occurrence Some recent findings have revealed an increased risk to have concomitant autoimmune disease in women with endometriosis, but no study has so far investigated whether this association could affect IVF/ICSI outcomes. Indeed, autoimmune phenomena, including proinflammatory cytokines and auto-antibody production, may result in diminished quality of oocytes/embryos with lower pregnancy rates among these patients. Study design, size, duration This was a retrospective observational study carried out at the Fertility Unit of IRCSS San Raffaele Hospital (Milan). We reviewed medical patients’ notes of women with a confirmed diagnosis of endometriosis who referred to our Fertility Unit from October 2018 to January 2021. Participants/materials, setting, methods Out of 1441 patients undergoing IVF/ICSI, 98 women had surgical/histopathological diagnosis of endometriosis. 25 of them had a clinical and/or serological diagnosis of autoimmunity. Autoimmunity was assessed by clinical data (blood tests for auto-antibodies or rheumatological records) obtained from the electronic patient files stored in the database of our Fertility Centre. Clinical pregnancy was defined as the presence of at least one intrauterine gestational sac with a viable embryo at week 6 after transfer. Main results and the role of chance 25/98 (25.5%) endometriosis women with a concomitant autoimmune disease (cases) were compared with 73/98 (74.5%) endometriosis patients without autoimmunity (controls). The mean age was 37.36±3.63 and 36.93±3.79 (p=.623) in cases and controls respectively. The mean number of oocytes retrieved was higher in cases (5.78±4.07) than in controls (3.82±2.69;p=.041); similarly, cases showed an higher number of embryos (2.13±1.93 vs. 1.19±1.37;p=.041) and blastocysts (1.89±2.02 vs. 0.85±1.61;p=.041) obtained. A total of 47 fresh embryo transfer (ET) were performed. Considering all the endometriosis patients, the clinical pregnancy rate (CPR) per cycle was 34.0% (16/47); when stratifying for the presence of autoimmunity the CPR was 23.1% (3/13) in cases, and 38.2% (13/34) in controls (p=.494). Limitations, reasons for caution This is a retrospective study based on data extraction from electronic records of our Fertility Centre. The sample size is limited and some information about past medical history could be missed. Results should be interpreted with caution until validated by future research providing more standardized data collection. Wider implications of the findings: Despite significantly higher numbers of oocytes retrieved and embryos/blastocysts formed, the presence of concomitant autoimmune disease in patients with endometriosis may impair pregnancy rates. Whether this finding is confirmed and whether it could be due to a defect in embryo/blastocysts quality or in endometrial receptivity deserves further studies. Trial registration number Not applicable


BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e024970 ◽  
Author(s):  
Michelle Greiver ◽  
Sumeet Kalia ◽  
Teja Voruganti ◽  
Babak Aliarzadeh ◽  
Rahim Moineddin ◽  
...  

ObjectivesTo study systematic errors in recording blood pressure (BP) as measured by end digit preference (EDP); to determine associations between EDP, uptake of Automated Office BP (AOBP) machines and cardiovascular outcomes.DesignRetrospective observational study using routinely collected electronic medical record data from 2006 to 2015 and a survey on year of AOBP acquisition in Toronto, Canada in 2017.SettingPrimary care practices in Canada and the UK.ParticipantsAdults aged 18 years or more.Main outcome measuresMean rates of EDP and change in rates. Rates of EDP following acquisition of an AOBP machine. Associations between site EDP levels and mean BP. Associations between site EDP levels and frequency of cardiovascular outcomes.Results707 227 patients in Canada and 1 558 471 patients in the UK were included. From 2006 to 2015, the mean rate of BP readings with both systolic and diastolic pressure ending in zero decreased from 26.6% to 15.4% in Canada and from 24.2% to 17.3% in the UK. Systolic BP readings ending in zero decreased from 41.8% to 32.5% in the 3 years following the purchase of an AOBP machine. Sites with high EDP had a mean systolic BP of 2.0 mm Hg in Canada, and 1.7 mm Hg in the UK, lower than sites with no or low EDP. Patients in sites with high levels of EDP had a higher frequency of stroke (standardised morbidity ratio (SMR) 1.15, 95% CI 1.12 to 1.17), myocardial infarction (SMR 1.16, 95% CI 1.14 to 1.19) and angina (SMR 1.25, 95% CI 1.22 to 1.28) than patients in sites with no or low EDP.ConclusionsAcquisition of an AOBP machine was associated with a decrease in EDP levels. Sites with higher rates of EDP had lower mean BPs and a higher frequency of adverse cardiovascular outcomes. The routine use of manual office-based BP measurement should be reconsidered.


2021 ◽  
Vol 15 (10) ◽  
pp. 2540-2542
Author(s):  
Maria Shireen ◽  
Sarah Shoaib Qureshi ◽  
Arsalan Nawaz ◽  
Wasim Amir ◽  
Mehrin Farooq ◽  
...  

Background: Covid-19 is a very contagious and quickly spreading viral infection, caused by a corona virus SARS-COV-2 which was originally reported in China on December 5, 2019. It was confirmed as pandemic by WHO on March 11, 2020. This disease is yet under research. It has variable severity which includes no symptoms to pneumonia. This can cause death of the patient. Aim: To evaluate the association of Lymphopenia with severity of COVID 19 in COVID-19 patients Methods: It was a retrospective observational study conducted in COVID wards of Ghurki hospital Lahore. Record of 100 COVID-19 patients that were admitted between March and July 2021 fulfilling the inclusion criteria was included in the study. A pre-structured pro forma was filled to collect the data. Results: Out of 100 patients, 30 patients were included in Non-severe group while severe group had 70 patients. The mean age of study population was 52.5±10.38 with 60% male and 40% female. 70% patients in severe group had some co-existent comorbidity. The most commonly reported symptoms were fever and cough in both groups while shortness of breath was more commonly reported in severe group. Conclusion: Lymphopenia is associated with severe Coronavirus disease 2019 (COVID-19) infections. Lymphocytes count can be used to assess the severity of COVID 19. Keywords: Lymphocytes, Lymphopenia, Coronavirus disease 2019, COVID 19.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Heewon Yang ◽  
Woochan Jeon ◽  
Yura Ko ◽  
Sooin Jeong ◽  
Jisook Lee

Abstract Background In mildly to moderately dehydrated patients with acute gastroenteritis (AGE), oral rehydration therapy (ORT) is the treatment of choice. Though ondansetron is a very effective antiemetics and leads to succeed ORT, there have been reports QT prolongation in patients using it. We investigated the effect of oral ondansetron on QT interval in mildly to moderately dehydrated children with AGE. Methods This retrospective observational study was conducted in a single pediatric emergency department (ED) of a tertiary university hospital. We collected the medical records of patients with a primary diagnosis of AGE who received oral ondansetron and underwent an electrocardiogram between January 2017 and June 2018. A pediatric emergency physician calculated the corrected QT interval (QTc) by Bazett’s method, and the calculations were reviewed by a pediatric cardiologist. QTc values before (preQTc) and after (postQTc) ondansetron administration were analyzed. ΔQTc was calculated as the change from preQTc to postQTc. We also investigated any cardiac complications from oral ondansetron. Results Total 80 patients were included. The mean age of the patients was 53.31 ± 32.42 months, and 45% were male. The mean dose of oral ondansetron was 0.18 ± 0.04 mg/kg. The mean interval from administration of ondansetron to performance of the electrocardiogram was 65 ± 26 min. The mean preQTc was 403.3 ± 24.0 ms, and the mean postQTc was 407.2 ± 26.7 ms. Two patients had a preQTc ≥460 ms, and one patient had a postQTc ≥460 ms. ΔQTc was ≥30 ms in seven patients (8.8%). No ΔQTc was ≥60 ms. No pre- or postQTc was ≥500 ms. No patient had a fatal cardiac arrhythmia after taking ondansetron. Conclusion Oral administration of a single dose of ondansetron in children with AGE did not cause high-risk QTc prolongation or fatal arrhythmia.


2020 ◽  
Author(s):  
Yin-Yu Chen ◽  
Yin-Kai Chao ◽  
Yi-Ching Huang ◽  
Chung-Hsien Chao ◽  
Ming-Ju Hsieh

Abstract Background Robotic-assisted surgery learning is highly self-governance, albeit its flourishing. Novices of robotic-assisted surgery are usually trained by virtual reality simulators. This study aims to evaluate whether novices’ prior experiences of aiding robotic-assisted surgery, simulation on virtual reality or game-playing gives weight to their learning outcomes. Methods Novices’ attitudes towards robotic-assisted surgery and video game-playing experiences were investigated using a questionnaire. Voluntary novices (n = 70) comprising surgical trainees (first-year to sixth-year residents) and surgeons were then examined on a VR simulator. The simulator automatically generated examination scores. Questionnaires and examination scores were analysed using SPSS. Results Participants’ prior experiences of aiding robotic-assisted surgery (p < .01) and having robotic surgical simulation within six months (p < .01) was associated with significantly higher VR simulator performance, but not prior video game-playing (p > .05). Resident participant years 3–5 performed significantly better than resident participant years 1–2, and 6 and visiting staff (p < .01). Conclusions When formal robotic surgical training is lacking, novices’ learning can be developed via both simulation and engaging in real cases. Formal robotic surgical training should be ideally introduced during the middle part of the residency period.


2020 ◽  
Author(s):  
Bisakh Bhattacharya ◽  
Rohit Kumar ◽  
Ved Prakash Meena ◽  
Manish Soneja ◽  
Saurabh Vig ◽  
...  

AbstractBackgroundDespite being in the 5th month of pandemic, knowledge with respect to viral dynamics, infectivity and RT-PCR positivity continues to evolve.AimTo analyse the SARS CoV-2 nucleic acid RT-PCR profiles in COVID-19 patients.DesignIt was a retrospective, observational study conducted at COVID facilities under AIIMS, New Delhi.MethodsPatients admitted with laboratory confirmed COVID-19 were eligible for enrolment. Patients with incomplete details, or only single PCR tests were excluded. Data regarding demographic details, comorbidities, treatment received and results of SARS-CoV-2 RT-PCR performed on nasopharyngeal and oropharyngeal swabs, collected at different time points, was retrieved from the hospital records.Results298 patients were included, majority were males (75·8%) with mean age of 39·07 years (0·6-88 years). The mean duration from symptom onset to first positive RT-PCR was 4·7 days (SD 3·67), while that of symptom onset to last positive test was 17·83 days (SD 6·22). Proportions of positive RT-PCR tests were 100%, 49%, 24%, 8·7% and 20·6% in the 1st, 2nd, 3rd, 4th & >4 weeks of illness. 12 symptomatic patients had prolonged positive test results even after 3 weeks of symptom onset. Age >= 60 years was associated with prolonged RT-PCR positivity (statistically significant).ConclusionThis study showed that the average period of PCR positivity is more than 2 weeks in COVID-19 patients; elderly patients have prolonged duration of RT-PCR positivity and requires further follow up.


2020 ◽  
Author(s):  
Bisakh Bhattacharya ◽  
Rohit Kumar ◽  
Ved Prakash Meena ◽  
Manish Soneja ◽  
Amit Singh ◽  
...  

Abstract Background Despite being in the 5th month of pandemic, knowledge with respect to viral dynamics, infectivity and RT-PCR positivity continues to evolve. Aim To analyse the SARS CoV-2 nucleic acid RT-PCR profiles in COVID-19 patients. Design It was a retrospective, observational study conducted at COVID facilities under AIIMS, New Delhi. Methods Patients admitted with laboratory confirmed COVID-19 were eligible for enrolment. Patients with incomplete details, or only single PCR tests were excluded. Data regarding demographic details, comorbidities, treatment received and results of SARS-CoV-2 RT-PCR performed on nasopharyngeal and oropharyngeal swabs, collected at different time points, was retrieved from the hospital records. Results 298 patients were included, majority were males (75·8%) with mean age of 39·07 years (0·6–88 years). The mean duration from symptom onset to first positive RT-PCR was 4·7 days (SD 3·67), while that of symptom onset to last positive test was 17·83 days (SD 6·22). Proportions of positive RT-PCR tests were 100%, 49%, 24%, 8·7% and 20·6% in the 1st, 2nd, 3rd, 4th & &gt;4 weeks of illness. 12 symptomatic patients had prolonged positive test results even after 3 weeks of symptom onset. Age &gt; = 60 years was associated with prolonged RT-PCR positivity (statistically significant). Conclusion This study showed that the average period of PCR positivity is more than 2 weeks in COVID-19 patients; elderly patients have prolonged duration of RT-PCR positivity and requires further follow up.


Author(s):  
Javier Collado-Aliaga ◽  
Ángela Romero-Alegría ◽  
Montserrat Alonso-Sardón ◽  
Amparo López-Bernus ◽  
Inmaculada Galindo-Pérez ◽  
...  

Abstract Background Cystic echinococcosis (CE) is a chronic, complex and neglected zoonotic disease caused by Echinococcus granulosus. Eosinophilia in CE is a classic analytic alteration, although its presentation and importance is very variable and not well established. Methods We performed a retrospective observational study of inpatients diagnosed with CE and eosinophilia from January 1998 to December 2017 in the Complejo Asistencial Universitario de Salamanca in western Spain. Results During the study period, 475 patients with a CE diagnosis underwent a haemogram and 118 (24.8%) patients had eosinophilia. Eighty-two (69.5%) were male and the mean age was 52.1±20.8 y, which was younger in the group with eosinophilia (p<0.001). The patients with eosinophilia had less comorbidity (33.1% vs 52.9%; p<0.001) and they were diagnosed with more complications (60.2% vs 39.8% asymptomatic; p<0.001). Clinical manifestations appeared in 71 cases (60.2%). The eosinophilia was related to the presence of pre-surgical fistulas (p=0.005). We observed significant differences when considering whether eosinophilia is a marker of the type of treatment (p<0.001). Conclusions Eosinophilia can be an indicator for an active search in CE because as much as 40% of cases are asymptomatic at diagnosis. In patients with eosinophilia, management is usually more aggressive and is usually a combined treatment. Our work shows the importance of eosinophilia in our patients with CE and raises unresolved questions.


Author(s):  
Deepak Karn

Aim: to determine the prevalence and clinical profile of patients presented with posterior fossa extra dural hematoma. Materials and Methods: The present retrospective observational study was conducted in the Department of Neurosurgery, SKMCH, Muzaffarpur, Bihar, India.  The records were retrospectively analyzed for clinical presentation, admission Glasgow Coma Scale (GCS), mode of injury, type of intervention and postoperative outcome. Outcomes were assessed on the basis of Glasgow Outcome Score (GOS) at the time of discharge and at 3 months Results: Of these 39 patients, 28 were males and 11 females. The mean age of patients was 29.21 years. 24 patients had GCS 13-15 at admission followed by 9 with GCS 9-12 and only 5 of them had GCS <9 at admission. Mean EDH volume was 28.7 ml. 36 patients were operated, 5 patients managed conservatively. Conclusion: The posterior fossa is an uncommon site for epidural haematomas. Due to the small volume of the posterior fossa and contained important structures mortality can be high if the haematoma is missed. Clinical progress is silent and slow, but the deterioration is sudden and quick to become fatal if not promptly treated. Early recognition is extremely important. Keywords: Extradural hematoma, Posteriors fossa, GCS, Trauma


Dermatology ◽  
2020 ◽  
pp. 1-6
Author(s):  
Stefano Caccavale ◽  
Giulia Calabrese ◽  
Emanuela Mattiello ◽  
Paolo Broganelli ◽  
Alice Ramondetta ◽  
...  

<b><i>Background:</i></b> Congenital melanocytic nevi (CMN) are benign proliferations of melanocytes usually present at birth. The magnitude of the melanoma risk for CMN is controversial, generating an ongoing debate on the best approach to manage these lesions. <b><i>Objective:</i></b> To perform a retrospective, observational study with the aim to evaluate the prevalence of CMN-associated melanomas in tertiary referral centers, as well as the eventual correlation between clinical, dermoscopic, and histological features of CMN-associated melanomas. <b><i>Methods:</i></b> A single-center retrospective observational study was performed on all clinical and dermoscopic images of histologically confirmed melanomas arising on CMN over a 14-year period (January 2005 to March 2019). <b><i>Results:</i></b>Our database included 2,159 melanomas in the considered period. Of those, 27 (1.3%) were CMN-associated melanomas. The mean age of patients with CMN-associated melanoma was 33 years (range, 11–70 years). The mean diameter of CMN-associated melanoma was 18 mm (range, 6 mm to 20 cm), and 56% were located on the back. Twenty-one (77.8%) of CMN-associated melanomas arose on small CMN (&#x3c;1.5 cm), 5 (18.5%) on medium-sized CMN (1.5–19.9 cm), and 1 (3.7%) on a large/giant type (≥20 cm). The majority of CMN-associated melanomas (63%) exhibited a globular dermoscopic pattern in their benign part, while a blue-white veil and irregular blotches were the most frequent dermoscopic features in the malignant part. About three quarters of melanomas occupied 10–50% of the nevus surface. Breslow thickness was higher in melanomas involving less than 10% of nevus surface (mean thickness, 1 mm) than in those affecting 10–50 and &#x3e;50% of the nevus surface (0.8 and 0.7 mm, respectively). <b><i>Conclusions:</i></b> In our series, small CMN was the most frequent type of CMN-associated melanoma. Although the risk of melanoma is increasing by the increasing size of CMN, our finding is definitely related to the much higher prevalence of small CMN in the general population as compared to the prevalence of intermediate-sized and large CMN. <b><i>Limitations:</i></b> Small sample size, single-center experience, retrospective design.


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