scholarly journals Experimental study on the effects of Kursi Ziyabet on the rat model of diabetes mellitus

2019 ◽  
Vol 02 (01) ◽  
pp. 7-11
Author(s):  
Alimjan Parhat ◽  
Haibaier Huojiaaihemaiti ◽  
Nabijan Mohammadturusn ◽  
Mammat Nurahmat
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Sugar ◽  
Water Intake ◽  
Fasting Blood Sugar ◽  
Diabetic Rat ◽  
Intragastric Administration ◽  
Model Group ◽  
Rat Models ◽  
Significant Difference

Objective: To evaluate the hyperglycemic effects of Kursi Ziyabet (KZ) tablets on the rat models of diabetes mellitus. Methods: In total, 58 male SD rats were assigned randomly to six groups. All except the normal group were transformed into experimental diabetes mellitus rat models by injecting streptozocin. The hyperglycemic effect and the mechanism of Ziyabet were evaluated by body weight, food and water intake, fasting blood sugar, and related parameters by measuring the oxidative stress-related factors and lipid metabolism indicator level by the corresponding kits using the rat experimental models. Results: Compared with the model group, body weight markedly increased after 3–6 weeks of intragastric administration of Ziyabet tablets ([Formula: see text]), while the water intake significantly decreased in the same period of time ([Formula: see text]). Food intake and fasting blood sugar level also decreased with the high dosage of Ziyabet tablets ([Formula: see text]). There is no significant difference in pancreas’ MDA content of the Ziyabet groups when compared to the model group ([Formula: see text]), while significant increase in SOD level was observed in high-dosage KZ group ([Formula: see text]). The blood serum insulin and free fatty acid level also decreased in the high-dosage KZ group compared with the model group ([Formula: see text]). Conclusion: We conclude that Ziyabet tablets demonstrated protective effects on the diabetic rat models.

Effectiveness of Gita Gymnastics on Blood Sugar Level Among Elderly With Diabetes Mellitus in Kediri

2020 ◽  
Vol 4 (1) ◽  
pp. 60
Author(s):  
Anindini Winda Amalia ◽  
Paramita Ratna Gayatri ◽  
Hartati Tuna
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
The Elderly ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Mean Deviation ◽  
Significant Difference ◽  
Group 10 ◽  
Sugar Levels ◽  
And Control

The Elderly has a high risk of degenerative diseases. Diabetes Mellitus is a degenerative disease that occurred in the elderly. Excercise regularly can reduce blood sugar levels in the elderly. GITA gymnastic is a mild exercise that can be applied and not burdensome if done routinely by elderly. The purpose of this study was to determine the effect of GITA gymnastic on blood sugar levels in the elderly with diabetes mellitus. This research is an experimental design of the field with pre-post group design. Respondents are elderly with diabetes mellitus in Clinic Bandar Lor Kediri. Respondent 20 people, divided into two groups, gymnastic group 10 people and control group 10 people. In gymnastic group is given training of GITA gymnastic for 8 weeks, 3 times a week, with a duration of 30 minutes each session. The control group did not have treatment. The result of this study indicates the post-test of fasting blood sugar levels in the gymnastic group is significantly lower than the pre-test of fasting blood sugar levels (p= 0.003). In the independent T test, there was a significant difference in the mean deviation of fasting blood sugar levels in the gymnastic group and control group (p=0,001). GITA gymnastic for eight weeks is effective in reducing blood sugar levels among the elderly with diabetes mellitus.

scholarly journals Study on Synergistic Effect of Bromocriptine and Sitagliptin in Streptozotocin-induced Diabetic Rats

2021 ◽  
Author(s):  
Govindaraj Nileshraj ◽  
Chandrasekaran Swithraa ◽  
Murugesan Sakthibalan ◽  
Maruti Shripati Sawadkar
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Wistar Rats ◽  
Low Dose ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Liver Parameters ◽  
Dose Combination

Introduction: Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. Restoration of euglycemia in type 2 diabetes mellitus is difficult to achieve due to its multifactorial pathogenesis and frequently requires multiple anti-diabetic medications with different mechanism of action. This study is based on the possible synergistic effect of Sitagliptin and Bromocriptine in reducing blood sugar in diabetic animal models. Aim: To evaluate the effect of Sitagliptin and Bromocriptinemonotherapy and their combination in three different doses on blood sugar, Lipid profile, Liver and renal parameters in diabetic albino Wistar rats. Materials and Methods: An experimental animal study was conducted on 48 adult male albino wistar rats for a period of one month (August 2014). Streptozotocin induced (40 mg/kg IP) diabetic rats were divided into six groups of eight animals each weighing 150-200 gms. Group I- Vehicle (distilled water), Group II- Sitagliptin (100 mg/kg), Group III- Bromocriptine (10 mg/kg), Group IV- Sitagliptin (75 mg/kg) + Bromocriptine (7.5 mg/kg), Group V- Sitagliptin (100 mg/kg) + Bromocriptine (10 mg/kg), Group VI- Sitagliptin (125 mg/kg) + Bromocriptine (12.5 mg/kg). All drugs were given once daily (p.o) for four weeks. Body weight, fasting blood sugar, fasting lipid profile, liver parameters and renal parameters were estimated before and after administration of the drugs. Results were analyzed with SPSS software version 16.0 using one-way ANOVA followed by post-hoc Dunnett t test. P<0.05 was considered statistically significant. Results: The low dose combination therapy [Sitagliptin (75 mg/kg) + Bromocriptine (7.5 mg/kg)] showed a significant decrease in body weight (p<0.05), fasting blood sugar (p<0.001) compared with the vehicle group. It also showed a favorable lipid profile, renal and liver parameters compared with the vehicle, monotherapy and other combination regimens. Conclusion: The low dose combination therapy of Sitagliptin and Bromocriptine showed a better control over fasting blood sugar along with a beneficial effect on lipid profile, liver parameters and renal parameters than compared to other groups.

scholarly journals The Effectiveness of Acupressure and Smart Gymnastic on Fasting Blood Sugar Levels among Patients with Type II Diabetes Mellitus

2020 ◽  
Vol 3 (6) ◽  
pp. 687-694
Author(s):  
Dian Apri Nelyanti ◽  
Ta’adi Ta’adi ◽  
M. Choiroel Anwar
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Blood Sugar Level ◽  
Type Ii Diabetes Mellitus ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Type Ii ◽  
Significant Difference ◽  
Sugar Levels

Diabetes mellitus (DM) is a glucose metabolism disease characterized by an increase in blood sugar levels and impaired metabolism of fats, protein, and carbohydrates due to a lack of the hormone insulin, both absolutely and relatively. Alternative treatment of diabetes mellitus with complementary therapies, namely acupressure and smart gymnastic, can improve the fasting blood sugar level. This study aims to determine the effectiveness of acupressure and smart gymnastic on fasting blood sugar levels among patients with type II diabetes mellitus. True experimental study pretest and post-test with non-equivalent control group design were applied in this study. Repeated Measure, ANOVA test, showed a significant difference with the mean fasting blood sugar level p-value 0.000 (<0.05). The intervention group is better at lowering fasting blood sugar levels than control group 1 and control group 2 seen from the higher value difference. Conclusion of acupressure therapy with smart gymnastics three times a week for four weeks effectively reduces fasting blood sugar level in a patient with type II diabetes mellitus. This study can be used as a reference for further research, with a larger sample size, controlling the patient's diet, and a longer duration of intervention, so that the results obtained are more valid.

Evaluation of the alterations in the serum blood sugar level, the activity of AST and ALT enzymes of diabetes mellitus type 2 in Iraqi women patients

2021 ◽  
Vol 16 (8) ◽  
pp. 98-102
Author(s):  
Hashim Abdul Razzaq Iman ◽  
Hussein Murtadha Jinan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Diabetes Mellitus Type 2 ◽  
Correlation Factor ◽  
Diabetes Mellitus Type ◽  
Fasting Blood Sugar ◽  
Diabetic Patients ◽  
Cell Dysfunction ◽  
Iraqi Women

Diabetes mellitus type 2 (T2DM) results from beta cell dysfunction or reduced action of insulin responsive. The objective of this study was to examine the relevance between blood sugar, the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in fasting women diabetic patients in different durations. A total of sixty-eight women were divided into three groups: first a healthy group – non-diabetic (twenty-six women), second and third groups (twenty-one) were diabetic patients of age 35 – 50 and 51 – 69 years respectively. Serum fasting blood sugar was significantly (P < 0.05) elevated to 181.60 mg/dl in female patients with 35 – 50 years. The same effect happened in activity of AST to 32.91 u/L in 51 – 69 years and ALT was 28.43 u/L in 35 – 50 years. No significant differences were found between the aged and fasting blood sugar, AST and ALT in diabetic patients. The correlation factor (r) between fasting blood sugar and the activity of ALT was highly significant.

scholarly journals Regression of gestational diabetes induced cardiomegaly in offspring of diabetic rat

2009 ◽  
Vol 24 (4) ◽  
pp. 251-255 ◽  
Author(s):  
Honório Sampaio Menezes ◽  
Cláudio Galeano Zettler ◽  
Alice Calone ◽  
Jackson Borges Corrêa ◽  
Carla Bartuscheck ◽  
...  
Keyword(s):  
Body Weight ◽  
Wistar Rats ◽  
Weight Ratio ◽  
Diabetic Rats ◽  
Heart Weight ◽  
Diabetic Rat ◽  
Control Group ◽  
Computer Assisted ◽  
Significant Difference ◽  
Levene Test

PURPOSE: To compare body weight and length, heart weight and length, heart-to-body weight ratio, glycemia, and morphometric cellular data of offspring of diabetic rats (ODR) and of normal rats (control). METHODS: Diabetes was induced in 3 pregnant Wistar rats, bearing 30 rats, on the 11th day after conception by intraperitoneal injection of 50 mg/kg of streptozotocin. Six normal pregnant Wistar rats, bearing 50 rats, made up the control group. Morphometric data were obtained using a scale for the weight, length, heart and body measurements. Morphometric cellular data were obtained by a computer assisted method applied to the measurements of myocytes. Statistical analysis utilized Student's t-test, ANOVA and Levene test. RESULTS: Control offspring had greater mean body weight and length than offspring of diabetic rats (p < 0.001). Heart weight and length and heart-to-body ratios of newborn rats differed between groups at birth (p < 0.001), but showed no difference at 21 days. Mean nuclei area and perimetric value of the myocytes decrees throughout the first 21 days of life (p < 0.01) in the diabetic group. CONCLUSIONS: Heart hypertrophy on the offspring of diabetic rats at birth was demonstrated by the significant difference between the groups. After the eleventh day, no difference was found, which confirmed regression of cardiomegaly. The significant difference between the first and the 21th day of life, for nuclei area feature, demonstrate regression of cardiac hypertrophy in the offspring of diabetic rats.

scholarly journals Effects of Vitamin E Supplementation to Metabolic Markers on Diet-Induced Obesity in Mice 

Folia Medica ◽  
2021 ◽  
Vol 63 (6) ◽  
pp. 895-900
Author(s):  
Eka Roina Megawati ◽  
Lokot Donna Lubis ◽  
Febi Yanti Harahap
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Blood Sugar ◽  
Adiponectin Level ◽  
Metabolic Markers ◽  
Diet Induced Obesity ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Obesity In Mice ◽  
Vitamin E Supplementation

Introduction: Obesity creates health problems by increasing the risks of chronic diseases such as type 2 diabetes and cardiovascular disorders. Obesity leads to insulin resistance, higher blood glucose and cholesterol levels. Adipose tissues synthesize adiponectin which acts as anti-inflammatory, antidiabetic, and anti-atherogenic agent. Meanwhile, vitamin E is an antioxidant that acts as an anti-inflammation. Aim: The purpose of this study was to analyze the effects of vitamin E supplementation to metabolic markers on diet-induced obesity in mice. Materials and methods: Twenty-four mice (Mus musculus, L) aged four weeks were divided into six groups which were fed different diets and given vitamin E in different dosages or methods. The period of treatment was 18 weeks. The mice body weights were measured every week; blood sugar and cholesterol levels were measured every six weeks, and the adiponectin level measurement was done at week 18. Results: A repeated measures ANOVA showed that body weight and cholesterol level within groups were not significantly different [F(15,&nbsp;54)=1.417, 0.173 and F(10,&nbsp;36)=1.391, 0.224 respectively]. The glucose levels were found to be significantly different [F(7.646,&nbsp;27.526)=2.625, 0.030]. There was no significant difference in the adiponectin levels. Conclusions: Vitamin E supplementation could not prevent the increase of body weight, the elevation of blood sugar and cholesterol levels, and also could not increase adiponectin level.

scholarly journals Pengaruh Pelayanan Kefarmasian di Rumah pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Wilayah Kota Yogyakarta

2020 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Nur Rasdianah ◽  
Suwaldi Martodiharjo ◽  
Tri Murti Andayani ◽  
Lukman Hakim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Adherence ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Level Of Knowledge ◽  
Sugar Levels

The increasing prevalence of diabetes mellitus (DM) in Indonesia requires participation of all parties including pharmacists. This study aims to determine the impact of the implementation of home pharmacy service guidelines for patients with type 2 diabetes mellitus on the level of knowledge, medication adherence, therapeurical satisfaction and glycemic control. This study used a quasi-experimental design with one group pre-test and post-test design involving 37 patients with type 2 diabetes mellitus who met the requirements of inclusion and exclusion criterias. The Diabetes Knowledge Questionnaire (DKQ-24) and the Diabetes Medication Satisfaction Tool (DMSAT) were used for collecting the data. Patient adherence was measured using a pillcount method and fasting blood sugar levels (FSB) data were obtained from the laboratory results. The study was conducted in two community health centers and patient’s home in the Yogyakarta Municipality area. The data were analysed using Wilcoxon and Spearman test. The results showed the change of the level of knowledge, medication adherence, therapeutic satisfaction and glycemic control before and after intervention of pharmacy services at home. The average decreasing of fasting blood sugar levels 17.09 mg/dL ± 1.43

scholarly journals Effect of Metformin Therapy on Clinical and Hormonal Indices of Patients with Polycystic Ovary Syndrome

2021 ◽  
Vol 15 (5) ◽  
pp. 1522-1525
Author(s):  
S. Inayat ◽  
H. F. Khattak ◽  
M. G. Muhammad ◽  
K. Robeen ◽  
A. Inayat ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Blood Sugar ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Fasting Blood Sugar ◽  
Ovary Syndrome ◽  
Group Ii

Objective: The main objective of this study is to determine the efficacy of metformin therapy on clinical and hormonal indices of patients with polycystic ovary syndrome. Study Design: Randomized control trial Place and Duration: Study was conducted at Obstetrics & Gynaecology department of Northwest General Hospital and Research Center, Peshawar and Mian Rashid Hussain Shaheed Memorial Hospital, Pabbi for duration of nine months from March 2020 to November 2020. Methods: Total 100 patients of polycystic ovary syndrome were presented in this study. Patients were aged between 18 to 45years. Patients detailed demographics including age, body mass index and socio-economicstatus were recorded after taking informed written consent. Patients were divided into 2-groups, group I had 50 patients and received metformin (500 mg) three times a day and group II had 50 patients and received pioglitazone (30 mg) three times a day for 3months.Clinical (body weight, blood pressure (BP), and body mass index) and indices fasting blood sugar (FBS), serum triglyceride (TG), cholesterol, low-density lipoprotein, high-density lipoprotein, insulin, testosterone, and dehydroepiandrosterone (DHEA) were measured before and after therapy. Complete data was analyzed by SPSS 22.0 version. Results: Mean age of the patients in group I was 29.18 ± 2.25 years with mean BMI 26.14 ± 8.86 kg/m2 and in group II mean age was 29.8 ± 2.52 years with mean BMI 27.64 ± 7.68 kg/m2.Significantly decrease in blood pressure (systolic 105.41±8.57, diastolic 67.19±8.9), hair loss 20 (40%),oligomenorrhea 23 (46%), body weight 74.45±9.72, waist circumference and dehydroepiandrosterone (DHEA) 2.35±0.67 and as compared to group II. Only triglycerides gave results of reduction in group II 115.39±64.11. Among both groups serum insulin, acne, menstrual disturbance and fasting blood sugar were controlled after treatment. Conclusion: We concluded in this study that use of metformin in patients with polycystic ovary syndrome resulted in to decrease clinical body weight, blood pressure (BP), body mass index and hormonal indices with reduction of serum insulin, acne, menstrual disturbance and fasting blood sugar but pioglitazone was an alternative effective and reliable method in PCOS patients. Keywords: Polycystic ovary syndrome, Insulin resistance, Metformin, Pioglitazone

scholarly journals Detection of Anti-Helicopacter pylori IgG Antibody, Anti-GAD antibody, Anti-Beta islets cell in a sample of serum with type-2 Diabetes mellitus patients

2013 ◽  
Vol 10 (4) ◽  
pp. 1157-1161
Author(s):  
Baghdad Science Journal
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Igg Antibody ◽  
H Pylori

We have investigated twenty five patients with type-2 diabetes mellitus aged (35-60) years and fifteen healthy persons as control group to detect Anti-Helicobacter pylori IgG antibody. All studied groups were carried out to measure fasting blood sugar, anti- Glutamic acid decarboxylase (GAD), anti-? islets cells antibody by IFAT, Anti-H. pylori IgG antibody by ELISA technique. There was significant elevation in the concentration of fasting blood sugar than in control group (P < 0.05), the patients had negative results for anti-GAD antibody and anti- ? islets cells antibody, there were significant differences (P < 0.05) of anti-H. pylori IgG antibody in 28 % of patients had type-2 diabetes than control group. This lead to suggestion that type -2 diabetes mellitus patients are more susceptible to H. pylori .

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