scholarly journals Advances and Computational Tools towards Predictable Design in Biological Engineering

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Lorenzo Pasotti ◽  
Susanna Zucca
Keyword(s):  
Mathematical Models ◽  
Design Process ◽  
Systems Engineering ◽  
Biological Systems ◽  
Biological Engineering ◽  
Bottom Up ◽  
Whole Process ◽  
Ribosome Binding Sites ◽  
Intrinsic Complexity ◽  
Selection Of

The design process of complex systems in all the fields of engineering requires a set of quantitatively characterized components and a method to predict the output of systems composed by such elements. This strategy relies on the modularity of the used components or the prediction of their context-dependent behaviour, when parts functioning depends on the specific context. Mathematical models usually support the whole process by guiding the selection of parts and by predicting the output of interconnected systems. Such bottom-up design process cannot be trivially adopted for biological systems engineering, since parts function is hard to predict when components are reused in different contexts. This issue and the intrinsic complexity of living systems limit the capability of synthetic biologists to predict the quantitative behaviour of biological systems. The high potential of synthetic biology strongly depends on the capability of mastering this issue. This review discusses the predictability issues of basic biological parts (promoters, ribosome binding sites, coding sequences, transcriptional terminators, and plasmids) when used to engineer simple and complex gene expression systems inEscherichia coli. A comparison between bottom-up and trial-and-error approaches is performed for all the discussed elements and mathematical models supporting the prediction of parts behaviour are illustrated.

From classrooms to Centres: Mary and David Medd’s contribution to postwar school design in Britain

2020 ◽  
Vol 24 (3) ◽  
pp. 251-264
Author(s):  
Paula Lacomba Montes ◽  
Alejandro Campos Uribe
Keyword(s):  
Great Britain ◽  
Design Process ◽  
School Design ◽  
Ministry Of Education ◽  
Learning Spaces ◽  
Close Collaboration ◽  
Innovative Strategies ◽  
Whole Process ◽  
Conventional School ◽  
Selection Of

This paper reports on the primary school design processes carried out around the 1940s in the County of Hertfordshire in Great Britain, which later evolved into innovative strategies developed by Mary and David Medd in the Ministry of Education from the late 1950s. The whole process, undertaken during more than three decades, reveals a way of breaking with the traditional spatial conception of a school. The survey of the period covered has allowed an in-depth understanding of how learning spaces could be transformed by challenging the conventional school model of closed rooms, suggesting a new way of understanding learning spaces as a group of Centres rather than classrooms. Historians have thoroughly shown the ample scope of this process, which involved many professionals, fostering a true cross-disciplinary endeavour where the curriculum and the learning spaces were developed in close collaboration. A selection of schools built in the county has been used to typologically analyse how architectural changes began to arise and later flourished at the Ministry of Education. The Medds had indeed a significant role through the development of a design process known as the Built-in variety and the Planning Ingredients. A couple of examples will clarify some of these strategies, revealing how the design of educational space could successfully respond to an active way of learning.

Evolution and Selection of Quantitative Traits

2018 ◽  
Author(s):  
Bruce Walsh ◽  
Michael Lynch
Keyword(s):  
Mathematical Models ◽  
Quantitative Genetics ◽  
Complex Traits ◽  
Evolutionary Biology ◽  
Quantitative Traits ◽  
Specific Gene ◽  
Real World Data ◽  
Holistic Treatment ◽  
Genetics And Genomics ◽  
Selection Of

Quantitative traits—be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene—usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences. This extensive work of reference is suitable for graduate level students as well as professional researchers (both empiricists and theoreticians) in the fields of evolutionary biology, genetics, and genomics. It will also be of particular relevance and use to plant and animal breeders, human geneticists, and statisticians.

An algebraic approach to N-soft sets with application in decision-making using TOPSIS

2021 ◽  
pp. 1-21
Author(s):  
Muhammad Shabir ◽  
Rimsha Mushtaq ◽  
Munazza Naz
Keyword(s):  
Decision Making ◽  
Mathematical Models ◽  
Real World ◽  
Algebraic Approach ◽  
Multi Criteria Decision Making ◽  
Commutative Monoids ◽  
Soft Sets ◽  
Algebraic Properties ◽  
Different Types ◽  
Selection Of

In this paper, we focus on two main objectives. Firstly, we define some binary and unary operations on N-soft sets and study their algebraic properties. In unary operations, three different types of complements are studied. We prove De Morgan’s laws concerning top complements and for bottom complements for N-soft sets where N is fixed and provide a counterexample to show that De Morgan’s laws do not hold if we take different N. Then, we study different collections of N-soft sets which become idempotent commutative monoids and consequently show, that, these monoids give rise to hemirings of N-soft sets. Some of these hemirings are turned out as lattices. Finally, we show that the collection of all N-soft sets with full parameter set E and collection of all N-soft sets with parameter subset A are Stone Algebras. The second objective is to integrate the well-known technique of TOPSIS and N-soft set-based mathematical models from the real world. We discuss a hybrid model of multi-criteria decision-making combining the TOPSIS and N-soft sets and present an algorithm with implementation on the selection of the best model of laptop.

scholarly journals Potential Energy Implications of Connected and Automated Vehicles: Exploring Key Leverage Points through Scenario Screening and Analysis

2019 ◽  
Vol 2673 (5) ◽  
pp. 84-94 ◽  
Author(s):  
Brian Bush ◽  
Laura Vimmerstedt ◽  
Jeff Gonder
Keyword(s):  
Systems Engineering ◽  
Large Scale ◽  
Operating Cost ◽  
Dynamics Model ◽  
Transportation Service ◽  
Service Outcomes ◽  
Behavioral Parameters ◽  
Computationally Intensive ◽  
Different Levels ◽  
Selection Of

Connected and automated vehicle (CAV) technologies could transform the transportation system over the coming decades, but face vehicle and systems engineering challenges, as well as technological, economic, demographic, and regulatory issues. The authors have developed a system dynamics model for generating, analyzing, and screening self-consistent CAV adoption scenarios. Results can support selection of scenarios for subsequent computationally intensive study using higher-resolution models. The potential for and barriers to large-scale adoption of CAVs have been analyzed using preliminary quantitative data and qualitative understandings of system relationships among stakeholders across the breadth of these issues. Although they are based on preliminary data, the results map possibilities for achieving different levels of CAV adoption and system-wide fuel use and demonstrate the interplay of behavioral parameters such as how consumers value their time versus financial parameters such as operating cost. By identifying the range of possibilities, estimating the associated energy and transportation service outcomes, and facilitating screening of scenarios for more detailed analysis, this work could inform transportation planners, researchers, and regulators.

Mathematical Modeling of Machining Parameters in Electrical Discharge Machining with Cu-B4C Composite Electrode

2012 ◽  
Vol 488-489 ◽  
pp. 871-875
Author(s):  
V. Anandakrishnan ◽  
V. Senthilkumar
Keyword(s):  
Mathematical Models ◽  
Current Pulse ◽  
Electrical Discharge ◽  
Electrical Discharge Machining ◽  
Removal Rate ◽  
Machining Parameters ◽  
Pulse On Time ◽  
Pulse Off Time ◽  
Off Time ◽  
Selection Of

Copper based metal matrix composite reinforced with Boron Carbide is a newly developed Electrical Discharge Machining (EDM) electrode showing better performance than the conventional copper based electrode. Right selection of machining parameters such as current, pulse on time and pulse off time is one of the most important aspects in EDM. In this paper an attempt has been made to develop mathematical models for relating the Material Removal Rate (MRR), Tool Removal Rate (TRR) and Surface roughness (Ra) to machining parameters (current, pulse-on time and pulse-off time). Furthermore, a study was carried out to analyze thSubscript texte effects of machining parameters on various performance parameters such as, MRR, TRR and Ra. The results of Analysis of Variance (ANOVA) indicate that the proposed mathematical models, can adequately describe the performance within the limits of the factors being studied. Response surface modeling is used to develop surface and contour graphs to analyze the effects of EDM input parameters on outer parameters.

scholarly journals The quantum mitochondrion and optimal health

2016 ◽  
Vol 44 (4) ◽  
pp. 1101-1110 ◽  
Author(s):  
Alistair V.W. Nunn ◽  
Geoffrey W. Guy ◽  
Jimmy D. Bell
Keyword(s):  
Natural Selection ◽  
Energy Production ◽  
Healthy Aging ◽  
Evolutionary Process ◽  
Emergent Behaviour ◽  
Whole Process ◽  
Optimal Health ◽  
Response To Stress ◽  
Will Self ◽  
Selection Of

A sufficiently complex set of molecules, if subject to perturbation, will self-organize and show emergent behaviour. If such a system can take on information it will become subject to natural selection. This could explain how self-replicating molecules evolved into life and how intelligence arose. A pivotal step in this evolutionary process was of course the emergence of the eukaryote and the advent of the mitochondrion, which both enhanced energy production per cell and increased the ability to process, store and utilize information. Recent research suggest that from its inception life embraced quantum effects such as ‘tunnelling’ and ‘coherence’ while competition and stressful conditions provided a constant driver for natural selection. We believe that the biphasic adaptive response to stress described by hormesis–a process that captures information to enable adaptability, is central to this whole process. Critically, hormesis could improve mitochondrial quantum efficiency, improving the ATP/ROS ratio, whereas inflammation, which is tightly associated with the aging process, might do the opposite. This all suggests that to achieve optimal health and healthy aging, one has to sufficiently stress the system to ensure peak mitochondrial function, which itself could reflect selection of optimum efficiency at the quantum level.

Automated phase attribute-based picking applied to reflection seismics

Geophysics ◽  
2016 ◽  
Vol 81 (2) ◽  
pp. V141-V150 ◽  
Author(s):  
Emanuele Forte ◽  
Matteo Dossi ◽  
Michele Pipan ◽  
Anna Del Ben
Keyword(s):  
Signal To Noise Ratio ◽  
Phase Method ◽  
Data Sets ◽  
Reflection Seismic ◽  
Instantaneous Phase ◽  
Whole Process ◽  
Specific Analysis ◽  
Reflection Seismics ◽  
Selection Of ◽  
Energy Package

We have applied an attribute-based autopicking algorithm to reflection seismics with the aim of reducing the influence of the user’s subjectivity on the picking results and making the interpretation faster with respect to manual and semiautomated techniques. Our picking procedure uses the cosine of the instantaneous phase to automatically detect and mark as a horizon any recorded event characterized by lateral phase continuity. A patching procedure, which exploits horizon parallelism, can be used to connect consecutive horizons marking the same event but separated by noise-related gaps. The picking process marks all coherent events regardless of their reflection strength; therefore, a large number of independent horizons can be constructed. To facilitate interpretation, horizons marking different phases of the same reflection can be automatically grouped together and specific horizons from each reflection can be selected using different possible methods. In the phase method, the algorithm reconstructs the reflected wavelets by averaging the cosine of the instantaneous phase along each horizon. The resulting wavelets are then locally analyzed and confronted through crosscorrelation, allowing the recognition and selection of specific reflection phases. In case the reflected wavelets cannot be recovered due to shape-altering processing or a low signal-to-noise ratio, the energy method uses the reflection strength to group together subparallel horizons within the same energy package and to select those satisfying either energy or arrival time criteria. These methods can be applied automatically to all the picked horizons or to horizons individually selected by the interpreter for specific analysis. We show examples of application to 2D reflection seismic data sets in complex geologic and stratigraphic conditions, critically reviewing the performance of the whole process.

scholarly journals Hydrodynamics characteristics of the small ships rudders

2020 ◽  
Vol 43 ◽  
pp. 21-26
Author(s):  
Dan Obreja
Keyword(s):  
Design Process ◽  
Computer Code ◽  
Short Description ◽  
Research Centre ◽  
Research Activities ◽  
Optimum Position ◽  
Practical Research ◽  
Small Ship ◽  
Control Forces ◽  
Selection Of

The estimation of the hydrodynamics characteristics of the small ships rudders is an important issue in the initial design process. The manoeuvring performance depends on the type and geometry of the rudder. The control forces and moments generated by the rudder deflection can be calculated on the basis of the hydrodynamics characteristics of the rudder. A short description of the Mordvinov theoretical model is presented in this paper, in order to determine the hydrodynamics characteristics of a small ship rudder, with the propeller and hull influences. On the basis of the control forces and moments, the optimum position of the rudder stock and the selection of the steering gear can be performed. Using the Mordvinov method, the computer code PHP NM-MAN-HC was develop at the Research Centre of the Naval Architecture Faculty of “Dunarea de Jos” University of Galati. This computer code is integrated in the software platform PHP (Preliminary Hydrodynamics Performance) and is used for didactic applications and practical research activities in the small ship design process

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