scholarly journals Skeletal changes associated with the onset of type 2 diabetes in the ZDF and ZDSD rodent models

2009 ◽  
Vol 296 (4) ◽  
pp. E765-E774 ◽  
Author(s):  
Susan Reinwald ◽  
Richard G. Peterson ◽  
Matt R. Allen ◽  
David B. Burr
Keyword(s):  
Type 2 Diabetes ◽  
The United States ◽  
Diabetic Rats ◽  
Sprague Dawley ◽  
Preclinical Research ◽  
Three Point Bending ◽  
Skeletal Changes ◽  
Adult Onset Diabetes ◽  
The Impact

The incidence and prevalence of type 2 diabetes (T2D) continue to escalate at an unprecedented rate in the United States, particularly among populations with high rates of obesity. The impact of T2D on bone mass, geometry, architecture, strength, and resistance to fracture has yet to be incontrovertibly characterized because of the complex and heterogeneous nature of this disease. This study utilized skeletally mature male diabetic rats of the commonly used Zucker diabetic fatty (ZDF) and Zucker diabetic Sprague-Dawley (ZDSD) strains as surrogate models to assess alterations in bone attributable to T2D-like states. After the animals were euthanized, bone data were collected using dual-energy X-ray absorptiometry, peripheral quantitative tomography, and micro-CT imaging modalities and via three-point bending or compression mechanical testing methods. ZDF and ZDSD diabetic rats exhibited lower bone mineral densities, which coincided with declines in structural strength and increased fragility at the femoral midshaft and the L4 vertebral body in response to monotonic loading. Vertebral trabecular morphology was compromised in both diabetic rodent strains, and ZDSD diabetic rats exhibited additional phenotypic impairments to bone material properties at the spine. Because the metabolic origin of the T2D-like state that develops in the ZDSD rat strain is highly relevant to adult-onset diabetes, it is a particularly attractive novel model for future preclinical research.

scholarly journals Type 2 diabetes and tuberculosis in a dynamic bi-national border population

2006 ◽  
Vol 135 (3) ◽  
pp. 483-491 ◽  
Author(s):  
B. I. RESTREPO ◽  
S. P. FISHER-HOCH ◽  
J. G. CRESPO ◽  
E. WHITNEY ◽  
A. PEREZ ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Large Population ◽  
The United States ◽  
South Texas ◽  
Control Programmes ◽  
Mexico Border ◽  
Northeastern Mexico ◽  
The Impact ◽  
Border Population

The epidemic of type 2 diabetes in the United States prompted us to explore the association between diabetes and tuberculosis (TB) on the South Texas–Mexico border, in a large population of mostly non-hospitalized TB patients. We examined 6 years of retrospective data from all TB patients (n=5049) in South Texas and northeastern Mexico and found diabetes self-reported by 27·8% of Texan and 17·8% of Mexican TB patients, significantly exceeding national self-reported diabetes rates for both countries. Diabetes comorbidity substantially exceeded that of HIV/AIDS. Patients with TB and diabetes were older, more likely to have haemoptysis, pulmonary cavitations, be smear positive at diagnosis, and remain positive at the end of the first (Texas) or second (Mexico) month of treatment. The impact of type 2 diabetes on TB is underappreciated, and in the light of its epidemic status in many countries, it should be actively considered by TB control programmes, particularly in older patients.

scholarly journals Protective effect of crocin and voluntary exercise against oxidative stress in the heart of high-fat diet-induced type 2 diabetic rats

2016 ◽  
Vol 103 (4) ◽  
pp. 459-468 ◽  
Author(s):  
V Ghorbanzadeh ◽  
M Mohammadi ◽  
G Mohaddes ◽  
H Dariushnejad ◽  
L Chodari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
High Fat Diet ◽  
Critical Role ◽  
Diabetic Rats ◽  
Voluntary Exercise ◽  
High Fat ◽  
The Impact ◽  
Type 2 Diabetic

Background Oxidative stress plays a critical role in the pathogenesis and progression of type 2 diabetes and diabetic-associated cardiovascular complications. This study investigated the impact of crocin combined with voluntary exercise on heart oxidative stress indicator in high-fat diet-induced type 2 diabetic rats. Materials and methods Rats were divided into four groups: diabetes, diabetic-crocin, diabetic-voluntary exercise, diabetic-crocin-voluntary exercise. Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (intraperitoneally, 35 mg/kg). Animals received crocin orally (50 mg/kg); voluntary exercise was performed alone or combined with crocin treatment for 8 weeks. Finally, malondialdehyde (MDA), activity of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured spectrophotometrically. Results Treatment of diabetic rats with crocin and exercise significantly decreased the levels of MDA (p < 0.001) and increased the activity of SOD, GPx, and CAT compared with the untreated diabetic group. In addition, combination of exercise and crocin amplified their effect on antioxidant levels in the heart tissue of type 2 diabetic rats. Conclusion We suggest that a combination of crocin with voluntary exercise treatment may cause more beneficial effects in antioxidant defense system of heart tissues than the use of crocin or voluntary exercise alone.

scholarly journals Impact of overlapping risks of type 2 diabetes and obesity on coronavirus disease severity in the United States

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wataru Ando ◽  
Takeshi Horii ◽  
Takayuki Uematsu ◽  
Hideaki Hanaki ◽  
Koichiro Atsuda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Critical Care ◽  
Risk Score ◽  
The United States ◽  
Risk Scores ◽  
Research Database ◽  
Male Sex ◽  
The Impact ◽  
Diabetes And Obesity

AbstractThe impact of overlapping risk factors on coronavirus disease (COVID-19) severity is unclear. To evaluate the impact of type 2 diabetes (T2D) and obesity on COVID-19 severity, we conducted a cohort study with 28,095 anonymized COVID-19 patients using data from the COVID-19 Research Database from January 1, 2020 to November 30, 2020. The mean age was 50.8 ± 17.5 years, and 11,802 (42%) patients were male. Data on age, race, sex, T2D complications, antidiabetic medication prescription, and body mass index ≥ 30 kg/m2 (obesity) were analysed using Cox proportional hazard models, with hospitalization risk and critical care within 30 days of COVID-19 diagnosis as the main outcomes. The risk scores were 0–4 for age ≥ 65 years, male sex, T2D, and obesity. Among the participants, 11,294 (61.9%) had obesity, and 4445 (15.8%) had T2D. T2D, obesity, and male sex were significantly associated with COVID-19 hospitalization risk. Regarding hospitalization risk scores, compared with those for hospitalization risk score 0 and critical care risk score 0, hazard ratios [95% confidence intervals] were 19.034 [10.470–34.600] and 55.803 [12.761–244.015] (P < 0.001) (P < 0.001), respectively, for risk score 4. Complications from diabetes and obesity increased hospitalization and critical care risks for COVID-19 patients.

The Impact of Partnership Status on Diabetes Control and Self-Management Behaviors

2018 ◽  
Vol 45 (5) ◽  
pp. 668-671 ◽  
Author(s):  
Lindsay Haines ◽  
Natalie Coppa ◽  
Yael Harris ◽  
Juan P. Wisnivesky ◽  
Jenny J. Lin
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Monitoring ◽  
The United States ◽  
Diabetes Control ◽  
Self Management ◽  
Partnership Status ◽  
The Impact ◽  
Management Behaviors

According to the Centers for Disease Control and Prevention, diabetes affects 29.1 million people in the United States. Marriage has been suggested to have a protective effect on overall health outcomes, but few studies have evaluated the role of partnership status on patients with type 2 diabetes. This study aimed to assess this role of partnership status on diabetes control and self-management behaviors. Patients with type 2 diabetes taking at least one oral hypoglycemic agent were assessed over a 3-month period to measure hemoglobin A1c (HbA1c) changes and adherence to medication, exercise, diet, and glucose monitoring. Partnered participants were more likely to adhere to their medications, but there was no significant difference in HbA1c changes over 3 months or exercise, diet, or glucose monitoring adherence. This study suggests that being partnered improves medication adherence; further analysis with a larger population is required to fully assess the role of partner support for patients with type 2 diabetes.

scholarly journals THE IMPACT OF QUERCETIN ON THE FUNCTIONAL STATE OF CARDIOVASCULAR SYSTEM AND HEMOSTASE IN RATS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
Vol 77 (3) ◽  
pp. 105-110
Author(s):  
Olha Ivanova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Cardiovascular System ◽  
Functional State ◽  
Cardiovascular Complications ◽  
Diabetic Rats ◽  
The Impact

Introduction. Type 2 diabetes mellitus (T2DM) increases the risk for atherosclerotic cardiovascular disease and other cardiovascular complications such as cardiac arrhythmias, heart failure, and thrombotic events. Quercetin (Q) possesses a wide range of multiple activities: anti-diabetic, anti-proliferative, anti-atherosclerotic, antioxidant, anti-inflammatory, anti-thrombotic, anti-apoptotic effects and is regarded as a candidate for the role of cardiovascular complications protecting agent. The aim of this study was to assess the effects of Q on the functional state of cardiovascular system and haemostasis in diabetic rats. Materials and Methods. T2DM was induced in Wistar rats by a high-caloric diet during 14 weeks combined with intraperitoneal injections of 25 mg/kg streptozotocin twice per week. All diabetic animals were divided into three groups: treated with solvent and with Q (in dose 10 and 50 mg/kg/day per os) for 8 weeks after diabetes induction. Fibrinogen concentration and induced euglobulin fibrinolysis time were measured in plasma using reagent kits. Electrocardiograms were recorded in leads II. Results. It was established that Q in dose 50 mg/kg b.w. prevents in the formation of sinus tachycardia in experimental animals. In addition, Q in both doses inhibits the development of myocardial diastolic dysfunction, which was confirmed by prolongation of T-P interval and a decrease of duration of the T wave in comparison with diabetic rats. Q in both doses restorated the processes of coagulations and fibrinolysis, as indicated by a decrease of fibrinogen levels and the time of thrombolysis compared to diabetic rats. Conclusions. Q, independently of dose, inhibits the development of myocardial diastolic dysfunction and reduces prothrombotic potential in rats with type 2 diabetes, which may ameliorate diabetic cardiovascular risk. This data justify the perspective of Q for the prevention and management of cardiovascular complications in patients with type 2 diabetes.

THE IMPACT OF SELECTIVE ESTROGEN RECEPTOR MODUL ATOR PE0607 ON MITOCHONDRIA FUNCTIONAL STATE IN HE ART OF OVARIECTOMIZED RATS WITH TYPE 2 DIABETES

2017 ◽  
Vol 60 (2) ◽  
pp. 57-63
Author(s):  
Tetiana Kiprich
Keyword(s):  
Type 2 Diabetes ◽  
Estrogen Receptor ◽  
Diabetic Rats ◽  
Ovariectomized Rats ◽  
Oxygen Species ◽  
Receptor Modulator ◽  
The Impact ◽  
Gender Specific ◽  
Specific Agent

The impact of selective estrogen receptor modulator PE0607 on mitochondrial dysfunction in heart of ovariectomized rats with type 2 diabetes was investigated. It was established that oral administration of PE0607 decreases production of reactive oxygen species (hydrogen peroxide) in cardiomyocyte mitochondria and increasesaconitase activity and cytochromes с, с1, b, аа3concentration by control rate in heart of diabetic rats with hypoestrogenia. These results justify the PE0607 availability as a gender-specific agent to impair cardiovascularrisk in diabetic women with estrogen deficiency.

scholarly journals Euglycemia in Diabetic Rats Leads to Reduced Liver Weight via Increased Autophagy and Apoptosis through Increased AMPK and Caspase-3 and Decreased mTOR Activities

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Jun-Ho Lee ◽  
Soo-Bong Choi ◽  
Mingli Jin ◽  
Ju-Han Lee ◽  
Sang-Don Han ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Weight ◽  
Molecular Mechanisms ◽  
Caspase 3 ◽  
Liver Weight ◽  
Diabetic Rats ◽  
Insulin Deficiency ◽  
Sprague Dawley ◽  
Ad Libitum

Euglycemia is the ultimate goal in diabetes care to prevent complications. However, the benefits of euglycemia in type 2 diabetes are controversial because near-euglycemic subjects show higher mortality than moderately hyperglycemic subjects. We previously reported that euglycemic-diabetic rats on calorie-control lose a critical liver weight (LW) compared with hyperglycemic rats. Here, we elucidated the molecular mechanisms underlying the loss of LW in euglycemic-diabetic rats and identified a potential risk in achieving euglycemia by calorie-control. Sprague-Dawley diabetic rats generated by subtotal-pancreatectomy were fed a calorie-controlled diet for 7 weeks to achieve euglycemia using 19 kcal% (19R) or 6 kcal% (6R) protein-containing chow or fedad libitum(19AL). The diet in both R groups was isocaloric/kg body weight to the sham-operated group (19S). Compared with 19S and hyperglycemic 19AL, both euglycemic R groups showed lower LWs, increased autophagy, and increased AMPK and caspase-3 and decreased mTOR activities. Though degree of insulin deficiency was similar among the diabetic rats, Akt activity was lower, and PTEN activity was higher in both R groups than in 19AL whose signaling patterns were similar to 19S. In conclusion, euglycemia achieved by calorie-control is deleterious in insulin deficiency due to increased autophagy and apoptosis in the liver via AMPK and caspase-3 activation.

scholarly journals The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus

2021 ◽  
Vol 11 (2) ◽  
pp. 242
Author(s):  
Basem H. Elesawy ◽  
Bassem M. Raafat ◽  
Aya Al Muqbali ◽  
Amr M. Abbas ◽  
Hussein F. Sakr
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Diabetic Rats ◽  
Intermittent Fasting ◽  
Neurotrophin 3 ◽  
The Impact

Type 2 diabetes mellitus (T2DM) is known to be associated with an increased risk of dementia, specifically Alzheimer’s disease and vascular dementia. Intermittent fasting (IF) has been proposed to produce neuroprotective effects through the activation of several signaling pathways. In this study, we investigated the effect of IF on rat behavior in type 2 diabetic rats. Forty male Wistar Kyoto rats were divided into four groups (n = 10 for each): the ad libitum (Ad) group, the intermittent fasting group (IF), the streptozotocin-induced diabetic 2 group (T2DM) fed a high-fat diet for 4 weeks followed by a single intraperitoneal (i.p.) injection of streptozotocin (STZ) 25 mg kg−1, and the diabetic group with intermittent fasting (T2DM+IF). We evaluated the impact of 3 months of IF (16 h of food deprivation daily) on the levels of brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), serotonin, dopamine, and glutamate in the hippocampus, and rat behavior was assessed by the forced swim test and elevated plus maze. IF for 12 weeks significantly increased (p < 0.05) the levels of NT3 and BDNF in both control and T2DM rats. Additionally, it increased serotonin, dopamine, and glutamic acid in diabetic rats. Moreover, IF modulated glucose homeostasis parameters, with a significant decrease (p < 0.05) in insulin resistance and downregulation of serum corticosterone level. Interestingly, T2DM rats showed a significant increase in anxiety and depression behaviors, which were ameliorated by IF. These findings suggest that IF could produce a potentially protective effect by increasing the levels of BDNF and NT3 in both control and T2DM rats. IF could be considered as an additional therapy for depression, anxiety, and neurodegenerative diseases.

scholarly journals Methanolic Extract of Maytenus Procumbens Roots Ameliorates Erectile Dysfunction in Fructose-Streptozotocin Induced Type 2 Diabetic in Rats

2021 ◽  
Author(s):  
Nkosinathi Cele ◽  
Sihle Ephraim Mabhida ◽  
Thembeka Nyawo ◽  
Khanyisani Ziqubu ◽  
Sthandiwe Mazibuko-Mbeje ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Erectile Dysfunction ◽  
Methanolic Extract ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
High Fructose

Erectile dysfunction (ED) due to diabetes mellitus remains difficult to treat despite advances in pharmacotherapeutic approaches in the field. Therefore, this study investigated the erectogenic effect of the methanolic extract of Maytenus procumbens roots on type 2 diabetes in rats. The fructose-streptozotocin model was used to induce type 2 diabetes-linked ED in male rats. The sexually active male Sprague Dawley rats were randomly divided into two major groups; normal group and high fructose fed group for 120 days. After 120 days, the high fructose fed group rats were given a single intraperitoneal injection of a freshly prepared streptozotocin solution (30 mg/kg). The diabetic ED rats were orally administered with the extract at 250 mg/kg, daily for 28 days. The serum, brain and penile tissues were removed for biochemical analysis and protein expression. Increased testosterone level, mounting frequency, reduced blood glucose level and serum fructosamine content was observed after 28 days of treatment in diabetic rats. Methanolic extract also exhibited an inhibitory effect on arginase, AChE, and ACE activities. The crude extract further downregulated proteins PDE-5, RhoA and increased expression of eNOS in the diabetic ED treated rats. The results obtained indicate that the methanolic extract of Maytenus procumbens roots ameliorates erectile dysfunction in type 2 diabetes-induced erectile dysfunction in rats.

Farming for Life: Pilot assessment of the impact of medical prescriptions for vegetables on health and food security among Latino adults with type 2 diabetes

2020 ◽  
Vol 26 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Benjamin York ◽  
Mary Kujan ◽  
Casey Conneely ◽  
Namino Glantz ◽  
David Kerr
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Food Security ◽  
Waist Circumference ◽  
The United States ◽  
Post Intervention ◽  
Female Age ◽  
Organic Vegetables ◽  
The Impact

Background: In the United States, Latino families have a disproportionate burden of diabetes and associated complications. Aim: This pilot study assessed the feasibility of using medical prescriptions of organic vegetables to improve health outcomes among Latinos with type 2 diabetes (T2D). Methods: Latino participants ( n = 21, 91% female, age 56 ± 11.1 years) with T2D received 12 weeks of medically prescribed organic vegetables. Weight, waist circumference, blood pressure, and HbA1c were measured pre and post-intervention. Food security was also assessed. Results: Over 12 weeks, there was a significant fall in systolic ( p = 0.03) and diastolic ( p = 0.01) blood pressure. A total of 14 participants lost weight (median weight loss among responders was 1.9 pounds), and waist circumference decreased in 9 of 19 responders by a median of 1.5 inches. HbA1c was unchanged (6.7 ± 1.1% at baseline versus 7.0 ± 1.1% post-intervention). Conclusions: Medical prescriptions of organic vegetables may have measurable health benefits for adult Latinos with T2D.

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