Bioboard

2020 ◽  
Vol 24 (04) ◽  
pp. 54-65
Keyword(s):  
Coral Reef ◽  
Muscular Dystrophy ◽  
Reef Fishes ◽  
Asia Pacific ◽  
Antibody Drug Conjugate ◽  
Reverse Conversion ◽  
The World ◽  
New Research ◽  
The Impact ◽  
Antibody Drug

The following topics are under this section: ASIA-PACIFIC — Identification of Therapeutic Points for Genetically Diverse and Fatal Leukaemia ASIA-PACIFIC — Novel Microfluidic Processes for Drug Development ASIA-PACIFIC — Development of Anti-Microbial Coating against COVID-19 ASIA-PACIFIC — Partnership between Arcturus Therapeutics and Duke-NUS Medical School to develop COVID-19 Vaccine ASIA-PACIFIC — Nanoscopic Insights to Proteins against Huntington’s Disease ASIA-PACIFIC — Unravelling the Impact of Marine Heatwave on Coral Reef Fishes ASIA-PACIFIC — Regulation of Plant Pores by MicroRNAs ASIA-PACIFIC — Discovering Clues to Longevity in Our Genome ASIA-PACIFIC — Repurposing Nature’s Products to Viable Materials ASIA-PACIFIC — Reverse Conversion of Oestrogens to Androgens REST OF THE WORLD — HER2-targeted Antibody Drug Conjugate Shows Promise in Patients with Non-Breast-Gastric Cancers REST OF THE WORLD — New Research finds Teeth as a Biological Archive REST OF THE WORLD — Finding Treatment for Muscular Dystrophy using CRISPR

THE ACTIVITIES OF THE USA AND CHINA IN THE REGIONS OF THE WORLD, AFFECTING THE REALIZATION OF RUSSIA'S INTERESTS. Part 1: country interests and activities

2021 ◽  
Vol 1 (10) ◽  
pp. 149-166
Author(s):  
Dmitry V. Gordienko ◽  
Keyword(s):  
United States ◽  
Russian Federation ◽  
The United States ◽  
Asia Pacific ◽  
The Arctic ◽  
The World ◽  
The Usa ◽  
The Russian Federation ◽  
The Military ◽  
The Impact

The paper examines the interests of Russia, the United States and China in the regions of the world and identifies the priorities of Russia's activities in Europe, Central Asia and the Caucasus, the Asia-Pacific region, the Arctic, Africa, the Middle East and Latin America, their comparative assessment with the interests of the United States and China. An approach to assessing the impact of possible consequences of the activities of the United States and China on the realization of Russia's interests is proposed. This makes it possible to identify the priorities of the policy of the Russian Federation in various regions of the world. The results of the analysis can be used to substantiate recommendations to the military-political leadership of our country. It is concluded that the discrepancy between the interests of the United States and China is important for the implementation of the current economic and military policy of the Russian Federation.

scholarly journals Assessing the impact of static and fluctuating ocean acidification on the behavior of Amphiprion percula

2021 ◽  
Author(s):  
Matthew A. Vaughan ◽  
Danielle L. Dixson
Keyword(s):  
Coral Reef ◽  
Ocean Acidification ◽  
Reef Fishes ◽  
Amphiprion Percula ◽  
Behavioral Abnormalities ◽  
Negative Impacts ◽  
Ground Truthing ◽  
Chemosensory Behavior ◽  
The Impact

AbstractCoral reef organisms are exposed to both an increasing magnitude of pCO2, and natural fluctuations on a diel scale. For coral reef fishes, one of the most profound effects of ocean acidification is the impact on ecologically important behaviors. Previous behavioral research has primarily been conducted under static pCO2 conditions and have recently come under criticism. Recent studies have provided evidence that the negative impacts on behavior may be reduced under more environmentally realistic, fluctuating conditions. We investigated the impact of both present and future day, static (500 and 1000 μatm) and diel fluctuating (500 ± 200 and 1000 ± 200 μatm) pCO2 on the lateralization and chemosensory behavior of juvenile anemonefish, Amphiprion percula. Our static experimental comparisons support previous findings that under elevated pCO2, fish become un-lateralized and lose the ability to discriminate olfactory cues. Diel-fluctuating pCO2 may aid in mitigating the severity of some behavioral abnormalities such as the chemosensory response, where a preference for predator cues was significantly reduced under a future diel-fluctuating pCO2 regime. This research aids in ground truthing earlier findings and contributes to our growing knowledge of the role of fluctuating conditions.

scholarly journals The role of tourism in the economy. The formation of tourist flows to the ASEAN countries

2021 ◽  
Vol 42 (18) ◽  
pp. 66-77
Author(s):  
Sazhida S. SAFINA ◽  
◽  
Irina G. TETERKINA ◽  
Keyword(s):  
Asia Pacific ◽  
Tourist Flows ◽  
The World ◽  
World Tourism Organization ◽  
Asean Countries ◽  
Tourist Demand ◽  
Tourism Organization ◽  
Statistical Yearbook ◽  
The Impact

In the presented article on the base of statistical data from the World Tourism and Travel Council, the World Tourism Organization, the ASEAN Statistical Yearbook, and the official websites of national tourism organizations of the ASEAN countries the impact of tourism on the economy of the ASEAN countries is assessed. The region’s tourist demand and supply are analyzed. The factors of the formation of the main tourist flows from Asia-Pacific, European, American and Australia and Oceania macroregions are studied.

scholarly journals Kelimpahan Mikroplastik Pada Sedimen Ekosistem Terumbu di Taman Nasional Laut Karimunjawa

2020 ◽  
Vol 24 (1) ◽  
pp. 1-6
Author(s):  
Sakti Imam Muchlissin ◽  
Prastyo Abi Widyananto ◽  
Agus Sabdono ◽  
Ocky Karna Radjasa
Keyword(s):  
Coral Reef ◽  
National Park ◽  
Sampling Method ◽  
Initial Step ◽  
Asia Pacific ◽  
Conservation Areas ◽  
Marine Biotechnology ◽  
Purposive Sampling ◽  
Coral Reef Ecosystems ◽  
The Impact

Eleven billion microplastic particles are entangled in coral reef ecosystems in the Asia - Pacific Region. The presence of microplastics in coral reef ecosystems in Indonesia, especially in the Karimunjawa Marine National Park, was found as many as 22.7 and 12.8 particles / kilogram samples in two locations. The presence of microplastics in coral reef ecosystems allows threats to the health of coral reefs. Therefore, the importance of this study is to complement the data on the distribution of microplastics in the Karimunjawa Marine National Park as an initial step for conservation and mitigation of the impact of plastic/ microplastic pollution. Sampling using purposive sampling method. Sediment collection using SCUBA set and sediment grab at a depth of 3 - 5 meters. ± 1000 g of sediment was taken and stored in double zip lock plastic. The samples were then analyzed by microplastics in the Tropical Marine Biotechnology Laboratory, FPIK UNDIP. The results showed that the greatest abundance of microplastics was in the Karang Tengah area with the number of microplastics 96 particles / kilogram, and the farthest in the Ujung Gelam and Lego was 11 particles / kilogram. Research shows that the abundance of microplastics in areas with human activities such as tourism, ports, and boat routes has a high abundance compared to conservation areas or areas with little human activity. It is hoped that the available data from this type of research will be able to produce decisions on conservation measures in Karimunjawa Marine National Park.  Sebelas miliar partikel mikroplastik terjerat pada ekosistem terumbu karang di Kawasan Asia – Pasifik. Keberadaan mikroplastik pada ekosistem terumbu karang di Indonesia, khususnya di Taman Nasional Laut Karimunjawa, ditemukan sebanyak 22,7 dan 12,8  partikel/kilogram sampel di dua lokasi. Keberadaan mikroplastik di ekosistem terumbu karang memungkinkan adanya ancaman terhadap kesehatan terumbu karang. Oleh karena itu pentingnya penelitian ini untuk melengkapi data sebaran mikroplastik di Kawasan Taman Nasional Laut Karimunjawa sebagai langkah awal konservasi dan mitigasi dari dampak polusi plastik/mikroplastik. Pengambilan sampel menggunakan metode purposive sampling. Pengambilan sedimen menggunakan SCUBA set dan sediment grab pada kedalaman 3 – 5 meter. Sedimen diambil ± 1000 gr dan disimpan dalam plastik double zip lock. Sampel kemudian dianalisis mikroplastik di laboratorium Tropical Marine Biotechnology, FPIK UNDIP. Hasil menunjukkan bahwa kelimpahan mikroplastik terbesar pada daerah karang tengah dengan jumlah mikroplastik 96 partikel/kilogram, dan terkecil pada perairan ujung gelam dan lego yaitu sebanyak 11 partikel/kilogram. Penelitian menunjukkan bahwa kelimpahan mikroplastik didaerah dengan aktivitas manusia seperti pariwisata, pelabuhan, dan jalur kapal memiliki kelimpahan tinggi dibanding dengan daerah konservasi atau daerah dengan aktivitas manusia yang kecil. diharapkan dengan data yang tersedia dari penelitian sejenis ini, mampu menghasilkan keputusan terhadap langkah konservasi di Taman Nasional Laut Karimunjawa. 

MILITARY COMPONENT OF THE POLICY OF THE RUSSIAN FEDERATION IN THE STRATEGIC TRIANGLE RUSSIA – CHINA – USA: STRATEGIC PLANNING DOCUMENT SYSTEM

2020 ◽  
Vol 1 (4) ◽  
pp. 135-160
Author(s):  
D. V. GORDIENKO ◽  
Keyword(s):  
Russian Federation ◽  
Comparative Assessment ◽  
Asia Pacific ◽  
The Arctic ◽  
The World ◽  
Soviet Space ◽  
The Russian Federation ◽  
The Military ◽  
The Impact ◽  
Post Soviet Space

The purpose of this article is to assess the impact of the military component of the Russian Federation policy in the strategic triangle Russia – China – USA on its current Russian policy in the post-Soviet space, in Asia- Pacific and Euro-Atlantic regions, the Arctic, the middle East and in other regions of the world. An approach to the comparative assessment of this influence is proposed, which allows us to identify the priorities of Russia's policy in this area.

scholarly journals Condition of Coral Fish in Tapanuli Tengah Waters

2018 ◽  
Vol 3 (2) ◽  
pp. 105
Author(s):  
Sasanti Retno Suharti ◽  
Isa Nagib Edrus
Keyword(s):  
Community Structure ◽  
Coral Reef ◽  
Coral Reefs ◽  
Reef Fish ◽  
Reef Fishes ◽  
The Other ◽  
Human Being ◽  
The World ◽  
Coral Fish ◽  
Complex Architecture

Coral reefs is a center for biodiversity in the world with a complex architecture and has an aesthetics value. It also offers beneficial for human being in many aspects such as economics, social and culture. Research was conducted in July 2016 and aim to understand community structure and biomass of coral reef fishes in Tapanuli Tengah waters. Result from all stations in Tapanuli Tengah waters showed that 49 species from seven families of economically reef fish i.e.  Acanthuridae, Serranidae, Haemulidae, Lutjanidae, Lehtrinidae, Siganidae and Scaridae were found. Density average of those seven families was 163 individual/350 m<sup>2</sup> or 4668 individual/ha with biomass average of 1.564 ton/ha. Moreover, biomass from other target fishes from nine families was accounted as 0.56 ton/ha. On the other hand, over all coralifore fish represented by Chaetodontidae was eight species from two genus, namely <em>Chaetodon</em> and <em>Heniochus </em>with four species. The density from family Chaetodotidae varies among station between 3-28 individual/350 m<sup>2</sup>

scholarly journals Global Tourism and COVID-19

Tourism ◽  
2021 ◽  
Vol 69 (2) ◽  
pp. 262-280
Author(s):  
Priya Harchandani ◽  
Samik Shome
Keyword(s):  
Consumer Confidence ◽  
Asia Pacific ◽  
Special Focus ◽  
Normal Functioning ◽  
Tourism Sector ◽  
The World ◽  
Travel Restrictions ◽  
Global Tourism ◽  
The Impact ◽  
Opening Up

The world is facing an unprecedented situation with COVID-19. The normal functioning of economies has been completely interrupted with the lockdowns in place. The consequences of pandemic have been deeply felt across the entire global tourism ecosystem. Travel restrictions that were put in place to reduce the outbreak of coronavirus, affected various sectors of every economy. Since recovery of tourism is crucial for the turnaround of any economy, this study aims to provide an overview of the impact of COVID-19 on global tourism and highlighted the ways that can lead the path of revival of the sector. To make this assessment, the paper studied three associated industries of tourism viz. airlines; hospitality with special focus on the hotel segment; and the MSMEs involved directly in tourism related business. Region-wise analysis reveals that the Asia-Pacific zone has been the worst affected followed by the Middle East. As countries are opening up their borders and encouraging tourism, the sector is facing the challenge of rebuilding the consumer confidence in order to promote future tourism. Hence, the paper also provides an overview of policy decisions taken worldwide which will be crucial for sustenance of the global tourism sector.

scholarly journals Tumor volumes as a predictor of response to the anti-EGFR antibody drug conjugate Depatuxizumab Mafadotin

2021 ◽  
Author(s):  
Hui K Gan ◽  
Sagun Parakh ◽  
Andrew B Lassman ◽  
Aidan Seow ◽  
Eddie Lau ◽  
...  
Keyword(s):  
Overall Survival ◽  
Clinical Data ◽  
Tumor Size ◽  
Tumor Volume ◽  
Drug Distribution ◽  
Volumetric Analysis ◽  
Antibody Drug Conjugate ◽  
Biodistribution Studies ◽  
The Impact ◽  
Antibody Drug

Abstract Background The adverse impact of increasing brain tumor size on the efficacy of antibody drug conjugates (ADCs) was investigated preclinically then validated with clinical data. Methods Preclinical study: The impact of tumor size on ADC tumor delivery and treatment response was evaluated in an EGFR-amplified patient derived glioblastoma (GBM) model following treatment with Depatuxizumab mafadotin (Depatux-M). Biodistribution and imaging studies correlated drug distribution with starting treatment volume and anti-tumor activity. Clinical study: M12-356 was a Phase I study of Depatux-M in patients with GBM. Blinded volumetric analysis of baseline tumor volumes of M12-356 patients was undertaken by two reviewers and results correlated with response and survival. Results Preclinically, imaging and biodistribution studies showed specific and significantly higher tumor uptake of zirconium-89 labeled Depatux-M ( 89Zr-Depatux-M) in mice with smaller tumor volume (~98mm 3) versus those with larger volumes (~365mm 3); concordantly, mice with tumor volumes ≤100mm 3 at treatment commencement had significantly better growth inhibition by Depatux-M (93% vs 27%, p&lt;0.001) and significantly longer overall survival (p&lt;0.0001) compared to tumors ≥400mm 3. Clinically, patients with tumor volumes &lt; 25cm 3 had significantly higher response rates (17% vs. 0%, p=0.009) and longer overall survival (0.5 vs 0.89 years, p=0.001) than tumors above 25 cm 3. Conclusion Both preclinical and clinical data showed intra-tumoral concentration and efficacy of Depatux-m inversely correlated with tumor size. This finding merit further investigation with pre-treatment tumor volume as a predictor for response to ADCs, in both gliomas and other solid tumors.

scholarly journals Body size and mortality rates in coral reef fishes: a three-phase relationship

2016 ◽  
Vol 283 (1841) ◽  
pp. 20161858 ◽  
Author(s):  
Christopher Harry Robert Goatley ◽  
David Roy Bellwood
Keyword(s):  
Body Size ◽  
Coral Reef ◽  
Meta Analysis ◽  
Phase Relationship ◽  
Reef Fishes ◽  
Mortality Rates ◽  
Coral Reef Fishes ◽  
Multiple Species ◽  
The Many ◽  
The Impact

Body size is closely linked to mortality rates in many animals, although the overarching patterns in this relationship have rarely been considered for multiple species. A meta-analysis of published size-specific mortality rates for coral reef fishes revealed an exponential decline in mortality rate with increasing body size, however, within this broad relationship there are three distinct phases. Phase one is characterized by naive fishes recruiting to reefs, which suffer extremely high mortality rates. In this well-studied phase, fishes must learn quickly to survive the many predation risks. After just a few days, the surviving fishes enter phase two, in which small increases in body size result in pronounced increases in lifespan (estimated 11 d mm –1 ). Remarkably, approximately 50% of reef fish individuals remain in phase two throughout their lives. Once fishes reach a size threshold of about 43 mm total length (TL) they enter phase three, where mortality rates are relatively low and the pressure to grow is presumably, significantly reduced. These phases provide a clearer understanding of the impact of body size on mortality rates in coral reef fishes and begin to reveal critical insights into the energetic and trophic dynamics of coral reefs.

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