scholarly journals Dual function of lectins — new perspectives in targeted photodynamic therapy

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1241-1250 ◽  
Author(s):  
Vanya Bogoeva ◽  
Lidiya Petrova ◽  
Julie Bouckaert ◽  
Anna Yordanova ◽  
Ivan Ivanov ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Dual Function ◽  
Tumor Tissues ◽  
Potential Applications ◽  
Specific Antigens ◽  
Imaging Detection ◽  
New Perspective ◽  
Targeted Photodynamic Therapy

Porphyrins and phthalocyanines are photosensitizers (PS) that are used in clinical imaging, detection of cancer cells and are particularly applied in photodynamic therapy (PDT). Many scientists have been focused on the design of different porphyrin compounds. However, similar to other anti-cancer agents, they cannot selectively recognize tumor tissues. Scientists are seeking new methods to overcome this problem and to find appropriate targeted delivery strategies. Plant lectins are especially suitable molecules for such targeting as they preferentially recognize specific antigens on the glycosylated cancer cells. This review will give more detailed information about the dual function of lectins and their interactions with PSs, which is a new perspective in targeted PDT. The implications and potential applications of such studies will also be discussed.

Synthesis of surface functionalized hollow microporous organic capsules for doxorubicin delivery to cancer cells

2020 ◽  
Vol 11 (12) ◽  
pp. 2110-2118 ◽  
Author(s):  
Shumaila Razzaque ◽  
Ying Cheng ◽  
Irshad Hussain ◽  
Bien Tan
Keyword(s):  
Cancer Cells ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Potential Applications ◽  
Doxorubicin Delivery

Functionalized hypercrosslinked hollow microporous capsules are demonstrated to have potential applications in targeted delivery of anticancer drugs.

scholarly journals A Novel Approach to Anticancer Therapy: Molecular Modules Based on the Barnase:Barstar Pair for Targeted Delivery of HSP70 to Tumor Cells

Acta Naturae ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 85-91 ◽  
Author(s):  
A. M. Sapozhnikov ◽  
A. V. Klinkova ◽  
O. A. Shustova ◽  
M. V. Grechikhina ◽  
M. S. Kilyachus ◽  
...  
Keyword(s):  
Immune System ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Important Distinction ◽  
Tumor Tissues ◽  
Wide Range ◽  
Antitumor Immunotherapy ◽  
Surface Localization

One important distinction between many tumor cell types and normal cells consists in the translocation of a number of intracellular proteins, in particular the 70 kDa heat shock protein (HSP70), to the surface of the plasma membrane. It has been demonstrated that such surface localization of HSP70 on tumor cells is recognized by cytotoxic effectors of the immune system, which increases their cytolytic activity. The mechanisms behind this interaction are not fully clear; however, the phenomenon of surface localization of HSP70 on cancer cells can be used to develop new approaches to antitumor immunotherapy. At the same time, it is known that the presence of HSP70 on a cells surface is not a universal feature of cancer cells. Many types of tumor tissues do not express membrane-associated HSP70, which limits the clinical potential of these approaches. In this context, targeted delivery of exogenous HSP70 to the surface of cancer cells with the aim of attracting and activating the cytotoxic effectors of the immune system can be considered a promising means of antitumor immunotherapy. Molecular constructs containing recombinant mini-antibodies specific to tumor-associated antigens (in particular, antibodies specific to HER2/neu-antigen and other markers highly expressed on the surface of a wide range of cancer cells) can be used to target the delivery of HSP70 to tumor tissues. In order to assess the feasibility and effectiveness of this approach, recombinant constructs containing a mini-antibody specific to the HER2/ neu-antigen in the first module and HSP70 molecule or a fragment of this protein in the second module were developed in this study. Strong selective interaction between the modules was ensured by a cohesive unit formed by the barnase:barstar pair, a heterodimer characterized by an unusually high constant of association. During testing of the developed constructs in in vitro models the constructs exhibited targeted binding to tumor cells expressing the HER2/neu antigen and the agents had a significant stimulating effect on the cytotoxic activity of NK cells against the respective cancer cells.

scholarly journals Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1933
Author(s):  
Sathish Sundar Dhilip Kumar ◽  
Heidi Abrahamse
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Targeting Therapy ◽  
Potential Applications ◽  
Carrier Molecule ◽  
Novel Material ◽  
Potential Benefits ◽  
Targeted Photodynamic Therapy

In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

scholarly journals RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles –switchableintegrin-targeted photodynamic treatment of melanoma cells

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9112-9119 ◽  
Author(s):  
Avraham Dayan ◽  
Gideon Fleminger ◽  
Osnat Ashur-Fabian
Keyword(s):  
Titanium Dioxide ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
High Selectivity ◽  
Titanium Dioxide Nanoparticles ◽  
Melanoma Cells ◽  
Dihydrolipoamide Dehydrogenase ◽  
Photodynamic Treatment ◽  
Targeted Photodynamic Therapy

This work presents a UVA switchable integrin-targeted photodynamic therapy in melanoma, composed of an RGD-modified DLDH conjugated to TiO2nanoparticles, with high selectivity towards integrin-expressing cancer cells.

scholarly journals Development of Folic Acid-Conjugated and Methylene Blue-Adsorbed Au@TNA Nanoparticles for Enhanced Photodynamic Therapy of Bladder Cancer Cells

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1351
Author(s):  
Che-Wei Hsu ◽  
Nai-Chi Cheng ◽  
Mei-Yi Liao ◽  
Ting-Yu Cheng ◽  
Yi-Chun Chiu
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Au Nanoparticle ◽  
Shell Nanoparticles ◽  
High Accumulation ◽  
Bladder Cancer Cells ◽  
Promising Treatment ◽  
Core Shell Nanoparticles

Photodynamic therapy (PDT) is a promising treatment for malignancy. However, the low molecular solubility of photosensitizers (PSs) with a low accumulation at borderline malignant potential lesions results in the tardy and ineffective management of recurrent urothelial carcinoma. Herein, we used tannic acid (TNA), a green precursor, to reduce HAuCl4 in order to generate Au@TNA core-shell nanoparticles. The photosensitizer methylene blue (MB) was subsequently adsorbed onto the surface of the Au@TNA nanoparticles, leading to the incorporation of a PS within the organic shell of the Au nanoparticle nanosupport, denoted as Au@TNA@MB nanoparticles (NPs). By modifying the surface of the Au@TNA@MB NPs with the ligand folate acid (FA) using NH2-PEG-NH2 as a linker, we demonstrated that the targeted delivery strategy achieved a high accumulation of PSs in cancer cells. The cell viability of T24 cells decreased to 87.1%, 57.1%, and 26.6% upon treatment with 10 ppm[Au] Au@TNA/MB NPs after 45 min, 2 h, and 4 h of incubation, respectively. We also applied the same targeted PDT treatment to normal urothelial SV-HUC-1 cells and observed minor phototoxicity, indicating that this safe photomedicine shows promise for applications aiming to achieve the local depletion of cancer sites without side effects.

scholarly journals Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

2018 ◽  
Vol 6 (45) ◽  
pp. 7373-7377 ◽  
Author(s):  
Koushambi Mitra ◽  
Montserrat Samsó ◽  
Charles E. Lyons ◽  
Matthew C. T. Hartman
Keyword(s):  
Photodynamic Therapy ◽  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Red Light ◽  
Selective Uptake ◽  
Grafted Nanoparticles ◽  
Targeted Photodynamic Therapy

Hyaluronic acid nanoparticles containing a platinum(ii)–silicon(iv) phthalocyanine conjugate exhibited selective uptake by cancer cells and potent mitochondria-targeted PDT and chemotherapy.

Mitochondria-Targeted Photodynamic Therapy with a Galactodendritic Chlorin to Enhance Cell Death in Resistant Bladder Cancer Cells

2016 ◽  
Vol 27 (11) ◽  
pp. 2762-2769 ◽  
Author(s):  
Patrícia M. R. Pereira ◽  
Sandrina Silva ◽  
Mafalda Bispo ◽  
Mónica Zuzarte ◽  
Célia Gomes ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Bladder Cancer Cells ◽  
Targeted Photodynamic Therapy
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