Brainstem Circuits for Locomotion

2022 ◽  
Vol 45 (1) ◽  
Author(s):  
Roberto Leiras ◽  
Jared M. Cregg ◽  
Ole Kiehn
Keyword(s):  
Motor Behavior ◽  
Annual Review ◽  
Publication Date ◽  
Brain Areas ◽  
Brain Functions ◽  
Functional Connectome ◽  
Locomotor Control ◽  
Context Specific ◽  
Recurrent Theme ◽  
Selection Of

Locomotion is a universal motor behavior that is expressed as the output of many integrated brain functions. Locomotion is organized at several levels of the nervous system, with brainstem circuits acting as the gate between brain areas regulating innate, emotional, or motivational locomotion and executive spinal circuits. Here we review recent advances on brainstem circuits involved in controlling locomotion. We describe how delineated command circuits govern the start, speed, stop, and steering of locomotion. We also discuss how these pathways interface between executive circuits in the spinal cord and diverse brain areas important for context-specific selection of locomotion. A recurrent theme is the need to establish a functional connectome to and from brainstem command circuits. Finally, we point to unresolved issues concerning the integrated function of locomotor control. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Protein Reconstitution Inside Giant Unilamellar Vesicles

2021 ◽  
Vol 50 (1) ◽  
Author(s):  
Thomas Litschel ◽  
Petra Schwille
Keyword(s):  
Optical Resolution ◽  
Microscopic Investigation ◽  
Annual Review ◽  
Publication Date ◽  
Protein Encapsulation ◽  
Resolution Limit ◽  
Giant Unilamellar Vesicles ◽  
Unilamellar Vesicles ◽  
Encapsulation Methods ◽  
Selection Of

Giant unilamellar vesicles (GUVs) have gained great popularity as mimicries for cellular membranes. As their sizes are comfortably above the optical resolution limit, and their lipid composition is easily controlled, they are ideal for quantitative light microscopic investigation of dynamic processes in and on membranes. However, reconstitution of functional proteins into the lumen or the GUV membrane itself has proven technically challenging. In recent years, a selection of techniques has been introduced that tremendously improve GUV-assay development and enable the precise investigation of protein–membrane interactions under well-controlled conditions. Moreover, due to these methodological advances, GUVs are considered important candidates as protocells in bottom-up synthetic biology. In this review, we discuss the state of the art of the most important vesicle production and protein encapsulation methods and highlight some key protein systems whose functional reconstitution has advanced the field. Expected final online publication date for the Annual Review of Biophysics, Volume 50 is May 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Clinical Staging for Youth Mental Disorders: Progress in Reforming Diagnosis and Clinical Care

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Patrick D. McGorry ◽  
Cristina Mei
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Developmental Psychology ◽  
Clinical Care ◽  
Clinical Staging ◽  
Annual Review ◽  
Publication Date ◽  
Diagnostic Systems ◽  
Illness Progression ◽  
Selection Of

Current silo-based diagnostic systems for mental disorders lack utility and fail to fulfil a fundamental purpose of diagnosis: to guide treatment planning and predict outcomes. Diagnostic reform has gained momentum, and clinical staging has emerged as a promising framework to improve the precision of diagnosis, particularly in early illness stages, and fill current gaps in linking diagnosis to more personalized and effective intervention, prognosis, and neurobiological markers. Transdiagnostic clinical staging recognizes that the early development of mental ill-health is marked by substantial fluidity and that symptoms may, although not inevitably, evolve into more stable diagnosable syndromes. Staging facilitates the selection of interventions that are proportionate to the current need and risk of illness progression and provides an efficient framework to organize biomarker data and guide service delivery. Here, we provide an overview of transdiagnostic clinical staging and summarize key evidence supporting its ability to integrate biomarkers and guide mental health care. Expected final online publication date for the Annual Review of Developmental Psychology, Volume 3 is December 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Developmental Cognitive Neuroscience in the Era of Networks and Big Data: Strengths, Weaknesses, Opportunities, and Threats

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Damien A. Fair ◽  
Nico U.F. Dosenbach ◽  
Amy H. Moore ◽  
Theodore Satterthwaite ◽  
Michael P. Milham
Keyword(s):  
Big Data ◽  
Cognitive Neuroscience ◽  
Developmental Psychology ◽  
Annual Review ◽  
Publication Date ◽  
Functional Magnetic Resonance ◽  
Brain Functions ◽  
New Directions ◽  
Functional Connectivity Mri ◽  
Developmental Cognitive Neuroscience

Developmental cognitive neuroscience is being pulled in new directions by network science and big data. Brain imaging [e.g., functional magnetic resonance imaging (fMRI), functional connectivity MRI], analytical advances (e.g., graph theory, machine learning), and access to large computing resources have empowered us to collect and process neurobehavioral data faster and in larger populations than ever before. The translational potential from these advances is unparalleled, as a better understanding of complex human brain functions is best grounded in the onset of these functions during human development. However, the maturation of developmental cognitive neuroscience has seen the emergence of new challenges and pitfalls, which have significantly slowed progress and need to be overcome to maintain momentum. In this review, we examine the state of developmental cognitive neuroscience in the era of networks and big data. In addition, we provide a discussion of the strengths, weaknesses, opportunities, and threats (SWOT) of the field to advance developmental cognitive neuroscience's scientific and translational potential. Expected final online publication date for the Annual Review of Developmental Psychology, Volume 3 is December 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Remembering the Past to See the Future

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Nicole C. Rust ◽  
Stephanie E. Palmer
Keyword(s):  
Visual System ◽  
Science Volume ◽  
Annual Review ◽  
Publication Date ◽  
Brain Areas ◽  
Vision Science ◽  
The Past ◽  
Future Events ◽  
The Relationship

In addition to the role that our visual system plays in determining what we are seeing right now, visual computations contribute in important ways to predicting what we will see next. While the role of memory in creating future predictions is often overlooked, efficient predictive computation requires the use of information about the past to estimate future events. In this article, we introduce a framework for understanding the relationship between memory and visual prediction and review the two classes of mechanisms that the visual system relies on to create future predictions. We also discuss the principles that define the mapping from predictive computations to predictive mechanisms and how downstream brain areas interpret the predictive signals computed by the visual system. Expected final online publication date for the Annual Review of Vision Science, Volume 7 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution

2021 ◽  
Vol 55 (1) ◽  
Author(s):  
Baptiste Libé-Philippot ◽  
Pierre Vanderhaeghen
Keyword(s):  
Neural Development ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Regulatory Elements ◽  
Annual Review ◽  
Publication Date ◽  
Human Species ◽  
Cellular Mechanisms ◽  
Brain Functions ◽  
Molecular Features

The cerebral cortex is at the core of brain functions that are thought to be particularly developed in the human species. Human cortex specificities stem from divergent features of corticogenesis, leading to increased cortical size and complexity. Underlying cellular mechanisms include prolonged patterns of neuronal generation and maturation, as well as the amplification of specific types of stem/progenitor cells. While the gene regulatory networks of corticogenesis appear to be largely conserved among all mammals including humans, they have evolved in primates, particularly in the human species, through the emergence of rapidly divergent transcriptional regulatory elements, as well as recently duplicated novel genes. These human-specific molecular features together control key cellular milestones of human corticogenesis and are often affected in neurodevelopmental disorders, thus linking human neural development, evolution, and diseases. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Syntactic Change in Contact: Romance

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Roberta D'Alessandro
Keyword(s):  
Language Contact ◽  
Language Change ◽  
Romance Languages ◽  
Annual Review ◽  
Publication Date ◽  
Differential Object Marking ◽  
Languages In Contact ◽  
Syntactic Change ◽  
Object Marking ◽  
Selection Of

Language change as a result of language contact is studied in many different ways using a number of different methodologies. This article provides an overview of the main approaches to syntactic change in contact (CIC), focusing on the Romance language group. Romance languages are widely documented both synchronically and diachronically. They have been in extensive contact with other language families both in bilingual contexts and in creolization contexts. Furthermore, they present great microvariation. They are therefore ideal to tackle language change in contact. Given the breadth of studies targeting Romance languages in contact, only a selection of facts is considered here, namely pro-drop, differential object marking (DOM), and deixis. The article shows that microcontact, i.e., contact between minimally different grammars, is a necessary dimension to be considered within contact studies, as it provides insights that are often radically different from those provided by the observation of contact between maximally different languages. Expected final online publication date for the Annual Review of Linguistics, Volume 7 is January 14, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals Bipolar (Bio)electroanalysis

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Laurent Bouffier ◽  
Dodzi Zigah ◽  
Neso Sojic ◽  
Alexander Kuhn
Keyword(s):  
Analytical Chemistry ◽  
Online Publication ◽  
Annual Review ◽  
Publication Date ◽  
New Ideas ◽  
Selection Of ◽  
Bipolar Electrochemistry

This contribution reviews a selection of the most recent studies on the use of bipolar electrochemistry in the framework of analytical chemistry. Despite the fact that the concept is not new, with several important studies dating back to the middle of the last century, completely novel and very original approaches have emerged over the last decade. This current revival illustrates that scientists still (re)discover some exciting virtues of this approach, which are useful in many different areas, especially for tackling analytical challenges in an unconventional way. In several cases, this “wireless” electrochemistry strategy enables carrying out measurements that are simply not possible with classic electrochemical approaches. This review will hopefully stimulate new ideas and trigger scientists to integrate some aspects of bipolar electrochemistry in their work in order to drive the topic into yet unexplored and eventually completely unexpected directions. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Price Transmission in Agricultural Markets

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Stephan von Cramon-Taubadel ◽  
Barry K. Goodwin
Keyword(s):  
Food Chain ◽  
Food System ◽  
Price Transmission ◽  
Empirical Literature ◽  
Annual Review ◽  
Agricultural Markets ◽  
Publication Date ◽  
Vertical Coordination ◽  
Marketing Information ◽  
Context Specific

We review recent developments in the analysis of price transmission in agricultural markets. Markets may be separated in time, form, and space (as well as in combinations of such factors). Transactions and storage costs as well as production and marketing factors delineate these markets. We show that much of the research on spatial market linkages has reflected methodological advances that have led to increasingly nonlinear time-series models. Advances in the theoretical and empirical literature over the last few decades have demonstrated that price relationships in the food chain are highly context specific. Improvements in marketing, information, and transportation technology have strengthened the links between prices in the food system, but at the same time links in the food chain are increasingly subject to vertical coordination and, thus, less visible to outside observers, including researchers. Expected final online publication date for the Annual Review of Resource Economics, Volume 13 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

scholarly journals The benefit of the diffusion kurtosis imaging in presurgical evaluation in patients with focal MR-negative epilepsy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michaela Bartoňová ◽  
Marek Bartoň ◽  
Pavel Říha ◽  
Lubomír Vojtíšek ◽  
Milan Brázdil ◽  
...  
Keyword(s):  
Refractory Epilepsy ◽  
Diffusion Kurtosis Imaging ◽  
Epileptogenic Zone ◽  
Diffusion Weighted Mri ◽  
Specific Detection ◽  
Presurgical Evaluation ◽  
Brain Areas ◽  
Specific Restriction ◽  
Diffusion Kurtosis ◽  
Selection Of

AbstractThe effectivity of diffusion-weighted MRI methods in detecting the epileptogenic zone (EZ) was tested. Patients with refractory epilepsy (N=25) who subsequently underwent resective surgery were recruited. First, the extent of white matter (WM) asymmetry from mean kurtosis (MK) was calculated in order to detect the lobe with the strongest impairment. Second, a newly developed metric was used, reflecting a selection of brain areas with concurrently increased mean Diffusivity, reduced fractional Anisotropy, and reduced mean Kurtosis (iDrArK). A two-step EZ detection was performed as (1) lobe-specific detection, (2) iDrArK voxel-wise detection (with a possible lobe-specific restriction if the result of the first step was significant in a given subject). The method results were compared with the surgery resection zones. From the whole cohort (N=25), the numbers of patients with significant results were: 10 patients in lobe detection and 9 patients in EZ detection. From these subsets of patients with significant results, the impaired lobe was successfully detected with 100% accuracy; the EZ was successfully detected with 89% accuracy. The detection of the EZ using iDrArK was substantially more successful when compared with solo diffusional parameters (or their pairwise combinations). For a subgroup with significant results from step one (N=10), iDrArK without lobe restriction achieved 37.5% accuracy; lobe-restricted iDrArK achieved 100% accuracy. The study shows the plausibility of MK for detecting widespread WM changes and the benefit of combining different diffusional voxel-wise parameters.

Endogenous Retroviruses Drive Resistance and Promotion of Exogenous Retroviral Homologs

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Elliott S. Chiu ◽  
Sue VandeWoude
Keyword(s):  
Immune Modulation ◽  
Viral Infections ◽  
Viral Evolution ◽  
Endogenous Retroviruses ◽  
Annual Review ◽  
Publication Date ◽  
Biological Functions ◽  
Self Tolerance ◽  
Vertebrate Hosts ◽  
Insight Into

Endogenous retroviruses (ERVs) serve as markers of ancient viral infections and provide invaluable insight into host and viral evolution. ERVs have been exapted to assist in performing basic biological functions, including placentation, immune modulation, and oncogenesis. A subset of ERVs share high nucleotide similarity to circulating horizontally transmitted exogenous retrovirus (XRV) progenitors. In these cases, ERV–XRV interactions have been documented and include ( a) recombination to result in ERV–XRV chimeras, ( b) ERV induction of immune self-tolerance to XRV antigens, ( c) ERV antigen interference with XRV receptor binding, and ( d) interactions resulting in both enhancement and restriction of XRV infections. Whereas the mechanisms governing recombination and immune self-tolerance have been partially determined, enhancement and restriction of XRV infection are virus specific and only partially understood. This review summarizes interactions between six unique ERV–XRV pairs, highlighting important ERV biological functions and potential evolutionary histories in vertebrate hosts. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 9 is February 16, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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