Effects of ileal transposition on food intake, dietary preference, and weight gain in Zucker obese rats

1990 ◽  
Vol 258 (1) ◽  
pp. R269-R273 ◽  
Author(s):  
D. C. Chen ◽  
J. S. Stern ◽  
R. L. Atkinson
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Corn Starch ◽  
Chow Diet ◽  
Base Line ◽  
Ileal Transposition ◽  
Digestible Energy ◽  
Dietary Preference ◽  
Obese Rats

This study evaluated the effects of ileal transposition (IT) surgery on food intake, body weight, and dietary preferences in Zucker obese rats. Eight rats had a 10-cm segment of terminal ileum transposed to the upper jejunum. Eight rats underwent sham IT (SIT) and six rats had no surgery (CON). During weeks 1-10 and 21-24, rats were fed a selection diet of protein (casein), carbohydrate (corn starch), and fat (lard) in three separate dishes. Rat chow was fed from weeks 11 to 20. IT rats had a lower weight and a lower change in weight from base line throughout most of the study. Energy intake was less in IT vs. SIT rats during the selection periods (weeks 1-10 and 21-24), but did not differ on the chow diet (weeks 11-20). Digestible energy, measured at weeks 10, 20, and 24, was lower in IT rats only at week 10. IT rats had no malabsorption by fecal calorie measurements. IT rats ate fewer fat calories at both selection periods. We conclude that IT causes long-term reduction in body weight, no malabsorption or long-term changes in digestible energy, and a persistent decrease in preference for dietary fat. Further studies are needed to determine whether increased energy expenditure is a mechanism for the long-term difference in body weight after IT.

The effects of ileal transposition on food intake and body weight loss in VMH-obese rats

1982 ◽  
Vol 35 (2) ◽  
pp. 284-293 ◽  
Author(s):  
H S Koopmans ◽  
A Sclafani ◽  
C Fichtner ◽  
P F Aravich
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Food Intake ◽  
Body Weight Loss ◽  
Ileal Transposition ◽  
Obese Rats

scholarly journals Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5559
Author(s):  
Renata leite Tavares ◽  
Maria Helena Araújo de Vasconcelos ◽  
Maria Letícia da Veiga Dutra ◽  
Aline Barbosa D’Oliveira ◽  
Marcos dos Santos Lima ◽  
...  
Keyword(s):  
Body Weight ◽  
Phenolic Compounds ◽  
Food Intake ◽  
Interleukin 6 ◽  
Male Rats ◽  
Mucuna Pruriens ◽  
Chow Diet ◽  
Antidepressant Effects ◽  
Obese Rats ◽  
Thoracic And Abdominal

This study evaluated the effect of Mucuna pruriens (MP) administration on neuroinflammation and behavioral and murinometric parameters in obese rats. Proximate composition, oligosaccharide and phenolic compound profile of MP were determined. Wistar adult male rats were randomized into healthy (HG) and obese group (OG). The HG consumed a control chow diet while OG consumed a cafeteria diet for eight weeks. Then, they were subdivided into: Healthy (HG); Healthy with MP administration (HGMP); Obese (OG); Obese with MP administration (OGMP), with the consumption of the respective diets remaining for another eight weeks, in addition to gavage with MP extract to supplemented groups (750 mg/kg weight). MP presented a composition rich in proteins and phenolic compounds, especially catechin, in addition to 1-kestose and levodopa. Supplementation reduced food intake, body weight, and thoracic and abdominal circumferences in obese rats. MP showed anxiolytic and antidepressant effects and reduced morphological damage and expression of interleukin 6 in the hippocampus of obese rats. MP treatment showed satietogenic, slimming, anxiolytic and antidepressant effects, besides to minimizing hippocampal neuroinflammation in obese rats. Our results demonstrated the potential anti-obesity of MP which are probably related to the high content of bioactive compounds present in this plant extract.

scholarly journals Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats

1998 ◽  
Vol 779 (1-2) ◽  
pp. 75-83 ◽  
Author(s):  
Jamie C.K Donahey ◽  
Gertjan van Dijk ◽  
Stephen C Woods ◽  
Randy J Seeley
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Obese Rats

scholarly journals A Ten-Day Grape Seed Procyanidin Treatment Prevents Certain Ageing Processes in Female Rats over the Long Term

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3647
Author(s):  
Carme Grau-Bové ◽  
Marta Sierra-Cruz ◽  
Alba Miguéns-Gómez ◽  
Esther Rodríguez-Gallego ◽  
Raúl Beltrán-Debón ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Young Animal ◽  
Tumor Development ◽  
Grape Seed ◽  
Female Rats ◽  
Chow Diet ◽  
Plasma Parameters ◽  
Age Related

Adaptive homeostasis declines with age and this leads to, among other things, the appearance of chronic age-related pathologies such as cancer, neurodegeneration, osteoporosis, sarcopenia, cardiovascular disease and diabetes. Grape seed-derived procyanidins (GSPE) have been shown to be effective against several of these pathologies, mainly in young animal models. Here we test their effectiveness in aged animals: 21-month-old female rats were treated with 500 mg GSPE/kg of body weight for ten days. Afterwards they were kept on a chow diet for eleven weeks. Food intake, body weight, metabolic plasma parameters and tumor incidence were measured. The GSPE administered to aged rats had an effect on food intake during the treatment and after eleven weeks continued to have an effect on visceral adiposity. It prevented pancreas dysfunction induced by ageing and maintained a higher glucagon/insulin ratio together with a lower decrease in ketonemia. It was very effective in preventing age-related tumor development. All in all, this study supports the positive effect of GSPE on preventing some age-related pathologies.

Long-Term Effects of CCK-Agonist and -Antagonist on Food Intake and Body Weight in Zucker Lean and Obese Rats

Peptides ◽  
1998 ◽  
Vol 19 (2) ◽  
pp. 291-299 ◽  
Author(s):  
Kerstin Meereis-Schwanke ◽  
Hanne Klonowski-Stumpe ◽  
Lieselotte Herberg ◽  
Claus Niederau
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Long Term Effects ◽  
Obese Rats ◽  
Agonist And Antagonist

scholarly journals Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats

2013 ◽  
Vol 305 (4) ◽  
pp. E507-E518 ◽  
Author(s):  
S. Nausheen ◽  
I. H. Shah ◽  
A. Pezeshki ◽  
D. L. Sigalet ◽  
P. K. Chelikani
Keyword(s):  
Body Weight ◽  
Sleeve Gastrectomy ◽  
Weight Gain ◽  
Food Intake ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Gut Hormones ◽  
Ileal Transposition ◽  
Gastric Restriction ◽  
Peripheral Tissues

Bariatric surgeries are hypothesized to produce weight loss and improve diabetes control by multiple mechanisms including gastric restriction and lower gut stimulation; the relative importance of these mechanisms remains poorly understood. We compared the effects of a typical foregut procedure, sleeve gastrectomy, (SG) with a primarily hindgut surgery, ileal transposition (IT), alone and together (SGIT), or sham manipulations, on food intake, body weight, gut hormones, glucose tolerance, and key markers of glucose homeostasis in peripheral tissues of adult male Sprague-Dawley rats (450–550 g, n = 7–9/group). SG, IT, and SGIT surgeries produced transient reduction in food intake and weight gain; the effects of SG and IT on intake and body weight were nonadditive. SG, IT, and SGIT surgeries resulted in increased tissue expression and plasma concentrations of the lower gut hormones glucagon-like peptide-1 and peptide YY and decreased plasma glucose-dependent insulinotropic peptide, insulin, and leptin concentrations. Despite transient effects on intake and weight gain, the SG, IT, and SGIT surgeries produced a significant improvement in glucose tolerance. In support of glycemic improvements, the protein abundance of key markers of glucose metabolism (e.g., GLUT4, PKA, IRS-1) in muscle and adipose tissue were increased, whereas the expression of key gluconeogenic enzyme in liver (G-6-Pase) were decreased following the surgeries. Therefore, our data suggest that enhanced lower gut stimulation following SG, IT, and SGIT surgeries leads to transient reduction in food intake and weight gain together with enhanced secretion of lower gut hormones and improved glucose clearance by peripheral tissues.

Effect of (-)-hydroxycitrate on development of obesity in the Zucker obese rat

1981 ◽  
Vol 240 (1) ◽  
pp. E72-E78 ◽  
Author(s):  
M. R. Greenwood ◽  
M. P. Cleary ◽  
R. Gruen ◽  
D. Blase ◽  
J. S. Stern ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Cell Size ◽  
Treatment Period ◽  
Body Fat ◽  
Substantial Reduction ◽  
Female Rats ◽  
Fat Cell ◽  
Fat Cell Size ◽  
Obese Rats

Young Zucker lean (Fa/-) and obese (fa/fa) female rats were fed the fatty acid synthesis inhibitor (-)-hydroxy-citrate as a dietary admixture for 39 days. In the lean rats, (-)-hydroxycitrate treatment decreased body weight, food intake, percent of body fat, and fat cell size. In the obese rat, food intake and body weight were reduced but the percent of body fat remained unchanged. Throughout the treatment period, obese rats maintained a fat cell size equivalent to their obese controls. Although a reduction in fat cell number in the obese rats occurred during the treatment period, marked hyperplasia was observed during the posttreatment period. The results of this study indicate that the obese rat, despite a substantial reduction in body weight produced by (-)-hydroxycitrate, still defends its obese body composition.

scholarly journals Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Irene Cimino ◽  
Debra Rimmington ◽  
Y. C. Loraine Tung ◽  
Katherine Lawler ◽  
Pierre Larraufie ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Balance ◽  
Food Intake ◽  
Energy Expenditure ◽  
Positive Energy ◽  
Chow Diet ◽  
Chromatin Regulator ◽  
Positive Energy Balance ◽  
The Impact ◽  
Deficient Mice

AbstractNeuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bimodal body weight. To better characterise this variability, we examined the key contributors to energy balance in Nnat+/−p mice that carry a paternal null allele and do not express Nnat. Consistent with our previous studies, Nnat deficient mice on chow diet displayed a bimodal body weight phenotype with more than 30% of Nnat+/−p mice developing obesity. In response to both a 45% high fat diet and exposure to thermoneutrality (30 °C) Nnat deficient mice maintained the hypervariable body weight phenotype. Within a calorimetry system, food intake in Nnat+/−p mice was hypervariable, with some mice consuming more than twice the intake seen in wild type littermates. A hyperphagic response was also seen in Nnat+/−p mice in a second, non-home cage environment. An expected correlation between body weight and energy expenditure was seen, but corrections for the effects of positive energy balance and body weight greatly diminished the effect of neuronatin deficiency on energy expenditure. Male and female Nnat+/−p mice displayed subtle distinctions in the degree of variance body weight phenotype and food intake and further sexual dimorphism was reflected in different patterns of hypothalamic gene expression in Nnat+/−p mice. Loss of the imprinted gene Nnat is associated with a highly variable food intake, with the impact of this phenotype varying between genetically identical individuals.

THE INFLUENCE OF THE AMOUNT OF PROTEIN AND ENERGY IN THE RATION OF REPLACEMENT EWE LAMBS ON BODY WEIGHT GAINS AND WOOL PRODUCTION

1959 ◽  
Vol 39 (1) ◽  
pp. 64-70 ◽  
Author(s):  
F. Whiting ◽  
S. B. Slen ◽  
L. M. Bezeau
Keyword(s):  
Body Weight ◽  
Wheat Straw ◽  
Corn Starch ◽  
Daily Intake ◽  
Limiting Factor ◽  
Oat Hulls ◽  
Digestible Energy ◽  
Wool Production ◽  
Ewe Lambs ◽  
Weight Gains

Three experiments were carried out with replacement ewe lambs to determine the influence of feeding rations containing three levels of protein, each at two levels of digestible energy. The three levels of protein were approximately 8, 9.5, and 11 per cent in the first two experiments, and 6, 9, and 12 per cent in the third experiment.Increasing the amount of protein in the ration resulted in an increase (p <.05) in the apparent digestibility of the protein, but no change in the percentage of protein retained or in the digestibility of the dry matter and gross energy. Increasing the digestible energy content of the ration by substituting corn starch for wheat straw or oat hulls reduced (p <.05) the digestibility and retention of protein in Experiments 2 and 3, but had no effect in Experiment 1.Body weight gains and wool growth of lambs fed rations containing wheat straw or oat hulls did not increase to so great an extent as those fed corn starch. This would indicate that energy was a limiting factor for maximum production in the lower digestible energy rations. In general, weight gains and wool production increased (p <.05) when the daily intake of D.C.P. was increased from approximately 0.10 to 0.13 pounds. Increasing the D.C.P. from 0.13 to 0.16 pounds (0.19 in Experiment 3) caused no further increase in body gains but increased (p <.05) wool production.On the basis of these results, the average D.C.P. requirements of a ewe lamb weighing 85 pounds and consuming 1.3 pounds T.D.N. was 0.13 pounds (0.16 pounds when wool production was considered).

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