scholarly journals Cannabis and epilepsy

2018 ◽  
Vol 18 (6) ◽  
pp. 465-471 ◽  
Author(s):  
Rhys H Thomas ◽  
Mark O Cunningham
Keyword(s):  
Treatment Options ◽  
Current Treatment ◽  
High Profile ◽  
High Street ◽  
The Usa ◽  
The Difference ◽  
The One ◽  
The Uk ◽  
Genetic Epilepsies ◽  
Trial Evidence

Click here to listen to the PodcastThe one-third of people who do not gain seizure control through current treatment options need a revolution in epilepsy therapeutics. The general population appears to be showing a fundamental and rapid shift in its opinion regarding cannabis and cannabis-related drugs. It is quite possible that cannabidiol, licensed in the USA for treating rare genetic epilepsies, may open the door for the widespread legalisation of recreational cannabis. It is important that neurologists understand the difference between artisanal cannabidiol products available legally on the high street and the cannabidiol medications that have strong trial evidence. In the UK in 2018 there are multiple high-profile reports of the response of children taking cannabis-derived medication, meaning that neurologists are commonly asked questions about these treatments in clinic. We address what an adult neurologist needs to know now, ahead of the likely licensing of Epidiolex in the UK in 2019.

scholarly journals How Universities Have Betrayed Reason and Humanity—And What's to Be Done About It

2021 ◽  
Vol 2 ◽  
Author(s):  
Nicholas Maxwell
Keyword(s):  
Mass Extinction ◽  
Social World ◽  
Social Progress ◽  
Know How ◽  
High Profile ◽  
The Social ◽  
Global Problems ◽  
The Usa ◽  
The One ◽  
The Uk

In 1984 the author published From Knowledge to Wisdom, a book that argues that a revolution in academia is urgently needed, so that problems of living, including global problems, are put at the heart of the enterprise, and the basic aim becomes to seek and promote wisdom, and not just acquire knowledge. Every discipline and aspect of academia needs to change, and the whole way in which academia is related to the rest of the social world. Universities devoted to the pursuit of knowledge and technological know-how betray reason and, as a result, betray humanity. As a result of becoming more intellectually rigorous, academic inquiry becomes of far greater benefit to humanity. If the revolution argued for all those years ago had been taken up and put into academic practice, we might now live in a much more hopeful world than the one that confronts us. Humanity might have begun to learn how to solve global problems; the Amazon rain forests might not face destruction; we might not be faced with mass extinction of species; Brexit might not have been voted for in the UK in 2016, and Trump might not have been elected President in the USA. An account is given of work published by the author during the years 1972–2021 that expounds and develops the argument. The conclusion is that we urgently need to create a high-profile campaign devoted to transforming universities in the way required so that humanity may learn how to make social progress toward a better, wiser, more civilized, enlightened world.

scholarly journals Leadership and chronic diseases: a bibliometric review

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Cabral ◽  
G Daminani
Keyword(s):  
Chronic Diseases ◽  
Leadership Role ◽  
Religious Communities ◽  
Mesh Terms ◽  
The Usa ◽  
Bibliometric Review ◽  
The One ◽  
The Uk ◽  
Health Field

Abstract Background Leadership and chronic diseases are two frequent topics in current public health discussions. We performed a bibliometric analysis to study what interactions exist between these two themes. This study allows an insight on what is being published and also identifies potential gaps that need to be addressed. Methods We have reviewed all the titles and abstracts of articles available at PUBMED with the MESH terms ’Leadership’ and ’Chronic Disease’. We collected information about the authors, year, journal and type of publication and country where the study was done. We have also done a qualitative analysis on the themes addressed. Results We have found 171 entries, of witch 85 (49,7%) referred to apparent peer reviewed studies in English. All other publications referred to editorials, commentaries or the PUBMED entry did not allow for greater clarification. From 1998 the publication of articles became regular, with a peak of 14 articles published in 2014. The average of authors per publication was 3,19. The most frequent country involved was the USA (62), follow by the UK (14), Canada (11) and Australia (10). 128 publications were identified, of which BMC Health Serv Res was the one with the highest number of articles included (5). There was some form of a call for greater leadership from nurses in 22 articles. We also highlight 5 articles that called for a greater role of pastors and religious communities in this field. Conclusions Despite the perception of being common topics, there is still a low rate of publication of studies in the field of leadership and chronic diseases. There is a predominance of articles from the USA. There was not a predominant publication in this field. Despite doctors being typically seen as the leaders within the health field, the articles included seem to point to a trend in calling for a bigger leadership role of other actors, such as nurses. Key messages There is a need for more research in the field of leadership in chronic diseases. There seems to be a trend calling for greater leadership in the field from non-physician actors.

Bladder cancer

2019 ◽  
Vol 13 (6) ◽  
pp. 271-277
Author(s):  
Ian Peate
Keyword(s):  
Bladder Cancer ◽  
Treatment Options ◽  
Older Person ◽  
Multiple Choice Questions ◽  
Men And Women ◽  
Treatment Regimens ◽  
Common Cancer ◽  
The One ◽  
The Uk

This article is the one in the cancer series that discusses bladder cancer. Bladder cancer can occur in men and women; however, in the UK, there are more men with bladder cancer than women. It is also a disease of the older person. This article provides an introduction that discusses the condition. An overview of the anatomy of the bladder and ureters is provided. In 2015, bladder cancer was the 10th most common cancer in the UK and was responsible for 3% of all new cancer cases. Diagnosis and treatment options are discussed, with an emphasis on ensuring that the patient is key in any decisions that are made about treatment regimens. The importance of follow-up after treatment is also discussed. A glossary of terms is provided and five multiple-choice questions are included to enhance learning and application to practice.

scholarly journals The current treatment landscape in the UK for stage III NSCLC

2020 ◽  
Vol 123 (S1) ◽  
pp. 3-9
Author(s):  
Matthew Evison ◽  
Keyword(s):  
Treatment Options ◽  
Survival Rates ◽  
Current Treatment ◽  
Stage Iii ◽  
Diverse Range ◽  
Unresectable Stage ◽  
Radical Therapy ◽  
Modal Treatment ◽  
Stage Iii Nsclc ◽  
The Uk

AbstractFor stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal treatment options, including systemic and local therapies for distant and local disease control, respectively. This complexity results in a number of challenges for the multi-disciplinary team (MDT) in achieving optimal treatment outcomes for patients. As multi-modality treatment is the preferred treatment strategy for all stage III disease, the focus of this article is the key surgical, chemotherapy and radiotherapy clinical trials as well as guidelines that currently outline radical therapy options for patients with both potentially resectable and unresectable stage III NSCLC.

Improvised first aid techniques for terrorist attacks

2018 ◽  
Vol 35 (8) ◽  
pp. 516-521 ◽  
Author(s):  
Andrew Loftus ◽  
Harvey Pynn ◽  
Paul Parker
Keyword(s):  
Medical Knowledge ◽  
Oral Morphine ◽  
First Aid ◽  
Wound Dressings ◽  
High Street ◽  
The Usa ◽  
Basic Medical Knowledge ◽  
The Uk ◽  
Terrorist Acts ◽  
The Military

Terrorist acts occur every day around the world. Healthcare professionals are often present as bystander survivors in these situations, with none of the equipment or infrastructure they rely on in their day-to-day practice. Within several countries there has been a move to disseminate the actions to take in the event of such attacks: in the UK, Run, Hide, Tell, and in the USA, Fight Back. This paper outlines how a very basic medical knowledge combined with everyday high-street items can render highly effective first aid and save lives. We discuss and summarise modern improvised techniques. These include the <C> ABCDE approach of treating catastrophic haemorrhage before airway management, bringing together improvised techniques from the military and wilderness medicine. We explain how improvised tourniquets, wound dressings, splinting and traction devices can be fabricated using items from the high street: nappies, tampons, cling film, duct tape and tablecloths. Cervical spine immobilisation is a labour-intensive protocol that is often practised defensively. With little evidence to support the routine use of triple immobilisation, this should be replaced with a common sense dynamic approach such as the Montana neck brace. Acid or alkali attacks are also examined with simple pragmatic advice. Analgesia is discussed in the context of a prehospital setting. Pharmacy-obtained oral morphine and diclofenac suppositories can be used to treat moderate pain without relying on equipment for intravenous/intraosseous infusion in prolonged hold situations. The differentiation between concealment and cover is summarised: scene safety remains paramount.

scholarly journals Malignant Melanoma of the Gastrointestinal Tract: Symptoms, Diagnosis, and Current Treatment Options

Cells ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 327
Author(s):  
Darina Kohoutova ◽  
Dominic Worku ◽  
Hala Aziz ◽  
Julian Teare ◽  
Justin Weir ◽  
...  
Keyword(s):  
Overall Survival ◽  
Malignant Melanoma ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Symptom Control ◽  
Current Treatment ◽  
Gi Tract ◽  
Systemic Treatments ◽  
Precise Diagnosis ◽  
The Uk

Malignant melanoma (MM) has become the fifth most frequent cancer in the UK. It is the most common carcinoma to metastasize to the gastrointestinal (GI) tract. MM particularly has an affinity to spread to the small bowel, which is followed by the involvement of the stomach and large intestine. Excellent endoscopic options including video capsule endoscopy and enteroscopy are available for a precise diagnosis of GI involvement by a metastatic MM. The complete surgical resection of GI metastatic MM in carefully selected patients not only provides symptom control, but has also been associated with an increase in overall survival. The approval of BRAF-targeted therapies and immune checkpoint inhibitors has transformed therapeutic approaches for patients with metastatic MM over the past decade. Currently, the overall survival of patients with advanced metastatic MM who have been treated with a combination of immunotherapeutic agents reaches 52% at five years. The role of surgery for patients with the metastatic involvement of the GI tract with MM is evolving in the era of effective systemic treatments.

Interdisciplinarity, Cultural Studies, Queer: Historical Contexts and Contemporary Contentions in France

Paragraph ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 215-232 ◽  
Author(s):  
Lisa Downing
Keyword(s):  
Cultural Studies ◽  
Queer Theory ◽  
French Studies ◽  
The Status ◽  
French Speaking ◽  
The Usa ◽  
Anglo American ◽  
The One ◽  
Anglophone World ◽  
The Uk

This article offers a comparative examination of the status of ‘interdisciplinarity’, ‘cultural studies’ and ‘queer’ in the discipline of French studies in the Anglophone world and in France. It is argued that, while the intellectual origins of both interdisciplinarity and queer theory are French, a series of disavowals and appropriations has de-gallicized them. On the one hand, the cultural hegemony of English studies in the USA and the UK has led to a colonization and anglicization of continental thought. On the other, the resistance to cultural studies within the Hexagone has meant that work done in critical sexuality studies within the Anglo-American world over the past forty years is only now beginning to be felt within French-speaking contexts. In tracing this double history of dislocation, the article contextualizes the difficulty of thinking queer in properly French terms — and the importance of doing so.

scholarly journals Kaleidoscope

2015 ◽  
Vol 207 (3) ◽  
pp. 277-278 ◽  
Author(s):  
Derek K. Tracy ◽  
Dan W. Joyce ◽  
Sukhwinder S. Shergill
Keyword(s):  
Alcoholic Beverage ◽  
Crystalline Form ◽  
Current Status ◽  
News Stories ◽  
House Of Lords ◽  
Internet Search Engine ◽  
The Usa ◽  
The Government ◽  
The One ◽  
The Uk

Palcohol. What is it? It's a powdered alcohol that has recently been approved for sale in the USA.On the one hand, it is just adding choice, offering a new, crystalline form of one of the world's most commonly used and enjoyed chemicals (although recent news stories1 of some Australians brewing moonshine from Vegemite are surely pushing choice beyond the pale). However, there are some specific challenges with palcohol, which are well articulated in an editorial in JAMA by Naimi & Mosher.2 The powder is sold at 50% alcohol by weight, but the strength by volume will depend on how it is diluted. It can be more easily concealed than liquid alcohol, and it could be added – surreptitiously – to another alcoholic beverage. The potential for misuse, including by children, is self-evident; indeed, a video of an individual eating palcohol has already been uploaded, along with discussions on inhaling it, though such acts appear unlikely to produce intoxication. What is its current status in the UK? Answering a parliamentary question in the House of Lords earlier this year Lord Bates noted3 that ‘The Government is not aware of powdered alcohol being marketed or made available to buy in England and Wales'. However, a very quick and simple check on a well-known internet search engine gave a web-link to buy palcohol online.

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