Cytogenetic studies in spontaneous abortion: the Calgary experience

1985 ◽  
Vol 27 (5) ◽  
pp. 565-570 ◽  
Author(s):  
C. C. Lin ◽  
M. De Braekeleer ◽  
Heidi Jamro
Keyword(s):  
Tissue Culture ◽  
Spontaneous Abortion ◽  
Gestational Age ◽  
Chromosome Analysis ◽  
Banding Technique ◽  
Spontaneous Abortions ◽  
Maternal Tissue ◽  
Cytogenetic Studies ◽  
Structural Aberrations ◽  
Tissue Contamination

In a series of 493 apparently consecutive products of spontaneous abortions obtained for cytogenetic studies, tissue culture was attempted in 428 cases; chromosome analysis using the Q-banding technique was completed in 215 cases (50.2%). Abnormal karyotypes were identified in 80 cases (37.2%). Maternal tissue contamination was apparent and the actual frequency of karyotypic abnormal abortuses could be as high as 50%. Comparison of the frequency of a specific type of chromosome abnormalities with nine other series of studies showed the lowest frequency of autosomal trisomies and the highest frequency of triploidies and structural aberrations in the Calgary series. In addition, a significantly lower gestational age was observed for triploidies 69,XXX as compared to the 69,XXY.Key words: abortion, Q-banding, human karyotypes, trisomy, triploidy.

scholarly journals Chromosomal Aneuploidy Associated with Spontaneous Abortions and Neonatal Losses in Cattle

1996 ◽  
Vol 8 (1) ◽  
pp. 91-95 ◽  
Author(s):  
S. M. Schmutz ◽  
J. S. Moker ◽  
E. G. Clark ◽  
J. P. Orr
Keyword(s):  
Tissue Culture ◽  
Chromosome Complement ◽  
Fetal Loss ◽  
Cost Effective ◽  
Chromosome Analysis ◽  
First Trimester ◽  
Spontaneous Abortions ◽  
Diagnostic Use ◽  
Culture Cells ◽  
Tissue Culture Cells

Pericardial sac samples from 77 bovine aborted fetuses and stillborn calves were submitted for tissue culture; cells from 55 of these samples were grown successfully in culture. Six of the 55 karyotyped fetuses (10.7%) had an abnormal chromosome complement, in 3 of which (5.5%) the abnormality was probably the cause of death. This level of abnormality is relatively high when one considers that most fetuses were gt; 8 months gestational age. Approximately 5–7% of human stillbirths and 50% of first-trimester aborted fetuses have chromosome anomalies. If a similar situation exists in cattle, as suggested by these data, chromosome abnormalities may be a major cause of early fetal loss in cattle. Most chromosomally abnormal fetuses had multiple malformations, which suggests that the diagnostic use of chromosome analysis is most cost effective for malformed fetuses and newborns. Twins were present in a higher proportion of these fetuses than expected based on their incidence among liveborn cattle.

scholarly journals THE STUDY OF EFFICACY OF SUBLINGUAL MISOPROSTOL IN TERMINATION OF EARLY PREGNANCY

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Arti Kumari ◽  
Usha Kumari ◽  
Anupama Sinha
Keyword(s):  
Side Effects ◽  
Spontaneous Abortion ◽  
Early Pregnancy ◽  
Gestational Age ◽  
High Efficacy ◽  
Missed Abortion ◽  
Pregnancy Failure ◽  
Products Of Conception ◽  
Early Pregnancy Failure ◽  
Sublingual Misoprostol

Introduction: Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy failure is varied and dose and route are not well established. AIM: To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. Results: Mean gestational age was 7.946+1.2 weeks. Mean induction abortion interval was 18.241+1.2 hours. Women with gestational age six to eight weeks had least mean induction-abortion interval time of 17.38+2.86. Mean dose required was 1560mcg. Efficacy of protocol was 92.85% in achieving complete abortion. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Thus by using a lower dose and appropriate interval between two doses (six hours), the side effects were lessened with high efficacy. Keywords: Efficacy, Missed Abortion, Misoprostol.

scholarly journals Clinical cytogenetic studies on patients with cleft lip and/or cleft palate. 2. Chromosome analysis of twins.

1990 ◽  
Vol 57 (1) ◽  
pp. 12-15
Author(s):  
Kenji Hashimoto ◽  
Shigetoshi Shioda ◽  
Hidemi Yoshimasu ◽  
Kohyoh Nakamura ◽  
Takashi Tamura ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Chromosome Analysis ◽  
Cytogenetic Studies

A morphometric approach to the relation of karyotype, gestational age and histological features in early spontaneous abortions

Placenta ◽  
1994 ◽  
Vol 15 (2) ◽  
pp. 189-200 ◽  
Author(s):  
G. Van Lijnschoten ◽  
J.W. Arends ◽  
F.B.J.M. Thunnissen ◽  
J.P.M. Geraedts
Keyword(s):  
Gestational Age ◽  
Spontaneous Abortions ◽  
Histological Features

CONSANGUINITY AND MATERNAL AGE;

2017 ◽  
Vol 24 (04) ◽  
pp. 511-515
Author(s):  
Nayyab Zehra ◽  
Ahmed Hassaan Malik ◽  
Zahabia Khalid ◽  
Misha Sabir ◽  
Simra Tanvir ◽  
...  
Keyword(s):  
Family History ◽  
Gestational Age ◽  
Maternal Age ◽  
Sampling Technique ◽  
Reproductive Age ◽  
Military Hospital ◽  
Age Group ◽  
Spontaneous Abortions ◽  
Cross Sectional ◽  
History Of

Objectives: To determine the frequency of risk factors i.e. consanguinity andmaternal age associated with spontaneous abortions in Pakistan and to propose ways toreduce them. Study design: Cross sectional descriptive study. Place of study: Gynecologydepartment of Military Hospital and Combined Military Hospital, Rawalpindi. Duration ofstudy: 6 months (September 2015 to February 2016). Sampling technique: Non probabilityconvenient sampling. Methodology: 150 married female patients in reproductive age group(15-49 years), who were confirmed cases of pregnancy and presented with abortions, wereinterviewed and responses were filled in a structured questionnaire after written consent.The collected data was then entered and analyzed by SPSS 20.0. Results: The major bulkof spontaneous abortions occurred in the maternal age group of 25-35 years (55.3%). A totalof 53.3% of abortions occurred in the gestational age of less than 12 weeks. Around 54.7% offemales had family history of spontaneous abortions and 65.3% had consanguineous marriage.Conclusion: Spontaneous abortions occur more frequently in the females of 25-35 yearsage group and among the fetuses with gestational age less than 12 weeks (1st trimester ofpregnancy). Family history of spontaneous abortions and consanguinity are associated withspontaneous abortions.

First Trimester Hemoglobin A1 and Risk for Major Malformation and Spontaneous Abortion

2021 ◽  
pp. 13-19
Author(s):  
Rachel Blake ◽  
Chloe Zera
Keyword(s):  
Spontaneous Abortion ◽  
Clinical Case ◽  
First Trimester ◽  
Spontaneous Abortions ◽  
Major Malformation ◽  
Fetal Malformations ◽  
Study Population ◽  
Hemoglobin A1 ◽  
Location Study

This chapter summarizes a landmark study on the association of first trimester hemoglobin A1 values with risk for spontaneous abortions and major fetal malformations during pregnancy in women with pregestational diabetes. Is there a correlation between glycemic control during the first trimester and risk for spontaneous abortion and major malformations? Starting with this question, it describes the basics of the study, including study location, study population, amount of patients, study design, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

scholarly journals The association between seasonal influenza-like illness cases and foetal death: a time series analysis

2018 ◽  
Vol 147 ◽  
Author(s):  
I. S. Rasmussen ◽  
L. H. Mortensen ◽  
T. G. Krause ◽  
A-M. Nybo Andersen
Keyword(s):  
Time Series ◽  
Time Series Analysis ◽  
Spontaneous Abortion ◽  
Seasonal Pattern ◽  
Influenza Virus Infection ◽  
Temporal Association ◽  
Spontaneous Abortions ◽  
Foetal Death ◽  
Influenza Like Illness ◽  
Series Analysis

AbstractIt has been reported that foetal death follows a seasonal pattern. Influenza virus infection has been postulated as one possible contributor to this seasonal variation. This ecological study explored the temporal association between the influenza activity and the frequency of foetal death. Time series analysis was conducted using weekly influenza-like illness consultation proportions from the Danish sentinel surveillance system and weekly proportions of spontaneous abortions and stillbirths from hospital registers from 1994 to 2009. The association was examined in an autoregressive (AR) integrated (I) moving average (MA) model and subsequently analysed with cross-correlation functions. Our findings confirmed the well-known seasonality in influenza, but also seasonality in spontaneous abortion. No clear pattern of seasonality was found for stillbirths, although the analysis exposed dependency between observations. One final AR integrated MA model was identified for the influenza-like illness (ILI) series. We found no statistically significant relationship between weekly influenza-like illness consultation proportions and weekly spontaneous abortion proportions (five lags: P = 0.52; 11 lags: P = 0.91) or weekly stillbirths (five lags: P = 0.93; 11 lags: P = 0.40). Exposure to circulating influenza during pregnancy was not associated with rates of spontaneous abortions or stillbirths. Seasonal variations in spontaneous abortion were confirmed and this phenomenon needs further investigation.

scholarly journals Human Papillomavirus Infection as a Possible Cause of Spontaneous Abortion and Spontaneous Preterm Delivery

2016 ◽  
Vol 2016 ◽  
pp. 1-19 ◽  
Author(s):  
Lea Maria Margareta Ambühl ◽  
Ulrik Baandrup ◽  
Karen Dybkær ◽  
Jan Blaakær ◽  
Niels Uldbjerg ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Preterm Delivery ◽  
Spontaneous Abortion ◽  
Adverse Outcome ◽  
Geographical Location ◽  
Full Term ◽  
Detection Methods ◽  
Spontaneous Abortions ◽  
Spontaneous Preterm Delivery ◽  
Hpv Prevalence

Based on the current literature, we aimed to provide an overview on Human Papillomavirus prevalence in normal pregnancies and pregnancies with adverse outcome. We conducted a systematic literature search in PubMed and Embase. Data extracted from the articles and used for analysis included HPV prevalence, pregnancy outcome, geographical location, investigated tissue types, and HPV detection methods. The overall HPV prevalence in normal full-term pregnancies was found to be 17.5% (95% CI; 17.3–17.7) for cervix, 8.3% (95% CI; 7.6–9.1) for placental tissue, 5.7% (95% CI; 5.1–6.3) for amniotic fluid, and 10.9% (95% CI; 10.1–11.7) for umbilical cord blood. Summary estimates for HPV prevalence of spontaneous abortions and spontaneous preterm deliveries, in cervix (spontaneous abortions: 24.5%, and preterm deliveries: 47%, resp.) and placenta (spontaneous abortions: 24.9%, and preterm deliveries: 50%, resp.), were identified to be higher compared to normal full-term pregnancies (P<0.05andP<0.0001). Great variation in HPV prevalence was observed between study populations of different geographical locations. This review demonstrates an association between spontaneous abortion, spontaneous preterm delivery, and the presence of HPV in both the cervix and the placenta. However, a reliable conclusion is difficult to draw due to the limited number of studies conducted on material from pregnancies with adverse outcome and the risk of residual confounding.

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