scholarly journals Current Status of Gil-Vernet Trigonoplasty Technique

2008 ◽  
Vol 2008 ◽  
pp. 1-6 ◽  
Author(s):  
Nasser Simforoosh ◽  
Mohammad H. Radfar
Keyword(s):  
Renal Damage ◽  
Surgical Techniques ◽  
Outpatient Setting ◽  
Current Status ◽  
Mattress Suture ◽  
Ureterovesical Junction ◽  
The Past ◽  
Ureterovesical Junction Obstruction ◽  
Successful Technique

Significant controversy exists regarding vesicoureteral reflux (VUR) management, due to lack of sufficient prospective studies. The rationale for surgical management is that VUR can cause recurrent episodes of pyelonephritis and long-term renal damage. Several surgical techniques have been introduced during the past decades. Open anti-reflux operations have high success rate, exceeding 95%, and long durability. The goal of this article is to review the Gil-Vernet trigonoplasty technique, which is a simple and highly successful technique but has not gained the attention it deserves. The mainstay of this technique is approximation of medial aspects of ureteral orifices to midline by one mattress suture. A unique advantage of Gil-Vernet trigonoplasty is its bilateral nature, which results in prevention from contralateral new reflux. Regarding not altering the normal course of the ureter in Gil-Vernet procedure, later catheterization of and retrograde access to the ureter can be performed normally. There is no report of ureterovesical junction obstruction following Gil-Vernet procedure. Gil-Vernet trigonoplasty can be performed without inserting a bladder catheter and drain on an outpatient setting. Several exclusive advantages of Gil-Vernet trigonoplasty make it necessary to reconsider the technique role in VUR management.

scholarly journals Combined Replacement of Aortic Valve and Ascending Aorta—A 70-Year Evolution of Surgical Techniques

Aorta ◽  
2021 ◽  
Author(s):  
Igor Vendramin ◽  
Uberto Bortolotti ◽  
Davide Nunzio De Manna ◽  
Andrea Lechiancole ◽  
Sandro Sponga ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Elderly Patients ◽  
Aortic Valve Disease ◽  
Surgical Techniques ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Long Term Results ◽  
The Past ◽  
Technical Advances

AbstractSimultaneous replacement of the ascending aorta and aortic valve has always been a challenging procedure. Introduction of composite conduits, through various ingenious procedures and their modifications, has changed the outlook of patients with aortic valve disease and ascending aorta pathology. In the past 70 years, progress of surgical techniques and prosthetic materials has allowed such patients to undergo radical procedures providing excellent early and long-term results in both young and elderly patients. This article aims to review the most important technical advances in the treatment of aortic valve disease and ascending aorta aneurysms recognizing the important contributions in this field.

scholarly journals Recent Patents and Designs on Hip Replacement Prostheses

2015 ◽  
Vol 9 (1) ◽  
pp. 92-102 ◽  
Author(s):  
H Derar ◽  
M Shahinpoor
Keyword(s):  
Robotic Surgery ◽  
Smart Materials ◽  
Hip Replacement ◽  
Surgical Techniques ◽  
Hip Prostheses ◽  
Replacement Surgery ◽  
Hip Replacement Surgery ◽  
The Past ◽  
Made In

Hip replacement surgery has gone through tremendous evolution since the first procedure in 1840. In the past five decades the advances that have been made in technology, advanced and smart materials innovations, surgical techniques, robotic surgery and methods of fixations and sterilization, facilitated hip implants that undergo multiple design revolutions seeking the least problematic implants and a longer survivorship. Hip surgery has become a solution for many in need of hip joint remedy and replacement across the globe. Nevertheless, there are still long-term problems that are essential to search and resolve to find the optimum implant. This paper reviews several recent patents on hip replacement surgery. The patents present various designs of prostheses, different materials as well as methods of fixation. Each of the patents presents a new design as a solution to different issues ranging from the longevity of the hip prostheses to discomfort and inconvenience experienced by patients in the long-term.

scholarly journals A Decade with VAMDC: Results and Ambitions

Atoms ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 76 ◽  
Author(s):  
Damien Albert ◽  
Bobby K. Antony ◽  
Yaye Awa Ba ◽  
Yuri L. Babikov ◽  
Philippe Bollard ◽  
...  
Keyword(s):  
Data Management ◽  
International Cooperation ◽  
Technological Development ◽  
Molecular Data ◽  
Heterogeneous Data ◽  
Current Status ◽  
Data Centre ◽  
The Past ◽  
User Communities

This paper presents an overview of the current status of the Virtual Atomic and Molecular Data Centre (VAMDC) e-infrastructure, including the current status of the VAMDC-connected (or to be connected) databases, updates on the latest technological development within the infrastructure and a presentation of some application tools that make use of the VAMDC e-infrastructure. We analyse the past 10 years of VAMDC development and operation, and assess their impact both on the field of atomic and molecular (A&M) physics itself and on heterogeneous data management in international cooperation. The highly sophisticated VAMDC infrastructure and the related databases developed over this long term make them a perfect resource of sustainable data for future applications in many fields of research. However, we also discuss the current limitations that prevent VAMDC from becoming the main publishing platform and the main source of A&M data for user communities, and present possible solutions under investigation by the consortium. Several user application examples are presented, illustrating the benefits of VAMDC in current research applications, which often need the A&M data from more than one database. Finally, we present our vision for the future of VAMDC.

Evolution of pancreatic cancer survival over the past two decades.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15722-e15722
Author(s):  
Veronica Mariotti ◽  
Ricardo Daniel Parrondo ◽  
Miguel Gonzalez Velez ◽  
Narjust Duma ◽  
Lori Ann Leslie ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Survival ◽  
Single Agent ◽  
Surgical Techniques ◽  
Pancreatic Head ◽  
Age At Diagnosis ◽  
Cancer Center ◽  
The Past ◽  
Significant Difference

e15722 Background: Pancreatic cancer (PaCa) is a highly lethal disease, with a 5-year overall survival (OS) rate of approximately 6%, and a median OS of only 3–6 months (m). Despite recent improvements in surgical techniques and increased use of combination chemotherapy (CT), OS remains poor. This study aims to examine the factors that led to increased OS in PaCa patients (pts) over the past two decades in a single academic institution. Methods: All medical records of pts diagnosed with PaCa at the John Theurer Cancer Center from 1990 to 2012 were reviewed, and 916 PaCa pts were included in this analysis. We compared one group of pts diagnosed from 1990 to 2003 (G1, n = 482), with a group of pts diagnosed from 2004 to 2012 (G2, n = 434) in terms of OS, demographics, tumor features and treatment (tx). Results: Median age at diagnosis was 70.5 years (range 26-96). There was no significant difference between G1 and G2 in terms of age at diagnosis, stage of disease and number of pts who received surgery. A significantly higher percentage of pts received CT in G2 compared to G1 (66.5% vs 51.0%, p = .00). Tumors of the pancreatic head were more common in G1 compared to G2 (51.8% vs 44.4% p = .02). More pts in G2 received two or more CT agents compared to G1 (49.0% vs 34.1%, p = .00). Median OS was significantly longer in G2 compared to G1 (9m vs 5m, p = .00), in pts who received CT compared to pts who did not (3m vs 9m, p = .00) and in pts who received surgery compared to pts who did not (5m vs 19m, p = .00). Pancreatic head location was associated with improved OS compared to other locations (9m vs 5m, p = .00). No OS difference was found between pts who received combination with two or more agents vs single agent CT. Conclusions: In line with multiple studies, analysis of PaCa data from our institution showed an increase OS in pts diagnosed with PaCa in more recent years, and in those who received surgery and CT. CT was administered in a larger number of pts in G2, which might account for the better OS in this group. Pts diagnosed with tumors of the pancreatic head had better survival, which could be explained by earlier presentation leading to earlier diagnosis and tx. Further research in PaCa therapeutics is needed, as long-term OS in PaCa pts remains poor despite recent advances.

Targeted therapy for epithelial ovarian cancer: Current status and future prospects

2003 ◽  
Vol 13 (6) ◽  
pp. 701-734 ◽  
Author(s):  
H. T. See ◽  
J. J. Kavanagh ◽  
W. Hu ◽  
R. C. Bast
Keyword(s):  
Ovarian Cancer ◽  
Molecular Targets ◽  
Current Status ◽  
Cell Cycle Regulators ◽  
Future Prospects ◽  
Small Molecular Weight ◽  
The Past ◽  
Long Run ◽  
The Impact

Despite advances in surgery and chemotherapy, less than 20% of patients with stage III or IV ovarian cancer survive long-term. In the past, cytotoxic regimens have been developed empirically, combining active agents at maximally tolerated doses, often without a clear rationale for their interaction. Advances in understanding the biology of ovarian cancer have identified multiple molecular targets that differ in normal and malignant cells. Targets include cell cycle regulators, growth factor receptors, signal transduction pathways, molecules that confer drug resistance, and angiogenic mechanisms. A number of targeted agents have entered clinical trials. Small molecular weight inhibitors, monoclonal antibodies, and antisense and gene therapy are all being evaluated alone and in combination with cytotoxic drugs. In contrast to earlier studies, the impact of each agent on the designated target can be assessed and agents can be matched to the genotype and phenotype of malignant and normal cells. In the long run, this should facilitate individualization of more effective, less toxic therapy for women with ovarian cancer.

scholarly journals How Anesthetic, Analgesic and Other Non-Surgical Techniques During Cancer Surgery Might Affect Postoperative Oncologic Outcomes: A Summary of Current State of Evidence

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 592 ◽  
Author(s):  
Patrice Forget ◽  
Jose A. Aguirre ◽  
Ivanka Bencic ◽  
Alain Borgeat ◽  
Allessandro Cama ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Surgical Techniques ◽  
Oncologic Outcomes ◽  
The European Union ◽  
European Network ◽  
Surgical Interventions ◽  
Cancer Resection ◽  
The Past ◽  
Current State

The question of whether anesthetic, analgesic or other perioperative intervention during cancer resection surgery might influence long-term oncologic outcomes has generated much attention over the past 13 years. A wealth of experimental and observational clinical data have been published, but the results of prospective, randomized clinical trials are awaited. The European Union supports a pan-European network of researchers, clinicians and industry partners engaged in this question (COST Action 15204: Euro-Periscope). In this narrative review, members of the Euro-Periscope network briefly summarize the current state of evidence pertaining to the potential effects of the most commonly deployed anesthetic and analgesic techniques and other non-surgical interventions during cancer resection surgery on tumor recurrence or metastasis.

Publication Trends and Global Collaborations on Esophageal Atresia Research: A Bibliometric Study

2020 ◽  
Author(s):  
Xiaoyan Feng ◽  
Illya Martynov ◽  
Anne Suttkus ◽  
Martin Lacher ◽  
Steffi Mayer
Keyword(s):  
Esophageal Atresia ◽  
Pediatric Surgery ◽  
Perioperative Complications ◽  
Citation Rate ◽  
Surgical Techniques ◽  
Global Network ◽  
Term Outcome ◽  
Long Term Outcome ◽  
The Past

Abstract Introduction Research on esophageal atresia (EA) has been heavily published over the past decades. Herein, we aimed to study the quantity and quality as well as key topics in EA research with regards to global collaborations among countries and authors. Material and Methods Publications on EA from 1945 to 2018 were extracted from the Web of Science core collection database. Productivity (quantity) was assessed by the number of publications. Quality was estimated from the number of citations, citation rate per item and year, h-index, and impact index. Collaborative networks were evaluated using VOSviewer. All measures were analyzed for countries, authors, and journals. The 10 most cited original articles between 1969 and 2018 in 5-year intervals (n = 100) were manually screened to assess the key points of EA research. Results A total of 2,170 publications from 85 countries published in 388 journals were identified yielding 26,755 citations, both significantly increasing over time (p < 0.001). The most productive countries and authors also accounted for high-quality publications and benefited from an active global network. The most productive journals derived from the field of pediatric surgery but accounted only for one-third of EA papers. The best cited journals were unspecific for pediatric surgery. Long-term outcome remained the most important topic in EA research, followed by surgical techniques, epidemiology, associated anomalies, perioperative complications, and postnatal management. In contrast, basic science was underrepresented. Conclusion Over the past seven decades, EA publications increased tremendously. Productiveness and quality benefited from global networking. Long-term outcome remains the key interest of EA research.

scholarly journals Postmastectomy Breast Reconstruction: Current Techniques

2001 ◽  
Vol 8 (5) ◽  
pp. 419-426 ◽  
Author(s):  
Alan R. Shons ◽  
Gerard Mosiello
Keyword(s):  
Breast Cancer ◽  
Breast Reconstruction ◽  
Cancer Patients ◽  
Recent Literature ◽  
Surgical Techniques ◽  
Breast Cancer Patients ◽  
Patient Benefit ◽  
The Past ◽  
Long Term Studies

Background The techniques of breast reconstruction have evolved and matured over the past 25 years. Recent studies have proven the benefit of breast reconstruction for breast cancer patients. Methods The authors reviewed the recent literature on the techniques of breast reconstruction and the effects of reconstruction on patients following surgery for breast cancer. The findings in recent studies are correlated with the experience of the authors. Results A better understanding has been gained regarding surgical techniques of breast reconstruction as well as the proper indications for the various methods. The criteria of patient benefit have been defined by recent long-term studies. Conclusions Breast reconstruction following mastectomy has been proven to be a safe and beneficial procedure.

scholarly journals Development of mRNA Vaccines: Scientific and Regulatory Issues

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 81
Author(s):  
Ivana Knezevic ◽  
Margaret A. Liu ◽  
Keith Peden ◽  
Tiequn Zhou ◽  
Hye-Na Kang
Keyword(s):  
Vaccine Development ◽  
Rapid Development ◽  
Current Status ◽  
Safety And Efficacy ◽  
The Past ◽  
Core Function ◽  
International Convergence ◽  
Long Term Performance ◽  
Term Performance

The global research and development of mRNA vaccines have been prodigious over the past decade, and the work in this field has been stimulated by the urgent need for rapid development of vaccines in response to an emergent disease such as the current COVID-19 pandemic. Nevertheless, there remain gaps in our understanding of the mechanism of action of mRNA vaccines, as well as their long-term performance in areas such as safety and efficacy. This paper reviews the technologies and processes used for developing mRNA prophylactic vaccines, the current status of vaccine development, and discusses the immune responses induced by mRNA vaccines. It also discusses important issues with regard to the evaluation of mRNA vaccines from regulatory perspectives. Setting global norms and standards for biologicals including vaccines to assure their quality, safety and efficacy has been a WHO mandate and a core function for more than 70 years. New initiatives are ongoing at WHO to arrive at a broad consensus to formulate international guidance on the manufacture and quality control, as well as nonclinical and clinical evaluation of mRNA vaccines, which is deemed necessary to facilitate international convergence of manufacturing and regulatory practices and provide support to National Regulatory Authorities in WHO member states.

scholarly journals Engineering strategies towards overcoming bleeding and glial scar formation around neural probes

2022 ◽  
Author(s):  
Elisabeth Otte ◽  
Andreas Vlachos ◽  
Maria Asplund
Keyword(s):  
Surgical Techniques ◽  
Microelectrode Arrays ◽  
Biological Response ◽  
Neural Probes ◽  
Clinical Neuroscience ◽  
The Past ◽  
Brain Interface ◽  
Glial Scarring ◽  
The Brain

AbstractNeural probes are sophisticated electrophysiological tools used for intra-cortical recording and stimulation. These microelectrode arrays, designed to penetrate and interface the brain from within, contribute at the forefront of basic and clinical neuroscience. However, one of the challenges and currently most significant limitations is their ‘seamless’ long-term integration into the surrounding brain tissue. Following implantation, which is typically accompanied by bleeding, the tissue responds with a scarring process, resulting in a gliotic region closest to the probe. This glial scarring is often associated with neuroinflammation, neurodegeneration, and a leaky blood–brain interface (BBI). The engineering progress on minimizing this reaction in the form of improved materials, microfabrication, and surgical techniques is summarized in this review. As research over the past decade has progressed towards a more detailed understanding of the nature of this biological response, it is time to pose the question: Are penetrating probes completely free from glial scarring at all possible?

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