Herbal medicines are being used since ancient times and are an important part of the alternative and traditional
medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number
of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have
lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be
around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost,
ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the
commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving
the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing
the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of
herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations.
Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This
article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and
reported nano-phytomedicines based delivery systems.