scholarly journals Eosinophilic Esophagitis: Clinical Features, Endoscopic Findings and Response to Treatment

2010 ◽  
Vol 24 (9) ◽  
pp. 547-551 ◽  
Author(s):  
Robert Enns ◽  
Pooya Kazemi ◽  
Wiley Chung ◽  
Mitchell Lee
Keyword(s):  
Family History ◽  
Eosinophilic Esophagitis ◽  
Patient Characteristics ◽  
Response To Treatment ◽  
Treatment Modalities ◽  
Telephone Interviews ◽  
Endoscopic Findings ◽  
History Of ◽  
One Year ◽  
Seasonal Allergies

Eosinophilic esophagitis (EE) is a motility disorder of the esophagus that typically presents with dysphagia. The objective of the present study was to explore patient characteristics, clinical and endoscopic features, and response to treatment of patients with EE. Patients were selected retrospectively based on a review of biopsy results from previous endoscopies performed between 2004 and 2008. A total of 54 patients (41 men and 13 women) with biopsy-proven EE were included in the study. Further information regarding the patients’ clinical and endoscopic features, and response to treatment were obtained through chart reviews and patient telephone interviews. The mean age of the patients at symptom onset was 30 years. All patients complained of dysphagia, 81% had a history of bolus obstruction, 43% had a history of asthma and 70% had a history of environmental allergies. Thirty-three per cent had a family history of asthma, while 52% had a family history of food or seasonal allergies. The most common endoscopic findings were rings and/or corrugations, which were found in 63% of patients. Swallowed fluticasone therapy resulted in symptom resolution in 74% of patients; however, 79% of these patients relapsed after discontinuing fluticasone therapy and required repeat treatments. Esophageal dilation was complication free and resulted in improvement in 80% of patients. However, 83% of those reporting improvement relapsed within one year. The clinical and endoscopic findings were similar to those found in the literature, with most patients requiring ongoing, repeated therapies. Further studies are needed to assess the safety and efficacy of treatment modalities ideally suited to patients with EE.

scholarly journals Eosinophilic esophagitis: clinical features, endoscopic findings and response to treatment

2018 ◽  
Vol 5 (4) ◽  
pp. 1514
Author(s):  
Manoranjan U. D. ◽  
Nikhil S. ◽  
Divyarani M. N. ◽  
Akhila N. T.
Keyword(s):  
Eosinophilic Esophagitis ◽  
Controlled Trial ◽  
Response To Treatment ◽  
Treatment Modalities ◽  
Common Symptom ◽  
Inflammatory Disorder ◽  
Endoscopic Findings ◽  
History Of ◽  
Study Population

Background: Eosinophilic esophagitis (EoE) considered to be an allergic inflammatory disorder of the esophagus characterised by an inherent impairment in epithelial barrier integrity, possibly worsened by reflux of gastric contents. The aim of this study was to study EoE and its clinical and endoscopic evaluation and response to treatment with relapse rates.Methods: Fifty patients in the study were selected based on a review of biopsy results from previous endoscopies performed between August 2015 to August 2017. All patients with biopsy-proven EoE, defined as more than 20 eosinophils/HPF. Biopsy samples were taken from the mid and distal esophagus and sent for analysis. The endoscopic findings were noted grossly. Twenty five patients were started on PPI’s only and the remaining 25 patients were started on fluticasone MDI 440mcg inhaled two times day and PPI. Follow up of the patients was done at 1, 3 and 6 months after treatment.Results: The mean age in the study population was 42 years, males affected more often (64%) with rings and corrugations and linear furrows being the most commonly seen endoscopic findings (64% and 27%). Normal study was seen in 40% of the patients. Most common symptom was dysphagia 26%. Steroids are the mainstay of the treatment along with PPI. Relapse rate was 61.1% in the study.Conclusions: EoE is an inflammatory condition of the oesophagus that occurs predominantly in young and middle-aged men, EE should be strongly considered in those who present with dysphagia and/or food impaction, particularly with a history of atopic disorders. Swallowed fluticasone is a safe and effective treatment; however, relapse rates are very high. In adults, there remains a need for a randomized controlled trial to assess the safety and efficacy of various treatment modalities. 

scholarly journals Predictors of Progressive Course of Multifocal Atherosclerosis in Patients With Myocardial Infarction

Kardiologiia ◽  
2019 ◽  
Vol 59 (5) ◽  
pp. 36-44 ◽  
Author(s):  
D. Yu. Sedykh ◽  
A. N. Kazantsev ◽  
R. S. Tarasov ◽  
V. V. Kashtalap ◽  
A. N. Volkov ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Family History ◽  
Syntax Score ◽  
Coronary Syndrome ◽  
History Of ◽  
One Year ◽  
Ica Stenosis ◽  
The Impact ◽  
Progression Of Atherosclerosis ◽  
Progressive Course

Purpose. Determination of clinical and instrumental predictors of progressive course of multifocal atherosclerosis (MFA) in patients one year after myocardial infarction (MI), initially having hemodynamically insignificant stenoses of carotid arteries.Materials and methods. From database of patients with acute coronary syndrome treated in the Kemerovo Regional Clinical Cardiac Dispensary in 2009–2010 we selected for this study 141 patients with verified diagnosis of MI and hemodynamically insignificant lesions in the internal carotid artery (ICA) (stenosis up ≤ 55 %). All patients had coronary atherosclerosis verified on coronary angiography at admission because of MI. A multivariate analysis of possible predictors of the progressive course of multifocal atherosclerosis was made based on assessment of the development of cardiovascular complications (CVC) (death, MI, stroke and transient cerebral circulatory attacks [TIA]), as well as revascularizations and negative dynamics of parameters of color duplex scanning (CDS) of ICA during one year after MI. Results. One year after MI the overall incidence of CVC was 16.3 % (n=23). Structure of registered events was as follows: death from MI 7.1 % (n=10), deaths from stroke 2.1 % (n=3) and other causes 2.1 % (n=3), non-fatal MI 5.0 % (n=7), non-fatal stroke / TIA 2.1 % (n=3), carotid revascularization 2.8 % (n=4), coronary revascularization 14.9 % (n=21). CDC of ICAs was repeated in 125 patients. There were 17 (13.6 %) cases of progression of carotid atherosclerosis in the form of de novo bilateral stenoses in 14 (11.2 %) patients, stenoses in the left and right ICA 1 patient and 2 patients, respectively. The following predictors of progression of atherosclerosis of cerebral arteries were identified: family history of cardiovascular diseases (CVD),ICA stenosis ≥45 %, baseline circular atherosclerotic plaque (ASP). Predictors of high risk of stroke were family history of CVD, history of stroke,ICA stenosis ≥45 %, heterogeneous hypoechoic ASP. As predictors of lethal outcome, we identified history of MI, high functional class of angina preceding the index MI, severe coronary vascular bed involvement (SYNTAX score >23), presence of any bilateral atherosclerotic lesion in ICAs, and heterogeneous hypoechoic ASP. Assessment of the contribution of adherence to therapy in the prognosis 1 year after hospital discharge was fulfilled in 125 alive patients. It allowed to conclude that patients with progression of atherosclerosis and nonfatal CVC were characterized by insufficient adherence to standard therapy.Conclusion. Predictors of the progressive course of multifocal atherosclerosis during one year after MI were identified in this study. It is necessary to strengthen therapeutic and preventive measures aimed at minimization of the impact of these factors in this category of patients.   

224 A RETROSPECTIVE CASE–CONTROL STUDY ASSESSING THE CLINICAL AND ENDOSCOPIC CHARACTERISTICS OF EOSINOPHILIC ESOPHAGITIS IN JAPAN

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Kazumi Imamura ◽  
Ken Haruma ◽  
Hiroshi Matsumoto ◽  
Yasuhiko Maruyama ◽  
Maki Ayaki ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
Japanese Population ◽  
Case Control Study ◽  
High Power Field ◽  
Retrospective Case ◽  
Male Predominance ◽  
Endoscopic Findings ◽  
History Of ◽  
Endoscopic Characteristics ◽  
Control Study

Abstract   Eosinophilic esophagitis (EoE) is an allergy-associated clinicopathologic condition gaining an increasing amount of recognition in various areas of the world. While the clinical definition and characteristics may differ depending on country and region, sufficient studies have not yet been performed in Japan. To assess the prevalence of EoE among the Japanese population and the clinical features and the prognosis associated with the disease. Methods Medical data from January 2012 to October 2018 was gathered from nine Japanese clinical institutes. EoE, defined as more than 15 intraepithelial eosinophils per high power field, was determined based on esophageal biopsies. Clinical and endoscopic patterns in the cases with EoE were investigated and compared with 186 age- and sex-matched controls. We also analyzed the treatment and prognosis of an individual patient. Results From 130,013 upper endoscopic examinations, 66 cases of EoE were identified (0.051%; mean age: 45.2 years (range 7-79); 45 males). Patients with EoE had more symptoms (69.7 vs. 10.8%; P < 0.01) such as dysphagia and food impaction, and more allergies (63.6 vs. 23.7%; P < 0.01) compared with the controls. The prevalence of atrophic gastritis was lower in EoE patients than in the controls (20.0% vs. 33.3%). In 55 patients analyzed, 32 patients (78.0%) received proton pump inhibitors with or without swallowed topical corticosteroids. During the follw-up period (mean 23 months), no patient got worse regarding clinical and endoscopic findings. Conclusion The prevalence of EoE in the Japanese population was 0.051% which was comparable with previous reports in Japan. Male predominance, a history of allergies, and the absence of Helicobacter pylori infection might be risk factors for EoE. Our study also indicated that the prognosis of EoE might be relatively good in Japanese populations.

What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

2020 ◽  
Vol 31 (2) ◽  
pp. 33-44
Author(s):  
Simon Francis ◽  
Obadia V. Nyongole
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Positive Family History ◽  
Negative Attitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adult Men ◽  
History Of ◽  
One Year ◽  
High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

scholarly journals Prevalence and Risk Factors for Glucose Intolerance among Saudi Women with Gestational Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hayfaa Wahabi
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Gestational Diabetes ◽  
Glucose Intolerance ◽  
Fasting Blood Glucose ◽  
Positive Family History ◽  
Family History Of Diabetes ◽  
Saudi Women ◽  
History Of ◽  
One Year

Objectives. The objective of this study was to determine the incidence and risk factors of glucose intolerance one year after delivery in women with gestational diabetes (GDM). Methods. All women who had GDM and completed one year since delivery at King Khalid University Hospital were contacted to participate in the study. Based on to the American Diabetes Association criteria and the results of fasting blood glucose (FPG) and HbA1c, participants were classified into three groups: diabetic, impaired glucose tolerance (IGT), and normal. The incidence of diabetes and IGT was calculated. Clinical, biochemical, and sociodemographic predictors of glucose intolerance were compared between the three groups. Odds ratio (OR) for risk factors with P value less than 0.05 was calculated. Results. From a total 316 eligible women, 133 fulfilled the inclusion criteria and agreed to participate in the study. From the study participants, 58 (44%) women were normoglycemic, 60 (45%) women had IGT, and 15 (11%) women were diabetic. The odds of developing IGT or diabetes increased to nearly fourfold when women needed insulin for the control of GDM during pregnancy (OR 3.8, 95% CI 0.81–18.3, P=0.08) and to nearly one-and-a-half-fold when they have positive family history of T2DM (OR 1.2, 95% CI 0.74–2.09, P=0.40). Nevertheless, none of the odds ratios was statistically significant. Conclusion. The incidence of postpartum hyperglycemia (diabetes and IGT) is very high in Saudi women with GDM. Family history of diabetes and insulin treatment of GDM may be predictors of postpartum hyperglycemia.

scholarly journals PERSONALITY AND FAMILY HISTORY OF ALZHEIMER’S DISEASE AS PREDICTORS OF OLDER ADULTS’ SELF-REPORTED MEMORY PROBLEMS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S220-S220
Author(s):  
Sakshi Bhargava ◽  
Nikki Hill ◽  
Jacqueline Mogle ◽  
Tyler R Bell ◽  
Rachel Wion
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Family History ◽  
Multilevel Modeling ◽  
Individual Factors ◽  
Memory Decline ◽  
Memory Problems ◽  
History Of ◽  
One Year

Abstract Understanding individual factors (e.g., personality) associated with self-reported memory problems is important to refine identification of individuals at a higher risk of developing Alzheimer’s disease (AD). Using multilevel modeling, we examined the association of family history of AD and personality traits with self-reported memory problems in older adults (n = 421; 72.21% White; 62.95% female; Mage = 76.69). Results showed that individuals with a family history of AD reported more frequent memory problems and greater one-year memory decline. Similar findings were reported for individuals with higher extraversion scores. Further, older adults with higher neuroticism scores reported greater one- and ten-year memory decline. Neuroticism was positively related to frequency of memory problems, but only among participants with a family history of AD. Findings suggest that higher neuroticism and lower extraversion may increase older adults’ reports of memory problems. Family history of AD may further exacerbate this tendency.

scholarly journals Demographic profile of patients treated for melasma with glycolic acid and trichloroacetic acid: an institutional experience

2021 ◽  
Author(s):  
Bikkasani U. P. Lakshmi Kishan Rao ◽  
K. Satyanarayana Rao
Keyword(s):  
Family History ◽  
School Level ◽  
Female Ratio ◽  
Medical College ◽  
Number Of Patients ◽  
Institutional Experience ◽  
History Of ◽  
Epidemiological Pattern ◽  
One Year ◽  
Number Of Individuals

<p class="abstract"><strong>Background:</strong> Melasma is an acquired disorder of hyperpigmentation characterised by forehead, cheeks, around eyelids and chin mostly in the sun-exposed areas of the skin. The etiology for melasma is not clear, various factors like genetic or hormonal influences the cause. The aim was to understand the demographical distribution and epidemiological pattern of pigmentation in melasma patients.</p><p class="abstract"><strong>Methods:</strong> A total of 50 patients were participated in the present study at department of dermatology of Mamata medical college and hospital, Khammam over a period of one year.<strong></strong></p><p class="abstract"><strong>Results:</strong> The mean age of patients with melasma was 33.84±5.76 years, with the youngest and oldest being 20 and 40 years with female preponderance, with a male to female ratio of 1:9. The maximum number of patients educated up to middle school level (38%) followed by primary school. The maximum number of individuals participated in the present study were housewife’s and out of 50 individuals 92% patients in the present series were married whereas family history of melasma was noted only 16% of the melasma patients.</p><p class="abstract"><strong>Conclusions:</strong> The present observations demonstrates that the melasma is a female predominant, affecting young adults, etiological observations like sunlight, married, pregnancy, indoor, family history followed by cosmetics plays an important role in the melasma.</p>

Association of MRI and locoregional recurrence (LRR) rates in ductal carcinoma in situ (DCIS) patients treated with or without radiation therapy (RT).

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 57-57
Author(s):  
Melissa Louise Pilewskie ◽  
Cristina Olcese ◽  
Anne Eaton ◽  
Sujata Patil ◽  
Elizabeth Ann Morris ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Ductal Carcinoma ◽  
Menopausal Status ◽  
Patient Characteristics ◽  
Breast Conserving Surgery ◽  
Entire Cohort ◽  
History Of ◽  
History Presentation

57 Background: Perioperative MRI is frequently obtained in women with breast cancer; however, studies have not shown decreased rates of re-excision, and some report unnecessary increases in mastectomy rates. We examined LRR rates among women with DCIS who underwent perioperative MRI as compared to those who did not. Methods: All women who underwent breast-conserving surgery for DCIS in 1997-2010 were included from a prospectively maintained database. Patient characteristics and rates of LRR were compared in women with and without an MRI. Univariate and multivariate analyses were performed. Analysis was repeated in the subset of women who did not receive RT. Results: 2,321 cases were identified; 596 had MRI and 1,725 did not. Women who had MRI were younger, more likely to be premenopausal, have a family history of breast cancer, have a clinical presentation, receive RT and endocrine therapy, be treated in later years, and had fewer close/positive margins. At median follow-up of 57 months there were 184 IBTRs; 5-year LRR rates were 8.5% (MRI) and 7.2% (no MRI) (p = 0.52), and 8-year rates were 14.6% and 10.2%, respectively. MRI was not associated with lower LRR rates after adjustment for age, menopausal status, family history, presentation, adjuvant therapy, margin status, number of excisions, and year of surgery in both the entire cohort and in the subgroup who did not receive RT. Select factors from multivariate analysis for patients with all covariates available are shown in the Table. Conclusions: We observed no association between perioperative MRI and LRR rates for patients with DCIS, even when RT was not given. The benefit of perioperative MRI for DCIS remains uncertain. [Table: see text]

Progression of Symptoms and Endoscopic Findings with Age: Clues of the Natural History of Eosinophilic Esophagitis?

2009 ◽  
Vol 104 ◽  
pp. S24
Author(s):  
Evan Dellon ◽  
Wood Gibbs ◽  
Karen Fritchie ◽  
Tara Rubinas ◽  
Lindsay Wilson ◽  
...  
Keyword(s):  
Natural History ◽  
Eosinophilic Esophagitis ◽  
Endoscopic Findings ◽  
History Of

scholarly journals Four Years Analysis of Cancer Genetic Clinics Activity in France from 1994 to 1997: A Survey on 801 Patients

1999 ◽  
Vol 15 (1-3) ◽  
pp. 15-29 ◽  
Author(s):  
Hagay Sobol ◽  
Yves-Jean Bignon ◽  
Catherine Bonaiti ◽  
Jean Cuisenier ◽  
Christine Lasset ◽  
...  
Keyword(s):  
Family History ◽  
Cancer Genetics ◽  
National Level ◽  
Cancer Genetic ◽  
Variation Of Parameters ◽  
Genetic Activity ◽  
History Of ◽  
Frequent Site ◽  
The Mean ◽  
One Year

AIM: In order to evaluate the characteristics and the evolution of cancer genetics activity in France, a survey was conducted at the national level during a period of 4 years from 1994 to 1997 through the French Cooperative Network, a multidisciplinary group formed to investigate inherited tumors.METHOD: A questionnaire was sent to all the 29 French non-specialized cancer genetic clinics to evaluate activity during a period of 4 consecutive weeks each year from 1994 to 1997. Items concerning the cancer genetic clinics, the consultees and the types of consultation were explored.RESULTS: A total number of 801 consultees were seen during the period of analysis. Some prominent characteristics of patients attending cancer genetic clinics were found. The majority of these are women (88%), and the mean age of consultees is 48 years. Fifty five percent of consultees are affected with cancer, and breast (personal and/or family history) is the most frequent site involved (63%). A genetic predisposition is certain or likely in about 53% of cases and unlikely in only 13% of consultations. The majority of consultations are devoted to new families (71%). The mean duration of consultations is 50 minutes, but 40% have a duration of at least 1 hour. Variations of several parameters during the 4 years period were observed and analyzed. Finally, since duration of consultations (more or equal to 1 hour) and personal or family history of breast/ovarian cancer appeared as pivotal elements in our study and consequently may affect the organization of clinics and the structuring as well as the evolution of cancer genetic activity in France, we analyzed more precisely the factors significantly associated with these 2 elements.CONCLUSION: Study compliance was fair (60% of centers) and these results give a good measure of cancer genetic activity in France. The variation of parameters from one year to another may reflect modifications in medical practice (medical orientation rather than research focus and content of cancer genetic clinics) and/or scientific breakthroughs in cancer genetics such as identification of genes predisposing to cancer.

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