Industry Watch

2008 ◽  
Vol 12 (05) ◽  
pp. 36-63
Keyword(s):  
Rural Areas ◽  
Joint Venture ◽  
Production Plant ◽  
In Vitro Diagnostics ◽  
Oncology Research ◽  
Synthetic Rubber ◽  
Roche Diagnostics ◽  
Life Sciences Industry ◽  
And Training

Invitrogen Enters into a Licensing Agreement with IMBcom. Stem Cell Sciences Enters into an Agreement with Myelin Repair Foundation. European Company NovaSecta Joins First Chinese CRO Service Alliance for Drug Discovery Solutions. DuPont (DD) Opens Fluoropolymer Production Plant in China. Satyam Opens Center to Cater to Life Sciences Industry. Eisai and Accenture Launch Clinical Data Management in India. Sanofi Pasteur and Statens Serum Institute Team Up against Tuberculosis. Roche Diagnostics and Mankind Pharma Collaborate on Accu-Chek Go. Nicholas Unit Signs Drug Development Pact with Eli Lilly & Co. Pierre Fabre and Nicholas Piramal Sign Oncology Research Agreement. Fortis HealthWorld Works with Godrej Aadhaar to Reach Out to Rural Areas in India. Karo Bio and Zydus Cadila Sign Research Agreement. ICGEB Joins with Emory Vaccine Center. DiscoveRx Corporation Signs Agreement with Cosmo Bio. Sysmex and bioMérieux Form Commercial Joint Venture for the Japanese In Vitro Diagnostics Market. Progeniq Launches Next-generation BioBoost v4.0 Accelerator. Celltrion and CSL Announce Collaboration to Develop and Manufacture Monoclonal Antibody. Antitope Ltd Announces Research Agreement with China Synthetic Rubber Corporation. Merck and DCB Announce Cooperation to Create New Biotech Services and Training Center. Taiwan's PharmaEssentia Signs Deal with Malaysia's Black Gold Global.

scholarly journals Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hubert Brueckl ◽  
Astrit Shoshi ◽  
Stefan Schrittwieser ◽  
Barbara Schmid ◽  
Pia Schneeweiss ◽  
...  
Keyword(s):  
Thin Film ◽  
Nanoimprint Lithography ◽  
Thin Film Deposition ◽  
Film Deposition ◽  
In Vitro Diagnostics ◽  
Top Down ◽  
Highly Sensitive ◽  
Optical And Magnetic Properties ◽  
Lift Off

AbstractMultifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes.

scholarly journals Nanotomography of Cell Surfaces with Evanescent Fields

2008 ◽  
Vol 2008 ◽  
pp. 1-7 ◽  
Author(s):  
Michael Wagner ◽  
Petra Weber ◽  
Wolfgang S. L. Strauss ◽  
Henri-Pierre Lassalle ◽  
Herbert Schneckenburger
Keyword(s):  
Total Internal Reflection ◽  
3D Imaging ◽  
Cell Swelling ◽  
Cholesterol Depletion ◽  
In Vitro Diagnostics ◽  
Axial Resolution ◽  
Cell Surfaces ◽  
Cell Substrate ◽  
Cell Topology

The technique of variable-angle total internal reflection fluorescence microscopy (TIRFM) and its application to nanotomography of cell surfaces are described. Present applications include (1) 3D imaging of chromosomes in their metaphase to demonstrate axial resolution in the nanometre range, (2) measurements of cell-substrate topology, which upon cholesterol depletion shows some loosening of cell-substrate contacts, and (3) measurements of cell topology upon photodynamic therapy (PDT), which demonstrate cell swelling and maintenance of focal contacts. The potential of the method for in vitro diagnostics, but also some requirements and limitations are discussed.

Design and Construction of Three-Dimensional Physiologically-Based Vascular Branching Networks for Respiratory Assist Devices

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Jose Santos ◽  
Alla A Gimbel ◽  
Athanasios Peppas ◽  
James G Truslow ◽  
Daniel Lang ◽  
...  
Keyword(s):  
Drug Development ◽  
Three Dimensional ◽  
Lab On A Chip ◽  
In Vitro Diagnostics ◽  
Assist Devices ◽  
Branching Networks ◽  
Physiologically Based ◽  
Vascular Branching ◽  
Design And Construction

Microfluidic lab-on-a-chip devices are changing the way that in vitro diagnostics and drug development are conducted, based on the increased precision, miniaturization and efficiency of these systems relative to prior...

Platinum-Decorated Gold Nanoparticles with Dual Functionalities for Ultrasensitive Colorimetric in Vitro Diagnostics

Nano Letters ◽  
2017 ◽  
Vol 17 (9) ◽  
pp. 5572-5579 ◽  
Author(s):  
Zhuangqiang Gao ◽  
Haihang Ye ◽  
Dianyong Tang ◽  
Jing Tao ◽  
Sanaz Habibi ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
In Vitro Diagnostics

Fistulous-type vein of Galen malformation phantom model for endovascular training and research

2016 ◽  
Vol 9 (9) ◽  
pp. 880-886
Author(s):  
Dan Meila ◽  
Katharina Melber ◽  
Dominik Grieb ◽  
Collin Jacobs ◽  
Heinrich Lanfermann ◽  
...  
Keyword(s):  
Treatment Options ◽  
Endovascular Embolization ◽  
High Flow ◽  
Vein Of Galen ◽  
Vein Of Galen Malformation ◽  
Phantom Model ◽  
Before And After ◽  
And Training

IntroductionVein of Galen malformation (VGM), a high-flow intracranial arteriovenous shunt, is among the most severe neurovascular diseases in childhood. In many cases untreated children die or survive only severely disabled. Endovascular embolization is the preferred treatment.ObjectiveTo develop a simple fistulous-type VGM phantom model for teaching and training of different endovascular treatment methods and to investigate new treatment options and devices.MethodsAn experimental in vitro pulsatile phantom model was developed imitating a high-flow fistulous-type VGM, which is typical, especially in the neonatal phase. Pressure measurements at different arterial sites were performed before and after closure of the VGM. Closure of the VGM was achieved by coiling using a combined microcatheter-based transvenous and transarterial approach called ‘kissing microcatheter technique’.ResultsThe behaviour of the phantom model in vitro under fluoroscopy and under angiographic runs was extremely similar to that in in vivo conditions in children. The results showed that intra-arterial pressures changed and increased statistically significantly at all measurement sites after embolization, as in human arteriovenous malformation. We also demonstrated different and complementary visualizations of hemodynamics and angioarchitecture by antegrade and retrograde microcatheter injections.ConclusionsOur phantom model behaves like a typical fistulous-type VGM and can be used in vitro for teaching and training and for further research. It offers a new and better understanding of hemodynamics and angioarchitecture in the endovascular management of VGM.

scholarly journals Combining in Vitro Diagnostics with in Vivo Imaging for Earlier Detection of Pancreatic Ductal Adenocarcinoma: Challenges and Solutions

Radiology ◽  
2015 ◽  
Vol 277 (3) ◽  
pp. 644-661 ◽  
Author(s):  
Paul F. Laeseke ◽  
Ru Chen ◽  
R. Brooke Jeffrey ◽  
Teresa A. Brentnall ◽  
Jürgen K. Willmann
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
In Vivo Imaging ◽  
Ductal Adenocarcinoma ◽  
In Vitro Diagnostics

scholarly journals IMPLEMENTASI PERCEPATAN PEMBANGUNAN DESA DALAM MEWUJUDKAN PEMBANGUNAN BERKELANJUTAN BERDASARKAN UNDANG-UNDANG NOMOR 6 TAHUN 2014 TENTANG DESA

2019 ◽  
Vol 1 (02) ◽  
pp. 216-227
Author(s):  
Abustan Abustun
Keyword(s):  
Sustainable Development ◽  
Rural Areas ◽  
Public Facilities ◽  
State Administration ◽  
Development Policies ◽  
The Government ◽  
Village Government ◽  
The Village ◽  
And Training

Dalam perjalanan ketatanegaraan Indonesia, sistem pemerintahan desa kembali mulai diseragamkan melalui Undang-Undang Nomor 6 Tahun 2014 tentang Desa. Penelitian ini bertujuan untuk menjelaskan peran lembaga pemerintahan desa dalam pelaksanaan pembangunan berkelanjutan di pedesaan serta tata kelola kebijakan pembangunan desa melalui pemanfaatan Dana Desa. Metode yang digunakan dalam penelitian ini adalah penelitian hukum empiris. Hasil penelitian ini menjelaskan bahwa faktor pendukung pelaksanaan tugas Kepala Desa di Kecamatan Trucuk yaitu adanya pengarahan, bimbingan, serta pelatihan bagi Kepala Desa dalam menyusun rancangan peraturan desa untuk mewujudkan percepatan pembangunan desa yang berkelanjutan. Sedangkan faktor yang menghambat pelaksanaan tugas Kepala Desa di Kecamatan Trucuk yaitu rendahnya partisipasi masyarakat dalam menyikapi program kerja yang dijalankan oleh pemerintah desa serta rendahnya kesadaran masyarakat dalam memelihara fasilitas umum yang ada di desa. Pemerintahan desa yang baik adalah sebuah kerangka institusional untuk memperkuat otonomi desa karena secara substantif desentralisasi dan otonomi desa bukan hanya masalah pembagian kewenangan antarlevel pemerintah, melainkan sebagai upaya membawa pemerintah untuk lebih dekat dengan masyarakat. Pemerintah desa yang kuat dan otonom tidak akan bermakna bagi masyarakat tanpa ditopang oleh transparansi, akuntabilitas, responsivitas, dan partisipasi masyarakat.   IMPLEMENTATION OF ACCELERATION OF VILLAGE DEVELOPMENT IN REALIZING SUSTAINABLE DEVELOPMENT BASED ON LAW NUMBER 6 YEAR 2014 ABOUT VILLAGE Abstract In the course of the Indonesian state administration, the village government system began to be uniform again through Law Number 6 of 2014 concerning Villages. This research aims to explain the role of village government institutions in the implementation of sustainable development in rural areas and the governance of village development policies through the use of Village Funds. The method used in this research is empirical legal research. The results of this research explain that the supporting factors for the implementation of the duties of the village head in Trucuk Village are direction, guidance, and training for village heads in drafting village regulations to realize the acceleration of sustainable village development. Meanwhile, the factors that hinder the implementation of the duties of the village head in Trucuk Village are the low participation of the community in responding to the work programs run by the village government and the low awareness of the community in maintaining public facilities in the village. Good village governance is an institutional framework to strengthen village autonomy because substantively decentralization and village autonomy are not just a matter of sharing authority between levels of government, but as an effort to bring the government closer to the community. A strong and autonomous village government will not be meaningful to the community without being supported by transparency, accountability, responsiveness and community participation.  

scholarly journals ASSESSMENT OF SNAKE ANTIVENOM ACTIVITY OF TAMARINDUS INDICA SEED COAT EXTRACT

2021 ◽  
Vol 9 (09) ◽  
pp. 489-497
Author(s):  
Priyanka D. Mundhe ◽  
◽  
Balasaheb S. Pawade ◽  
Indrasen G. Waykar ◽  
Innus K. Shaikh ◽  
...  
Keyword(s):  
Snake Venom ◽  
Seed Coat ◽  
Rural Areas ◽  
Proteolytic Enzymes ◽  
Lethal Dose ◽  
Medical Emergency ◽  
Dependent Manner ◽  
Tamarindus Indica

Snakebite is a life-threatening medical emergency, and globally responsible for millions of deaths. In snakebites accidents only deaths are not a concern, it leads to more morbidities. Due to scanty healthcare facilities in rural areas of India, many people seek alternative treatment available in ethnic practices. Tamarindus Indica (TI) plant is rich in medicinal value and used to treat many diseases including snakebite treatment traditionally. In view of this TI seed coat extract (TISCE) was evaluated for antivenom activity. The phytochemical screening of TISCE was performed to understand its chemical composition. TISCE was evaluated for antivenom activity against Indian cobra venom (ICV), common krait venom (CKV), Russells viper venom (RVV), and saw-scaled viper venom (SCV) for phospholipase A2 (PLA-2), haemorrhagic in vitro and in vivo, procoagulant, proteolytic activity, and lethality studies. TISCE majorly contains saponins, glycosides, alkaloids, and phenolic compounds. Minimum indirect haemorrhagic dose (MIHD) observed for ICV (12.5 µg), CKV (5.0 µg),RVV (10.0 µg), and SVV (12.5 µg). TISCE inhibits the procoagulant activity of all venoms at a concentration of 18.0 µg. It also shows the neutralization of proteolytic enzymes of venom in a dose-dependent manner. A pre-incubated mixture containing five lethal dose 50 (LD50) of venom and TISCE was injected intravenously, all mice survived as venom neutralized by TISCE. The present study demonstrates the ability of TISCE to neutralize snake venom using suitable in vivo and in vitro methods. Further studies required to unravelling the specific active chemical constituent of TISCE that may used as novel alternative snakebite treatment. TISCE was able to prolong the deaths during the simulation study and may be used in the topical pharmaceutical formulation that will reduce local venom reactions causing much morbidity, which will collectively with Anti-snake venom (ASV), used to treat envenomed patients more effectively.

scholarly journals Education in Lukavac in the period 1945-1953.

2018 ◽  
Vol 1 (1) ◽  
pp. 218-241
Author(s):  
Semir Hadžimusić ◽  
Keyword(s):  
Elementary Schools ◽  
Elementary Education ◽  
Rural Areas ◽  
School Facilities ◽  
New Schools ◽  
Cultural Life ◽  
The Village ◽  
Regular Classes ◽  
Training Of Personnel ◽  
And Training

To present opportunities in Lukavac education in the period 1945-1953. means talking about primary education, first of all about four-year, and later also eight-year elementary schools, for the reconstruction of school facilities, education and training of personnel for the needs of the economy, links between education and culture, and other similar issues. In Lukavac old schools are being rebuilt and new schools are being raised. The inclusion of pupils in elementary education in this period was considerably higher than before. In addition to regular classes, schools participate in organized work on the literacy of the population through analytical courses. The school becomes the center of both educational and cultural life. The cultural function of the school is particularly prominent in rural areas, where educational workers were the main bearers of the cultural life of the village.

scholarly journals Study of Profile, Pattern and Outcome of Oral Poisoning Cases admitted in Emergency Department of a Tertiary Care Teaching Hospital in North India.

JMS SKIMS ◽  
2018 ◽  
Vol 21 (1) ◽  
pp. 24-30
Author(s):  
Susan Jalali ◽  
Shahnawaz Hamid Khan ◽  
Farooq A Jan ◽  
Illahay Jalali
Keyword(s):  
Emergency Department ◽  
Rural Areas ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Medical Sciences ◽  
Medicine Department ◽  
Health Practitioners ◽  
Public Health Practitioners ◽  
And Training

Introduction: Poisoning is a common medico-social problem. It is a significant contributor to morbidity and mortality. Knowledge of the epidemiology of poisoning and its changes is important to both emergency physicians and public health practitioners. Our study was to determine the socio-demographic profile, pattern and outcome of the poisoning cases reported to the Emergency Department of a tertiary care hospital. Methods: The study was a Retrospective observational type of study conducted at Sheri-Kashmir Institute of medical sciences, Srinagar J&K.  The patients with acute poisonings presenting to and managed in the Emergency Medicine department between February 2016 to February 2018 were reviewed for inclusion. Data was collected by reviewing records . Using a pre-structured format, case records of poisoning cases were reviewed for gender, age, residence, type of poison, route of poison and outcome of treatment. The collected data was analyzed using descriptive statistical analysis. Results: In the present study the Female: male ratio was 1.9:1 (131 Females and 68 Males).Females outnumbered the males. Highest cases of Poisoning were reported in the age group of 10-20 years. The poisoning in extreme of ages was less observed. Maximum cases of Poisoning belongs to rural areas (60.8%). The most common implicating agents were Pesticides (75.3%). The second common cause of poisoning was drug overdose (20.52%) Maximum cases recovered after treatment (94%). Conclusion: Pattern and magnitude of poisoning are multidimensional and demand multi-sectorial approach for facing this problem. There is a need for stringent pesticide regulation laws and counseling and training programs to reduce the incidence of poisonings. JMS 2018;21(1):24-30

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