Body energy status and the metabolic response to acute inflammation

1995 ◽  
Vol 269 (5) ◽  
pp. R1024-R1031 ◽  
Author(s):  
T. A. Lennie ◽  
D. O. McCarthy ◽  
R. E. Keesey
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Acute Inflammation ◽  
Metabolic Response ◽  
Body Weight Gain ◽  
Nitrogen Loss ◽  
Energy Status ◽  
Reduced Body ◽  
Body Weights ◽  
Body Energy

An animal model of acute inflammation was used to examine how body energy status influences the syndrome of anorexia, negative nitrogen balance, and body weight loss typically seen in response to injury. Specifically, the metabolic response to acute inflammation was studied in rats of normal, elevated, or reduced body weights. Rats induced to overeat and gain weight prior to inflammation displayed protracted anorexia, greater subsequent weight loss, higher metabolic rates, and greater negative energy balance than rats of normal weight. Conversely, rats with reduced body weights displayed elevated food intakes, body weight gain, attenuated nitrogen loss, and normal rates of energy expenditure. Prior weight reduction did not affect postinflammation fever or levels of fibrinogen, iron, and interleukin-6-like activity, suggesting that the ability to mount an acute phase response was not impaired in weight-reduced rats. These results suggest that the usual postinflammation adjustments in body energy flux and body nitrogen are regulated components of a metabolic response to acute inflammation which renders normally protected sources of endogenous energy and substrate available for repair and recovery.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

scholarly journals POTENTIAL OF DUNALIELLA SALINA MICROALGAE TO AMELIORATE HIGH-FAT DIET‑INDUCED OBESITY IN ANIMALS’ RODENT

2018 ◽  
Vol 11 (3) ◽  
pp. 312 ◽  
Author(s):  
Farouk K El-baz ◽  
Hanan F Aly
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Dunaliella Salina ◽  
Body Weight Gain ◽  
Ethanolic Extract ◽  
High Fat ◽  
Related Complication ◽  
Standard Drug ◽  
Reduced Body ◽  
Obese Rats

 Objective: This study was carried out to investigate the potential of Dunaliella salina microalgae to ameliorate obesity induced by high-fat diet (HFD) in male Wistar rats.Methods: Fifty rats weighing 150–160 g were fed HFD for 12 weeks. The rats were randomly divided into five groups of ten rats each. Obese rats were orally administered D. salina ethanolic extract (150 mg/Kg body weight), and orlistat as standard drug (12 mg/Kg body weight), for 6 weeks.Results: Treatment of obese rats with both D. salina and orlistat had a significant effect in reducing body and liver weights as well as visceral fat, inhibiting pancreatic lipase activity, decreased lipid profile, and increased fecal fat and ameliorating liver function enzymes activity, insulin, blood glucose, and leptin levels. Besides, food intake was insignificantly increased as a result of D. salina and orlistat treatments compared with normal control rats.Conclusion: It could be concluded that D. salina rich in β-carotene significantly reduced body weight gain and ameliorated several metabolic pathways implicated in obesity and its related complication. Hence, further intensive study must be carried out to formulate D. Salina extracts to apply as a promising natural anti-obesity nutraceutical drug.

scholarly journals 1343. Prophylactic Dosing of Baloxavir Acid Eliminates Mortality in Mice Lethal Influenza A Virus Infection Model

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S410-S411
Author(s):  
Shinya Shano ◽  
Keita Fukao ◽  
Takeshi Noshi ◽  
Kenji Sato ◽  
Masashi Sakuramoto ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Lethal Dose ◽  
Body Weight Loss ◽  
Prophylactic Efficacy ◽  
Body Weights ◽  
Single Dosing

Abstract Background Baloxavir acid (BXA), an active form of orally available prodrug baloxavir marboxil (BXM, formerly S-033188), is a novel small molecule inhibitor of cap-dependent endonuclease (CEN) of influenza A and B virus, and was recently launched for the treatment of acute and uncomplicated influenza with single dosing of BXM (the trade name XOFLUZA™) in Japan in March 2018. Here, we evaluated the prophylactic efficacy of BXA in mice lethally infected with influenza A virus. Methods T1/2 of BXA in human is more than 10 times longer than that in mice. Therefore, suspension of BXA was subcutaneously administered at 0.8 or 1.6 mg/kg in mice to maintain the plasma concentration of BXA as seen in humans, and then mice were intranasally inoculated with a lethal dose of A/PR/8/34 strain at 48, 72, or 96 hours after the administration of BXA. Survival time and body weight change were then monitored through a 28-day period after virus infection. Mice were euthanized and regarded as dead if their body weights were lower than 70% of the initial body weights according to humane endpoints. Results Single dosing of BXA (1.6 mg/kg) completely eliminated mortality in mice, when the mice were administrated the drug at 48, 72, or 96 hours before virus infection (Figure 1). BXA treatment also significantly prevented body weight loss, consistent with the prolonged survival. Conclusion Prophylactic dosing of BXA exhibited significant protective efficacy against mortality and body weight loss in mice following a lethal infection with influenza A virus. The significant prophylactic efficacy observed in our mouse model suggests the potential utility of BXM for the prophylaxis of influenza in human. Disclosures S. Shano, Shionogi & Co., Ltd.: Employee, Salary. K. Fukao, Shionogi & Co., Ltd.: Employee, Salary. T. Noshi, Shionogi & Co., Ltd.: Employee, Salary. K. Sato, Shionogi & Co., Ltd.: Employee, Salary. M. Sakuramoto, Shionogi & Co., Ltd.: Employee, Salary. K. Baba, Shionogi TechnoAdvance Research & Co., Ltd.: Employee, Salary. T. Shishido, Shionogi & Co., Ltd.: Employee, Salary. A. Naito, Shionogi & Co., Ltd.: Employee, Salary.

scholarly journals Performance, Carcass Traits and Meat Quality Evaluation of Sheep Fed Diets Containing Napier Grass and Graded Levels of Cocoa Pod Husk with Soursop Pulp Meals

2017 ◽  
Vol 5 (2) ◽  
pp. 74
Author(s):  
M. I. Okoruwa ◽  
D. O. Okunlola
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Meat Quality ◽  
Quality Evaluation ◽  
Body Weight Gain ◽  
Nitrogen Loss ◽  
Carcass Traits ◽  
Napier Grass ◽  
Daily Weight Gain ◽  
Cocoa Pod Husk

This study was conducted to determine performance, carcass traits and meat quality evaluation of sheep fed napier grass and different proportion of cocoa pod husk and soursop pulp meals. Eighteen (18) West African Dwarf rams, aged between 7 and 8 months old with mean weight of 7.00 ± 0.55kg were allotted to three dietary treatments with two replicates of three sheep per treatment in a completely randomized design. The compared treatment diets were; TA (70% napier grass and 30% concentrate diet), TB (45% cocoa pod husk with 25% soursop pulp and 30% concentrate diet) and TC (50% cocoa pod husk with 20% soursop pulp and 30% concentrate diet). The experimental diets were given to the sheep at 6% of their body weight and the experiment lasted for 84days after 14days of adjustment period. The results showed that average daily feed intake (221.79g), nitrogen intake (18.02g/day), total nitrogen loss (5.08g/day) and chilling losses (12.85%) were significantly (P < 0.05) higher in diet TA compared with diets TB and TC. Treatment diet TC was significantly (P < 0.05) better in total body weight gain (3.66kg), average daily weight gain (43.57g), total digestible nutrient (74.69%), nitrogen retention (77.58%, slaughter weight (11.02kg), hot carcass weight (5.68kg), cold carcass yields (5.23kg), hot with cold carcass yields (51.54 and 47.46%), appearance (6.81), tenderness (6.20) and overall acceptability (6.85) than other treatment diets. Initial body weight, flavor and juiciness were not significantly (P > 0.05) affected by the treatment diets. It was concluded that 50% cocoa pod husk with 20% soursop pulp and 30% concentrate diet has the potential to enhance performance, carcass traits and meat quality evaluation in sheep.

scholarly journals Effects of gut microbiota on leptin expression and body weight are lessened by high-fat diet in mice

2020 ◽  
Vol 124 (4) ◽  
pp. 396-406 ◽  
Author(s):  
Hongyang Yao ◽  
Chaonan Fan ◽  
Xiuqin Fan ◽  
Yuanyuan Lu ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Body Weight ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
High Fat ◽  
Hepatic Expression ◽  
Reduced Body ◽  
Expression Of Genes ◽  
Underlying Mechanisms ◽  
Leptin Expression

AbstractAberration in leptin expression is one of the most frequent features in the onset and progression of obesity, but the underlying mechanisms are still unclear and need to be clarified. This study investigated the effects of the absence of gut microbiota on body weight and the expression and promoter methylation of the leptin. Male C57 BL/6 J germ-free (GF) and conventional (CV) mice (aged 4–5 weeks) were fed either a normal-fat diet (NFD) or a high-fat diet (HFD) for 16 weeks. Six to eight mice from each group, at 15 weeks, were administered exogenous leptin for 7 d. Leptin expression and body weight gain in GF mice were increased by NFD with more CpG sites hypermethylated at the leptin promoter, whereas there was no change with HFD, compared with CV mice. Adipose or hepatic expression of genes associated with fat synthesis (Acc1, Fas and Srebp-1c), hydrolysis and oxidation (Atgl, Cpt1a, Cpt1c, Ppar-α and Pgc-1α) was lower, and hypothalamus expression of Pomc and Socs3 was higher in GF mice than levels in CV mice, particularly with NFD feeding. Exogenous leptin reduced body weight in both types of mice, with a greater effect on CV mice with NFD. Adipose Lep-R expression was up-regulated, and hepatic Fas and hypothalamic Socs3 were down-regulated in both types of mice. Expression of fat hydrolysis and oxidative genes (Atgl, Hsl, Cpt1a, Cpt1c, Ppar-α and Pgc-1α) was up-regulated in CV mice. Therefore, the effects of gut microbiota on the leptin expression and body weight were affected by dietary fat intake.

Reduced body weight or increased muscle quality: Which is more important for improving physical function following exercise and weight loss in overweight and obese older women?

2018 ◽  
Vol 108 ◽  
pp. 159-165 ◽  
Author(s):  
Chad R. Straight ◽  
Alison C. Berg ◽  
Rachelle A. Reed ◽  
Mary Ann Johnson ◽  
Ellen M. Evans
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Physical Function ◽  
Older Women ◽  
Muscle Quality ◽  
Reduced Body

Feeding of heifers for survival on whole and cracked sorghum grain under simulated drought conditions

1968 ◽  
Vol 8 (35) ◽  
pp. 668 ◽  
Author(s):  
JG Morris
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Dry Matter ◽  
Body Weight Loss ◽  
Initial Body Weight ◽  
Fresh Weight Basis ◽  
Significant Difference ◽  
Simulated Drought ◽  
Sorghum Grain ◽  
Body Energy

Groups of Hereford heifers of a mean (� SE.) body weight 187 � 3 kg were fed in yards a sole ration of sorghum grain + one per cent limestone for 26 weeks. Four groups were fed the equivalent of 1.36 kg of sorghum grain per head per day as either whole or cracked grain at either daily or twice weekly intervals. A fifth group was fed 1.64 kg of whole sorghum grain per head per day which provided a digestible dry matter intake comparable to that of 1.36 kg of cracked grain. When heifers were fed the same quantity of dry matter as whole and cracked grain, the rate of body weight loss of those fed whole grain was significantly greater than that of those fed cracked grain; and the rate of body weight loss of those fed daily was significantly greater than that of those fed twice weekly. With similar intakes of digestible dry matter from whole and cracked grain, there was no significant difference in the rate of body weight loss. Heifers from sub-groups of high initial body weight lost significantly more body weight than heifers from sub-groups of low initial body weight. The whole bodies of three heifers that died from undernutrition contained less than 0.3 per cent ether extract on a fresh weight basis, indicating complete exhaustion of body energy reserves.

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