scholarly journals How Do Cytokines Trigger Genomic Instability?

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Ioannis L. Aivaliotis ◽  
Ioannis S. Pateras ◽  
Marilena Papaioannou ◽  
Christina Glytsou ◽  
Konstantinos Kontzoglou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Genomic Instability ◽  
The Other ◽  
Cancer Development ◽  
Tumor Initiation ◽  
Dual Effect ◽  
Other Hand ◽  
Shed Light ◽  
Comprehensive Study

Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.

Akrasia et enkrateia dans les Mémorables de Xénophon

Dialogue ◽  
2003 ◽  
Vol 42 (4) ◽  
pp. 645-672 ◽  
Author(s):  
Louis-André Dorion
Keyword(s):  
The Other ◽  
Other Hand ◽  
Shed Light

AbstractThis article aims to shed light on both the foundations and the consistency of the position regarding akrasia Xenophon attributes to Socrates in the Memorabilia. As does Plato's Socrates, Xenophon's Socrates maintains that akrasia is impossible in the presence of knowledge. On the other hand, he differs from the platonic Socrates by granting to enkrateia, instead of knowledge, the role of foundation for virtue. If enkrateia is the very condition for acquiring knowledge and virtue, consequently the responsibility for countering akrasia falls to enkrateia.

BLOCKADE OF THE SURGE OF PROLACTIN AT PRO-OESTRUS BY ADMINISTRATION OF ANTI-OESTROGENIC SUBSTANCE, MER-25

1973 ◽  
Vol 74 (4) ◽  
pp. 769-774 ◽  
Author(s):  
Akira Yokoyama ◽  
Hiroshi Tomogane ◽  
Katuaki Ôta
Keyword(s):  
Strong Evidence ◽  
The Other ◽  
Other Hand

ABSTRACT A non-steroidal oestrogen antagonist, MER-25, was administered to cycling rats for elucidating the role of oestrogen in the surge of prolactin observed on the afternoon of pro-oestrus (POe). In animals injected with 20 mg of MER-25 intramuscularly on the afternoon (16.30 h) of the first day of dioestrus (D-1), the surge of prolactin was blocked while the level of prolactin on the afternoon of POe of these animals was significantly higher than that of the corresponding controls injected with oil. Ovulation was also blocked in these animals treated with the drug on the afternoon of D-l. On the other hand, treatment on the morning (10.30 h) of the 2nd day of dioestrus failed to prevent not only the surge of prolactin but also ovulation. These observations provide strong evidence for the view that oestrogen is responsible for the surge of prolactin on the afternoon of POe, and that the surge is accompanied by that of LH.

Covid-19 – rumours and facts in media

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 171-174
Author(s):  
Tarare Toshida ◽  
Chaple Jagruti
Keyword(s):  
Social Media ◽  
Preventive Measures ◽  
Vital Role ◽  
The Other ◽  
Sources Of Information ◽  
Other Hand ◽  
Corona Virus ◽  
The People ◽  
The World

The covid-19 resulted in broad range of spread throughout the world in which India has also became a prey of it and in this situation the means of media is extensively inϑluencing the mentality of the people. Media always played a role of loop between society and sources of information. In this epidemic also media is playing a vital role in shaping the reaction in ϑirst place for both good and ill by providing important facts regarding symptoms of Corona virus, preventive measures against the virus and also how to deal with any suspect of disease to overcome covid-19. On the other hand, there are endless people who spread endless rumours overs social media and are adversely affecting life of people but we always count on media because they provide us with valuable answers to our questions, facts and everything in need. Media always remains on top of the line when it comes to stop the out spread of rumours which are surely dangerous kind of information for society. So on our side we should react fairly and maturely to handle the situation to keep it in the favour of humanity and help government not only to ϑight this pandemic but also the info emic.

The Policy of the EEC on Concentrative Joint Ventures

1992 ◽  
Vol 5 (1) ◽  
pp. 53-67
Author(s):  
D.S. Nava
Keyword(s):  
Structural Change ◽  
Joint Ventures ◽  
The Other ◽  
Legal Instrument ◽  
Other Hand ◽  
Philip Morris ◽  
Competition Rules

The EEC Treaty contains no specific provisions for the control of concentrations. Only the competition rules. Articles 85 and 86 EEC, could be considered as possible legal instruments for regulating concentrations. The Commission has had to examine whether and to what extent these provisions could be used to this end.The Commission's view has been that Article 85 does not apply to operations resulting in structural change, as is the case of concentrations and concentrative joint ventures. Cooperative operations, such as cooperative joint ventures, on the other hand fall to be assessed under Article 85. The Philip Morris case has made this position uncertain. According to the extensive interpretation of this judgement Article 85 is now applicable to certain concentrations and thus to concentrative joint ventures.There is no such uncertainty regarding the role of Article 86 in controlling concentrative joint ventures, for the Court has established in the Continental Can case that concentrations can be caught by Article 86.With the adoption in 1989 of the Regulation on concentration control the Commission finally has a legal instrument specifically designed to regulate concentrations. However, only concentrations and concentrative joint ventures which comply with certain turnover thresholds (the so-called concentrations or concentrative joint ventures with a Community dimension) can be assessed by the Commission under the Regulation. This means that the provisions of the Regulation can not be applied to concentrative joint ventures beneath the threshold.Because of the difficulty in distinguishing concentrative operations from cooperative ones, the Commission published the Notice regarding the concentrative and cooperative operations under the Regulation on the control of concentrations.

scholarly journals Notes from the Editors

2014 ◽  
Vol 108 (2) ◽  
pp. iii-ix
Keyword(s):  
Basic Research ◽  
Decision Makers ◽  
The Other ◽  
Good Effect ◽  
Scholarly Journals ◽  
Other Hand ◽  
Relevant Work

We introduce this issue with a thought. There has been much made of the need for our discipline to be “policy relevant,” and much ridicule has been directed at the Review recently that comments how little the Review offers that is relevant for decision makers. But what does it mean to be policy relevant? Generally, scholarly journals publish the best in basic research, which hopefully can be used by those in positions of authority to good effect. This often means that there are no catchy titles, nor opinion-editorial pieces that are so often portrayed as the model of policy relevant work. In our view, the role of the Review is to expand knowledge on important scholarly questions, not only to publish work that is currently popular or somehow ordained as useful by pundits. There is certainly a place for such work, but not in the pages of the Review. On the other hand, we as the editors of the Review understand the need to make the Review accessible to as broad an audience as possible, and we have made great efforts to do just that.

The influence of concealing academic achievement on the self-esteem of adolescents with low achievement

2009 ◽  
Vol 37 (6) ◽  
pp. 805-810
Author(s):  
Baoshan Zhang ◽  
Jun-Yan Zhao ◽  
Guoliang Yu
Keyword(s):  
Academic Achievement ◽  
Social Interaction ◽  
Social Interactions ◽  
Self Esteem ◽  
Low Achievers ◽  
The Self ◽  
The Other ◽  
Other Hand ◽  
Positive Performance

An examination was carried out of the influences of concealing academic achievement on self-esteem in an academically relevant social interaction based on the assumption that concealing socially devalued characteristics should influence individuals' self-esteem during social interactions. An interview paradigm called for school-aged adolescents who either were or were not low (academic) achievers to play the role of students who were or were not low achievers while answering academically relevant questions. The data suggest that the performance self-esteem of low achievers who played the role of good students was more positive than that of low achievers who played the role of low achievers. On the other hand, participants who played the role of good students had more positive performance self-esteem than did participants who played the role of low achievers.

Analysis of the Collaborative Learning Application in Reading Material at Ninth Grade of SMPN 7 Kinali Pasaman Barat

2021 ◽  
Vol 1 (1) ◽  
pp. 71-88
Author(s):  
Sukini Sukini ◽  
Hilma Pami Putri
Keyword(s):  
Qualitative Research ◽  
Collaborative Learning ◽  
Learning Strategy ◽  
Research Question ◽  
Ninth Grade ◽  
The Other ◽  
Reading Material ◽  
Other Hand ◽  
Object Based

This research was designed to find out and analyze of the collaborative learning application in reading material at ninth grade of SMPN 7 Kinali Pasaman Barat. This research conducted due to several problems found in the field which were students make a fuss when working in groups, students do not listen to given the assignment by the teacher. It can be seen that there were students who work on group assignments that care and others were just busy talking with others. This research was done in order to answer the research question “What were the role of student and what were the role of teacher in collaborative learning at the ninth grade of SMPN 7 Kinali Pasaman Barat?” This research was a qualitative research using collaborative learning strategy. The purpose of this research was to find out and analyze the collaborative learning applicationin reading material at the ninth grade of SMPN 7 KinaliPasaman Barat by analyzing the teacher’s and students’ role in the collaborative learning. The researcher used interview and observation as the instrument of the research. The interview was directed to both students and teacher, which for the students contained 12 questions and for the teacher contained 7 questions. The researcher took 2 classes namely IX1 and IX2 as the observation object.                    Based on the finding from interview and observation of the collaborative learning in SMPN 7 Kinali Pasaman Barat, it was found that the teacher already fulfilled her role in the collaborative learning effectively, in the other hand the students still lack of the role as the cheer leader. They still laughed at their friends mistake. Besides that, the other roles that the students supposed to have were already done effectively. As the conclusion, the collaborative learning in SMPN 7 Kinali Pasaman Barat was good since the students and the teacher were doing their role effectively

Cognitive Reflection Task and Stumpers

2021 ◽  
Author(s):  
Wendy Ross ◽  
Frédéric Vallée-Tourangeau
Keyword(s):  
Cognitive Processes ◽  
Mental Model ◽  
The Other ◽  
Cognitive Reflection ◽  
Other Hand ◽  
And Performance ◽  
Shed Light

There is a type of riddle that Bar-Hillel, Noah and Frederick (2018) call “stumpers”. A stumper is a riddle which is initially intractable because the mental model or representation of the situation described in the riddle does not contain the vital information which is required to solve it. The Cognitive Reflection Task (CRT; Frederick, 2005) on the other hand relies on seemingly completely different cognitive processes. However, exploratory work from Bar-Hillel et al. (2019) suggests that success on stumpers correlates with performance on the CRT. This finding may shed light on the cognitive processes underlying both the resolution of stumpers and the CRT. We replicated the work from Bar-Hillel et al. (2019) suggesting a relationship between performance on the CRT and performance on stumpers as well as extending this to show a relationship between performance on the CRT-v. This may point to the underexplored importance of suppression in solving stumpers and traditional riddles.

Dyadic Cancer-Related Distress and The Role Of Mindfulness and Spiritual Well-Being in Couples with Cancer: An Actor-Partner Interdependence Model

2021 ◽  
Author(s):  
Afarin Rajaei ◽  
Saeideh Heshmati
Keyword(s):  
Cancer Patient ◽  
Well Being ◽  
The Other ◽  
Dyadic Data ◽  
Actor Partner Interdependence Model ◽  
Other Hand ◽  
Spiritual Well Being ◽  
Adaptive Processes ◽  
Partner Effect

The present study draws attention to the significance of considering mindfulness and spiritual well-being on cancer-related distress among couples with cancer during the pandemic. Dyadic data was analyzed among couples with cancer (80 couples; N=160) to examine the within-person (actor effects) and between-partner (partner effects) associations among links between mindfulness, spiritual well-being, and cancer-related distress through the use of the actor-partner interdependence model (APIM; Kashy & Kenny, 2000). Significant actor and/or partner effects were found for mindfulness and spiritual well-being in couples with cancer, a factor that predicted cancer-related distress. Spirituality seemed to only play an important role in patients’ own cancer-related distress (actor effect), with patients’ higher levels of spiritual well-being predicting patients’ lower levels of distress. On the other hand, mindfulness was not only significantly related to the cancer patient and partner’s own distress (actor effect), partner’s mindfulness was also significantly associated with the patient’s distress (partner effect). The findings underscore the need to adopt a systemic perspective that accounts for multiple, simultaneous adaptive processes including mindfulness and spiritual well-being as influences on cancer-related distress in the time of COVID-19.

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