scholarly journals Gastroprotective Effects of Methanolic Leaves and Stem Extracts of Sphagneticola trilobata on Indomethacin-Induced Gastric Ulcer in Rats

2021 ◽  
Vol 34 (1) ◽  
pp. 111-117
Author(s):  
Kartik Singhal ◽  
Chandana Majee ◽  
Bhavani Pentela ◽  
Vikas Sharma
Keyword(s):  
Gastric Ulcer ◽  
South America ◽  
Medicinal Plant ◽  
Protective Effect ◽  
Folk Medicine ◽  
Gastric Ulcers ◽  
Control Group ◽  
Methanolic Extracts ◽  
Neutrophil Percentage ◽  
Stem Extract

The medicinal plant Sphagneticola trilobata native to South America is used in local folk medicine to treat inflammation and analgesics. In present study, gastroprotective effects of methanolic extracts of S. trilobata leaves and stem were investigated in indomethacin-induced gastric ulcers in rats at doses of 200 mg/kg for leave extract and 350 mg/kg for stem extract. Indomethacin produced stomach ulcers and increased neutrophil percentage and MDA levels compared to the control group (p < 0.001). Co-administration of indomethacin and omeprazole, methanolic extracts of leaves (200 mg/kg) (p < 0.001) and methanolic extracts (350 mg/kg) (p < 0.05) of stem compared to indomethacin group to ulcers was low (p < 0.001). Methanolic extracts (200 mg/kg) of leaves and methanolic extracts (350 mg/kg) of stem reduced MDA levels (p < 0.001). Methanolic extracts (200 mg/kg) of leaves and methanolic extracts (350 mg/kg) of the stem significantly decreased neutrophil percentage compared to indomethacin group (p < 0.001). The results suggest that the methanolic extracts of Sphagneticola trilobata leaves and stem have a protective effect on indomethacin-induced gastric ulcers.

A STUDY ON THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND TRACE ELEMENTS IN GASTRIC MUCOSA

2006 ◽  
Vol 16 (01n02) ◽  
pp. 55-68
Author(s):  
T. FUKUDA ◽  
S. SAKURAI ◽  
M. KUDO
Keyword(s):  
Helicobacter Pylori ◽  
Trace Elements ◽  
Gastric Ulcer ◽  
Gastric Mucosa ◽  
Gastric Ulcers ◽  
Control Group ◽  
Human Gastric Mucosa ◽  
H2 Receptor Antagonist ◽  
Zinc Levels ◽  
The Relationship

H2 receptor antagonist (H2RA) and proton pump inhibitor(PPI) are often used to treat gastric ulcers, in addition to the zinc-L-carcino-complex which is commonly adopted for such therapies. However, there have been no previous reports detailing the levels and distribution of zinc in human gastric mucosa. The aim of our current study is to clarify the relationship between Helicobacter pylori infection and trace elements such as zinc in gastric mucosa using particle induced X-ray emission (PIXE). Forty gastric ulcer patients were chosen as subjects of this study and divided into two groups. One is a new ulcer patients group(twenty nine cases). And the other, eleven of these patients had been prescribed zinc-L-carcino-complex (polapreZinc®), at a dose of 150mg/day for periods ranging from 16 to 20 weeks. The zinc levels in the gastric ulcer group were found to be significantly less than those of the control group and the concentrations of zinc in gastric mucosa were observed to increase following the administration of treatments containing this element.

scholarly journals Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Vivian Molina Cuevas ◽  
Yazmín Ravelo Calzado ◽  
Yohani Pérez Guerra ◽  
Ambar Oyarzábal Yera ◽  
Sonia Jiménez Despaigne ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Gastric Ulcer ◽  
Vitamin E ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Positive Control ◽  
Negative Control ◽  
Seed Extract ◽  
Gastric Ulcers ◽  
Control Group

Effects of GSE and vitamins C and E on aspirin- and ethanol-induced gastric ulcer and associated increases of lipid peroxidation in rats were compared. Two experiments were conducted. Rats were randomized into eight groups: a negative control and seven groups that received aspirin or ethanol for ulcer induction: one positive control (vehicle) and six with VC, VE, or GSE (25 and 250 mg/kg). Ulcer indexes and gastric levels of malondialdehyde (MDA) were quantified. VC, VE, and GSE (25 and 250 mg/kg) decreased aspirin, and ethanol-induced ulcers and MDA values compared with positive control group. The magnitude of aspirin ulcer reduction was comparable for all treatments, and MDA decrease with GSE was higher than with VC and tended to be greater, albeit none significantly, than with VE. GSE was more effective than VC and VE for lowering the ethanol ulcers, while the decrease of MDA levels with GSE was greater than with VC, but comparable to that achieved with VE. GSE protected against ethanol-induced gastric ulcers more effectively than VC or VE, while its protection against aspirin ulcers was comparable for all treatments. GSE produced the greatest reductions of gastric MDA in both models.

scholarly journals EVALUATION OF ANTI ULCER ACTIVITY OF HYDROALCOHOLIC LEAVES EXTRACT OF LEUCAS ASPERA

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Surjeet Kumar ◽  
Narendra Patel ◽  
Prabhakar Budholiya
Keyword(s):  
Gastric Ulcer ◽  
Secondary Metabolites ◽  
Lethal Dose ◽  
Folk Medicine ◽  
Gastric Ulcers ◽  
Leucas Aspera ◽  
Pharmacologic Activity ◽  
Pre Treatment ◽  
Repeated Dosing ◽  
Dose Dependent

The main aim of the study was to determine the phytoconstituents present in Leaves of Leucas aspera. The present study was therefore carried out to evaluate the anti-ulcer activity of Hydroalcoholic (70% methanol) leaf extract of Leucas aspera in rats. The effect of Leucas aspera extract on gastric ulcer in rats in indomethacin induced gastric ulcers model and ethanol-induced models was studied using single dosing (100, 200 mg/kg) and repeated dosing (200 mg/kg for 5 days) approaches. Ranitidine (50 mg/kg) and cimetidine (100 mg/kg) were used as the standard drugs. Depending on the model, outcome measures were volume ulcer index. Data were analyzed using one-way analysis of variance and P<0.05 was considered as statistically significant. Leucas aspera significantly (P<0.001) reduced gastric ulcer, respectively, in indomethacin induced gastric ulcers model and ethanol-induced models at the 200 mg/kg dose, which is comparable to the standard drugs. 5 days pre-treatment with Leucas aspera 200 mg/kg exhibited significant (P<0.001) ulcer inhibition. Leucas aspera  possesses both dose-dependent and time-dependent anti-ulcer effect in the two models. The oral median lethal dose (LD50) is estimated to be higher than 2000 mg/kg for the crude hydroalcoholic extract, and secondary metabolites such as flavonoids, tannins, and saponins were present. The findings of this study confirmed that Leucas aspera has anti-ulcer pharmacologic activity due to one or more of the secondary metabolites present in it. Therefore, this study validates its anti-ulcer use in Ethiopian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed.

scholarly journals Tablet of Spondias mombin L. Developed from Nebulized Extract Prevents Gastric Ulcers in Mice via Cytoprotective and Antisecretory Effects

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1581
Author(s):  
Maria Elaine Araruna ◽  
Pablo Silva ◽  
Maria Almeida ◽  
Renaly Rêgo ◽  
Raiff Dantas ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Katp Channels ◽  
Gastric Ulcers ◽  
Control Group ◽  
Gastroprotective Activity ◽  
Oral Toxicity ◽  
Quality Requirements ◽  
Spondias Mombin ◽  
Worldwide Distribution ◽  
Endogenous Prostaglandins

Spondias mombin L. (Anacardiaceae) has a worldwide distribution and is present in all regions of Brazil. Its leaves, flowers and bark are used as teas in folk medicine to treat diseases of the digestive system. This study aimed to evaluate the acute non-clinical toxicity, gastroprotective activity, and the related mechanisms of action of nebulized extract and tablets based on dried Spondias mombin (SmNE). SmNE screening showed the presence of flavonoids (0.65%), polyphenols (25.50%), where the major compound is gallic acid. In the acute oral toxicity assay, a dose of 2000 mg/kg of SmNE administered orally in Swiss mice did not induce any behavioral changes. SmNE (250 or 500 mg/kg p.o) significantly reduced the ulcerative lesion area when compared to the control group in ethanol and non-steroidal anti-inflammatory drug (NSAIDs) models. Results showed that treatment with SmNE (250 mg/kg) reduced acid secretion and gastric content, accompanied with an increase in pH. Previous administration of indomethacin and glibenclamide reversed the protection provided by SmNE, confirming the participation of prostaglandins (PGs) and ATP-sensitive potassium channels (KATP) in its gastroprotective effect. The SmNE tablets met the pharmacopeial quality requirements with gastroprotective activity and similar protection in comparison to the isolated extract administrated. In conclusion, SmNe has a gastroprotective activity related to cytoprotective mechanisms, such as the participation of endogenous prostaglandins and KATP channels, having an anti-secretory effect with systemic action. The formulation obtained presented gastroprotective effects similar to the administration of the extract, the tablets showed favorable compression characteristics by the direct route and met the pharmacopeial quality requirements.

scholarly journals Anti-Gastric Ulcer Activity of the Water Extract from Payawanorn (Pseuderanthemum Palatiferum)

2018 ◽  
Vol 36 (2) ◽  
pp. 89
Author(s):  
Kannika Inchab ◽  
Parirat Khonsung ◽  
Natthakarn Chiranthanut ◽  
Puongtip Kunanusorn ◽  
Saranyapin Potikanond ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Alcian Blue ◽  
Water Immersion ◽  
Gastric Wall ◽  
Water Extract ◽  
Gastric Ulcers ◽  
Control Group ◽  
P Value ◽  
Ulcer Formation ◽  
Traditional Use

Objective: To examine the anti-gastric ulcer activity of Payawanorn (Psuderanthemum palatiferum)  water extract (PPE) in rats.Material and Methods: Evaluation of anti-gastric ulcer activity of PPE was performed using three induced gastric ulcers models: (1) ethanol/hydrochloric acid (EtOH/HCl), (2) restraint water immersion stress and (3) indomethacin. Ulcer indices were determined by microscopic examination (10X). Pylorus ligation and gastric-wall mucus determination were used to investigate the mechanism of anti-gastric ulcer activity of PPE.Results: Oral administration of PPE (150, 300 and 600 mg/kg) significantly inhibited gastric ulcer formation induced by EtOH/HCl, by water immersion restraint stress, and by indomethacin in rats (p-value<0.05). PPE at 600 mg/kg showed a high percent inhibition of gastric ulcer formation in all models. In the pylorus-ligated model, pretreatment with PPE had no effect on pH, acidity output or the gastric acid secretion rate, demonstrating that PPE lacks an anti-secretory effect. Gastric wall mucus was markedly preserved by pretreatment PPE at 600 mg/kg (18.91±2.57 μg alcian blue/g wet stomach) after ethanol-induced ulcer when compared to that the control group (12.38±1.02 μg alcian blue/ g wet stomach).Conclusion: PPE possesses an anti-gastric ulcer effect related to the preservation of gastric mucus, supporting the traditional use of P. palatiferum to treat gastric ulcers.

scholarly journals EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION

2020 ◽  
Vol 30 (1) ◽  
pp. 8
Author(s):  
Audi Salman Faza ◽  
Linda Dewanti ◽  
Ema Qurnianingsih
Keyword(s):  
Body Weight ◽  
Gastric Ulcer ◽  
Low Dose ◽  
Food Additives ◽  
Gastric Ulcers ◽  
Control Group ◽  
High Dose ◽  
Ulcer Formation ◽  
Group 3 ◽  
Group 1

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Material and Method: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p <0.050. Result: The results showed that body weight was significantly different on the 6 th week between Control vs Group 1 (p= 0.010) and Control vs Group 3 (p= 0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p= 0.019 and 0.011 respectively). Conclusion:  Both of low dose (150mg / kg BW) and high dose (300mg / kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.  

scholarly journals The Effects of Administration of Mangosteen Pericap's Ethanolic Extract and Xanthone on Angiogenesis of Gastric Ulcer Healing in Wistar Rats Observed Through the Increase in the level of NO and VEGF and CD-31 Expressions

2011 ◽  
Vol 3 (3) ◽  
pp. 191
Author(s):  
Ika Kustiyah Oktaviyanti ◽  
Djanggan Sargowo ◽  
Mohammad Aris Widodo ◽  
Karyono Mintaroem
Keyword(s):  
Gastric Ulcer ◽  
Treatment Group ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Immunohistochemical Analysis ◽  
The Other ◽  
Gastric Ulcers ◽  
Control Group ◽  
Cd 31 ◽  
Post Test

BACKGROUND: NSAIDs can cause gastric ulcer or may delay the healing of it. Upon exposure to indomethacin, gastric ulcer can occur due to oxidants. Mangosteen rind contains xanthone, which is a natural antioxidant. Administration of this antioxidant may increase angiogenesis that can accelerate healing of gastric ulcer.METHODS: This study used an experimental method with randomized post test control only design using Wistar rats. The rats were put on fasting for 24 hours, then a single dose of 30mg/kg body weight (BW) Indomethacine was given. The rats were divided into control group and treatment group. The treatment group was further divided into two subgroups: one group was given a daily 200 mg/kg BW mangosteen pericap extract, and the other group was given 35 mg/kg BW Xanthone. Both the control group and treatment group were decapitated on the 3rd day, 6th day and 12th day, respectively. After decapitation, the stomach of each rat was taken and divided into two portions, one portion was used for NO examination by ELISA, and the other portion for hispathological examination and immunohistochemical analysis for assessing CD 31 and VEGF expressions.RESULTS: Administration of mangoosteen pericap and xanthone could accelerate healing of gastric ulcers as compared with the control, as shown by the decrease in the severity level of the ulcers. Mangoosteen pericap and xanthone could also increase NO, VEGF expression, and CD-31 as compared with the control, especially on the 3rd day of treatment. Explanation of this finding might be that the antioxidants contained in the mangoosteen pericap or in xanthone could bind with radical superoxide and accelerate release of free NO. The increase of NO caused increase of VEGF and CD-31 that could accelerate angiogenesis, which eventually could accelerate healing of the gastric ulcers.CONCLUSIONS: The effect of mangosteen pericap's extract and xanthone can improve healing of gastric ulcers by increasing nitric oxide and also can increase angiogenesis as shown by the increase of VEGF and CD-31 expressions.KEYWORDS: mangosteen, healing, gastric Ulcer, angiogenesis

Protective effect of polysaccharides from Radix Hedysari on gastric ulcers induced by acetic acid in rats

2019 ◽  
Vol 10 (7) ◽  
pp. 3965-3976 ◽  
Author(s):  
Zhiyuan Xue ◽  
Gengen Shi ◽  
Yaoyao Fang ◽  
Xiaohua Liu ◽  
Xianglin Zhou ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Protective Effect ◽  
Gastric Ulcers

The potential anti-gastric ulcer effects of Hedysarum polysaccharides (HPS-50 and HPS-80) were explored in rats.

scholarly journals Anti-ulcer activity of Ipomoea batatas tubers (sweet potato)

2012 ◽  
Vol 2 (3) ◽  
pp. 48 ◽  
Author(s):  
Vandana Panda ◽  
Madhav Sonkamble
Keyword(s):  
Lipid Peroxidation ◽  
Gastric Ulcer ◽  
Cold Stress ◽  
Sweet Potato ◽  
Ulcer Healing ◽  
Ipomoea Batatas ◽  
Significant Inhibition ◽  
Gastric Ulcers ◽  
Peptic Ulcers ◽  
Methanolic Extracts

Background: Peptic ulcers occur in that part of the gastrointestinal tract which is exposed to gastric acid and pepsin, i.e., the stomach and duodenum. Gastric and duodenal ulcers are common pathologies that may be induced by a variety of factors such as stress, smoking and noxious agents including non-steroidal anti-inflammatory drugs. Ipomoea batatas tubers (sweet potato) contain ample amounts of antioxidants. It has been proven already by many scientific studies that antioxidants have ulcer healing properties. In reference to this, we tried assessing the ulcer healing effect of Ipomoea batatas tubers. Methods: The anti-ulcer activity of the tubers of Ipomoea batatas (sweet potato) was studied in cold stress and aspirin-induced gastric ulcers in Wistar rats. Methanolic extracts of Ipomoea batatas tubers (TE) at two doses, viz., 400 and 800 mg /kg were evaluated in cold stress and aspirin-induced gastric ulcer models using cimetidine and omeprazole respectively as standards. The standard drugs and the test drugs were administered orally for 7 days in the cold stress model and for 1 day in the aspirin-induced gastric ulcer model. Gastroprotective potential, status of the antioxidant enzymes {superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase(GR)} along with GSH, and lipid peroxidation were studied in both models. Results: The results of the present study showed that TE possessed gastroprotective activity as evidenced by its significant inhibition of mean ulcer score and ulcer index and a marked increase in GSH, SOD, CAT, GPx, and GR levels and reduction in lipid peroxidation in a dose dependant manner.Conclusion: The present experimental findings suggest that tubers of Ipomoea batatas may be useful for treating peptic ulcers.Key Words: Sweet potato tubers, cold stress, aspirin, ulcer, antioxidants.

scholarly journals The feasibility of a novel injectable hydrogel for protecting artificial gastrointestinal ulcers after endoscopic resection: an animal pilot study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuko Miura ◽  
Yosuke Tsuji ◽  
Rina Cho ◽  
Ayano Fujisawa ◽  
Masahiko Fujisawa ◽  
...  
Keyword(s):  
Pilot Study ◽  
Protective Effect ◽  
Physical Properties ◽  
Gastric Ulcers ◽  
Control Group ◽  
Perforation Rate ◽  
Coating Materials ◽  
Injectable Hydrogel ◽  
Residual Rate ◽  
Secondary Endpoints

AbstractRecently, covering materials for protecting post-endoscopic ulcers are being developed using hydrogels. Existing hydrogels are not ideal coating materials because it is difficult to control their physical properties. Therefore, we conducted an animal pilot study to investigate the protective effect of a novel ulcer coating material, whose physical properties can be easily controlled and designed. We applied the novel injectable hydrogel to artificial ulcers induced on the gastric mucosa of rats. Rats were assigned to the hydrogel or the control group. To measure the protective effect of hydrogel on ulcers, the perforation rate, ulcer diameter, and ulcer area were evaluated 48 h after gel application. As secondary endpoints, we assessed the residual rate of the hydrogel at the bottom of the ulcer, performed histological analysis, and analyzed adverse events associated with hydrogel. The perforation rate was significantly lower (16% vs. 75%) and the mean diameter of ulcers was significantly smaller (5.4 ± 1.8 mm vs. 7.8 ± 2.8 mm) in the hydrogel group. Histopathological findings revealed the inflammatory cell count was significantly higher in the control group. Our novel hydrogel showed a protective effect on artificial gastric ulcers in a rat model.

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