Effect of Changes in Ambient Temperature on Spontaneous Activity, Food Intake and Body Weight of Goldthioglucose-Obese and Nonobese Mice

1957 ◽  
Vol 188 (3) ◽  
pp. 435-438 ◽  
Author(s):  
M. J. Fregly ◽  
N. B. Marshall ◽  
J. Mayer
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Ambient Temperature ◽  
The Body ◽  
Lower Body ◽  
Obese Mice ◽  
Ambient Temperatures ◽  
Exposure To Cold ◽  
Running Activity ◽  
Body Weights

Goldthioglucose-obese mice cannot adjust their food intake to meet the increased energy requirements due to cold. At all ambient temperatures above 15°C the spontaneous running activity of these animals is less than that observed for nonobese controls. Activity of obese mice is maximal at 19°C and minimal at 15°C or lower. Body weights decrease during exposure to cold. In contrast to that of obese mice, running activity of nonobese controls is maximal at an ambient temperature of 25°C but nearly ceases at 15°C or lower. The food intake of these animals increases in the cold and remains elevated even at temperatures at which activity decreases. The body weight of nonobese controls is either maintained constant or increases during exposure to cold air.

Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY

2020 ◽  
Vol 20 (8) ◽  
pp. 1262-1267
Author(s):  
Haojun Yang ◽  
Hanyang Liu ◽  
YuWen Jiao ◽  
Jun Qian
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Metabolic Diseases ◽  
Peptide Yy ◽  
The Body ◽  
Wild Type ◽  
L Cells ◽  
Body Weights ◽  
Gastrointestinal Bypass ◽  
G Protein Coupled

Background: G protein-coupled bile acid receptor (TGR5) is involved in a number of metabolic diseases. The aim of this study was to identify the role of TGR5 after Roux-en-Y gastric bypass (GBP). Methods: Wild type and TGR5 knockout mice (tgr5-/-) were fed a high-fat diet (HFD) to establish the obesity model. GBP was performed. The changes in body weight and food intake were measured. The levels of TGR5 and peptide YY (PYY) were evaluated by RT-PCR, Western blot, and ELISA. Moreover, the L-cells were separated from wild type and tgr5-/- mice. The levels of PYY in L-cells were evaluated by ELISA. Results: The body weights were significantly decreased after GBP in wild type mice (p<0.05), but not tgr5-/- mice (p>0.05). Food intake was reduced after GBP in wild type mice, but also not significantly affected in tgr5-/- mice (p>0.05). The levels of PYY were significantly increased after GBP compared with the sham group (p<0.05); however, in tgr5-/- mice the expression of PYY was not significantly affected (p>0.05). After INT-777 stimulation in L-cells obtained from murine intestines, the levels of PYY were significantly increased in L-cells tgr5+/+ (p<0.05). Conclusion: Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines, and increased the levels of PYY, which further reduced food intake and decreased the body weight.

scholarly journals Food intake in Antarctica

1967 ◽  
Vol 21 (1) ◽  
pp. 7-15 ◽  
Author(s):  
D. L. Easty
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Young Men ◽  
Skinfold Thickness ◽  
The Body ◽  
Temperate Climate ◽  
Calorie Intake ◽  
The United Kingdom ◽  
Body Weights ◽  
Active Worker

1. Body-weight, skinfold thickness and food intake were measured at regular intervals in twenty-five young men while on an Antarctic expedition.2. The mean calorie intake over the year was 3600 kcal/man per day; 12.1% of these calories were supplied by protein, 39.8% by fat, and 48.1% by carbohydrate.3. The calorie intake was equivalent to that which would be expected in a moderately active worker living in a temperate climate. The chemical composition of the diets did not differ from average values for young men in the United Kingdom.4. There was a significant fall in food intake during the winter months, when the outside temperatures were greatly reduced and there was polar night. During this period the men were largely confined to the limits of the base hut and the levels of physical activity showed a marked fall.5. During the year there was a gain in body-weight of 2.7 kg. Of this gain 2.5 kg occurred in the first 2 months.6. Skinfold thickness followed the trend of the body-weights except for the April-May increment which was unaccompanied by a weight change. This dissociation could not be explained.

Studies of the effects of the gene N on body growth and fleece development of the New Zealand Romney. I. The body growth of the N type lamb

1959 ◽  
Vol 10 (3) ◽  
pp. 387 ◽  
Author(s):  
F Cockrem ◽  
AL Rae
Keyword(s):  
Body Weight ◽  
New Zealand ◽  
Body Growth ◽  
The Body ◽  
Environment Interaction ◽  
Lower Body ◽  
Initial Weight ◽  
Ewe Lambs ◽  
Body Weights ◽  
Ram Lambs

A study has been made of the pleiotropic effects of the gene N on the body growth and the carcass of the Sew Zealand Romney lamb. Measurements of body weight and height at withers were taken from birth to about 5 months of age for lambs born in 1952 and 1953 from matings of N/+ x +/+, N/N x N/N, N/N x N/+, and N/+ x N/+ parents. In 1952, +/+ lambs grew faster than N/+ or N/N lambs and this was shown in the greater body weight of the +/+ lambs at 30 days of age. The differences in weight gains corrected for initial weight were greater for single lambs than for twin lambs. The differences in the height at withers were proportional to those in body weight except for the N/N lambs. The N/N lambs had a greater height at withers for their body weight but this could have been the result of factors other than the gene N which were associated with the N–type flock. N–type ewe lambs kept up to 18 months of age maintained lower body weights than +/+ lambs. In 1953 no differences between N/+ and +/+ lambs were found in body growth. It is suggested that a genetic-environment interaction exists for body growth and that the environmental factor is possibly one of climate. No differences were found between the carcass measurements of N/+ and +/+ ram lambs which could not be attributed to the previous differences in body growth.

scholarly journals GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents

2014 ◽  
Vol 306 (5) ◽  
pp. R352-R362 ◽  
Author(s):  
Jianping Ye ◽  
Zheng Hao ◽  
Michael B. Mumphrey ◽  
R. Leigh Townsend ◽  
Laurel M. Patterson ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Gut Hormones ◽  
The Body ◽  
Receptor Signaling ◽  
Lower Body ◽  
Loss Of Function ◽  
Physiological Control ◽  
Lower Body Weight ◽  
Gut Hormone

Exaggerated GLP-1 and PYY secretion is thought to be a major mechanism in the reduced food intake and body weight after Roux-en-Y gastric bypass surgery. Here, we use complementary pharmacological and genetic loss-of-function approaches to test the role of increased signaling by these gut hormones in high-fat diet-induced obese rodents. Chronic brain infusion of a supramaximal dose of the selective GLP-1 receptor antagonist exendin-9–39 into the lateral cerebral ventricle significantly increased food intake and body weight in both RYGB and sham-operated rats, suggesting that, while contributing to the physiological control of food intake and body weight, central GLP-1 receptor signaling tone is not the critical mechanism uniquely responsible for the body weight-lowering effects of RYGB. Central infusion of the selective Y2R-antagonist BIIE0246 had no effect in either group, suggesting that it is not critical for the effects of RYGB on body weight under the conditions tested. In a recently established mouse model of RYGB that closely mimics surgery and weight loss dynamics in humans, obese GLP-1R-deficient mice lost the same amount of body weight and fat mass and maintained similarly lower body weight compared with wild-type mice. Together, the results surprisingly provide no support for important individual roles of either gut hormone in the specific mechanisms by which RYGB rats settle at a lower body weight. It is likely that the beneficial effects of bariatric surgeries are expressed through complex mechanisms that require combination approaches for their identification.

scholarly journals Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight

2021 ◽  
Author(s):  
Barbara Hammer ◽  
Latha Kadalayil ◽  
Eistine Boateng ◽  
Dominik Buschmann ◽  
Faisal I. Rezwan ◽  
...  
Keyword(s):  
Body Weight ◽  
Early Life ◽  
The Body ◽  
Epigenetic Changes ◽  
Lower Body ◽  
Male And Female ◽  
Body Weights ◽  
F1 Progeny ◽  
Paternal Smoking ◽  
Mainstream Cigarette Smoke

Abstract Background Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested that preconceptional paternal smoking is associated with adolescent obesity in boys. We developed a murine adolescent smoking model before conception to investigate the paternal molecular causes of changes in offspring’s phenotype. Method Male and female C57BL/6J mice were exposed to increasing doses of mainstream cigarette smoke (CS) from onset of puberty for 6 weeks and mated with room air (RA) controls. Results Thirteen miRNAs were upregulated and 32 downregulated in the spermatozoa of CS-exposed fathers, while there were no significant differences in the count and morphological integrity of spermatozoa, as well as the proliferation of spermatogonia between CS- and RA-exposed fathers. Offspring from preconceptional CS-exposed mothers had lower body weights (p = 0.007). Moreover, data from offspring from CS-exposed fathers suggested a potential increase in body weight (p = 0.062). Conclusion We showed that preconceptional paternal CS exposure regulates spermatozoal miRNAs, and possibly influences the body weight of F1 progeny in early life. The regulated miRNAs may modulate transmittable epigenetic changes to offspring, thus influence the development of respiratory- and metabolic-related diseases such as obesity, a mechanism that warrants further studies for elaborate explanations.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

scholarly journals Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Nakamura ◽  
Mai Nampei ◽  
Takayo Murase ◽  
Etsuko Satoh ◽  
Seigo Akari ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Ketone Body ◽  
The Body ◽  
Xanthine Oxidoreductase ◽  
Diabetic Mellitus ◽  
Triglyceride Content ◽  
Xanthine Oxidoreductase Inhibitor ◽  
Single Regression ◽  
Muscle Triglyceride

AbstractPlasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed standard diets with or without topiroxostat for 4 weeks. Body weight and food intake were constantly monitored, along with monitoring plasma biochemical markers, including insulin and XOR activity. Additionally, hepatic hypoxanthine and XOR activity were also documented. Single regression analysis was performed to determine the mechanism. Topiroxostat treatment suppressed weight gain relative to the vehicle without any impact on food intake. However, the weight of fat pads and hepatic and muscle triglyceride content did not change. Topiroxostat decreased the plasma uric acid and increased hepatic hypoxanthine in response to the inhibition of XOR activity. Plasma ketone body and free fatty acid were also increased. Moreover, fat weight was weakly associated with plasma XOR activity in the diabetic state and was negatively associated with ketone body by topiroxostat. These results suggested that topiroxostat amplified the burning of lipids and the salvage pathway, resulting in predisposing the body toward catabolism. The inhibition of plasma XOR activity may contribute to weight loss.

Seasonal changes in pancreatic B-cell function in euthermic yellow-bellied marmots

1985 ◽  
Vol 249 (2) ◽  
pp. R159-R165 ◽  
Author(s):  
G. L. Florant ◽  
A. K. Lawrence ◽  
K. Williams ◽  
W. A. Bauman
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
B Cell ◽  
Cell Function ◽  
Peripheral Resistance ◽  
The Body ◽  
Pancreatic B Cell ◽  
Peripheral Insulin Resistance ◽  
Body Weights ◽  
System Input

Fasting plasma insulin (PI) and glucose (PG) concentrations were measured throughout the body weight cycle of marmots. Animals gained weight during summer, and in late fall body weight peaked, after which they ceased feeding. Each month euthermic animals were injected intra-arterially with either dextrose (500 mg/kg) or porcine insulin (0.1 U/kg), and blood samples were collected over the subsequent 2 h. During weight gain fasting PI concentration and pancreatic B-cell response to injected dextrose increased markedly. Maximal insulin release to a dextrose challenge was measured during peak body weight or when body weight initially began to decline. The PG concentration after exogenous insulin administration was slight (less than 10%) in the fall but increased approximately 25% in the spring after marmots lost weight. Basal PG levels were not significantly different throughout the year. Basal fasting PI concentrations were significantly higher during the fall (P less than 0.01). It is suggested that in the fall, when marmots are obese, hyperinsulinemia and peripheral insulin resistance appear. Furthermore, in two animals with an increase in body weight of approximately 30% or less over the summer, peripheral resistance was demonstrable, albeit not as marked as in animals that appropriately doubled their body weights when given food ad libitum. Thus we hypothesize that factors other than adiposity, i.e., food intake, central nervous system input to the pancreatic B-cell, and/or changes in B-cell sensitivity to PG, may contribute to the observed peripheral insulin resistance and may be involved in body weight regulation.

Effects of Agave tequilana fructans with different degree of polymerization profiles on the body weight, blood lipids and count of fecal Lactobacilli/Bifidobacteria in obese mice

2013 ◽  
Vol 4 (8) ◽  
pp. 1237 ◽  
Author(s):  
Ana Laura Márquez-Aguirre ◽  
Rosa Maria Camacho-Ruiz ◽  
Myriam Arriaga-Alba ◽  
Eduardo Padilla-Camberos ◽  
Manuel Reinhart Kirchmayr ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Lipids ◽  
Degree Of Polymerization ◽  
The Body ◽  
Agave Tequilana ◽  
Obese Mice

scholarly journals Composition of the human foetus

1972 ◽  
Vol 27 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Sharad V. Apte ◽  
Leela Iyengar
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Gestational Age ◽  
Maternal Nutrition ◽  
The Body ◽  
Human Foetus ◽  
Free Weight ◽  
Body Weights ◽  
Calcium Phosphorus ◽  
Ca:P Ratio

1. The body composition was determined of forty-one fetuses of different gestational ages born to mothers belonging to a low socio-economic group of the population.2. With increasing gestational age the water content fell from 88% at 28 weeks to 76% at term; the fat content increased from 2.1% to 11.2% and the protein content increased from 6.9 to 9.3%.3. The changes in body composition were more closely related to body-weight than to gestational age.4. The calcium, Phosphorus and magnesium contents of the body per unit fat-free weight progressively increased with gestational age, and at term the values appeared to be considerably lower than those reported in the literature. The Ca:P ratio was constant at different body-weights.5. The body iron content per unit of fat-free weight increased marginally with increasing gestational age. The value was almost 30% lower than the values reported from elsewhere.6. It is suggested that chemical composition and nutrient stores of the developing foetus can be considerably influenced by the state of maternal nutrition.

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