A compendium of the histone H1 family of somatic subtypes: An elusive cast of characters and their characteristics

2001 ◽  
Vol 79 (3) ◽  
pp. 289-304 ◽  
Author(s):  
Missag H Parseghian ◽  
Barbara A Hamkalo
Keyword(s):  
Historical Context ◽  
Histone H1 ◽  
General Function ◽  
Linker Histones ◽  
Chromatin Compaction ◽  
The Core ◽  
The Past ◽  
Current State ◽  
Core Histones

The last 35 years has seen a substantial amount of information collected about the somatic H1 subtypes, yet much of this work has been overshadowed by research into highly divergent isoforms of H1, such as H5. Reports from several laboratories in the past few years have begun to call into question some of the traditional views regarding the general function of linker histones and their heterogeneity. Hence, the impression in some circles is that less is known about these ubiquitous nuclear proteins as compared with the core histones. The goal of the following review is to acquaint the reader with the ubiquitous somatic H1s by categorizing them and their characteristics into several classes. The reasons for our current state of misunderstanding is put into a historical context along with recent controversies centering on the role of H1 in the nucleus. Finally, we propose a model that may explain the functional role of H1 heterogeneity in chromatin compaction.Key words: histone H1, linker histones, chromatin organization, chromatin compaction, heat shock.

Chromatin structures condensed by linker histones

2019 ◽  
Vol 63 (1) ◽  
pp. 75-87 ◽  
Author(s):  
Bing-Rui Zhou ◽  
Yawen Bai
Keyword(s):  
Structural Unit ◽  
Linker Histone ◽  
Histone H2a ◽  
Linker Histones ◽  
The Core ◽  
High Order Chromatin Structure ◽  
Core Histones ◽  
Order Structures ◽  
Made In

Abstract In eukaryotic cells, genomic DNA exists in the form of chromatin through association with histone proteins, which consist of four core histone (H2A, H2B, H3, and H4) families and one linker histone (H1) family. The core histones bind to DNA to form the nucleosome, the recurring structural unit of chromatin. The linker histone binds to the nucleosome to form the next structural unit of chromatin, the chromatosome, which occurs dominantly in metazoans. Linker histones also play an essential role in condensing chromatin to form higher order structures. Unlike the core histones in the formation of the nucleosome, the role of linker histone in the formation of the chromatosome and high-order chromatin structure is not well understood. Nevertheless, exciting progress in the structural studies of chromatosomes and nucleosome arrays condensed by linker histones has been made in the last several years. In this mini-review, we discuss these recent experimental results and provide some perspectives for future studies.

Current state and main directions of preservation and strengthening of health of the working population of Russia

2020 ◽  
pp. 527-532 ◽  
Author(s):  
I. V. Bukhtiyarov
Keyword(s):  
Working Conditions ◽  
Russian Federation ◽  
Production Environment ◽  
Working Population ◽  
Industrial Enterprises ◽  
The Past ◽  
Production Factors ◽  
Current State ◽  
The Russian Federation

The article presents the results of the analysis of health, working conditions and prevalence of adverse production factors, the structure of the detected occupational pathology in the working population of the Russian Federation. The article presents Statistical data on the dynamics of the share of workplaces of industrial enterprises that do not meet hygienic standards, occupational morbidity in 2015-2018 for the main groups of adverse factors of the production environment and the labor process. The indicators of occupational morbidity over the past 6 years in the context of the main types of economic activity, individual subjects of the Russian Federation, classes of working conditions, levels of specialized occupational health care. The role of the research Institute of occupational pathology and occupational pathology centers in solving organizational, methodological and practical tasks for the detection, treatment, rehabilitation and prevention of occupational diseases is shown. The basic directions of activity in the field of preservation and strengthening of health of workers, and also safety at a workplace are defined.

Acid ceramidase, a double-edged sword in cancer aggression: A minireview

2020 ◽  
Vol 20 ◽  
Author(s):  
Helen Shiphrah Vethakanraj ◽  
Niveditha Chandrasekaran ◽  
Ashok Kumar Sekar
Keyword(s):  
Cell Fate ◽  
Cancer Progression ◽  
Potential Role ◽  
Tumour Progression ◽  
Acid Ceramidase ◽  
The Core ◽  
The Past ◽  
Sphingosine 1 Phosphate ◽  
Key Enzyme

: Acid ceramidase (AC), the key enzyme of the ceramide metabolic pathway hydrolyzes pro-apoptotic ceramide to sphingosine, which by the action of sphingosine-1-kinase is metabolized to mitogenic sphingosine-1-phosphate. The intracellular level of AC determines ceramide/sphingosine-1-phosphate rheostat which in turn decides the cell fate. The upregulated AC expression during cancerous condition acts as a “double-edged sword” by converting pro-apoptotic ceramide to anti-apoptotic sphingosine-1-phosphate, wherein on one end, the level of ceramide is decreased and on the other end, the level of sphingosine-1-phosphate is increased, thus altogether aggravating the cancer progression. In addition, cancer cells with upregulated AC expression exhibited increased cell proliferation, metastasis, chemoresistance, radioresistance and numerous strategies were developed in the past to effectively target the enzyme. Gene silencing and pharmacological inhibition of AC sensitized the resistant cells to chemo/radiotherapy thereby promoting cell death. The core objective of this review is to explore AC mediated tumour progression and the potential role of AC inhibitors in various cancer cell lines/models.

scholarly journals Site-specific ubiquitylation acts as a regulator of linker histone H1

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Eva Höllmüller ◽  
Simon Geigges ◽  
Marie L. Niedermeier ◽  
Kai-Michael Kammer ◽  
Simon M. Kienle ◽  
...  
Keyword(s):  
Posttranslational Modifications ◽  
Histone H1 ◽  
Linker Histone ◽  
Active Chromatin ◽  
Site Specific ◽  
Linker Histone H1 ◽  
Fundamental Process ◽  
Core Histones ◽  
Wide Scale

AbstractDecoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is well studied for PTMs of core histones but not for linker histone H1 in general and its ubiquitylation in particular due to a lack of proper tools. Here, we report on the chemical synthesis of site-specifically mono-ubiquitylated H1.2 and identify its ubiquitin-dependent interactome on a proteome-wide scale. We show that site-specific ubiquitylation of H1 at position K64 modulates interactions with deubiquitylating enzymes and the deacetylase SIRT1. Moreover, it affects H1-dependent chromatosome assembly and phase separation resulting in a more open chromatosome conformation generally associated with a transcriptionally active chromatin state. In summary, we propose that site-specific ubiquitylation plays a general regulatory role for linker histone H1.

Jerzy Topolski’s Marxist Anthropocentrism

2021 ◽  
Vol 15 (3) ◽  
pp. 361-377
Author(s):  
Ewa Domańska ◽  
Paul Vickers
Keyword(s):  
Historical Materialism ◽  
Philosophy Of History ◽  
Marxist Theory ◽  
Collective Agency ◽  
Future Developments ◽  
The Past ◽  
Current State ◽  
The World ◽  
Separate Discipline

Abstract In this article I demonstrate that the ideas outlined in Jerzy Topolski’s Methodology of History (Polish 1968, English translation 1976) could not only offer a reference point for and indeed enrich ongoing debates in the philosophy of history, but also help to set directions for future developments in the field. To support my argument, I focus on two themes addressed in Topolski’s work: 1) the understanding of the methodology of history as a separate discipline and its role both in defending the autonomy of history and in creating an integrated knowledge of the past, which I read here through the lens of the current merging of the humanities and natural sciences; and 2) the role of a Marxist anthropocentrism based on the notion of humans as the creators of history, which I consider here in the context of the ongoing critique of anthropocentrism. I point to the value of continuing to use concepts drawn from Marxist vocabulary, such as alienation, emancipation, exploitation and overdetermination, for interpreting the current state of the world and humanity. I stress that Marxist anthropocentrism, with its support for individual and collective agency, remains crucial to the creation of emancipatory theories and visions of the future, even if it has faced criticism for its Eurocentrism and might seem rather familiar and predictable when viewed in the context of the contemporary humanities. Nevertheless, new manifestations of Marxist theory, in the form of posthumanist Marxism and an interspecies historical materialism that transcends anthropocentrism, might play an important role in redefining the humanities and humanity, including its functions and tasks within human and multispecies communities.

Struggling with the Past: Women's Theatre in Search of a History

1989 ◽  
Vol 5 (18) ◽  
pp. 107-112 ◽  
Author(s):  
Susan Bassnett
Keyword(s):  
Cultural Change ◽  
Historical Context ◽  
Feminist Criticism ◽  
Elizabeth I ◽  
The Past ◽  
Feminist Study ◽  
Introductory Article ◽  
Theatre Studies ◽  
The University

Theatre scholarship is only just beginning to respond to the insights and emphases suggested by feminist criticism. In this introductory article to what we intend to be a strong and continuing thread in NTQ, Susan Bassnett outlines the resulting problems, and explores the historical context and conditions in terms of one central issue – the role of women as performers (and non-performers) in the sixteenth and seventeenth centuries. She also examines some of the wider implications for theatre studies, affected as these also are by new historicist approaches to the study of cultural change. Susan Bassnett teaches in the Graduate School of Comparative Literary Theory in the University of Warwick, and has been a regular contributor to New Theatre Quarterly and other journals, notably in the field of Italian theatre. Her most recent books include a feminist study of Elizabeth I, and (in collaboration with John Stokes and Michael Booth) Bernhardt. Terry, Duse: the Actress in Her Time.

The Place of Political Science in Canadian Universities

1998 ◽  
Vol 31 (4) ◽  
pp. 643-658 ◽  
Author(s):  
Tom Pocklington
Keyword(s):  
Political Science ◽  
Reflective Inquiry ◽  
Remedial Action ◽  
Canadian Universities ◽  
The Past ◽  
Proper Role ◽  
Current State

AbstractThis article addresses the proper role of political science in Canadian universities. The thesis is twofold: first, the main tasks of political scientists are first-rate teaching and reflective inquiry about citizenship: second, in the past few years we have been moving away from this understanding, and remedial action is required. Our delinquency stems mainly from our obsession with “frontier research,” the main result of which is the widespread decline of attentive teaching, which we rationalize with a number of implausible myths. We are primarily responsible for the current state of political science, and only we can remedy it.

On the Laws and Theories of Sliding Friction

2015 ◽  
Author(s):  
Nannaji Saka
Keyword(s):  
Sliding Friction ◽  
Historical Context ◽  
Patterned Surfaces ◽  
Wear Particles ◽  
The Past ◽  
Delamination Wear ◽  
The Many ◽  
Novel Concept ◽  
Lubricated Sliding

The many seminal contributions made by Professor Nam P. Suh to the theories of wear, such as the delamination wear and the solution wear, are well known. The contributions made by him and his associates to the theories of friction, however, are less known; but they are equally significant. In this article, I first briefly survey, to provide an historical context, the laws and theories of sliding friction as proposed over the past centuries and decades. Then the contributions of Prof. Suh and his associates in recent decades are reviewed. Specifically, the role of wear particles in the frictional phenomena of dry and boundary-lubricated sliding is examined. A novel concept of undulating, or patterned, surfaces has been advanced to minimize friction in both dry and boundary-lubricated sliding. The undulating surfaces trap wear debris and thus minimize plowing friction in dry sliding, above the transition temperature in boundary-lubricated sliding, and even in hydrodynamic bearings during start/stop operations. The concept is especially appropriate for heavily loaded tribological systems with tighter clearances in which the likelihood of seizure is imminent.

The role of pulmonary intravascular macrophages in porcine reproductive and respiratory syndrome virus infection

2000 ◽  
Vol 1 (2) ◽  
pp. 95-102 ◽  
Author(s):  
Roongroje Thanawongnuwech ◽  
Patrick G. Halbur ◽  
Eileen L. Thacker
Keyword(s):  
Virus Titer ◽  
Respiratory Syndrome Virus ◽  
The Past ◽  
Current State ◽  
Viral Particles ◽  
Increased Susceptibility ◽  
Pulmonary Intravascular Macrophages

AbstractThe objective of this article is to summarize the current state of knowledge of the complex interaction of porcine reproductive and respiratory syndrome virus (PRRSV) and porcine pulmonary intravascular macrophages (PIMs). PIMs play an important role in pulmonary surveillance, and in the past few years we have investigated their role in PRRSV infection. PRRSV antigens and nucleic acids have been demonstrated in PIMs bothin vitroandin vivo. Examination of cultured PIMs infected with PRRSV revealed the accumulation of viral particles in the smooth-walled vesicles. PRRSV-infected PIMsin vitroyielded a virus titer similar to pulmonary alveolar macrophages. PRRSV infection induces either apoptosis or cell lysis of PIMs. Thein vitrobactericidal activity of PRRSV-infected PIMs is significantly decreased. Phagocytic activity of PIMs, as measured by pulmonary copper clearance, is significantly decreased in PRRSV-infected pigs. This evidence supports the hypothesis that PRRSV-induced damage to PIMs results in increased susceptibility to bacteremic diseases. Recent studies with PRRSV andStreptococcus suiscoinfection confirmed that PRRSV predisposes pigs toS. suisinfection and bacteremia. These results could explain the increase in bacterial respiratory diseases and septicemias observed in PRRSV-infected pigs.

scholarly journals TAFSIR GENDER

2016 ◽  
Vol 10 (1) ◽  
pp. 79-98
Author(s):  
Tri Wahyudi Ramdhan
Keyword(s):  
Gender Equality ◽  
Gender Bias ◽  
Historical Context ◽  
Men And Women ◽  
The Past ◽  
Limited Role ◽  
Islamic Thought ◽  
Role Of Women ◽  
At Will

Traditional Islamic thought in general provides limited role of women as wives and mothers. Based on the view of classical Islamic texts and literature are still seen that women are still marginalized, or in other words, women are still under the domination of men. Therefore, women need to construct a discourse or text at will. It is undeniable that the interpretation of the classical scholars on the concept of equality of men and women from the perspective of today may well be judged as biased. For interpretations of the past can not be released to the socio-historical context of the time. Departing from the problems mentioned above then this article would like to see and analyze how the concepts offered and presented Islam in view of gender equality between men and women starting from the concept of gender so that the concept of gender bias by sex.Selanjutnyan followed by a discussion of the word gender mufrodat in the Qur'an and concludes with the interpretation of the discourse of gender equality. Dalama This commentary will set forth the extent where the equality between men and women

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