scholarly journals Reproducibility in Evolutionary Computation

2021 ◽  
Vol 1 (4) ◽  
pp. 1-21
Author(s):  
Manuel López-ibáñez ◽  
Juergen Branke ◽  
Luís Paquete
Keyword(s):  
Evolutionary Computation ◽  
Experimental Studies ◽  
Evolutionary Learning ◽  
Computing Machinery ◽  
Different Types ◽  
Scientific Fields

Experimental studies are prevalent in Evolutionary Computation ( EC ), and concerns about the reproducibility and replicability of such studies have increased in recent times, reflecting similar concerns in other scientific fields. In this article, we discuss, within the context of EC, the different types of reproducibility and suggest a classification that refines the badge system of the Association of Computing Machinery ( ACM ) adopted by ACM Transactions on Evolutionary Learning and Optimization ( TELO ). We identify cultural and technical obstacles to reproducibility in the EC field. Finally, we provide guidelines and suggest tools that may help to overcome some of these reproducibility obstacles.

METHODS FOR SIMULATION OF ACUTE BRAIN ISCHEMIA: PATHOPHYSIOLOGICAL SUBSTANTIATION OF SELECTION AND IMPORTANCE FOR CLINICAL PRACTICE

2019 ◽  
pp. 142-152
Author(s):  
Б.И. Гельцер ◽  
Э.В. Слабенко ◽  
Ю.В. Заяц ◽  
В.Н. Котельников
Keyword(s):  
Clinical Practice ◽  
Experimental Studies ◽  
Cerebrovascular Diseases ◽  
Experimental Models ◽  
Pathological Process ◽  
Ischemic Brain ◽  
Actual Clinical Practice ◽  
Acute Cerebral Ischemia ◽  
Different Types ◽  
Acute Brain Ischemia

Одним из основных требований к разработке экспериментальных моделей цереброваскулярных заболеваний является их максимальная приближенность к реальной клинической практике. В работе систематизированы данные по основным методам моделирования острой ишемии головного мозга (ОИГМ), представлена их классификация, анализируются данные о преимуществах и недостатках той или иной модели. Обсуждаются результаты экспериментальных исследований по изучению патогенеза ОИГМ с использованием различных моделей (полной и неполной глобальной, локальной и мультифокальной ишемии) и способов их реализации (перевязка артерий, клипирование, коагуляция, эмболизация и др.). Особое внимание уделяется «стабильности» последствий острого нарушения мозгового кровообращения: необратимых ишемических повреждений головного мозга или обратимых с реперфузией заданной продолжительности. Отмечается, что важное значение в этих исследованиях должно принадлежать современным методам прижизненной визуализации очагов острого ишемического повреждения, что позволяет оценивать динамику патологического процесса. Предлагаемый метод отвечает требованиям гуманного обращения с животными. Подчеркивается, что выбор релевантной модели ОИГМ определяется задачами предстоящего исследования и технологическими ресурсами научной лаборатории. Development of experimental models for acute forms of cerebrovascular diseases is essential for implementation of methods for their prevention and treatment. One of the principal requirements to such models is their maximum approximation to actual clinical practice. This review systematized major models of acute cerebral ischemia (ACI), their classification, and presented information about their advantages and shortcomings. Also, the review presented results of experimental studies on pathophysiological mechanisms of different types of modeled ACI (complete and incomplete global, local, and multifocal ischemia) and methods for creating these models (arterial ligation, clipping, coagulation, embolization, etc.). Particular attention was paid to “stability” of the consequences of acutely impaired cerebral circulation - an irreversible ischemic brain injury or a reversible injury with reperfusion of a given duration. The authors emphasized that in such studies, a special significance should be given to intravital imaging of acute ischemic damage foci using modern methods, which allow assessing the dynamics of the pathological process and meet the requirements to humane treatment of animals. The choice of a relevant ACI model is determined by objectives of the planned study and the technological resources available at the research laboratory.

scholarly journals Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2506
Author(s):  
Wamidh H. Talib ◽  
Ahmad Riyad Alsayed ◽  
Alaa Abuawad ◽  
Safa Daoud ◽  
Asma Ismail Mahmod
Keyword(s):  
Clinical Trials ◽  
Current Knowledge ◽  
Biological Activities ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Cell Proliferation Inhibition ◽  
Different Types ◽  
Solid Foundation

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

scholarly journals Animal Models in Pharmacology: A Brief History Awarding the Nobel Prizes for Physiology or Medicine

Pharmacology ◽  
2021 ◽  
pp. 1-13
Author(s):  
Catarina V. Jota Baptista ◽  
Ana I. Faustino-Rocha ◽  
Paula A. Oliveira
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
20Th Century ◽  
Scientific Knowledge ◽  
Mode Of Action ◽  
Experimental Protocol ◽  
Domestic Species ◽  
Scientific Area ◽  
Different Types ◽  
Scientific Fields

<b><i>Background:</i></b> The Nobel Prize of Physiology or Medicine (NPPM) has recognized the work of 222 scientists from different nationalities, from 1901 until 2020. From the total, 186 award researchers used animal models in their projects, and 21 were attributed to scientists and projects directly related to Pharmacology. In the most recent years, genetics is a dominant scientific area, while at the beginning of the 20th century, most of the studies were more related to anatomy, cytology, and physiology. <b><i>Summary:</i></b> Mammalian models were used in 144 NPPM projects, being rodents the most used group of species. Moreover, 92 researchers included domestic species in their work. The criteria used to choose the species, the number of animals used and the experimental protocol is always debatable and dependent on the scientific area of the study; however, the 3R’s principle can be applied to most scientific fields. Independently of the species, the animal model can be classified in different types and criteria, depending on their ecology, genetics, and mode of action. <b><i>Key-Messages:</i></b> The use of animal models in NPPM awarded projects, namely in Pharmacology, illustrates their importance, need and benefit to improve scientific knowledge and create solutions. In the future, with the contribute of technology, it might be possible to refine the use of animal models in pharmacology studies.

scholarly journals Effects of Concrete Core Technological Defects on the Strength of Tube Confined Concrete Elements

2018 ◽  
Vol 7 (3.2) ◽  
pp. 376
Author(s):  
Oleksandr Semko ◽  
Olga Gukasian ◽  
Serhii Skliarenko
Keyword(s):  
Concrete Strength ◽  
Experimental Studies ◽  
Fracture Pattern ◽  
Confined Concrete ◽  
Concrete Core ◽  
Different Types ◽  
Technological Defects ◽  
Concrete Elements ◽  
Core Production ◽  
Physical And Mechanical Characteristics

The paper sums up a series of experimental studies describing the influence of most types of concreting common defects, such as core weakening: weak compression inclusions, voids, height heterogeneity of concrete. The basis of the experimental study is the research on the concrete core production conditions influence on tube confined concrete elements and the change in physical and mechanical characteristics of the elements. The concrete strength is estimated based on the results of the study of specially shaped samples with given dimensions. According to the results of concreting samples with different types of modeled defects (abnormalities) inspection, the most dangerous damages of the concrete core were identified and different variants of the height strength retrogression of the elements under study were analyzed. As a result, the degree and type of damage to the tube confined concrete elements core of the samples, which affect the fracture pattern, was established. 

scholarly journals Investigation of a Turbogenerator Based on the Vortex Expansion Machine with a Peripheral Side Channel

2021 ◽  
Vol 8 (1) ◽  
pp. F11-F18
Author(s):  
S.M. Vaneev ◽  
V.S. Martsynkovskyy ◽  
A. Kulikov ◽  
D.V. Miroshnichenko ◽  
Ya.І. Bilyk ◽  
...  
Keyword(s):  
Electricity Generation ◽  
Experimental Studies ◽  
Geometric Parameters ◽  
Working Fluid ◽  
Advantages And Disadvantages ◽  
Lateral Channel ◽  
Different Types ◽  
Flow Part ◽  
Special Stand ◽  
Constant Improvement

The creation of energy-saving turbogenerators is an essential component of the development of small energy systems. The gradual growth of interest in distributed electricity generation necessitates the constant improvement of these units. Moreover, they implement a more environmentally friendly generation method than when using microturbine units that use fuel to carry out the work process. Nowadays, turbogenerators are created based on different types of expansion machines, which have their advantages and disadvantages, given in this article. Compared to competitors, vortex expansion machines have good prospects and the necessary potential to expand their research and produce turbogenerators. An experimental vortex expansion machine with a peripheral-lateral channel and ability to change the geometric parameters of its flowing part was created to meet these needs. Experimental studies of the machine were performed on a special stand with air as a working fluid. As a result of the tests, the data were successfully obtained and processed. They are presented in the form of tables and graphical dependencies. The nature of the influence of thermodynamic parameters and geometric parameters of the flow part on the efficiency of the vortex expansion machine and turbogenerator based on it to further improve and create new turbogenerators is clarified.

scholarly journals Physico-technical approach to design of composites from mineral and polymer technogenic resources

2015 ◽  
Vol 1 ◽  
pp. 162 ◽  
Author(s):  
Gotfrīds Noviks
Keyword(s):  
Composite Materials ◽  
Experimental Studies ◽  
Process Efficiency ◽  
Operating Characteristics ◽  
Forming Process ◽  
Polymer Waste ◽  
Composite Forming ◽  
Different Types ◽  
Low Levels

<p class="R-AbstractKeywords"><span lang="EN-US">Artificial composite materials are currently being produced in large quantities, they are diverse and they are widely used in the economy. There have been extensive theoretical and experimental studies of different types of components, developed the calculation methods of composites production with predefined properties.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">At the same time industry produces a lot of mineral and polymer waste, which are practically technogenic resources, but their use is currently at quite low levels. The paper examines the possibilities to use technogenic resources- mineral (such as ash and clay) and organic (polymers -PET containers) for producing qualitative composite materials. For this purpose theoretical analysis and calculations of the physical properties of components and process parameters that determine the operating characteristics of the composite material were carried out.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">Composite-forming process efficiency determinative parameters were analysed: adhesion, the specific surface energy, specific free surface, adsorption capacity and the degree of dispersion of the particles.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">The role of external factors in processing of composite were examined – temperature, concentration of components.</span></p><p class="R-AbstractKeywords"><span lang="EN-US">The characteristics of prepared samples of composites showed the possibility to use these waste for the development of qualitative products for different purposes.</span></p>

scholarly journals Consumer Information Search Behavior for Experiential and Material Purchases

2014 ◽  
Vol 6 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Asli Elif Aydin
Keyword(s):  
Direct Observation ◽  
Information Search ◽  
Experimental Studies ◽  
Search Behavior ◽  
Consumer Information ◽  
Sources Of Information ◽  
Different Types ◽  
Material Purchases ◽  
Information Search Behavior ◽  
Consumer Information Search

The objective of this study is to determine whether sources of information consulted and the extent of information search differ between experiential and material purchases. For this purpose two experimental studies were conducted. It is demonstrated that moving along the experiential-material purchase continuum; consumers’ reliance on personal sources, especially personal independent sources intensifies towards experiential purchase pole and decreases towards material purchase pole. In addition, for material purchases; direct observation is preferred more compared to personal sources of information. Finally, it is revealed that the total amount of search is greater for experiential purchases than material purchases. The results suggest that experiential and material purchases require different types of search conduct due to their distinct natures.

scholarly journals Transport of engineered nanoparticles in soils and aquifers

2019 ◽  
Vol 27 (1) ◽  
pp. 43-70 ◽  
Author(s):  
Mahmood Fazeli Sangani ◽  
Gary Owens ◽  
Amir Fotovat
Keyword(s):  
Experimental Studies ◽  
Engineered Nanoparticles ◽  
Background Solution ◽  
Contributing Factors ◽  
Factors Affecting ◽  
Soil Systems ◽  
Aquifer Systems ◽  
Different Types ◽  
Transport Behaviour ◽  
The Media

Transport and deposition behaviour of engineered nanoparticles (ENPs) in natural aquifers and soil systems is a key determinant of the fate of these materials in environmental systems. A growing number of experimental studies are being conducted worldwide to address transport and deposition of ENPs in porous media (PM). Here we comprehensively review the main mechanisms and factors affecting the mobility of the environmentally important ENPs in natural PM. A variety of different processes including those that promote mobility and result in elution from the PM and those that hinder their mobility and promote ENP retention can influence ENP’s mobility through soil and aquifer media. The most important contributing factors regarding ENP transport in PM include: the physicochemical properties of the ENP, the media, the hydrodynamics of the system, and the background solution characteristics. Results from several studies conducted on the most common and environmentally important ENPs have shown that under natural environmental conditions, different types of ENPs show different transport behaviour in soil and aquifer systems. Additionally, the importance of media matrix and mobile solution factors in governing mobility of ENPs varies from one type of ENP to another.

scholarly journals Agro-economic yield of taro clones in Brazil, propagated with different types of cuttings, in three crop seasons

2013 ◽  
Vol 85 (2) ◽  
pp. 785-798
Author(s):  
NESTOR A. HEREDIA ZARATE ◽  
MARIA C. VIEIRA ◽  
LUCIANE A. TABALDI ◽  
DANILO A. HEREDIA VIEIRA ◽  
ROSIMEIRE P.G. JORGE ◽  
...  
Keyword(s):  
Analysis Of Variance ◽  
Experimental Studies ◽  
Dry Weight ◽  
Joint Analysis ◽  
Net Income ◽  
Average Yield ◽  
Fresh Weight ◽  
Crop Season ◽  
Different Types

The experimental studies were conducted in 2007-2008, 2008-2009 and 2009-2010 crop seasons, in order to know the agro-economic yield of 'Chinês' and "Macaquinho" taro clones, propagated using huge, extra, large, medium, small and tiny cormels. The harvest was done on average on 202 days after planting, in three crop seasons. Based on the joint analysis of variance carried out, it was observed that taro clones showed significant differences in the yield of fresh and dry weight of leaves, cormels, and commercial and non-commercial comels; besides, there were significant differences in yield of a crop season to another and the size of the cuttings induced significant differences in yield. In the conditions that the experiments were conducted, and considering the highest average yield of fresh weight of commercial cormels (28.69 t.ha-1) and highest net income (US $14,741.14) correspondent to the three crop seasons, it is recommended to cultivate 'Macaquinho' clone using small cuttings in propagation.

scholarly journals When is Sustainability a Liability, and When Is It an Asset? Quality Inferences for Core and Peripheral Attributes

2020 ◽  
Author(s):  
Siv Skard ◽  
Sveinung Jørgensen ◽  
Lars Jacob Tynes Pedersen
Keyword(s):  
Product Quality ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Current Understanding ◽  
Product Packaging ◽  
Sustainable Products ◽  
Functional Quality ◽  
Different Types ◽  
Asset Quality

AbstractSustainable products offered in today’s marketplace are labelled with product-related green attributes (i.e. green core attributes) or non-product-related green attributes (i.e. green peripheral attributes). The current research investigates consumers’ inferences about a product’s functional quality when its core attributes are green (e.g. the ingredients) and when its peripheral attributes are green (e.g. the product packaging). Four experimental studies and an internal meta-analysis show that there is a sustainability liability effect in strength-dependent categories (for both core and peripheral attributes), and a sustainability asset effect in gentleness-dependent categories (for core attributes only). Our research contributes to the current understanding of how consumers make inferences about product quality when contemplating different types of green attributes. The findings have implications for how strength-dependent and gentleness-dependent products should be labelled as green.

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