scholarly journals Metabolic Engineering of Yeast and Plants for the Production of the Biologically Active Hydroxystilbene, Resveratrol

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Philippe Jeandet ◽  
Bertrand Delaunois ◽  
Aziz Aziz ◽  
David Donnez ◽  
Yann Vasserot ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Stilbene Synthase ◽  
Molecular Engineering ◽  
Biologically Active ◽  
The Other ◽  
Alternative Mechanism ◽  
Comprehensive Review ◽  
Transgenic Lines ◽  
Key Enzyme ◽  
Recombinant Microorganisms

Resveratrol, a stilbenic compound deriving from the phenyalanine/polymalonate route, being stilbene synthase the last and key enzyme of this pathway, recently has become the focus of a number of studies in medicine and plant physiology. Increased demand for this molecule for nutraceutical, cosmetic and possibly pharmaceutic uses, makes its production a necessity. In this context, the use of biotechnology through recombinant microorganisms and plants is particularly promising. Interesting results can indeed arise from the potential of genetically modified microorganisms as an alternative mechanism for producing resveratrol. Strategies used to tailoring yeast as they do not possess the genes that encode for the resveratrol pathway, will be described. On the other hand, most interest has centered in recent years, onSTSgene transfer experiments from various origins to the genome of numerous plants. This work also presents a comprehensive review on plant molecular engineering with theSTSgene, resulting in disease resistance against microorganisms and the enhancement of the antioxidant activities of several fruits in transgenic lines.

Problems of species and the features of geographical distribution in colonial volvocine algae (Chlorophyta)

2020 ◽  
Vol 54 (2) ◽  
pp. 299-311
Author(s):  
A. G. Desnitskiy
Keyword(s):  
New Species ◽  
Geographical Distribution ◽  
World Literature ◽  
The Other ◽  
Disjunct Distribution ◽  
Published Data ◽  
Species Problem ◽  
Comprehensive Review ◽  
Volvocine Algae ◽  
Cryptic Taxa

More than ten new species of colonial volvocine algae were described in world literature during recent years. In present review, the published data on taxonomy, geographical distribution and the species problem in this group of algae, mainly from the genera Gonium, Pandorina, Eudorina, and Volvox, are critically discussed. There are both cosmopolitan volvocalean species and species with local or disjunct distribution. On the other hand, the description of new cryptic taxa in some genera of the colonial family Volvocaceae, such as Pandorina and Volvox, complicates the preparation of a comprehensive review on their geography.

scholarly journals Ultrasonically-Extracted Marine Polysaccharides as Potential Green Antioxidant Alternatives

Proceedings ◽  
2020 ◽  
Vol 67 (1) ◽  
pp. 23
Author(s):  
Hanaa L. Essa ◽  
Hania A. Guirguis ◽  
Mayyada M. H. El-Sayed ◽  
Dalia Rifaat ◽  
Mohamed S. Abdelfattah
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Algal Species ◽  
Avicennia Marina ◽  
Ulva Lactuca ◽  
Biologically Active ◽  
Sulfated Polysaccharides ◽  
Total Phenolic ◽  
Sugar Substitutes ◽  
Pharmaceutical Industries

Marine-extracted sulfated polysaccharides (SPs) have been the subject of myriad research since they are considered an eco-friendly source of biologically active compounds. Meanwhile, food and pharmaceutical industries are urgently producing natural sugar substitutes and antioxidants as alternatives to synthetic ones which are associated with cytotoxicity and safety issues. This study assesses the potential of using marine SPs obtained via the ultrasonic-assisted extraction of different marine species, to utilize them as antioxidant sugar substitutes. The carbohydrate, total phenolic contents and antioxidant activities were measured for SP extracts of the algal species of Ulva lactuca, Jania rubens and the marine plant mangrove Avicennia marina. These SPs were structurally elucidated by Fourier Transform Infrared (FTIR) spectroscopic and high-performance liquid chromatography (HPLC) analyses. The results revealed that SPs’ highest yield percent was obtained from Ulva lactuca, 5.50 ± 0.25%. The SPs of Avicennia marina had the highest carbohydrate content, 44 ± 1% and antioxidant activity, 78.85 ± 0.06 at the 100 μg/mL concentration and 89.50 ± 0.21 at the 250 μg/mL concentration. Meanwhile, the highest phenolic content was exhibited by algal SPs obtained from Jania rubens, 132.60 ± 2.50 mgGa/g. Results also showed that all extracts have potent antioxidant activity, while the highest antioxidant activity belonged to the SPs of Avicennia marina owing possibly to their balanced glucose and galactose contents as measured by HPLC. This work emphasizes the need to consider sulfated polysaccharides from marine sources for their antioxidant activity and to correlate it with their monosaccharide content to determine the effect of reducing sugar concentration on the antioxidant activity.

NO, CO and H2S based pharmaceuticals in the mission of vision (eye health): a comprehensive review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jan Mohammad Mir ◽  
Ram Charitra Maurya ◽  
Mohd Washid Khan
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Human Physiology ◽  
Hydrogen Sulfide ◽  
The Other ◽  
Normal Functioning ◽  
Comprehensive Review ◽  
Molecular Systems ◽  
Eye Health ◽  
Highly Sensitive

Abstract A set of well defined signaling molecules responsible for normal functioning of human physiology including nitric oxide along with carbon monoxide and hydrogen sulphide are referred as “gasotransmitters”. Due to their involvement in almost every system of a human body, the care of highly sensitive organs using these molecules as drugs represents highly fascinating area of research. In connection with these interesting aspects, the applied aspects of these gaseous molecules in maintaining healthy eye and vision have been targeted in this review. Several examples of eye-droppers including NORMs like latanoprost and nipradiol, CORMs like CORM-3 and CORM-A1, and Hydrogen sulfide releasing system like GYY4137 have been discussed in this context. Therefore the relation of these trio-gasotransmitters with the ophthalmic homeostasis on one hand, and de-infecting role on the other hand has been mainly highlighted. Some molecular systems capable of mimicking gasotransmitter action have also been introduced in connection with the titled theme.

Efficient Synthesis of Novel N-[4-Methyl-3-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)thiazol-2(3H)-ylidene]benzamide Hybrid Ring System as Potential Antibacterial Agents

2021 ◽  
Vol 17 ◽  
Author(s):  
Hummera Rafique ◽  
Aamer Saeed ◽  
Muhammad Naseem ◽  
Tauqeer Riaz ◽  
Fouzia Perveen ◽  
...  
Keyword(s):  
Bacterial Resistance ◽  
Antioxidant Activities ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Ring System ◽  
Biologically Active ◽  
Thiazole Ring ◽  
Spectroscopic Techniques ◽  
Hybrid Ring

Background: Heterocyclic compounds display versatile biological applications, so the aim of this paper was to prepare biologically important heterocycles with enhanced bacterial resistance and to evaluate for their various structural features that are responsible for their biological properties. Objective: The objective was to synthesize bacterial resistance compounds with enhanced antibacterial properties. Method: Ester moiety containing thiazole ring was converted into its hydrazide derivatives. These heterocyclic derivatives were cyclized into another ring oxadiazole; hence a hybrid ring system of two biologically active rings was prepared. Result: All the synthesized compounds were characterized by spectroscopic techniques and were screened for their antibacterial potential; they possess significant antibacterial activities. Conclusion: New hybrid heterocyclic ring systems were synthesized by cyclization of hydrazide derivatives by adopting two step strategy in good yields. All the synthesized compounds were evaluated for their antioxidant activities; they showed moderate to significant activities. QSAR and Molecular docking studies were performed to determine the mode of interaction. Experimental and computational data is in accordance with the determined antibacterial activities.

scholarly journals Managing Free Text for Secondary Use of Health Data

2014 ◽  
Vol 23 (01) ◽  
pp. 167-169 ◽  
Author(s):  
N. Griffon ◽  
J. Charlet ◽  
S. J. Darmoni ◽  
Keyword(s):  
Language Processing ◽  
Meaningful Use ◽  
Health Data ◽  
Structured Data ◽  
The Other ◽  
Free Text ◽  
Reference Resolution ◽  
Comprehensive Review ◽  
Secondary Use ◽  
Corpus Creation

Summary Objective: To summarize the best papers in the field of Knowledge Representation and Management (KRM). Methods: A comprehensive review of medical informatics literature was performed to select some of the most interesting papers of KRM and natural language processing (NLP) published in 2013. Results: Four articles were selected, one focuses on Electronic Health Record (EHR) interoperability for clinical pathway personalization based on structured data. The other three focus on NLP (corpus creation, de-identification, and co-reference resolution) and highlight the increase in NLP tools performances. Conclusion: NLP tools are close to being seriously concurrent to humans in some annotation tasks. Their use could increase drastically the amount of data usable for meaningful use of EHR.

scholarly journals Design, Synthesis, Antimicrobial, and Antioxidant Activities of Novel-{4, 5-(substituted diphenyl)-4H-1, 2, 4-triazol-3-ylthio} Acetyl Chloride

2017 ◽  
Vol 15 (2) ◽  
pp. 157-167
Author(s):  
Prabhakar Kumar VERMA ◽  
Mukesh KUMAR ◽  
Nelam MALIK ◽  
Priyanka DHIMAN ◽  
Anurag KHATAHAR
Keyword(s):  
Free Radical ◽  
Acetyl Chloride ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Biologically Active ◽  
Free Radical Scavenging Activity ◽  
Scavenging Activity ◽  
Standard Drug

A series of 20 new biologically active derivatives of 2-{4, 5-(substituted diphenyl)-4H-1,2,4-triazol-3-ylthio}acetyl chloride has been synthesized, with the aim to investigate antimicrobial, free radical scavenging activity. All the synthesized compounds were characterized by spectroscopic data and elemental analysis. The final compounds were tested for antibacterial activity against Gram-positive bacteria: Staphylococcus aureus MTCC 3160, Bacillus subtilis MTCC 441; Gram-negative bacteria: Escherichia coli MTCC 443, and, for antifungal activity, against Candida albicans MTCC 227 and Aspergillus niger MTCC 281, taking ciprofloxacin as antibacterial and fluconazole as antifungal standard drugs. Compound 7a6 was found to be the most effective antibacterial (MIC = 3.12 µg/ml), and compounds 7a2 and 7d1 (MIC = 3.12 and 6.25 µg/ml) had the most effective antifungal effects on the selected strains, as compared to the standard drugs. The results of antioxidant studies revealed that compound 7b1 was found to be most active antioxidant, with 40.4±0.687 µg/ml, and compounds 7b3, 7d7, and 7d4 also showed promising free radical scavenging activity, as compared with the standard drug ascorbic acid.

scholarly journals Ethnobotanical, phytochemical and pharmacological aspects of Bengal Pogostemon (Pogostemon benghalensis)

2020 ◽  
Vol 9 (4) ◽  
pp. 318-327
Author(s):  
Sangeeta Dahiya ◽  
Daizy R. Batish ◽  
Harminader Pal Singh
Keyword(s):  
Molecular Level ◽  
Antioxidant Activities ◽  
Chemical Compounds ◽  
Biologically Active ◽  
Pharmacological Activities ◽  
Plant Parts ◽  
Chemical Structures ◽  
Traditional Uses ◽  
Traditional Remedies ◽  
Pharmacological Studies

Pogostemon benghalensis (Burm.f.) Kuntze (Lamiaceae) is an important aromatic plant. Multiple classes of phytochemicals such as flavonoids, phenols, phytosteroids, carbohydrates, fatty acids, glycosides, sterols, terpenoids, tannins, essential oil, and alkaloids have been isolated from the title species. Different plant parts have been used as traditional remedies for various ailments. The present review aims to update and coherent the fragmented information on botanical aspects, phytochemistry, traditional uses, and pharmacological activities. An extensive review of the literature was carried out by using various search engines like PubMed, Scopus, Science Direct, Google Scholar, Google, Scifinder for information. The articles were searched using the keywords "Pogostemon", "Parviflorus’, "benghalensis". Chemical structures of the chemical compounds were drawn using software Chem Draw ultra 8.0. Most of the plant parts have been used for the treatment of various ailments. Phytochemistry reveals that the plant is a rich source of various biologically active compounds. Pogostemon extracts exhibited numerous pharmacological effects like anticancer, anti-inflammatory, antimicrobial and antioxidant activities. In sum, P. benghalensis is a promising aromatic and medicinal plant as depicted by its various traditional uses and pharmacological studies. Bioactive compounds, responsible for its various pharmacological activities at the molecular level, need further detailed investigations. Future clinical studies are also required to validate the various traditional uses of P. benghalensis.

scholarly journals A comprehensive review on Polygonum glabrum

2017 ◽  
Vol 8 (4) ◽  
pp. 457
Author(s):  
Raja S ◽  
Ramya I
Keyword(s):  
Trace Elements ◽  
Essential Oil ◽  
Phenolic Acids ◽  
Antioxidant Activities ◽  
Comprehensive Review ◽  
Traditional System ◽  
Perennial Plant

<p class="nova-e-paragraph"><em>Polygonum glabrum </em>commonly<em> </em><em>called as </em>dense flower knotweed <em>is a</em> perennial plant. It is an amphibious shrub<em> with </em>pink flowers and glossy brown seeds <em>found in most parts of India. Various parts of the plant </em>like leaves, stem, flowers and roots are used in traditional system of medicine. Traditionally, different decoctions/infusions are prepared using the <em>plant</em> parts and given for the treatment of rheumatism, jaundice, piles etc. From pharmacological point, the plant has been effectively screened for antihepatotoxic, antinephrotoxic, antimicrobial, anticancer, antidepressant, analgesic and antioxidant activities. The plant contains many flavonoids including diosmetin, rutin, hyperin and quercitrin. The lanceolate leaves are rich in essential oil which contains many compounds like 6, 6-dimethyl-1, 3-heptadien-5-ol, oleicacid, 9-octadecenamide, isodecyloctyl ester and 1,2,3-benzenetriol. Compounds like aliphatic, alicyclic compounds, sesqueterpenes, sterols, phenolic acids as well as other trace elements have been identified in the plant. This review provides morphological, ethnomedical, pharmacological and phytochemical data of the plant <em>Polygonum glabrum.</em></p>

Data science in economics: comprehensive review of advanced machine learning and deep learning methods

2020 ◽  
Author(s):  
Saeed Nosratabadi ◽  
Amir Mosavi ◽  
Puhong Duan ◽  
Pedram Ghamisi ◽  
Filip Ferdinand ◽  
...  
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Prediction Accuracy ◽  
Data Science ◽  
State Of The Art ◽  
Hybrid Models ◽  
The Other ◽  
Learning Models ◽  
Comprehensive Review

Abstract This paper provides the state of the art of data science in economics. Through a novel taxonomy of applications and methods advances in data science are investigated. The data science advances are investigated in three individual classes of deep learning models, ensemble models, and hybrid models. Application domains include stock market, marketing, E-commerce, corporate banking, and cryptocurrency. Prisma method, a systematic literature review methodology is used to ensure the quality of the survey. The findings revealed that the trends are on advancement of hybrid models as more than 51% of the reviewed articles applied hybrid model. On the other hand, it is found that based on the RMSE accuracy metric, hybrid models had higher prediction accuracy than other algorithms. While it is expected the trends go toward the advancements of deep learning models.

Decontamination Strategies for Filtering Facepiece Respirators (FFRs) in Healthcare Organizations: A Comprehensive Review

2020 ◽  
Author(s):  
Ashok Kumar Jena ◽  
Jitendra Sharan
Keyword(s):  
Hydrogen Peroxide ◽  
Ethylene Oxide ◽  
Time Use ◽  
Ultraviolet Irradiation ◽  
The Other ◽  
Limited Time ◽  
Healthcare Organizations ◽  
Comprehensive Review ◽  
Dry Heat ◽  
Other Hand

Abstract Filtering facepiece respirators (FFRs) are made for one-time use. A massive shortage of FFRs is widespread during pandemic events and has forced many healthcare organizations to decontaminate them and re-use for a limited time. Many decontamination methods have been proposed for the decontamination of FFRs. This review highlights various aspects of decontamination methods available in the literature. Among various methods available, vaporized hydrogen peroxide, ultraviolet irradiation, and dry heat seem to be the most promising decontaminants for FFRs. On the other hand, microwave, bleach, ethylene oxide, alcohol, hydrogen peroxide liquid, sanitizing wipes, and soap and water are not recommended methods for FFR decontamination.

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